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  1. Book: Metabolism of human diseases

    Lammert, Eckhard / Zeeb, Martin

    organ physiology and pathophysiology

    (Biomedicine)

    2014  

    Author's details Eckhard Lammert ; Martin Zeeb ed
    Series title Biomedicine
    Keywords Metabolism ; Metabolism--Disorders
    Subject code 612.39
    Language English
    Size IX, 416 S. : Ill., graph. Darst., 24 cm
    Publisher Springer
    Publishing place Wien u.a.
    Publishing country Austria
    Document type Book
    HBZ-ID HT018320421
    ISBN 978-3-7091-0714-0 ; 9783709107157 ; 3-7091-0714-8 ; 3709107156
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2014 A 2719 available for loan (reading room) Lesesaal EG

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  2. Book ; Online ; Thesis: Funktionelle Bedeutung attraktiver und repulsiver Signalwege für die Entwicklung des neuromuskulären Systems von Drosophila melanogaster

    Paul, Christine [Verfasser] / Aberle, Hermann [Gutachter] / Lammert, Eckhard [Gutachter]

    2024  

    Author's details Christine Paul ; Gutachter: Hermann Aberle, Eckhard Lammert
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language German
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  3. Book ; Online ; Thesis: Role of Human T Cells in Experimental Hypertension and Hypertensive Kidney Damage

    Rahman, Masudur [Verfasser] / Stegbauer, Johannes [Gutachter] / Lammert, Eckhard [Gutachter]

    2024  

    Author's details Masudur Rahman ; Gutachter: Johannes Stegbauer, Eckhard Lammert
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  4. Article ; Online: Role of vasodilation in liver regeneration and health.

    Große-Segerath, Linda / Lammert, Eckhard

    Biological chemistry

    2021  Volume 402, Issue 9, Page(s) 1009–1019

    Abstract: Recently, we have shown that an enhanced blood flow through the liver triggers hepatocyte proliferation and thereby liver growth. In this review, we first explain the literature on hepatic blood flow and its changes after partial hepatectomy (PHx), ... ...

    Abstract Recently, we have shown that an enhanced blood flow through the liver triggers hepatocyte proliferation and thereby liver growth. In this review, we first explain the literature on hepatic blood flow and its changes after partial hepatectomy (PHx), before we present the different steps of liver regeneration that take place right after the initial hemodynamic changes induced by PHx. Those parts of the molecular mechanisms governing liver regeneration, which are directly associated with the hepatic vascular system, are subsequently reviewed. These include β1 integrin-dependent mechanotransduction in liver sinusoidal endothelial cells (LSECs), triggering mechanically-induced activation of the vascular endothelial growth factor receptor-3 (VEGFR3) and matrix metalloproteinase-9 (MMP9) as well as release of growth-promoting angiocrine signals. Finally, we speculate how advanced age and obesity negatively affect the hepatic vasculature and thus liver regeneration and health, and we conclude our review with some recent technical progress in the clinic that employs liver perfusion. In sum, the mechano-elastic properties and alterations of the hepatic vasculature are key to better understand and influence liver health, regeneration, and disease.
    MeSH term(s) Animals ; Endothelial Cells ; Liver Regeneration ; Mechanotransduction, Cellular ; Mice ; Vasodilation
    Language English
    Publishing date 2021-04-27
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1334659-3
    ISSN 1437-4315 ; 1431-6730 ; 1432-0355
    ISSN (online) 1437-4315
    ISSN 1431-6730 ; 1432-0355
    DOI 10.1515/hsz-2021-0155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.50: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Book ; Online ; Thesis: Investigating the role of very long chain sphingolipids in pancreatic beta cell demise

    Grieß, Kerstin [Verfasser] / Lammert, Eckhard [Gutachter] / Burkart, Volker [Gutachter]

    2023  

    Author's details Kerstin Grieß ; Gutachter: Eckhard Lammert, Volker Burkart
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  6. Article: Novel Approaches to Restore Pancreatic Beta-Cell Mass and Function.

    Welters, Alena / Lammert, Eckhard

    Handbook of experimental pharmacology

    2021  Volume 274, Page(s) 439–465

    Abstract: Beta-cell dysfunction and beta-cell death are critical events in the development of type 2 diabetes mellitus (T2DM). Therefore, the goals of modern T2DM management have shifted from merely restoring normoglycemia to maintaining or regenerating beta-cell ... ...

    Abstract Beta-cell dysfunction and beta-cell death are critical events in the development of type 2 diabetes mellitus (T2DM). Therefore, the goals of modern T2DM management have shifted from merely restoring normoglycemia to maintaining or regenerating beta-cell mass and function. In this review we summarize current and novel approaches to achieve these goals, ranging from lifestyle interventions to N-methyl-D-aspartate receptor (NMDAR) antagonism, and discuss the mechanisms underlying their effects on beta-cell physiology and glycemic control. Notably, timely intervention seems critical, but not always strictly required, to maximize the effect of any approach on beta-cell recovery and disease progression. Conventional antidiabetic medications are not disease-modifying in the sense that the disease does not progress or reoccur while on treatment or thereafter. More invasive approaches, such as bariatric surgery, are highly effective in restoring normoglycemia, but are reserved for a rather small proportion of obese individuals and sometimes associated with serious adverse events. Finally, we recapitulate the broad range of effects mediated by peripheral NMDARs and discuss recent evidence on the potential of NMDAR antagonists to be developed as a novel class of antidiabetic drugs. In the future, a more refined assessment of disease risk or disease subtype might enable more targeted therapies to prevent or treat diabetes.
    MeSH term(s) Diabetes Mellitus, Type 2/drug therapy ; Humans ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Insulin/metabolism ; Insulin-Secreting Cells/physiology ; Receptors, N-Methyl-D-Aspartate
    Chemical Substances Hypoglycemic Agents ; Insulin ; Receptors, N-Methyl-D-Aspartate
    Language English
    Publishing date 2021-06-11
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/164_2021_474
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues
     danach: Sign. bei den Einzelbänden: Show issues

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  7. Article ; Online: The N-Methyl-D-Aspartate Receptor Antagonist Dextromethorphan Improves Glucose Homeostasis and Preserves Pancreatic Islets in NOD Mice.

    Wörmeyer, Laura / Nortmann, Oliver / Hamacher, Anna / Uhlemeyer, Celina / Belgardt, Bengt / Eberhard, Daniel / Mayatepek, Ertan / Meissner, Thomas / Lammert, Eckhard / Welters, Alena

    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

    2024  Volume 56, Issue 3, Page(s) 223–234

    Abstract: For treatment of type 1 diabetes mellitus, a combination of immune-based interventions and medication to promote beta-cell survival and proliferation has been proposed. Dextromethorphan (DXM) is ... ...

    Abstract For treatment of type 1 diabetes mellitus, a combination of immune-based interventions and medication to promote beta-cell survival and proliferation has been proposed. Dextromethorphan (DXM) is an
    MeSH term(s) Mice ; Animals ; Diabetes Mellitus, Type 2 ; Mice, Inbred NOD ; Dextromethorphan/pharmacology ; Dextromethorphan/therapeutic use ; Receptors, N-Methyl-D-Aspartate/therapeutic use ; Diabetes Mellitus, Type 1/drug therapy ; Insulin ; Islets of Langerhans ; Blood Glucose ; Homeostasis
    Chemical Substances Dextromethorphan (7355X3ROTS) ; Receptors, N-Methyl-D-Aspartate ; Insulin ; Blood Glucose
    Language English
    Publishing date 2024-01-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80125-2
    ISSN 1439-4286 ; 0018-5043
    ISSN (online) 1439-4286
    ISSN 0018-5043
    DOI 10.1055/a-2236-8625
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 681: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Book ; Online ; Thesis: Attenuation of VEGFR3 activity by intracellular versus extracellular mechanisms

    Hilger, Laura Sophie [Verfasser] / Lammert, Eckhard [Gutachter] / Gödecke, Axel [Gutachter]

    2022  

    Author's details Laura Sophie Hilger ; Gutachter: Eckhard Lammert, Axel Gödecke
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  9. Article ; Online: The Role of the Islet Niche on Beta Cell Structure and Function.

    Lammert, Eckhard / Thorn, Peter

    Journal of molecular biology

    2019  Volume 432, Issue 5, Page(s) 1407–1418

    Abstract: The islets of Langerhans or pancreatic islets are pivotal in the control of blood glucose and are complex microorgans embedded within the larger volume of the exocrine pancreas. Humans can have ~3.2 million islets [1] which, to our current knowledge, ... ...

    Abstract The islets of Langerhans or pancreatic islets are pivotal in the control of blood glucose and are complex microorgans embedded within the larger volume of the exocrine pancreas. Humans can have ~3.2 million islets [1] which, to our current knowledge, function in a similar manner to sense circulating blood glucose levels and respond with the secretion of a mix of different hormones that act to maintain glucose concentrations around a specific set point [2]. At a cellular level, the control of hormone secretion by glucose and other secretagogues is well-understood [3]. The key signal cascades have been identified and many details of the secretory process are known. However, if we shift focus from single cells and consider cells within intact islets, we do not have a comprehensive model as to how the islet environment influences cell function and how the islets work as a whole. This is important because there is overwhelming evidence that the structure and function of the individual endocrine cells are dramatically affected by the islet environment [4,5]. Uncovering the influence of this islet niche might drive future progress in treatments for Type 2 diabetes [6] and cell replacement therapies for Type 1 diabetes [7]. In this review, we focus on the insulin secreting beta cells and their interactions with the immediate environment that surrounds them including endocrine-endocrine interactions and contacts with capillaries.
    MeSH term(s) Animals ; Capillaries ; Cell Communication ; Diabetes Mellitus, Type 1 ; Diabetes Mellitus, Type 2 ; Extracellular Matrix/physiology ; Glucose/metabolism ; Humans ; Insulin Secretion/physiology ; Insulin-Secreting Cells/cytology ; Insulin-Secreting Cells/physiology ; Islets of Langerhans/cytology ; Islets of Langerhans/metabolism ; Signal Transduction
    Chemical Substances Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2019-11-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80229-3
    ISSN 1089-8638 ; 0022-2836
    ISSN (online) 1089-8638
    ISSN 0022-2836
    DOI 10.1016/j.jmb.2019.10.032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 867: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: The NMDA receptor regulates integrin activation, ATP release and arterial thrombosis through store-operated Ca

    Reusswig, Friedrich / Yilmaz, Münteha / Brechtenkamp, Marius / Krueger, Irena / Metz, Lisa Maria / Klöcker, Nikolaj / Lammert, Eckhard / Elvers, Margitta

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1171831

    Abstract: Introduction: Platelet activation and thrombus formation is crucial for hemostasis, but also trigger arterial thrombosis. Calcium mobilization plays an important role in platelet activation, because many cellular processes depend on the level of ... ...

    Abstract Introduction: Platelet activation and thrombus formation is crucial for hemostasis, but also trigger arterial thrombosis. Calcium mobilization plays an important role in platelet activation, because many cellular processes depend on the level of intracellular Ca
    Methods: In vitro
    Results: In this study, we analyzed
    Conclusion: NMDAR signaling is important for SOCE in platelets and contributes to platelet activation and arterial thrombosis. Thus, the NMDAR represents a novel target for anti-platelet therapy in cardiovascular disease (CVD).
    Language English
    Publishing date 2023-05-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1171831
    Database MEDical Literature Analysis and Retrieval System OnLINE

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