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  1. Article: Sources of energy for intestinal smooth muscle contraction.

    FURCHGOTT, R F / SHORR, E

    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)

    2010  Volume 61, Page(s) 280–286

    MeSH term(s) Gastrointestinal Motility ; Humans ; Intestines ; Muscle Contraction
    Language English
    Publishing date 2010-10-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 4015-0
    ISSN 1535-3699 ; 1525-1373 ; 0037-9727
    ISSN (online) 1535-3699 ; 1525-1373
    ISSN 0037-9727
    DOI 10.3181/00379727-61-15300
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The effect of succinate on respiration and certain metabolic processes of mammalian tissues at low oxygen tensions in vitro.

    FURCHGOTT, R F / SHORR, E

    The Journal of biological chemistry

    2008  Volume 175, Issue 1, Page(s) 201–215

    MeSH term(s) Animals ; Cell Respiration ; In Vitro Techniques ; Oxygen ; Respiration ; Succinates ; Succinic Acid
    Chemical Substances Succinates ; Succinic Acid (AB6MNQ6J6L) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2008-03-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
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  3. Article: Endothelium-derived relaxing factor: discovery, early studies, and identification as nitric oxide.

    Furchgott, R F

    Bioscience reports

    1999  Volume 19, Issue 4, Page(s) 235–251

    MeSH term(s) Acetylcholine/metabolism ; Animals ; Aorta, Thoracic/metabolism ; Cyclic GMP/metabolism ; Endothelium, Vascular/metabolism ; Hemoglobins/metabolism ; Methylene Blue/metabolism ; Nitric Oxide/antagonists & inhibitors ; Nitric Oxide/chemistry ; Nitric Oxide/physiology ; Rabbits ; Time Factors ; Vasodilator Agents/metabolism
    Chemical Substances Hemoglobins ; Vasodilator Agents ; Nitric Oxide (31C4KY9ESH) ; Cyclic GMP (H2D2X058MU) ; Acetylcholine (N9YNS0M02X) ; Methylene Blue (T42P99266K)
    Language English
    Publishing date 1999-04-19
    Publishing country England
    Document type Lecture ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 764946-0
    ISSN 1573-4935 ; 0144-8463
    ISSN (online) 1573-4935
    ISSN 0144-8463
    DOI 10.1023/a:1020537506008
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  4. Article: Nitric oxide: from basic research on isolated blood vessels to clinical relevance in diabetes.

    Furchgott, R F

    Anales de la Real Academia Nacional de Medicina

    1998  Volume 115, Issue 2, Page(s) 317–331

    MeSH term(s) Animals ; Arteries/physiology ; Diabetes Mellitus/physiopathology ; Diabetes Mellitus, Experimental/physiopathology ; Diabetic Angiopathies/physiopathology ; Endothelium, Vascular/physiology ; Humans ; Insulin/physiology ; Muscle Relaxation/physiology ; Muscle, Smooth, Vascular/physiology ; Nitric Oxide/physiology ; Nitric Oxide Synthase/physiology ; Nitric Oxide Synthase Type II ; Rats ; Vasodilation
    Chemical Substances Insulin ; Nitric Oxide (31C4KY9ESH) ; NOS2 protein, human (EC 1.14.13.39) ; Nitric Oxide Synthase (EC 1.14.13.39) ; Nitric Oxide Synthase Type II (EC 1.14.13.39) ; Nos2 protein, rat (EC 1.14.13.39)
    Language English
    Publishing date 1998-07-21
    Publishing country Spain
    Document type Address
    ZDB-ID 732450-9
    ISSN 0034-0634
    ISSN 0034-0634
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The 1996 Albert Lasker Medical Research Awards. The discovery of endothelium-derived relaxing factor and its importance in the identification of nitric oxide.

    Furchgott, R F

    JAMA

    1996  Volume 276, Issue 14, Page(s) 1186–1188

    Abstract: The discovery of endothelium-derived relaxing factor (EDRF) and its importance in the identification of nitric oxide (NO) originated with studies using rabbit aorta to examine drug-receptor interactions in vascular smooth muscle. Smooth muscle relaxation ...

    Abstract The discovery of endothelium-derived relaxing factor (EDRF) and its importance in the identification of nitric oxide (NO) originated with studies using rabbit aorta to examine drug-receptor interactions in vascular smooth muscle. Smooth muscle relaxation by acetylcholine and a number of other agonists was found to be dependent on the presence of endothelial cells, which, when stimulated by the agonist, released a diffusable, very labile, nonprostanoid substance, termed EDRF, that acted on vascular smooth muscle cells to activate relaxation. The characteristics of EDRF, when released from endothelial cells, were similar to the characteristics of NO. It is now established that EDRF, either as NO or some related nitrosyl substance, has a major role in a variety of important biological processes, including the regulation of vascular tone, local blood flow, and blood pressure, inhibition of platelet aggregation and adhesion, and involvement in postischemic reperfusion, memory function, and central nervous system degenerative diseases.
    MeSH term(s) Animals ; Awards and Prizes ; History, 20th Century ; Humans ; Muscle, Smooth, Vascular/metabolism ; Muscle, Smooth, Vascular/physiology ; Nitric Oxide/biosynthesis ; Nitric Oxide/physiology ; Rabbits ; Research/history ; United States ; Vasodilation/drug effects ; Vasodilation/physiology
    Chemical Substances Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 1996-10-09
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0098-7484 ; 0254-9077 ; 0002-9955
    ISSN (online) 1538-3598
    ISSN 0098-7484 ; 0254-9077 ; 0002-9955
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  6. Article: A research trail over half a century.

    Furchgott, R F

    Annual review of pharmacology and toxicology

    1995  Volume 35, Page(s) 1–27

    Abstract: The author describes his major research activities from the time of his PhD thesis work (1937-1940) on properties of erythrocyte membranes to the present. His involvement in research on circulatory shock during World War II led to a continuing interest ... ...

    Abstract The author describes his major research activities from the time of his PhD thesis work (1937-1940) on properties of erythrocyte membranes to the present. His involvement in research on circulatory shock during World War II led to a continuing interest in the physiology and pharmacology of smooth muscle and cardiac muscle. From 1956 to 1978, his main areas of research were photorelaxation of blood vessels, factors influencing contractility of cardiac muscle, peripheral adrenergic mechanisms, and receptor theory. The major findings of his and his collaborators in these areas are described. He then recounts how an accidental finding in an experiment in 1978 on preparations of rabbit aorta eventually led to the discovery of endothelium dependent relaxation and the endothelium-derived relaxing factor (EDRF); and how additional findings led him to propose in 1986 that EDRF is nitric oxide.
    MeSH term(s) Animals ; History, 20th Century ; Muscle, Smooth/drug effects ; Muscle, Smooth/physiology ; Pharmacology/history ; United States
    Language English
    Publishing date 1995
    Publishing country United States
    Document type Autobiography ; Biography ; Historical Article ; Journal Article ; Portrait
    ZDB-ID 196587-6
    ISSN 1545-4304 ; 0362-1642
    ISSN (online) 1545-4304
    ISSN 0362-1642
    DOI 10.1146/annurev.pa.35.040195.000245
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  7. Article: Infra-red absorption spectra of steroids; estrogens.

    FURCHGOTT, R F / ROSENKRANTZ, H / SHORR, E

    The Journal of biological chemistry

    2008  Volume 164, Issue 2, Page(s) 621–630

    MeSH term(s) Estrogens ; Infrared Rays ; Steroids
    Chemical Substances Estrogens ; Steroids
    Language English
    Publishing date 2008-09-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
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  8. Article: Infra-red absorption spectra of steroids; androgens and related steroids.

    FURCHGOTT, F R / ROSENKRANTZ, H / SHORR, E

    The Journal of biological chemistry

    2008  Volume 163, Page(s) 375–386

    MeSH term(s) Androgens ; Steroids/chemistry
    Chemical Substances Androgens ; Steroids
    Language English
    Publishing date 2008-09-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
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  9. Article: High energy phosphates and the force of contraction of cardiac muscle.

    FURCHGOTT, R F / LEE, K S

    Circulation

    2003  Volume 24, Page(s) 416–432

    MeSH term(s) Heart/physiology ; Humans ; Myocardium ; Phosphates/metabolism
    Chemical Substances Phosphates
    Language English
    Publishing date 2003-06-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/01.cir.24.2.416
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  10. Article: Infra-red absorption spectra of steroids; adrenal cortical hormones and related steroids.

    FURCHGOTT, R F / ROSENKRANTZ, H / SHORR, E

    The Journal of biological chemistry

    2008  Volume 171, Issue 2, Page(s) 523–529

    MeSH term(s) Adrenal Cortex Hormones ; Steroids
    Chemical Substances Adrenal Cortex Hormones ; Steroids
    Language English
    Publishing date 2008-09-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
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    ISSN 0021-9258
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