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  1. Article ; Online: Multispectral stealth multilayer etched film structure based on ultrathin silver.

    Wang, Heyan / Ren, Yingzheng / Geng, Wenjing / Han, Lin / Zhang, Yilei / Zheng, Danni / Lu, Zhengang / Tan, Jiubin

    Optics letters

    2024  Volume 49, Issue 6, Page(s) 1508–1511

    Abstract: Spontaneous infrared radiation dissipation is a critical factor in facilitating object cooling, which influences the thermal stability and stealth efficacy of infrared stealth devices. Furthermore, the compatibility between efficient visible, infrared, ... ...

    Abstract Spontaneous infrared radiation dissipation is a critical factor in facilitating object cooling, which influences the thermal stability and stealth efficacy of infrared stealth devices. Furthermore, the compatibility between efficient visible, infrared, and radar stealth is challenging due to different camouflage principles in different bands. This Letter presents a five-layer etched film structure to achieve multispectral stealth, and the utilization of the high-quality ultrathin silver films enables highly efficient infrared selective emission. This etched film structure with few layers demonstrates potential applications in diverse domains, including multi-band anti-detection and multispectral manipulation.
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.519362
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Role of CXCR5

    Zhou, Juan / He, Xiaojing / Ou, Yangjing / Peng, Shuang / Li, Dan / Zhou, Qing / Fu, Jingli / Long, Yunzhu / Tan, Yingzheng

    Journal of viral hepatitis

    2023  Volume 30, Issue 8, Page(s) 638–645

    Abstract: The replication of HBV in hepatocytes can be effectively inhibited by lifelong antiviral therapy. Because of the long-term presence of HBV reservoirs, the virus rebound frequently occurs once the treatment is stopped, which poses a considerable obstacle ... ...

    Abstract The replication of HBV in hepatocytes can be effectively inhibited by lifelong antiviral therapy. Because of the long-term presence of HBV reservoirs, the virus rebound frequently occurs once the treatment is stopped, which poses a considerable obstacle to the complete removal of the virus. In terms of gene composition, regulation of B cell action and function, CXCR5
    MeSH term(s) Humans ; Hepatitis B virus ; CD8-Positive T-Lymphocytes ; Cytokines/metabolism ; B-Lymphocytes ; Hepatitis B/complications ; Receptors, CXCR5/genetics ; Receptors, CXCR5/metabolism
    Chemical Substances Cytokines ; CXCR5 protein, human ; Receptors, CXCR5
    Language English
    Publishing date 2023-05-02
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1212497-7
    ISSN 1365-2893 ; 1352-0504
    ISSN (online) 1365-2893
    ISSN 1352-0504
    DOI 10.1111/jvh.13840
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    Zs.A 4119: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Inhibition of HSPA8 by rifampicin contributes to ferroptosis via enhancing autophagy.

    Zhou, Juan / Tan, Yingzheng / Hu, Lingli / Fu, Jingli / Li, Dan / Chen, Jun / Long, Yunzhu

    Liver international : official journal of the International Association for the Study of the Liver

    2022  Volume 42, Issue 12, Page(s) 2889–2899

    Abstract: Background and aim: Rifampicin is the most common pathogenic factor in anti-tuberculosis drug-induced liver injury (AT-DILI), the mechanisms that it promotes hepatocyte damage in AT-DILI are not yet to be thoroughly elucidated. In this study, we ... ...

    Abstract Background and aim: Rifampicin is the most common pathogenic factor in anti-tuberculosis drug-induced liver injury (AT-DILI), the mechanisms that it promotes hepatocyte damage in AT-DILI are not yet to be thoroughly elucidated. In this study, we investigated the potential molecular mechanisms for ferroptosis involving rifampicin hepatotoxicity.
    Methods: Animal and cell injury models of rifampicin were constructed, and the toxicity of rifampicin was assessed by physicochemical staining and cell viability assay. Next, flow cytometry was employed to detect changes in ferroptosis-related markers, and Western blotting was used to detect protein expression. Then, the important role of autophagy and ferroptosis was verified with small molecule compound intervention.
    Results: We found that ferritinophagy-induced ferroptosis participates in the toxicity of rifampicin, and the mechanism is that rifampicin precisely activates high-throughput autophagy, which leads to the massive degradation of ferritin and the increase of free iron. Moreover, rifampicin exhibited conspicuous inhibition of Human 71 kDa heat shock cognate protein (HSPA8) that is intimately associated with Microtubule-associated protein light chain 3 isoform B (LC3B) expression, in turn, HSPA8 inducer attenuated intracellular autophagy flux. Of note, inducing HSPA8 or inhibition of autophagy and ferroptosis considerably relieved the hepatotoxicity of rifampicin in mouse model.
    Conclusions: The present study highlights the crucial roles of the HSPA8 and autophagy in ferroptotic cell death driving by rifampicin, particularly illumines multiple promising regulatory nodes for therapeutic interventions in diseases involving AT-DILI.
    MeSH term(s) Mice ; Animals ; Humans ; Ferroptosis ; Rifampin/pharmacology ; Autophagy ; Ferritins ; Microtubule-Associated Proteins/metabolism ; Chemical and Drug Induced Liver Injury/etiology ; HSC70 Heat-Shock Proteins/metabolism
    Chemical Substances Rifampin (VJT6J7R4TR) ; Ferritins (9007-73-2) ; Microtubule-Associated Proteins ; HSPA8 protein, human ; HSC70 Heat-Shock Proteins
    Language English
    Publishing date 2022-10-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.15459
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1632: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Observation and analysis of 26 cases of asymptomatic SARS-COV2 infection.

    Zhou, Juan / Tan, Yingzheng / Li, Dan / He, Xiaojin / Yuan, Ting / Long, Yunzhu

    The Journal of infection

    2020  Volume 81, Issue 1, Page(s) e69–e70

    MeSH term(s) Asymptomatic Infections ; COVID-19 ; Humans ; Pneumonia ; RNA, Viral ; SARS-CoV-2
    Chemical Substances RNA, Viral
    Keywords covid19
    Language English
    Publishing date 2020-04-03
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2020.03.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1501: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 48: Show issues

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  5. Article ; Online: Role of eosinophils in the diagnosis and prognostic evaluation of COVID-19.

    Tan, Yingzheng / Zhou, Juan / Zhou, Qing / Hu, Lingli / Long, Yunzhu

    Journal of medical virology

    2020  Volume 93, Issue 2, Page(s) 1105–1110

    Abstract: Severe acute respiratory syndrome coronavirus 2 is responsible for the coronavirus disease 2019 (COVID-19) epidemic, which has severely affected global public health security. However, the diagnosis and treatment of the disease need further exploration. ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 is responsible for the coronavirus disease 2019 (COVID-19) epidemic, which has severely affected global public health security. However, the diagnosis and treatment of the disease need further exploration. Therefore, this retrospective analysis was conducted on multiple indicators of peripheral blood in patients with COVID-19 to determine the role of leukocytes, lymphocytes, and eosinophils in the diagnosis and prognostic evaluation of COVID-19. Baseline information and clinical records of 40 patients were collected, including demographic data, disease status, medication, and laboratory routine. The correlation between the inspection indicators and disease classification, as well as prognostic factors, was analyzed. Decreased eosinophils were detected in 33 out of 40 patients with COVID-19 on admission, while lymphocytes and eosinophils were inversely related to the severity of the disease, according to the Spearman's correlation coefficient. Thus, it could be deduced that eosinophils have better sensitivity for the diagnosis of COVID-19 and play a major role similar to lymphocytes in assessing the prognosis of patients.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; COVID-19/blood ; COVID-19/diagnosis ; COVID-19/immunology ; Eosinophils/immunology ; Humans ; Length of Stay/statistics & numerical data ; Lymphocytes/immunology ; Middle Aged ; Neutrophils/immunology ; Prognosis ; Retrospective Studies ; Statistics, Nonparametric ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-09-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26506
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Role of eosinophils in the diagnosis and prognostic evaluation of COVID‐19

    Tan, Yingzheng / Zhou, Juan / Zhou, Qing / Hu, Lingli / Long, Yunzhu

    Journal of Medical Virology ; ISSN 0146-6615 1096-9071

    2020  

    Keywords Virology ; Infectious Diseases ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1002/jmv.26506
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Effects of growth hormone/estrogen/androgen on COVID-19-type proinflammatory responses in normal human lung epithelial BEAS-2B cells.

    Zhu, Zemin / Zhao, Zhijian / Chen, Xun / Chu, Zhou / He, Yi / Tan, Yingzheng / Zhou, Juan / Tang, Caixi

    BMC molecular and cell biology

    2022  Volume 23, Issue 1, Page(s) 42

    Abstract: Background: COVID-19 is a disease caused by SARS-CoV-2, which can cause mild to serious infections in humans. We aimed to explore the effect of growth hormone (GH)/estrogen/androgen in normal human lung epithelial BEAS-2B cells on COVID-19-type ... ...

    Abstract Background: COVID-19 is a disease caused by SARS-CoV-2, which can cause mild to serious infections in humans. We aimed to explore the effect of growth hormone (GH)/estrogen/androgen in normal human lung epithelial BEAS-2B cells on COVID-19-type proinflammatory responses.
    Methods: A BEAS-2B COVID-19-like proinflammatory cell model was constructed. After that, the cells were treated with GH, 17β-estradiol (E2), and testosterone (Tes) for 24 h. CCK-8 assays were utilized to evaluate cell viability. The mRNA expression of ACE2, AGTR1, TMRRSS2, and ISG15 and the protein expression of ACE2, AGTR1, TMRRSS2, and ISG15 were measured by qRT‒PCR and Western blotting, respectively. ELISAs were performed to determine IL-6, MCP-1, MDA and SOD expression. Flow cytometry was used to measure ROS levels. Finally, MAPK/NF-κB pathway-related factor expression was evaluated.
    Results: The COVID-19-type proinflammatory model was successfully constructed, and 1000 ng/mL RBD treatment for 24 h was selected as the condition for the model group for subsequent experiments. After RBD treatment, cell viability decreased, the mRNA expression of ACE2, AGTR1, TMRRSS2, and ISG15 and the protein expression of ACE2, AGTR1, TMRRSS2, and ISG15 increased, IL-6, MCP-1, MDA and ROS levels increased, and MDA levels decreased. The mRNA levels of MAPK14 and RELA increased, but the protein levels did not change significantly. In addition, phospho-MAPK14 and phospho-RELA protein levels were also increased. Among the tested molecules, E2 had the most pronounced effect, followed by GH, while Tes showed the opposite effect.
    Conclusion: GH/E2 alleviated inflammation in a COVID-19-type proinflammatory model, but Tes showed the opposite effect.
    MeSH term(s) Androgens ; Angiotensin-Converting Enzyme 2 ; COVID-19/drug therapy ; Estradiol/pharmacology ; Estrogens ; Growth Hormone ; Humans ; Interleukin-6 ; Lung ; Mitogen-Activated Protein Kinase 14 ; NF-kappa B ; Reactive Oxygen Species ; SARS-CoV-2 ; Sincalide ; Superoxide Dismutase ; Testosterone
    Chemical Substances Androgens ; Estrogens ; Interleukin-6 ; NF-kappa B ; Reactive Oxygen Species ; Testosterone (3XMK78S47O) ; Estradiol (4TI98Z838E) ; Growth Hormone (9002-72-6) ; Superoxide Dismutase (EC 1.15.1.1) ; Mitogen-Activated Protein Kinase 14 (EC 2.7.11.24) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Sincalide (M03GIQ7Z6P)
    Language English
    Publishing date 2022-09-29
    Publishing country England
    Document type Journal Article
    ISSN 2661-8850
    ISSN (online) 2661-8850
    DOI 10.1186/s12860-022-00442-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Role of eosinophils in the diagnosis and prognostic evaluation of COVID-19

    Tan, Yingzheng / Zhou, Juan / Zhou, Qing / Hu, Lingli / Long, Yunzhu

    J. med. virol

    Abstract: Severe acute respiratory syndrome coronavirus 2 is responsible for the coronavirus disease 2019 (COVID-19) epidemic, which has severely affected global public health security. However, the diagnosis and treatment of the disease need further exploration. ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 is responsible for the coronavirus disease 2019 (COVID-19) epidemic, which has severely affected global public health security. However, the diagnosis and treatment of the disease need further exploration. Therefore, this retrospective analysis was conducted on multiple indicators of peripheral blood in patients with COVID-19 to determine the role of leukocytes, lymphocytes, and eosinophils in the diagnosis and prognostic evaluation of COVID-19. Baseline information and clinical records of 40 patients were collected, including demographic data, disease status, medication, and laboratory routine. The correlation between the inspection indicators and disease classification, as well as prognostic factors, was analyzed. Decreased eosinophils were detected in 33 out of 40 patients with COVID-19 on admission, while lymphocytes and eosinophils were inversely related to the severity of the disease, according to the Spearman's correlation coefficient. Thus, it could be deduced that eosinophils have better sensitivity for the diagnosis of COVID-19 and play a major role similar to lymphocytes in assessing the prognosis of patients.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #754794
    Database COVID19

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  10. Article: Lumbar infection caused by

    Tan, Ying-Zheng / Yuan, Ting / Tan, Liang / Tian, Yu-Qiu / Long, Yun-Zhu

    World journal of clinical cases

    2021  Volume 9, Issue 29, Page(s) 8879–8887

    Abstract: Background: Mycobacterium paragordonae: Case summary: Herein, we report the case of a 53-year-old patient who presented with fever and low back pain. Lumbar nuclear magnetic resonance imaging revealed the destruction of the lumbar vertebra with ... ...

    Abstract Background: Mycobacterium paragordonae
    Case summary: Herein, we report the case of a 53-year-old patient who presented with fever and low back pain. Lumbar nuclear magnetic resonance imaging revealed the destruction of the lumbar vertebra with peripheral abscess formation. After anti-infective and diagnostic anti-tuberculosis treatment, the patient had no further fever, but the back pain was not relieved. Postoperatively, the necrotic material was sent for pathological examination, and all tests related to tuberculosis were negative, but pus culture suggested nontuberculous mycobacteria. The necrotic tissue specimens were subjected to metagenomic next-generation sequencing, which indicated the presence of
    Conclusion: M. paragordonae
    Language English
    Publishing date 2021-10-22
    Publishing country United States
    Document type Case Reports
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v9.i29.8879
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