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Article: New Onset of Giant Cell Arteritis following ChAdOx1-S (Vaxevria

Lo Sardo, Luca / Parisi, Simone / Ditto, Maria Chiara / De Giovanni, Rosanna / Maletta, Francesca / Grimaldi, Serena / Brussino, Luisa / Fusaro, Enrico

Vaccines

2023 Volume 11, Issue 2

Abstract: ... the second dose of the SARS-CoV-2 vaccine (ChAdOx1-S) administration. Laboratory findings showed an elevated ...

Abstract	We report a 78-year-old man presenting with persistent headaches in vertex and temporo-parietal area; fatigue, worsening after walking; jaw claudication; scotomas; pharyngodynia; and dry cough after the second dose of the SARS-CoV-2 vaccine (ChAdOx1-S) administration. Laboratory findings showed an elevated C-reactive protein level and FDG-CT PET showed evidence of active large vessel vasculitis with diffuse abnormal artery uptake. Under suspicion of vasculitis, a temporal arteries biopsy was performed; the histopathologic findings demonstrated the transmural inflammatory infiltrate with giant cells, compatible with giant cell arteritis. Although the overall incidence of vaccine-triggered autoimmunity is low, rheumatologists worldwide should be aware of autoimmune diseases as a new potential adverse event of vaccines.
Language	English
Publishing date	2023-02-13
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines11020434
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effects of bisphenol S and bisphenol F on human spermatozoa: An in vitro study.

Castellini, Chiara / Di Giammarco, Noemi / D'Andrea, Settimio / Parisi, Antonio / Totaro, Maria / Francavilla, Sandro / Francavilla, Felice / Barbonetti, Arcangelo

Reproductive toxicology (Elmsford, N.Y.)

2021 Volume 103, Page(s) 58–63

Abstract: ... with several human health disorders. Accordingly, some restrictions on its use have been recommended. Bisphenol S (BPS) and ...

Abstract	Bisphenol A (BPA), the main chemical monomer of epoxy resins and polycarbonate plastics, has generated concerns about its endocrine disruptor properties, along with the reported possible links with several human health disorders. Accordingly, some restrictions on its use have been recommended. Bisphenol S (BPS) and bisphenol F (BPF) are the main replacements to BPA, with which they share homologies in chemical structure. However, to date, little is known about their possible adverse effects for human reproduction. As the in vitro exposure of human spermatozoa to BPA induces oxidative/pro-apoptotic effects, the aim of the present study was to verify whether BPS and BPF could represent safer compounds for human sperm functions. The exposure of motile sperm suspensions to scalar concentrations of BPS or BPF for 4 h did not significantly reduce sperm motility (as assessed by computer-aided semen analysis) and viability. At flow cytometry, no changes in mitochondrial membrane potential, or mitochondrial generation of reactive oxygen species were detected by using the JC-1 and MitoSOX red probes, respectively. Interestingly, it nor even the combination of both BPS and BPF at the highest concentrations impaired sperm mitochondrial functions. In conclusion, BPS and BPF seem to be safer alternatives to BPA for sperm biology, as they do not affect mitochondrial functions, sperm motility and viability. These findings could help regulatory agencies to identify more secure chemicals to replace BPA in industrial production of plastics.
MeSH term(s)	Benzhydryl Compounds/toxicity ; Endocrine Disruptors/toxicity ; Humans ; Male ; Mitochondria ; Oxidative Stress ; Phenols/toxicity ; Reactive Oxygen Species ; Sperm Motility ; Spermatozoa/drug effects ; Sulfones/toxicity
Chemical Substances	Benzhydryl Compounds ; Endocrine Disruptors ; Phenols ; Reactive Oxygen Species ; Sulfones ; bisphenol F ; bis(4-hydroxyphenyl)sulfone (80-09-1) ; bisphenol A (MLT3645I99)
Language	English
Publishing date	2021-06-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639342-1
ISSN	1873-1708 ; 0890-6238
ISSN (online)	1873-1708
ISSN	0890-6238
DOI	10.1016/j.reprotox.2021.05.011
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Article ; Online: The Relationship of Alcohol to ART Adherence Among Black MSM in the U.S.: Is it Any Different Among Black MSM in the South?

Canidate, Shantrel S / Schrimshaw, Eric W / Schaefer, Nancy / Gebru, Nioud Mulugeta / Powers, Noelani / Maisto, Stephen / Parisi, Christina / Leeman, Robert F / Fields, Sheldon / Cook, Robert L

AIDS and behavior

2021 Volume 25, Issue Suppl 3, Page(s) 302–313

Abstract: ... S.-particularly in the southern U.S.-despite the availability of antiretroviral therapy (ART ... MSM in the U.S. and in the South and to identify future research needs. A systematic review was ... adherence among Black MSM in the U.S. The search identified 240 articles, the study team reviewed 114 ...

Abstract	Alcohol-using Black MSM (Men who have sex with men) are disproportionately impacted by HIV in the U.S.-particularly in the southern U.S.-despite the availability of antiretroviral therapy (ART). The purpose of this study was to summarize the current evidence on alcohol use and ART adherence among Black MSM in the U.S. and in the South and to identify future research needs. A systematic review was conducted using eight databases to identify relevant peer-reviewed articles published between January 2010 and April 2021. The authors also snowballed remaining studies and hand-searched for additional studies. Including both quantitative and qualitative studies, five published studies examined alcohol and ART adherence among Black MSM in the U.S. The search identified 240 articles, the study team reviewed 114 in full-text and determined that only five met the inclusion criteria. Three of the five included studies identified alcohol use as a barrier to ART adherence. In conclusions, the general lack of literature on HIV disparities among alcohol-using Black MSM in the U.S. (specifically in the South) indicates a critical need for research on this population's unique risks and needs to inform the development of tailored interventions.
MeSH term(s)	African Americans ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Homosexuality, Male ; Humans ; Male ; Sexual and Gender Minorities ; Text Messaging
Language	English
Publishing date	2021-11-06
Publishing country	United States
Document type	Journal Article ; Systematic Review
ZDB-ID	1339885-4
ISSN	1573-3254 ; 1090-7165
ISSN (online)	1573-3254
ISSN	1090-7165
DOI	10.1007/s10461-021-03479-3
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Article ; Online: Crowdsourcing digital health measures to predict Parkinson’s disease severity

Solveig K. Sieberts / Jennifer Schaff / Marlena Duda / Bálint Ármin Pataki / Ming Sun / Phil Snyder / Jean-Francois Daneault / Federico Parisi / Gianluca Costante / Udi Rubin / Peter Banda / Yooree Chae / Elias Chaibub Neto / E. Ray Dorsey / Zafer Aydın / Aipeng Chen / Laura L. Elo / Carlos Espino / Enrico Glaab /

Ethan Goan / Fatemeh Noushin Golabchi / Yasin Görmez / Maria K. Jaakkola / Jitendra Jonnagaddala / Riku Klén / Dongmei Li / Christian McDaniel / Dimitri Perrin / Thanneer M. Perumal / Nastaran Mohammadian Rad / Erin Rainaldi / Stefano Sapienza / Patrick Schwab / Nikolai Shokhirev / Mikko S. Venäläinen / Gloria Vergara-Diaz / Yuqian Zhang / the Parkinson’s Disease Digital Biomarker Challenge Consortium / Yuanjia Wang / Yuanfang Guan / Daniela Brunner / Paolo Bonato / Lara M. Mangravite / Larsson Omberg

npj Digital Medicine, Vol 4, Iss 1, Pp 1-

the Parkinson’s Disease Digital Biomarker DREAM Challenge

2021 Volume 12

Abstract: ... symptom burden, particularly in the case of movement disorders like Parkinson’s disease (PD ...

Abstract	Abstract Consumer wearables and sensors are a rich source of data about patients’ daily disease and symptom burden, particularly in the case of movement disorders like Parkinson’s disease (PD). However, interpreting these complex data into so-called digital biomarkers requires complicated analytical approaches, and validating these biomarkers requires sufficient data and unbiased evaluation methods. Here we describe the use of crowdsourcing to specifically evaluate and benchmark features derived from accelerometer and gyroscope data in two different datasets to predict the presence of PD and severity of three PD symptoms: tremor, dyskinesia, and bradykinesia. Forty teams from around the world submitted features, and achieved drastically improved predictive performance for PD status (best AUROC = 0.87), as well as tremor- (best AUPR = 0.75), dyskinesia- (best AUPR = 0.48) and bradykinesia-severity (best AUPR = 0.95).
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7
Subject code	006
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: FURTHER CLARIFICATIONS ON THE MICRODOSIMETRIC D(Z) MODEL IN RESPONSE TO 'THE RECENT SUCCESS OF MICRODOSIMETRY' BY Y.S. HOROWITZ.

Parisi, Alessio

Radiation protection dosimetry

2020 Volume 189, Issue 4, Page(s) 534–538

Abstract: After a short review of the achievements of the Microdosimetric d(z) Model in describing and predicting the response of luminescent detectors for different exposure conditions, recent comments and suggestions are systematically addressed also in light of ...

Abstract	After a short review of the achievements of the Microdosimetric d(z) Model in describing and predicting the response of luminescent detectors for different exposure conditions, recent comments and suggestions are systematically addressed also in light of more recent findings.
MeSH term(s)	Radiometry
Language	English
Publishing date	2020-05-07
Publishing country	England
Document type	Journal Article
ZDB-ID	225912-6
ISSN	1742-3406 ; 0144-8420
ISSN (online)	1742-3406
ISSN	0144-8420
DOI	10.1093/rpd/ncaa055
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Article: Obesity, Pregnancy and the Social Contract with Today’s Adolescents

Berti, Cristiana / Elahi, Shirin / Catalano, Patrick / Bhutta, Zulfiqar A. / Krawinkel, Michael B. / Parisi, Francesca / Agostoni, Carlo / Cetin, Irene / Hanson, Mark

Nutrients. 2022 Aug. 28, v. 14, no. 17

2022

Abstract: ... contract with youth. The disruption of this contract is faced by today’s adolescents, with work, social and ... exposure to lifelong health risks, affecting their offspring’s life chances too. To break such vicious ... equity and healthy nutrition and environments for today’s adolescents. The involvement ...

Abstract	Adolescent health and well-being are of great concern worldwide, and adolescents encounter particular challenges, vulnerabilities and constraints. The dual challenges of adolescent parenthood and obesity are of public health relevance because of the life-altering health and socioeconomic effects on both the parents and the offspring. Prevention and treatment strategies at the individual and population levels have not been successful in the long term, suggesting that adolescent pregnancy and obesity cannot be managed by more of the same. Here, we view adolescent obese pregnancy through the lens of the social contract with youth. The disruption of this contract is faced by today’s adolescents, with work, social and economic dilemmas which perpetuate socioeconomic and health inequities across generations. The lack of employment, education and social opportunities, together with obesogenic settings, increase vulnerability and exposure to lifelong health risks, affecting their offspring’s life chances too. To break such vicious circles of disadvantage and achieve sustainable solutions in real-world settings, strong efforts on the part of policymakers, healthcare providers and the community must be oriented towards guaranteeing equity and healthy nutrition and environments for today’s adolescents. The involvement of adolescents themselves in developing such programs is paramount, not only so that they feel a sense of agency but also to better meet their real life needs.
Keywords	education ; employment ; health services ; nutrition ; obesity ; parenting ; pregnancy ; pregnant adolescents ; progeny ; public health ; youth
Language	English
Dates of publication	2022-0828
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14173550
Database	NAL-Catalogue (AGRICOLA)

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Article: Apparent Splitting of S Waves Propagating Through an Isotropic Lowermost Mantle.

Parisi, Laura / Ferreira, Ana M G / Ritsema, Jeroen

Journal of geophysical research. Solid earth

2018 Volume 123, Issue 5, Page(s) 3909–3922

Abstract: Observations of shear wave anisotropy are key for understanding the mineralogical structure and flow in the mantle. Several researchers have reported the presence of seismic anisotropy in the lowermost 150-250 km of the mantle (i.e., ... ...

Abstract	Observations of shear wave anisotropy are key for understanding the mineralogical structure and flow in the mantle. Several researchers have reported the presence of seismic anisotropy in the lowermost 150-250 km of the mantle (i.e., D
Language	English
Publishing date	2018-05-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2016813-5
ISSN	2169-9356 ; 2169-9313
ISSN (online)	2169-9356
ISSN	2169-9313
DOI	10.1002/2017JB014394
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Article ; Online: Why is there Socialism in the United States? Social Science and Industrial Society in Thorstein Veblen’s Line of Thought

Clemente Parisi

USAbroad, Vol 3, Iss

2020 Volume 1

Abstract: The article deals with Veblen’s vision of social conflict to critically reexamine his political ... organization and planning. These elements are used to highlight Veblen’s stance towards Progressive Era ...

Abstract	The article deals with Veblen’s vision of social conflict to critically reexamine his political thought. Retracing his intellectual biography, it focuses on three connected aspects: a twofold vision of social conflict that emerges from his reinvention of evolutionism; his reading of socialism in an industrial society; the relevance of an evolutionary concept of technology in order to understand new forms of conflict within the transition to a cooperative working process that is associated with scientific organization and planning. These elements are used to highlight Veblen’s stance towards Progressive Era social sciences and towards institutional and intellectual attempts to control the vagaries and conflicts of industrial capitalism.
Keywords	thorstein veblen ; united states ; social sciences ; industrial society ; technology ; History America ; E-F
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	University of Bologna
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: mHealth and wearable technology should replace motor diaries to track motor fluctuations in Parkinson’s disease

M. Kelley Erb / Daniel R. Karlin / Bryan K. Ho / Kevin C. Thomas / Federico Parisi / Gloria P. Vergara-Diaz / Jean-Francois Daneault / Paul W. Wacnik / Hao Zhang / Tairmae Kangarloo / Charmaine Demanuele / Chris R. Brooks / Craig N. Detheridge / Nina Shaafi Kabiri / Jaspreet S. Bhangu / Paolo Bonato

npj Digital Medicine, Vol 3, Iss 1, Pp 1-

2020 Volume 10

Abstract: ... with Parkinson’s disease (PD) is a major challenge, both during clinical management and when conducting clinical trials ...

Abstract	Abstract Accurately monitoring motor and non-motor symptoms as well as complications in people with Parkinson’s disease (PD) is a major challenge, both during clinical management and when conducting clinical trials investigating new treatments. A variety of strategies have been relied upon including questionnaires, motor diaries, and the serial administration of structured clinical exams like part III of the MDS-UPDRS. To evaluate the potential use of mobile and wearable technologies in clinical trials of new pharmacotherapies targeting PD symptoms, we carried out a project (project BlueSky) encompassing four clinical studies, in which 60 healthy volunteers (aged 23–69; 33 females) and 95 people with PD (aged 42–80; 37 females; years since diagnosis 1–24 years; Hoehn and Yahr 1–3) participated and were monitored in either a laboratory environment, a simulated apartment, or at home and in the community. In this paper, we investigated (i) the utility and reliability of self-reports for describing motor fluctuations; (ii) the agreement between participants and clinical raters on the presence of motor complications; (iii) the ability of video raters to accurately assess motor symptoms, and (iv) the dynamics of tremor, dyskinesia, and bradykinesia as they evolve over the medication cycle. Future papers will explore methods for estimating symptom severity based on sensor data. We found that 38% of participants who were asked to complete an electronic motor diary at home missed ~25% of total possible entries and otherwise made entries with an average delay of >4 h. During clinical evaluations by PD specialists, self-reports of dyskinesia were marked by ~35% false negatives and 15% false positives. Compared with live evaluation, the video evaluation of part III of the MDS-UPDRS significantly underestimated the subtle features of tremor and extremity bradykinesia, suggesting that these aspects of the disease may be underappreciated during remote assessments. On the other hand, live and video raters agreed on aspects ...
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7
Subject code	796
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: mHealth and wearable technology should replace motor diaries to track motor fluctuations in Parkinson’s disease

npj Digital Medicine, Vol 3, Iss 1, Pp 1-

2020 Volume 10

Abstract: ... with Parkinson’s disease (PD) is a major challenge, both during clinical management and when conducting clinical trials ...

Abstract	Abstract Accurately monitoring motor and non-motor symptoms as well as complications in people with Parkinson’s disease (PD) is a major challenge, both during clinical management and when conducting clinical trials investigating new treatments. A variety of strategies have been relied upon including questionnaires, motor diaries, and the serial administration of structured clinical exams like part III of the MDS-UPDRS. To evaluate the potential use of mobile and wearable technologies in clinical trials of new pharmacotherapies targeting PD symptoms, we carried out a project (project BlueSky) encompassing four clinical studies, in which 60 healthy volunteers (aged 23–69; 33 females) and 95 people with PD (aged 42–80; 37 females; years since diagnosis 1–24 years; Hoehn and Yahr 1–3) participated and were monitored in either a laboratory environment, a simulated apartment, or at home and in the community. In this paper, we investigated (i) the utility and reliability of self-reports for describing motor fluctuations; (ii) the agreement between participants and clinical raters on the presence of motor complications; (iii) the ability of video raters to accurately assess motor symptoms, and (iv) the dynamics of tremor, dyskinesia, and bradykinesia as they evolve over the medication cycle. Future papers will explore methods for estimating symptom severity based on sensor data. We found that 38% of participants who were asked to complete an electronic motor diary at home missed ~25% of total possible entries and otherwise made entries with an average delay of >4 h. During clinical evaluations by PD specialists, self-reports of dyskinesia were marked by ~35% false negatives and 15% false positives. Compared with live evaluation, the video evaluation of part III of the MDS-UPDRS significantly underestimated the subtle features of tremor and extremity bradykinesia, suggesting that these aspects of the disease may be underappreciated during remote assessments. On the other hand, live and video raters agreed on aspects of postural instability and gait. Our results highlight the significant opportunity for objective, high-resolution, continuous monitoring afforded by wearable technology to improve upon the monitoring of PD symptoms.
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7
Subject code	796
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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