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  1. Article ; Online: A new cardiology position in Bern, Switzerland.

    Rohr, Stephan

    European heart journal

    2018  Volume 39, Issue 17, Page(s) 1512–1513

    Language English
    Publishing date 2018-05-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehy206
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    Zs.A 1563: Show issues Location:
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    Zs.MO 640: Show issues

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  2. Article ; Online: Advancing mechanobiology by performing whole-cell patch clamp recording on mechanosensitive cells subjected simultaneously to dynamic stretch events.

    de Coulon, Etienne / Dellenbach, Christian / Rohr, Stephan

    iScience

    2021  Volume 24, Issue 2, Page(s) 102041

    Abstract: A comprehensive understanding of mechano-electrical coupling requires continuous intracellular electrical recordings being performed on cells undergoing ... ...

    Abstract A comprehensive understanding of mechano-electrical coupling requires continuous intracellular electrical recordings being performed on cells undergoing simultaneously
    Language English
    Publishing date 2021-01-07
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2021.102041
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  3. Article ; Online: Advancing Commotio cordis Safety Standards Using the Total Human Models for Safety (THUMS).

    Dickey, Grant James / Bian, Kewei / Islam, Sakib Ul / Khan, Habib R / Rohr, Stephan / Mao, Haojie

    Annals of biomedical engineering

    2023  Volume 51, Issue 9, Page(s) 2070–2085

    Abstract: Commotio cordis is one of the leading causes of sudden cardiac death in youth baseball. Currently, there are chest protector regulations regarding the prevention of Commotio cordis in baseball and lacrosse; however, they are not fully optimized. For the ... ...

    Abstract Commotio cordis is one of the leading causes of sudden cardiac death in youth baseball. Currently, there are chest protector regulations regarding the prevention of Commotio cordis in baseball and lacrosse; however, they are not fully optimized. For the advancement of Commotio cordis safety, it is vital to include various age groups and a variety of impact angles in the testing process. This study employed finite element models and simulated Commotio cordis-inducing baseball collisions for different velocities, impact angles, and age groups. Commotio cordis risk response was characterized in terms of left ventricular strain and pressure, chest band and rib deformation, and force from impact. Normalized rib and chest band deformation when correlated with left ventricular strain resulted in R
    MeSH term(s) Child ; Adolescent ; Humans ; Commotio Cordis/prevention & control ; Commotio Cordis/complications ; Ventricular Fibrillation ; Death, Sudden, Cardiac/etiology ; Death, Sudden, Cardiac/prevention & control ; Protective Devices ; Sports Equipment ; Wounds, Nonpenetrating
    Language English
    Publishing date 2023-05-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 185984-5
    ISSN 1573-9686 ; 0191-5649 ; 0090-6964
    ISSN (online) 1573-9686
    ISSN 0191-5649 ; 0090-6964
    DOI 10.1007/s10439-023-03235-9
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    Zs.A 1018: Show issues Location:
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  4. Book ; Thesis: Neugeborenen-Screening auf cystische Fibrose durch Bestimmung des Immun-Reaktiven-Trypsins aus Blutproben auf Filterpapierkarten

    Rohr, Stephan

    e. Studie an 12,100 Neugeborenen

    1987  

    Size 62 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Freie Univ., Diss., 1987
    HBZ-ID HT003240881
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    89 D 729 order for loan Magazin

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  5. Article ; Online: Arrhythmogenic implications of fibroblast-myocyte interactions.

    Rohr, Stephan

    Circulation. Arrhythmia and electrophysiology

    2012  Volume 5, Issue 2, Page(s) 442–452

    MeSH term(s) Animals ; Arrhythmias, Cardiac/etiology ; Arrhythmias, Cardiac/pathology ; Arrhythmias, Cardiac/physiopathology ; Cell Communication/physiology ; Electrophysiological Phenomena/physiology ; Fibrosis ; Humans ; Myocytes, Cardiac/pathology ; Myocytes, Cardiac/physiology ; Myofibroblasts/pathology ; Myofibroblasts/physiology ; Paracrine Communication/physiology
    Language English
    Publishing date 2012-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2426129-4
    ISSN 1941-3084 ; 1941-3149
    ISSN (online) 1941-3084
    ISSN 1941-3149
    DOI 10.1161/CIRCEP.110.957647
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    Zs.A 6667: Show issues Location:
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  6. Article ; Online: Advancing mechanobiology by performing whole-cell patch clamp recording on mechanosensitive cells subjected simultaneously to dynamic stretch events

    Etienne de Coulon / Christian Dellenbach / Stephan Rohr

    iScience, Vol 24, Iss 2, Pp 102041- (2021)

    2021  

    Abstract: Summary: A comprehensive understanding of mechano-electrical coupling requires continuous intracellular electrical recordings being performed on cells undergoing simultaneously in vivo like strain events. Here, we introduce a linear strain single-cell ... ...

    Abstract Summary: A comprehensive understanding of mechano-electrical coupling requires continuous intracellular electrical recordings being performed on cells undergoing simultaneously in vivo like strain events. Here, we introduce a linear strain single-cell electrophysiology (LSSE) system that meets these requirements by delivering highly reproducible unidirectional strain events with magnitudes up to 12% and strain rates exceeding 200%s−1 to adherent cells kept simultaneously in whole-cell patch-clamp recording configuration. Proof-of-concept measurements with NIH3T3 cells demonstrate that stable recording conditions are maintained over tens of strain cycles at maximal amplitudes and strain rates thereby permitting a full electrophysiological characterization of mechanically activated ion currents. Because mechano-electrical responses to predefined strain patterns can be investigated using any adherent wild-type or genetically modified cell type of interest, the LSSE system offers the perspective of providing advanced insights into mechanosensitive ion channel function that can finally be compared quantitatively among different types of channels and cells.
    Keywords Mechanobiology ; Cellular Neuroscience ; Techniques in Neuroscience ; Cell Biology ; Science ; Q
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
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  7. Article ; Online: Cardiac fibroblasts in cell culture systems: myofibroblasts all along?

    Rohr, Stephan

    Journal of cardiovascular pharmacology

    2011  Volume 57, Issue 4, Page(s) 389–399

    Abstract: The cytoarchitecture of the working myocardium is characterized by densely packed cardiomyocytes that are embedded in a three-dimensional network of numerous fibroblasts. Although the importance of cardiac fibroblasts in maintaining an orderly structured ...

    Abstract The cytoarchitecture of the working myocardium is characterized by densely packed cardiomyocytes that are embedded in a three-dimensional network of numerous fibroblasts. Although the importance of cardiac fibroblasts in maintaining an orderly structured extracellular matrix is well recognized, less is known about their potential paracrine and electrotonic interactions with cardiomyocytes. This is partly the result of the complex intermingling of both cell types in vivo that tends to preclude a direct investigation of heterocellular crosstalk. It is for that reason that most of our present knowledge regarding stromal-parenchymal cell interactions is based on culture systems that permit direct access to either cell type. An often disregarded feature of such studies is that cardiac fibroblasts in standard two-dimensional cell culture have a pronounced tendency to undergo a phenotype switch to myofibroblasts. This cell type typically appears in injured hearts where it contributes importantly to fibrotic remodeling. The present review focuses on recent insights into electrical and paracrine crosstalk between myofibroblasts and cardiomyocytes while acknowledging that a comprehensive understanding of stromal-parenchymal cell interactions will depend on future methodological developments that permit retaining the fibroblast phenotype in cell culture systems and that will, most importantly, allow direct investigations of heterocellular crosstalk in intact tissue.
    MeSH term(s) Animals ; Cell Culture Techniques ; Fibroblasts/metabolism ; Fibrosis ; Humans ; Myocardium/cytology ; Myocardium/metabolism ; Myocardium/pathology ; Myocytes, Cardiac/metabolism ; Myofibroblasts/metabolism ; Paracrine Communication ; Phenotype ; Stromal Cells/metabolism
    Language English
    Publishing date 2011-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 391970-5
    ISSN 1533-4023 ; 0160-2446
    ISSN (online) 1533-4023
    ISSN 0160-2446
    DOI 10.1097/FJC.0b013e3182137e17
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    Zs.A 1471: Show issues Location:
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  8. Article ; Online: Myofibroblasts in diseased hearts: new players in cardiac arrhythmias?

    Rohr, Stephan

    Heart rhythm

    2009  Volume 6, Issue 6, Page(s) 848–856

    Abstract: Cardiac pathologies leading to the development of organ fibrosis typically are associated with the appearance of interstitial myofibroblasts. This cell type plays a central role in excessive extracellular matrix deposition, thereby contributing to ... ...

    Abstract Cardiac pathologies leading to the development of organ fibrosis typically are associated with the appearance of interstitial myofibroblasts. This cell type plays a central role in excessive extracellular matrix deposition, thereby contributing to arrhythmogenic slow and discontinuous conduction by causing disorganization of the three-dimensional network of electrically coupled cardiomyocytes. Besides this involvement in structural remodeling, myofibroblasts recently have been discovered in-vitro to promote arrhythmogenesis by direct modification of cardiomyocyte electrophysiology following establishment of heterocellular electrical coupling. In particular, myofibroblasts were found to rescue impulse conduction between disjoined cardiac tissues by acting as passive electrical conduits for excitatory current flow. Although, in principle, such recovery of blocked conduction might be beneficial, propagation across myofibroblast conduits is substantially delayed, thereby promoting arrhythmogenic slow and discontinuous conduction. Second, moderately polarized myofibroblasts were found to induce cell density-dependent depolarization of cardiomyocytes, which causes arrhythmogenic slow conduction due to the reduction of fast inward currents. Finally, critical depolarization of cardiomyocytes by myofibroblasts was discovered to lead to the appearance of ectopic activity in a model of the infarct border zone. These findings obtained in vitro suggest that electrotonic interactions following gap junctional coupling between myofibroblasts and cardiomyocytes in structurally remodeled fibrotic hearts might directly initiate the main mechanisms underlying arrhythmogenesis, that is, abnormal automaticity and abnormal impulse conduction. If, in the future, similar arrhythmogenic mechanisms can be shown to be operational in intact hearts, myofibroblasts might emerge as a novel noncardiomyocyte target for antiarrhythmic therapy.
    MeSH term(s) Arrhythmias, Cardiac/etiology ; Arrhythmias, Cardiac/physiopathology ; Fibroblasts/pathology ; Fibroblasts/physiology ; Fibrosis/complications ; Fibrosis/physiopathology ; Humans ; Myocytes, Cardiac/pathology ; Myocytes, Cardiac/physiology ; Ventricular Remodeling
    Language English
    Publishing date 2009-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2009.02.038
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  9. Article ; Online: Enabling comprehensive optogenetic studies of mouse hearts by simultaneous opto-electrical panoramic mapping and stimulation.

    Rieger, Michael / Dellenbach, Christian / Vom Berg, Johannes / Beil-Wagner, Jane / Maguy, Ange / Rohr, Stephan

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 5804

    Abstract: During the last decade, cardiac optogenetics has turned into an essential tool for investigating cardiac function in general and for assessing functional interactions between different myocardial cell types in particular. To advance exploitation of the ... ...

    Abstract During the last decade, cardiac optogenetics has turned into an essential tool for investigating cardiac function in general and for assessing functional interactions between different myocardial cell types in particular. To advance exploitation of the unique research opportunities offered by this method, we develop a panoramic opto-electrical measurement and stimulation (POEMS) system for mouse hearts. The core of the experimental platform is composed of 294 optical fibers and 64 electrodes that form a cup which embraces the entire ventricular surface of mouse hearts and enables straightforward 'drop&go' experimentation. The flexible assignment of fibers and electrodes to recording or stimulation tasks permits a precise tailoring of experiments to the specific requirements of individual optogenetic constructs thereby avoiding spectral congestion. Validation experiments with hearts from transgenic animals expressing the optogenetic voltage reporters ASAP1 and ArcLight-Q239 demonstrate concordance of simultaneously recorded panoramic optical and electrical activation maps. The feasibility of single fiber optical stimulation is proven with hearts expressing the optogenetic voltage actuator ReaChR. Adaptation of the POEMS system to larger hearts and incorporation of additional sensors can be achieved by redesigning the system-core accordingly.
    MeSH term(s) Animals ; Electrophysiologic Techniques, Cardiac ; Heart/physiology ; Heart Rate ; Membrane Potentials ; Mice ; Mice, Transgenic ; Myocytes, Cardiac/physiology ; Optogenetics/instrumentation ; Optogenetics/methods ; Voltage-Sensitive Dye Imaging
    Language English
    Publishing date 2021-10-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-26039-8
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  10. Article ; Online: Enabling comprehensive optogenetic studies of mouse hearts by simultaneous opto-electrical panoramic mapping and stimulation

    Michael Rieger / Christian Dellenbach / Johannes vom Berg / Jane Beil-Wagner / Ange Maguy / Stephan Rohr

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 13

    Abstract: Current cardiac mapping systems provide either electrical or optical readouts. Here the authors report a panoramic opto-electrical measurement and stimulation (POEMS) system which embraces the entire ventricular surface of mouse hearts, allowing flexible ...

    Abstract Current cardiac mapping systems provide either electrical or optical readouts. Here the authors report a panoramic opto-electrical measurement and stimulation (POEMS) system which embraces the entire ventricular surface of mouse hearts, allowing flexible combinations of optical and electrical recording and stimulation modalities.
    Keywords Science ; Q
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
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