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Article ; Online: Study of vitamin D penetration in the human aqueous after topical administration.

Lorusso, Massimo / Micelli Ferrari, Luisa / Cicinelli, Maria Vittoria / Ciani, Saba / Ceci, Edmondo

2022 Volume 32, Issue 6, Page(s) 3693–3698

Abstract: Purpose: this study was designed to measure the concentration of Vitamin D in the aqueous and ... patients were instructed to instill one drop of vitamin D eye drops three times daily 10 days ... before surgery .Aqueous humor was collected with a 30-gauge needle immediately before surgery. Vitamin D ...

Abstract	Purpose: this study was designed to measure the concentration of Vitamin D in the aqueous and to investigate if its topical application can increase quantities in aqueous humor. Methods: 29 patients scheduled for cataract surgery were divided into two groups. Group 1 was used as a control group, in group 2 patients were instructed to instill one drop of vitamin D eye drops three times daily 10 days before surgery .Aqueous humor was collected with a 30-gauge needle immediately before surgery. Vitamin D concentrations were analyzed by liquid chromatography tandem mass spectrometry. Results: Aqueous humor (AH) samples in both groups had small but detectable vitamin D levels. In the AH concentrations of vitamin D were, respectively, 2.1ng/mL 0.4 in group 1 and 2.1ng/mL0.3 in group 2(P = 0.9). Conclusion: Our study confirmed the presence of vitamin D in AH. No significant difference of vitamin D concentration in AH was observed between the treatment and control group.
MeSH term(s)	Administration, Topical ; Aqueous Humor ; Cataract Extraction ; Chromatography, High Pressure Liquid ; Humans ; Ophthalmic Solutions ; Vitamin D/analysis
Chemical Substances	Ophthalmic Solutions ; Vitamin D (1406-16-2)
Language	English
Publishing date	2022-03-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	1089461-5
ISSN	1724-6016 ; 1120-6721
ISSN (online)	1724-6016
ISSN	1120-6721
DOI	10.1177/11206721221090800
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Article ; Online: First influenza D virus full-genome sequence retrieved from livestock in Namibia, Africa.

Molini, Umberto / Curini, Valentina / Jacobs, Eugene / Tongo, Eesie / Berjaoui, Shadia / Hemberger, Maria Yvonne / Puglia, Ilaria / Jago, Mark / Khaiseb, Siegfried / Cattoli, Giovanni / Dundon, William G / Lorusso, Alessio / Di Giallonardo, Francesca

Acta tropica

2022 Volume 232, Page(s) 106482

Abstract: Influenza D virus (IDV) was first isolated in 2011 in the USA and has since been shown to circulate ... Phylogenetic analysis of the HEF gene positioned the African virus variants within the D/OK lineage ... related to a different lineage (D/660), indicative of potential reassortment. This is the first genetic ...

Abstract	Influenza D virus (IDV) was first isolated in 2011 in the USA and has since been shown to circulate in cattle, pigs, sheep, wild boar, and camels. In Africa, there is limited data on the epidemiology of IDV and, so, we investigated the presence of IDV among domestic ruminants and wild animals in Namibia by screening nasal swabs using an IDV-specific molecular assay. IDV RNA was detected in bovines (n=2), giraffes (n=2) and wildebeest (n=1). The hemagglutinin-esterase-fusion (HEF) gene from one of the bovine and the wildebeest samples was successfully sequenced as well as the full genome for the second bovine sample. Phylogenetic analysis of the HEF gene positioned the African virus variants within the D/OK lineage but with a long branch. The African variant had an amino acid diversity of 2.41% and most likely represents a distinct genotype within the lineage. Notably, the polymerase acidic protein gene (PA) was more closely related to a different lineage (D/660), indicative of potential reassortment. This is the first genetic characterization of IDV in Africa and it adds important data to our understanding of the global IDV distribution.
MeSH term(s)	Animals ; Cattle ; Livestock ; Namibia/epidemiology ; Orthomyxoviridae Infections/epidemiology ; Orthomyxoviridae Infections/veterinary ; Phylogeny ; Sheep ; Swine ; Thogotovirus/genetics
Language	English
Publishing date	2022-05-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	210415-5
ISSN	1873-6254 ; 0001-706X
ISSN (online)	1873-6254
ISSN	0001-706X
DOI	10.1016/j.actatropica.2022.106482
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Article: The Vitamin D, IL-6 and the eGFR Markers a Possible Way to Elucidate the Lung-Heart-Kidney Cross-Talk in COVID-19 Disease: A Foregone Conclusion.

Balzanelli, Mario Giosuè / Distratis, Pietro / Lazzaro, Rita / Cefalo, Angelo / Catucci, Orazio / Aityan, Sergey Khachatur / Dipalma, Gianna / Vimercati, Luigi / Inchingolo, Alessio Danilo / Maggiore, Maria Elena / Mancini, Antonio / Santacroce, Luigi / Gesualdo, Loreto / Pham, Van Hung / Iacobone, Donatello / Contaldo, Maria / Serpico, Rosario / Scarano, Antonio / Lorusso, Felice /

Toai, Tran Cong / Tafuri, Silvio / Migliore, Giovanni / Inchingolo, Angelo Michele / Nguyen, Kieu Cao Diem / Inchingolo, Francesco / Tomassone, Diego / Gargiulo Isacco, Ciro

Microorganisms

2021 Volume 9, Issue 9

Abstract: ... accompanied by a severely low level of vitamin D, extremely high level of IL-6, and low ... by either a decreased level of vitamin D or the ageing process. The reduced presence of vitamin D was often found ... a low level of vitamin D and older age may be indicative of systemic worsening in patients with COVID-19 ...

Abstract	Background: Based on recent findings, we speculated the existence of the lung, heart, and kidney axis as the main pathway for the COVID-19 disease progression. Methods: This paper reports on an observational study conducted by a team of researchers and doctors of the 118-Pre-Hospital and Emergency Department of SG Moscati of Taranto City in Italy. The study was conducted on a totality of 185 participants that were divided into three groups. The study group included COVID-19 affected patients (PP Results: It was observed that the majority of COVID-19-infected patients showed a progressive multi-organ involvement, especially in regard to the lung, kidney, and heart. The majority of the COVID-19 patients exhibited preexisting comorbidities which include cardiovascular, respiratory, and renal disorders accompanied by a severely low level of vitamin D, extremely high level of IL-6, and low glomerular filtration rate (eGFR). The significant overall damages exerted by the immune-mediated responses under the hyper-expression of proinflammatory cytokines and interleukins, such as IL-6, may be facilitated by either a decreased level of vitamin D or the ageing process. The reduced presence of vitamin D was often found together with a reduced functionality of renal activity, as revealed by the low eGFR, and both were seen to be concomitant with an increased mortality risk in patients with lung disorders and heart failure (HF), whether it is showed at baseline or it develops during manifestation of COVID-19. Therefore, the documentation of the modifiable risk factors related to SARS-CoV-2 and lung impairment in older patients with kidney and heart disease may help the clinician to better manage the situation. Conclusions: This paper addresses how a low level of vitamin D and older age may be indicative of systemic worsening in patients with COVID-19, with a goal of providing a broader context in which to view a better therapeutic approach.
Language	English
Publishing date	2021-09-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms9091903
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Article: First influenza D virus full-genome sequence retrieved from livestock in Namibia, Africa

Acta tropica. 2022 Aug., v. 232

2022

Abstract	Influenza D virus (IDV) was first isolated in 2011 in the USA and has since been shown to circulate in cattle, pigs, sheep, wild boar, and camels. In Africa, there is limited data on the epidemiology of IDV and, so, we investigated the presence of IDV among domestic ruminants and wild animals in Namibia by screening nasal swabs using an IDV-specific molecular assay. IDV RNA was detected in bovines (n=2), giraffes (n=2) and wildebeest (n=1). The hemagglutinin-esterase-fusion (HEF) gene from one of the bovine and the wildebeest samples was successfully sequenced as well as the full genome for the second bovine sample. Phylogenetic analysis of the HEF gene positioned the African virus variants within the D/OK lineage but with a long branch. The African variant had an amino acid diversity of 2.41% and most likely represents a distinct genotype within the lineage. Notably, the polymerase acidic protein gene (PA) was more closely related to a different lineage (D/660), indicative of potential reassortment. This is the first genetic characterization of IDV in Africa and it adds important data to our understanding of the global IDV distribution.
Keywords	RNA ; amino acids ; cattle ; epidemiology ; genes ; genotype ; influenza ; nose ; phylogeny ; sheep ; viruses ; wild boars ; wildebeest ; Namibia
Language	English
Dates of publication	2022-08
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	210415-5
ISSN	1873-6254 ; 0001-706X
ISSN (online)	1873-6254
ISSN	0001-706X
DOI	10.1016/j.actatropica.2022.106482
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Article ; Online: The Vitamin D, IL-6 and the eGFR Markers a Possible Way to Elucidate the Lung–Heart–Kidney Cross-Talk in COVID-19 Disease

Mario Giosuè Balzanelli / Pietro Distratis / Rita Lazzaro / Angelo Cefalo / Orazio Catucci / Sergey Khachatur Aityan / Gianna Dipalma / Luigi Vimercati / Alessio Danilo Inchingolo / Maria Elena Maggiore / Antonio Mancini / Luigi Santacroce / Loreto Gesualdo / Van Hung Pham / Donatello Iacobone / Maria Contaldo / Rosario Serpico / Antonio Scarano / Felice Lorusso /

Tran Cong Toai / Silvio Tafuri / Giovanni Migliore / Angelo Michele Inchingolo / Kieu Cao Diem Nguyen / Francesco Inchingolo / Diego Tomassone / Ciro Gargiulo Isacco

Microorganisms, Vol 9, Iss 1903, p

A Foregone Conclusion

2021 Volume 1903

Abstract: ... of the current trial was focused on assessing the level of the vitamin D (serum 25(OH) D concentration), IL-6 ... accompanied by a severely low level of vitamin D, extremely high level of IL-6, and low ... by either a decreased level of vitamin D or the ageing process. The reduced presence of vitamin D was often found ...

Abstract	Background: Based on recent findings, we speculated the existence of the lung, heart, and kidney axis as the main pathway for the COVID-19 disease progression. Methods: This paper reports on an observational study conducted by a team of researchers and doctors of the 118-Pre-Hospital and Emergency Department of SG Moscati of Taranto City in Italy. The study was conducted on a totality of 185 participants that were divided into three groups. The study group included COVID-19 affected patients (PP n = 80), the first control group included patients with different pathologies (non-COVID-19 NNp n = 62) of the SG Moscati Hospital, and the second control group included healthy individuals (NNh n = 43). The core of the current trial was focused on assessing the level of the vitamin D (serum 25(OH) D concentration), IL-6, and the renal glomerular filtrate (eGFR) in COVID-19 disease and non-COVID-19 patients in both groups. Results: It was observed that the majority of COVID-19-infected patients showed a progressive multi-organ involvement, especially in regard to the lung, kidney, and heart. The majority of the COVID-19 patients exhibited preexisting comorbidities which include cardiovascular, respiratory, and renal disorders accompanied by a severely low level of vitamin D, extremely high level of IL-6, and low glomerular filtration rate (eGFR). The significant overall damages exerted by the immune-mediated responses under the hyper-expression of proinflammatory cytokines and interleukins, such as IL-6, may be facilitated by either a decreased level of vitamin D or the ageing process. The reduced presence of vitamin D was often found together with a reduced functionality of renal activity, as revealed by the low eGFR, and both were seen to be concomitant with an increased mortality risk in patients with lung disorders and heart failure (HF), whether it is showed at baseline or it develops during manifestation of COVID-19. Therefore, the documentation of the modifiable risk factors related to SARS-CoV-2 and lung ...
Keywords	vitamin D ; eGFR ; IL-6 ; SARS-CoV-2 ; Coronavirus 19 (COVID-19) ; lung–heart–kidney cross-talk ; Biology (General) ; QH301-705.5
Subject code	616
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The Vitamin D, IL-6 and the eGFR Markers a Possible Way to Elucidate the Lung–Heart–Kidney Cross-Talk in COVID-19 Disease: A Foregone Conclusion

Toai, Tran Cong / Tafuri, Silvio / Migliore, Giovanni / Inchingolo, Angelo Michele / Nguyen, Kieu Cao Diem / Inchingolo, Francesco / Tomassone, Diego / Gargiulo Isacco, Ciro

Microorganisms. 2021 Sept. 07, v. 9, no. 9

2021

Abstract	Background: Based on recent findings, we speculated the existence of the lung, heart, and kidney axis as the main pathway for the COVID-19 disease progression. Methods: This paper reports on an observational study conducted by a team of researchers and doctors of the 118-Pre-Hospital and Emergency Department of SG Moscati of Taranto City in Italy. The study was conducted on a totality of 185 participants that were divided into three groups. The study group included COVID-19 affected patients (PP n = 80), the first control group included patients with different pathologies (non-COVID-19 NNp n = 62) of the SG Moscati Hospital, and the second control group included healthy individuals (NNh n = 43). The core of the current trial was focused on assessing the level of the vitamin D (serum 25(OH) D concentration), IL-6, and the renal glomerular filtrate (eGFR) in COVID-19 disease and non-COVID-19 patients in both groups. Results: It was observed that the majority of COVID-19-infected patients showed a progressive multi-organ involvement, especially in regard to the lung, kidney, and heart. The majority of the COVID-19 patients exhibited preexisting comorbidities which include cardiovascular, respiratory, and renal disorders accompanied by a severely low level of vitamin D, extremely high level of IL-6, and low glomerular filtration rate (eGFR). The significant overall damages exerted by the immune-mediated responses under the hyper-expression of proinflammatory cytokines and interleukins, such as IL-6, may be facilitated by either a decreased level of vitamin D or the ageing process. The reduced presence of vitamin D was often found together with a reduced functionality of renal activity, as revealed by the low eGFR, and both were seen to be concomitant with an increased mortality risk in patients with lung disorders and heart failure (HF), whether it is showed at baseline or it develops during manifestation of COVID-19. Therefore, the documentation of the modifiable risk factors related to SARS-CoV-2 and lung impairment in older patients with kidney and heart disease may help the clinician to better manage the situation. Conclusions: This paper addresses how a low level of vitamin D and older age may be indicative of systemic worsening in patients with COVID-19, with a goal of providing a broader context in which to view a better therapeutic approach.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; blood serum ; disease progression ; filtrates ; glomerular filtration rate ; heart ; heart failure ; hospitals ; interleukin-6 ; kidneys ; lungs ; mortality ; observational studies ; therapeutics ; Italy
Language	English
Dates of publication	2021-0907
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms9091903
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Simultaneous determination of 1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl) uracil (FAU) and 1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl) 5-methyluracil (FMAU) in human plasma by liquid chromatography/tandem mass spectrometry.

Wiegand, Richard / Wu, Jianmei / Shields, Anthony F / Lorusso, Patricia / Li, Jing

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

2012 Volume 891-892, Page(s) 64–70

Abstract: ... validated for simultaneous determination of 1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl) uracil (FAU) and ... its active metabolite 1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl) 5-methyluracil (FMAU) in human plasma. FAU and FMAU ...

Abstract	A liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) assay was developed and validated for simultaneous determination of 1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl) uracil (FAU) and its active metabolite 1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl) 5-methyluracil (FMAU) in human plasma. FAU and FMAU were extracted from plasma samples using solid-phase extraction with Waters Sep-Pak® Vac C₁₈ cartridge. Chromatographic separation was achieved on a Waters Atlantis T3 C₁₈ column with a gradient mobile phase consisting of methanol and water with 0.45% formic acid (v/v) running at a flow rate of 0.2 ml/min. The analytes were monitored by triple quadrupole mass spectrometer under positive ionization mode. The lower limit of quantitation (LLOQ) was 10 and 2 ng/ml for FAU and FMAU in plasma, respectively. Calibration curves were linear over FAU and FMAU plasma concentration range of 10-2000 and 2-1000 ng/ml, respectively. The intra-day and inter-day accuracy and precision were within the generally accepted criteria for bioanalytical method (<15%). The method has been successfully employed to characterize the plasma pharmacokinetics of FAU and FMAU in cancer patients receiving 1-h intravenous infusion of FAU 50 mg/m².
MeSH term(s)	Arabinofuranosyluracil/analogs & derivatives ; Arabinofuranosyluracil/blood ; Chromatography, Liquid/methods ; Humans ; Limit of Detection ; Reference Standards ; Reproducibility of Results ; Tandem Mass Spectrometry/methods
Chemical Substances	2'-fluorodeoxyuracil-arabinofuranoside ; Arabinofuranosyluracil (3083-77-0) ; clevudine (IN51MVP5F1)
Language	English
Publishing date	2012-02-23
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1180823-8
ISSN	1873-376X ; 0378-4347 ; 1570-0232 ; 1387-2273
ISSN (online)	1873-376X
ISSN	0378-4347 ; 1570-0232 ; 1387-2273
DOI	10.1016/j.jchromb.2012.02.030
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Article ; Online: Cost-Effectiveness Analysis of HRD Testing for Previously Treated Patients with Advanced Ovarian Cancer in Italy.

Rognoni, Carla / Lorusso, Domenica / Costa, Francesco / Armeni, Patrizio

Advances in therapy

2024 Volume 41, Issue 4, Page(s) 1385–1400

Abstract: Introduction: Ovarian cancer (OC) is the eighth most common cancer among women, and homologous recombination deficiency (HRD) is present in approximately 50% of these patients. For this group, poly(ADP-ribose) polymerase (PARP) inhibitors are more ... ...

Abstract	Introduction: Ovarian cancer (OC) is the eighth most common cancer among women, and homologous recombination deficiency (HRD) is present in approximately 50% of these patients. For this group, poly(ADP-ribose) polymerase (PARP) inhibitors are more likely to be effective. The aim of the study was to investigate the cost-effectiveness of HRD testing versus BRCA testing (which identifies mutations present only in 25% of patients) in Italy to optimize the treatment management, possibly with PARP inhibitors. Methods: A cost-effectiveness partition survival model was developed to estimate the expected costs and outcomes (life years, LYs; quality-adjusted life years, QALYs) with lifetime horizon of HRD testing versus BRCA testing alone in women with high-grade serous or endometrioid advanced ovarian cancer. The option to perform the tests in sequence, that is, the BRCA test followed by the HRD test, in patients with BRCA-negative test was also considered, and the model accounted for the National Healthcare Service (NHS) perspective in Italy. The treatments represented the best available options according to the initial test results and according to PARP inhibitors available in Italy. A 3% discount rate was applied. Both deterministic and probabilistic sensitivity analyses were performed to test the robustness of the model results. Results: HRD testing was shown to be a cost-effective strategy compared to BRCA testing (incremental cost-utility ratio 22,610€/QALY) and a cost-saving strategy compared to the sequence of tests. The probabilistic sensitivity analysis showed that the HRD test is cost-effective compared to BRCA testing in 98.5% of model simulations considering a willingness-to-pay threshold of 50,000€/QALY. Conclusion: The identification of genetic anomalies in patients with advanced OC is a costly process. Regardless, HRD upfront testing compared to BRCA testing had a cost-effective profile, allowing the efficient use of healthcare resources and better life expectancy and quality of life for patients.
MeSH term(s)	Humans ; Female ; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use ; Cost-Effectiveness Analysis ; Quality of Life ; Carcinoma, Ovarian Epithelial ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/genetics ; Italy
Chemical Substances	Poly(ADP-ribose) Polymerase Inhibitors
Language	English
Publishing date	2024-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	632651-1
ISSN	1865-8652 ; 0741-238X
ISSN (online)	1865-8652
ISSN	0741-238X
DOI	10.1007/s12325-024-02791-3
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Article ; Online: First line ovarian cancer treatment: Scanning the horizon.

Lorusso, D / Daniele, G

Critical reviews in oncology/hematology

2021 Volume 160, Page(s) 103297

MeSH term(s)	Carcinoma, Ovarian Epithelial ; Female ; Humans ; Ovarian Neoplasms/drug therapy
Language	English
Publishing date	2021-03-05
Publishing country	Netherlands
Document type	Letter
ZDB-ID	605680-5
ISSN	1879-0461 ; 0737-9587 ; 1040-8428
ISSN (online)	1879-0461
ISSN	0737-9587 ; 1040-8428
DOI	10.1016/j.critrevonc.2021.103297
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Article ; Online: Preliminary Development of Items for a Nurses' Physical Environmental Stress Scale.

Rittenbacher, Dagmar / Bosch, Sheila J / Valipoor, Shabboo / Lorusso, Lesa

HERD

2024 , Page(s) 19375867241244468

Abstract: Research purpose: This study aimed to develop a preliminary Nurses' Physical Environmental Stress Scale (NPESS) that explores the relationships between the physical environment in the intensive care unit (ICU) and work-related stress among ICU nurses.!## ...

Abstract	Research purpose: This study aimed to develop a preliminary Nurses' Physical Environmental Stress Scale (NPESS) that explores the relationships between the physical environment in the intensive care unit (ICU) and work-related stress among ICU nurses. Background: Working within the healthcare field is stressful and comes with a high level of responsibility for nurses, especially ICU nurses. The ICU work environment is associated with risk factors such as excessive workload, increased expectations, and long working hours that can lead to burnout among nurses. There is some evidence that environmental design has the potential to prevent or mitigate work-related stress; however, an adequate assessment tool to identify physical environmental stressors or supports for moderating stress is lacking. Methods: To develop the preliminary environmental assessment tool, an exploratory sequential methodology was used. The approach consisted of three distinct phases, including (a) a qualitative content analysis of existing focus group data, (b) a qualitative content analysis of pertinent literature related to environmental assessment tools in a healthcare context, and (c) the development and refinement of the NPESS assessment tool. Tool refinement was based on interviews with ICU nurses. Results: The resulting NPESS tool was comprised of seven sections (sounds, lighting, smells, staff respite spaces, staff workspaces, patient rooms, and aesthetic qualities) containing a total of and 81 items that address factors that were identified as potential moderators of environmental stress in ICU settings. Conclusions: The resulting NPESS assessment tool provides a feasible approach for evaluating ICU settings to identify possible improvements to reduce stress among nurses. Future research will be conducted to assess the validity and reliability of the final tool by distributing it to a larger sample of ICU nurses.
Language	English
Publishing date	2024-04-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2525547-2
ISSN	2167-5112 ; 1937-5867
ISSN (online)	2167-5112
ISSN	1937-5867
DOI	10.1177/19375867241244468
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