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Article: An Isolated Second Carpometacarpal Joint Dislocation Treated With Open Reduction and Transfixation With K-wire: A Rare Case Report.

Alagesan, Saravanan / Nagasamy, Silambarasi / Elangovan, Pradeep / Pandian, Haemanath / Anantharaman, Ganesh

2024 Volume 16, Issue 3, Page(s) e56338

Abstract: ... dorsal dislocation of the second CMC joint, which required an open reduction and K-wire transfixation ... An extensor tendon was found to be interposed between the base and the trapezoid. K-wire removal was done ...

Abstract	Carpometacarpal (CMC) joint dislocation is a rare injury that can be easily missed due to non-specific clinical signs and radiologic findings. We report a patient with an isolated and irreducible dorsal dislocation of the second CMC joint, which required an open reduction and K-wire transfixation. An extensor tendon was found to be interposed between the base and the trapezoid. K-wire removal was done after three weeks and following the removal of the wire, rehabilitation was started.
Language	English
Publishing date	2024-03-17
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.56338
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Article ; Online: Adaptation and Validation of Overall Assessment of the Speaker's Experience of Stuttering for Adults in Kannada (OASES-A-K).

Mahesh, Sangeetha / Pushpavathi, Mariswamy / Seth, Divya / Saravanan, Sivaranjani / Yaruss, J Scott

Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP)

2023 Volume 76, Issue 1, Page(s) 30–38

Abstract: ... internal consistency and test-retest reliability for OASES-A-K.: Conclusion: The findings of the current ... research suggest that OASES-A-K is a sensitive and reliable tool to assess the impact of stuttering ...

Abstract	Introduction: Psychosocial aspects of stuttering may affect the quality of life of a person who stutters (PWS). Further, the social stigma and experiences of PWS may vary globally. The WHO-ICF guidelines recommend quality of life as an essential component in the assessment of individuals who stutter. However, the availability of linguistically and culturally appropriate tools is often a challenge. Thus, the current study adapted and validated the OASES-A for Kannada-speaking adults who stutter. Method: The original English version of OASES-A was adapted to Kannada using a standard reverse translation process. The adapted version was administered on 51 Kannada-speaking adults with very mild to very severe stuttering. The data were analyzed for item characteristics, reliability, and validity assessment. Results: The results revealed floor and ceiling effects for six and two items, respectively. The mean overall impact score indicated a moderate impact of stuttering. Further, the impact score for section II was relatively higher when compared to the data from other countries. The reliability and validity analyses showed good internal consistency and test-retest reliability for OASES-A-K. Conclusion: The findings of the current research suggest that OASES-A-K is a sensitive and reliable tool to assess the impact of stuttering in Kannada-speaking PWS. The findings also highlight cross-cultural differences and the need for research in this direction.
MeSH term(s)	Adult ; Humans ; Stuttering/diagnosis ; Stuttering/psychology ; Quality of Life/psychology ; Reproducibility of Results ; Surveys and Questionnaires
Language	English
Publishing date	2023-05-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1179765-4
ISSN	1421-9972 ; 1021-7762
ISSN (online)	1421-9972
ISSN	1021-7762
DOI	10.1159/000531048
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Article ; Online: k-Carrageenan based magnetic@polyelectrolyte complex composite hydrogel for pH and temperature-responsive curcumin delivery.

Santhamoorthy, Madhappan / Thirupathi, Kokila / Kumar, Sathish Sundar Dhilip / Pandiaraj, Saravanan / Rahaman, Mostafizur / Phan, Thi Tuong Vy / Kim, Seong-Cheol

International journal of biological macromolecules

2023 Volume 244, Page(s) 125467

Abstract: ... in the synthetic polymer polyhexamethylene guanidine (PHMG). Furthermore, the natural biopolymer k-carrageenan (kCG) was ...

Abstract	The dual stimuli-responsive drug delivery system has attracted a lot of interest in controlled drug delivery to specific sites. The magnetic iron oxide nanoparticles integrated polyelectrolyte complex-based hydrogel (MPEC HG) system was developed in this work. First, magnetic nanoparticles were produced in situ in the synthetic polymer polyhexamethylene guanidine (PHMG). Furthermore, the natural biopolymer k-carrageenan (kCG) was employed to form the polyelectrolyte complex (PEC) through charge-balancing interaction between positively charged guanidine units and negatively charged sulfonate groups. Various characterization approaches were used to characterize the developed magnetic polyelectrolyte complex hydrogel (MPEC HG) system. Curcumin (Cur) was employed as a model bioactive agent to examine the drug loading and stimuli-responsive drug release efficiency of the MPEC HG system. Under the combined pH and temperature stimuli conditions (pH 5.0/42 °C), the developed hydrogel system demonstrated great drug loading efficiency (∼ 68 %) and enhanced drug release. Furthermore, the MPEC HG system's in vitro cytotoxicity behavior was investigated on a human liver cancer (HepG2) cell line, and the results revealed that the MPEC HG system is biocompatible. As a result, the MPEC HG system might be used for dual pH and temperature stimuli-responsive drug delivery applications in cancer therapy.
MeSH term(s)	Humans ; Curcumin/chemistry ; Polyelectrolytes/chemistry ; Drug Carriers/chemistry ; Carrageenan ; Hydrogels/chemistry ; Temperature ; Drug Delivery Systems/methods ; Drug Liberation ; Hydrogen-Ion Concentration ; Magnetic Phenomena
Chemical Substances	Curcumin (IT942ZTH98) ; Polyelectrolytes ; Drug Carriers ; Carrageenan (9000-07-1) ; Hydrogels
Language	English
Publishing date	2023-06-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.125467
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Article ; Online: Letter to editor in response to 'Tian K, Ye J, Zhong Y, Jia Z, Xu W, Gao S, Cao S, Li K, Wu L. Autologous i-PRF promotes healing of radiation-induced skin injury. Wound Repair Regen. 2023;31:454-463'.

Sampoornam Pape Reddy, Saravanan / Francis, Delfin Lovelina / Harish, Ruchi / Manohar, Balaji / Chopra, Sukhbir Singh

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society

2023 Volume 31, Issue 6, Page(s) 729–730

MeSH term(s)	Humans ; Wound Healing ; Skin ; Skin Diseases ; Radiation Injuries/therapy
Language	English
Publishing date	2023-11-20
Publishing country	United States
Document type	Letter
ZDB-ID	1174873-4
ISSN	1524-475X ; 1067-1927
ISSN (online)	1524-475X
ISSN	1067-1927
DOI	10.1111/wrr.13125
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Article ; Online: k-Carrageenan based magnetic@polyelectrolyte complex composite hydrogel for pH and temperature-responsive curcumin delivery

Santhamoorthy, Madhappan / Thirupathi, Kokila / Kumar, Sathish Sundar Dhilip / Pandiaraj, Saravanan / Rahaman, Mostafizur / Phan, Thi Tuong Vy / Kim, Seong-Cheol

International Journal of Biological Macromolecules. 2023 July, v. 244 p.125467-

2023

Abstract: ... in the synthetic polymer polyhexamethylene guanidine (PHMG). Furthermore, the natural biopolymer k-carrageenan (kCG) was ...

Abstract	The dual stimuli-responsive drug delivery system has attracted a lot of interest in controlled drug delivery to specific sites. The magnetic iron oxide nanoparticles integrated polyelectrolyte complex-based hydrogel (MPEC HG) system was developed in this work. First, magnetic nanoparticles were produced in situ in the synthetic polymer polyhexamethylene guanidine (PHMG). Furthermore, the natural biopolymer k-carrageenan (kCG) was employed to form the polyelectrolyte complex (PEC) through charge-balancing interaction between positively charged guanidine units and negatively charged sulfonate groups. Various characterization approaches were used to characterize the developed magnetic polyelectrolyte complex hydrogel (MPEC HG) system. Curcumin (Cur) was employed as a model bioactive agent to examine the drug loading and stimuli-responsive drug release efficiency of the MPEC HG system. Under the combined pH and temperature stimuli conditions (pH 5.0/42 °C), the developed hydrogel system demonstrated great drug loading efficiency (∼ 68 %) and enhanced drug release. Furthermore, the MPEC HG system's in vitro cytotoxicity behavior was investigated on a human liver cancer (HepG2) cell line, and the results revealed that the MPEC HG system is biocompatible. As a result, the MPEC HG system might be used for dual pH and temperature stimuli-responsive drug delivery applications in cancer therapy.
Keywords	biopolymers ; cancer therapy ; cell lines ; curcumin ; cytotoxicity ; drug delivery systems ; drugs ; electrolytes ; guanidines ; humans ; hydrogels ; iron oxides ; liver neoplasms ; magnetism ; nanoparticles ; pH ; sulfonates ; temperature ; Polyelectrolyte complex ; Magnetic nanoparticles ; pH and temperature-stimuli ; Drug delivery ; HepG2 cells
Language	English
Dates of publication	2023-07
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.125467
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effect of ZnO on (ferroelectric) fatigue retention and thermal stability of ferroelectric properties in lead free (K

P, Vineetha / Jose, Roshan / Saravanan, K Venkata

RSC advances

2019 Volume 9, Issue 60, Page(s) 34888–34895

Abstract: This work investigates and reports the effect of ZnO addition on the ferroelectric properties of (K ...

Abstract	This work investigates and reports the effect of ZnO addition on the ferroelectric properties of (K
Language	English
Publishing date	2019-10-29
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/c9ra06526a
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Article ; Online: 1-substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-ones endowed with dual DNA-PK/PI3-K inhibitory activity.

Cano, Céline / Saravanan, Kappusamy / Bailey, Chris / Bardos, Julia / Curtin, Nicola J / Frigerio, Mark / Golding, Bernard T / Hardcastle, Ian R / Hummersone, Marc G / Menear, Keith A / Newell, David R / Richardson, Caroline J / Shea, K / Smith, Graeme C M / Thommes, Pia / Ting, Attilla / Griffin, Roger J

Journal of medicinal chemistry

2013 Volume 56, Issue 16, Page(s) 6386–6401

Abstract: Analogues of (dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-one (NU7441), a potent inhibitor of DNA-dependent protein kinase (DNA-PK; IC50 = 42 ± 2 nM), have been synthesized in which water-solubilizing groups [NHCO(CH₂)nNR¹R², where n = 1 or 2 ... ...

Abstract	Analogues of (dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-one (NU7441), a potent inhibitor of DNA-dependent protein kinase (DNA-PK; IC50 = 42 ± 2 nM), have been synthesized in which water-solubilizing groups [NHCO(CH₂)nNR¹R², where n = 1 or 2 and the moiety R¹R²N was derived from a library of primary and secondary amines, e.g., morpholine] were placed at the 1-position. Several of the newly synthesized compounds exhibited high potency against DNA-PK and potentiated the cytotoxicity of ionizing radiation (IR) in vitro 10-fold or more (e.g., 2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thio-phen-1-yl)acetamide, 39; DNA-PK IC₅₀ = 5.0 ± 1 nM, IR dose modification ratio = 13). Furthermore, 39 was shown to potentiate not only IR in vitro but also DNA-inducing cytotoxic anticancer agents, both in vitro and in vivo. Counter-screening against other members of the phosphatidylinositol 3-kinase (PI-3K) related kinase (PIKK) family unexpectedly revealed that some of the compounds were potent mixed DNA-PK and PI-3K inhibitors.
MeSH term(s)	DNA-Activated Protein Kinase/antagonists & inhibitors ; HeLa Cells ; Humans ; Morpholines/chemistry ; Morpholines/pharmacology ; Phosphoinositide-3 Kinase Inhibitors ; Protein Kinase Inhibitors/pharmacology
Chemical Substances	Morpholines ; Phosphoinositide-3 Kinase Inhibitors ; Protein Kinase Inhibitors ; DNA-Activated Protein Kinase (EC 2.7.11.1)
Language	English
Publishing date	2013-08-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/jm400915j
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Article ; Online: Ecological risk assessment of silicon dioxide nanoparticles in a freshwater fish Labeo rohita: Hematology, ionoregulation and gill Na(+)/K(+) ATPase activity.

Krishna Priya, K / Ramesh, M / Saravanan, M / Ponpandian, N

Ecotoxicology and environmental safety

2015 Volume 120, Page(s) 295–302

Abstract: ... groups. Likewise, plasma electrolytes such as plasma sodium (Na(+)), potassium (K(+)) and chloride (Cl ... levels and Na(+)/K(+) ATPase activity in gill of SiO2-NPs treated groups were altered ...

Abstract	The fate and effect of nanomaterials in the environment has raised concern about their environmental risk to aquatic organisms. Silica nanoparticles (SiO2-NPs) find its uses in various fields and are inevitably released into the environment. However, the ecotoxicological effects of SiO2-NPs on the freshwater fish remain poorly understood. The aim of this study was to evaluate the effect of different concentrations (1, 5 and 25mgL(-1)) of SiO2-NPs on certain hematological, ionoregulatory and enzymological profiles of a freshwater teleost fish Labeo rohita. Hematological parameters such as hemoglobin (Hb), hematocrit (Hct), red blood cells (RBC), white blood cells (WBC), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) values were altered in SiO2-NPs treated groups. Likewise, plasma electrolytes such as plasma sodium (Na(+)), potassium (K(+)) and chloride (Cl(-)) levels and Na(+)/K(+) ATPase activity in gill of SiO2-NPs treated groups were altered in all concentrations throughout the study period (96h). The alterations of these parameters were found to be dependent on dose and exposure period. The results of the present study indicate that the alterations of these parameters may relate to physiological stress system to SiO2-NPs toxicity and also demonstrate that manufactured metal oxide NPs in aquatic environment may affect the health condition of the aquatic organisms.
MeSH term(s)	Animals ; Cyprinidae/metabolism ; Erythrocyte Indices ; Erythrocytes ; Fresh Water/chemistry ; Gills/drug effects ; Gills/enzymology ; Hematocrit ; Hemoglobins/metabolism ; Leukocyte Count ; Nanoparticles/chemistry ; Nanoparticles/toxicity ; Potassium/blood ; Risk Assessment ; Silicon Dioxide/chemistry ; Silicon Dioxide/toxicity ; Sodium/blood ; Sodium-Potassium-Exchanging ATPase/metabolism ; Toxicity Tests, Acute ; Water Pollutants, Chemical/chemistry ; Water Pollutants, Chemical/toxicity
Chemical Substances	Hemoglobins ; Water Pollutants, Chemical ; Silicon Dioxide (7631-86-9) ; Sodium (9NEZ333N27) ; Sodium-Potassium-Exchanging ATPase (EC 3.6.3.9) ; Potassium (RWP5GA015D)
Language	English
Publishing date	2015-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2015.05.032
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Article ; Online: Performance analysis of k-means with different initialization methods for high dimensional data

Saravanan / Tajunisha

International Journal of Artificial Intelligence & Applications, Vol 1, Iss 4, Pp 44-

2010 Volume 52

Abstract: ... to the curse of dimensionality. Among all the partition based clusteringalgorithms, k-means is one of the most ... well known methods to partition a dataset intogroups of patterns. However, the k-means method converges ... means). Many methods have been proposed to improve the performance of k-meansalgorithm. In this paper ...

Abstract	Developing effective clustering method for high dimensional dataset is a challengingproblem due to the curse of dimensionality. Among all the partition based clusteringalgorithms, k-means is one of the most well known methods to partition a dataset intogroups of patterns. However, the k-means method converges to one of many localminima. And it is known that, the final result depends on the initial starting points(means). Many methods have been proposed to improve the performance of k-meansalgorithm. In this paper, we have analyzed the performance of our proposed method withthe existing works. In our proposed method, we have used Principal Component Analysis(PCA) for dimension reduction and to find the initial centroid for k-means. Next we haveused heuristics approach to reduce the number of distance calculation to assign the datapoint to cluster. By comparing the results on iris data set, it was found that the resultsobtained by the proposed method are more effective than the existing method.
Keywords	k-means ; principal component analysis ; dimension reduction ; initial centroid ; Electronic computers. Computer science ; QA75.5-76.95 ; Instruments and machines ; QA71-90 ; Mathematics ; QA1-939 ; Science ; Q ; DOAJ:Computer Science ; DOAJ:Technology and Engineering
Subject code	006
Language	English
Publishing date	2010-10-01T00:00:00Z
Publisher	Academy & Industry Research Collaboration Center (AIRCC)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Performance analysis of k-means with different initialization methods for high dimensional data

Tajunisha / Saravanan

International Journal of Artificial Intelligence & Applications, Vol 1, Iss 4, Pp 44-

2010 Volume 52

Abstract: ... to the curse of dimensionality. Among all the partition based clustering algorithms, k-means is one of the most ... well known methods to partition a dataset into groups of patterns. However, the k-means method ... starting points (means). Many methods have been proposed to improve the performance of k-means algorithm ...

Abstract	Developing effective clustering method for high dimensional dataset is a challenging problem due to the curse of dimensionality. Among all the partition based clustering algorithms, k-means is one of the most well known methods to partition a dataset into groups of patterns. However, the k-means method converges to one of many local minima. And it is known that, the final result depends on the initial starting points (means). Many methods have been proposed to improve the performance of k-means algorithm. In this paper, we have analyzed the performance of our proposed method with the existing works. In our proposed method, we have used Principal Component Analysis (PCA) for dimension reduction and to find the initial centroid for k-means. Next we have used heuristics approach to reduce the number of distance calculation to assign the data point to cluster. By comparing the results on iris data set, it was found that the results obtained by the proposed method are more effective than the existing method.
Keywords	k-means ; principal component analysis ; dimension reduction ; Electronic computers. Computer science ; QA75.5-76.95 ; Instruments and machines ; QA71-90 ; Mathematics ; QA1-939 ; Science ; Q
Subject code	006
Language	English
Publishing date	2010-10-01T00:00:00Z
Publisher	Academy & Industry Research Collaboration Center (AIRCC)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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