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  1. Article ; Online: Setting the Record Straight: A New Twist on the Chemiosmotic Mechanism of Oxidative Phosphorylation.

    Juhaszova, Magdalena / Kobrinsky, Evgeny / Zorov, Dmitry B / Aon, Miguel A / Cortassa, Sonia / Sollott, Steven J

    Function (Oxford, England)

    2022  Volume 3, Issue 3, Page(s) zqac018

    MeSH term(s) Oxidative Phosphorylation ; Proton-Motive Force ; Mitochondria/metabolism ; Adenosine Triphosphate/metabolism ; Biochemical Phenomena ; Nitric Oxide Synthase/metabolism
    Chemical Substances Adenosine Triphosphate (8L70Q75FXE) ; Nitric Oxide Synthase (EC 1.14.13.39)
    Language English
    Publishing date 2022-04-19
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Comment
    ISSN 2633-8823
    ISSN (online) 2633-8823
    DOI 10.1093/function/zqac018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Computational modeling of mitochondrial K

    Cortassa, Sonia / Aon, Miguel A / Juhaszova, Magdalena / Kobrinsky, Evgeny / Zorov, Dmitry B / Sollott, Steven J

    Journal of molecular and cellular cardiology

    2021  Volume 165, Page(s) 9–18

    Abstract: ATP synthase ( ... ...

    Abstract ATP synthase (F
    MeSH term(s) Adenosine Triphosphate ; Computer Simulation ; Mitochondria, Heart/metabolism ; Mitochondrial Membranes/metabolism ; Mitochondrial Proton-Translocating ATPases/metabolism ; Potassium/metabolism ; Protons
    Chemical Substances Protons ; Adenosine Triphosphate (8L70Q75FXE) ; Mitochondrial Proton-Translocating ATPases (EC 3.6.3.-) ; Potassium (RWP5GA015D)
    Language English
    Publishing date 2021-12-23
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 80157-4
    ISSN 1095-8584 ; 0022-2828
    ISSN (online) 1095-8584
    ISSN 0022-2828
    DOI 10.1016/j.yjmcc.2021.12.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 426: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: HNO Protects the Myocardium against Reperfusion Injury, Inhibiting the mPTP Opening via PKCε Activation.

    Mancardi, Daniele / Pagliaro, Pasquale / Ridnour, Lisa A / Tocchetti, Carlo G / Miranda, Katrina / Juhaszova, Magdalena / Sollott, Steven J / Wink, David A / Paolocci, Nazareno

    Antioxidants (Basel, Switzerland)

    2022  Volume 11, Issue 2

    Abstract: Donors of nitroxyl (HNO), the one electron-reduction product of nitric oxide ( ... ...

    Abstract Donors of nitroxyl (HNO), the one electron-reduction product of nitric oxide (NO
    Language English
    Publishing date 2022-02-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11020382
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Mitochondrial Ca

    Cortassa, Sonia / Juhaszova, Magdalena / Aon, Miguel A / Zorov, Dmitry B / Sollott, Steven J

    Journal of molecular and cellular cardiology

    2020  Volume 151, Page(s) 113–125

    Abstract: Heart failure (HF) is a progressive, debilitating condition characterized, in part, by altered ionic equilibria, increased ROS production and impaired cellular energy metabolism, contributing to variable profiles of systolic and diastolic dysfunction ... ...

    Abstract Heart failure (HF) is a progressive, debilitating condition characterized, in part, by altered ionic equilibria, increased ROS production and impaired cellular energy metabolism, contributing to variable profiles of systolic and diastolic dysfunction with significant functional limitations and risk of premature death. We summarize current knowledge concerning changes of intracellular Na
    MeSH term(s) Animals ; Calcium/metabolism ; Heart Failure/metabolism ; Humans ; Mitochondria, Heart/metabolism ; Oxidation-Reduction ; Oxidative Stress ; Reactive Oxygen Species/metabolism ; Sodium/metabolism
    Chemical Substances Reactive Oxygen Species ; Sodium (9NEZ333N27) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2020-12-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 80157-4
    ISSN 1095-8584 ; 0022-2828
    ISSN (online) 1095-8584
    ISSN 0022-2828
    DOI 10.1016/j.yjmcc.2020.11.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 426: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: ATP Synthase K

    Juhaszova, Magdalena / Kobrinsky, Evgeny / Zorov, Dmitry B / Nuss, H Bradley / Yaniv, Yael / Fishbein, Kenneth W / de Cabo, Rafael / Montoliu, Lluis / Gabelli, Sandra B / Aon, Miguel A / Cortassa, Sonia / Sollott, Steven J

    Function (Oxford, England)

    2022  Volume 3, Issue 2, Page(s) zqac001

    Abstract: We demonstrated that ATP synthase serves ... ...

    Abstract We demonstrated that ATP synthase serves the
    Language English
    Publishing date 2022-01-27
    Publishing country England
    Document type Journal Article
    ISSN 2633-8823
    ISSN (online) 2633-8823
    DOI 10.1093/function/zqac001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: ATP Synthase K

    Juhaszova, Magdalena / Kobrinsky, Evgeny / Zorov, Dmitry B / Nuss, H Bradley / Yaniv, Yael / Fishbein, Kenneth W / de Cabo, Rafael / Montoliu, Lluis / Gabelli, Sandra B / Aon, Miguel A / Cortassa, Sonia / Sollott, Steven J

    Function (Oxford, England)

    2021  Volume 3, Issue 2, Page(s) zqab065

    Abstract: ATP synthase ( ... ...

    Abstract ATP synthase (F
    Language English
    Publishing date 2021-12-13
    Publishing country England
    Document type Journal Article
    ISSN 2633-8823
    ISSN (online) 2633-8823
    DOI 10.1093/function/zqab065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Synchronized Cardiac Impulses Emerge From Heterogeneous Local Calcium Signals Within and Among Cells of Pacemaker Tissue.

    Bychkov, Rostislav / Juhaszova, Magdalena / Tsutsui, Kenta / Coletta, Christopher / Stern, Michael D / Maltsev, Victor A / Lakatta, Edward G

    JACC. Clinical electrophysiology

    2020  Volume 6, Issue 8, Page(s) 907–931

    Abstract: Objectives: This study sought to identify subcellular Ca: Background: The current paradigm of SAN impulse generation: 1) is that full-scale action potentials (APs) of a common frequency are initiated at 1 site and are conducted within the SAN along ... ...

    Abstract Objectives: This study sought to identify subcellular Ca
    Background: The current paradigm of SAN impulse generation: 1) is that full-scale action potentials (APs) of a common frequency are initiated at 1 site and are conducted within the SAN along smooth isochrones; and 2) does not feature fine details of Ca
    Methods: Immunolabeling was combined with a novel technique to detect the occurrence of LCRs and AP-induced Ca
    Results: At high magnification, Ca
    Conclusions: The study has discovered a novel, microscopic Ca
    MeSH term(s) Action Potentials ; Animals ; Calcium ; Mice ; Myocytes, Cardiac ; Pacemaker, Artificial ; Sinoatrial Node
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2020-08-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 2846739-5
    ISSN 2405-5018 ; 2405-500X ; 2405-500X
    ISSN (online) 2405-5018 ; 2405-500X
    ISSN 2405-500X
    DOI 10.1016/j.jacep.2020.06.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Heart's Pacemaker Mimics Brain Cytoarchitecture and Function: Novel Interstitial Cells Expose Complexity of the SAN.

    Bychkov, Rostislav / Juhaszova, Magdalena / Calvo-Rubio Barrera, Miguel / Donald, Lorenzo A H / Coletta, Christopher / Shumaker, Chad / Moorman, Kayla / Sirenko, Syevda Tagirova / Maltsev, Alexander V / Sollott, Steven J / Lakatta, Edward G

    JACC. Clinical electrophysiology

    2022  Volume 8, Issue 10, Page(s) 1191–1215

    Abstract: Background: The sinoatrial node (SAN) of the heart produces rhythmic action potentials, generated via calcium signaling within and among pacemaker cells. Our previous work has described the SAN as composed of a hyperpolarization-activated cyclic ... ...

    Abstract Background: The sinoatrial node (SAN) of the heart produces rhythmic action potentials, generated via calcium signaling within and among pacemaker cells. Our previous work has described the SAN as composed of a hyperpolarization-activated cyclic nucleotide-gated potassium channel 4 (HCN4)-expressing pacemaker cell meshwork, which merges with a network of connexin 43<sup>+</sup>/F-actin<sup>+</sup> cells. It is also known that sympathetic and parasympathetic innervation create an autonomic plexus in the SAN that modulates heart rate and rhythm. However, the anatomical details of the interaction of this plexus with the pacemaker cell meshwork have yet to be described.
    Objectives: This study sought to describe the 3-dimensional cytoarchitecture of the mouse SAN, including autonomic innervation, peripheral glial cells, and pacemaker cells.
    Methods: The cytoarchitecture of SAN whole-mount preparations was examined by three-dimensional confocal laser-scanning microscopy of triple immunolabeled with combinations of antibodies for HCN4, S100 calcium-binding protein B (S100B), glial fibrillary acidic protein (GFAP), choline acetyltransferase, or vesicular acetylcholine transporter, and tyrosine hydroxylase, and transmission electron microscopy.
    Results: The SAN exhibited heterogeneous autonomic innervation, which was accompanied by a web of peripheral glial cells and a novel S100B<sup>+</sup>/GFAP<sup>-</sup> interstitial cell population, with a unique morphology and a distinct distribution pattern, creating complex interactions with other cell types in the node, particularly with HCN4-expressing cells. Transmission electron microscopy identified a similar population of interstitial cells as telocytes, which appeared to secrete vesicles toward pacemaker cells. Application of S100B to SAN preparations desynchronized Ca<sup>2+</sup> signaling in HCN4-expressing cells and increased variability in SAN impulse rate and rhythm.
    Conclusions: The autonomic plexus, peripheral glial cell web, and a novel S100B<sup>+</sup>/GFAP<sup>-</sup> interstitial cell type embedded within the HCN4<sup>+</sup> cell meshwork increase the structural and functional complexity of the SAN and provide a new regulatory pathway of rhythmogenesis.
    MeSH term(s) Animals ; Mice ; Sinoatrial Node ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/metabolism ; Connexin 43/metabolism ; Glial Fibrillary Acidic Protein/metabolism ; Choline O-Acetyltransferase/metabolism ; Vesicular Acetylcholine Transport Proteins/metabolism ; Actins/metabolism ; Tyrosine 3-Monooxygenase/metabolism ; Potassium Channels/metabolism ; Brain ; Calcium-Binding Proteins/metabolism ; Nucleotides, Cyclic/metabolism
    Chemical Substances Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels ; Connexin 43 ; Glial Fibrillary Acidic Protein ; Choline O-Acetyltransferase (EC 2.3.1.6) ; Vesicular Acetylcholine Transport Proteins ; Actins ; Tyrosine 3-Monooxygenase (EC 1.14.16.2) ; Potassium Channels ; Calcium-Binding Proteins ; Nucleotides, Cyclic
    Language English
    Publishing date 2022-09-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 2846739-5
    ISSN 2405-5018 ; 2405-500X ; 2405-500X
    ISSN (online) 2405-5018 ; 2405-500X
    ISSN 2405-500X
    DOI 10.1016/j.jacep.2022.07.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: HNO Protects the Myocardium against Reperfusion Injury, Inhibiting the mPTP Opening via PKC Activation

    Mancardi, Daniele / Pagliaro, Pasquale / Ridnour, Lisa A. / Tocchetti, Carlo G. / Miranda, Katrina / Juhaszova, Magdalena / Sollott, Steven J. / Wink, David A. / Paolocci, Nazareno

    Antioxidants. 2022 Feb. 14, v. 11, no. 2

    2022  

    Abstract: Donors of nitroxyl (HNO), the one electron-reduction product of nitric oxide (NO.), positively modulate cardiac contractility/relaxation while limiting ischemia-reperfusion (I/R) injury. The mechanisms underpinning HNO anti-ischemic effects remain poorly ...

    Abstract Donors of nitroxyl (HNO), the one electron-reduction product of nitric oxide (NO.), positively modulate cardiac contractility/relaxation while limiting ischemia-reperfusion (I/R) injury. The mechanisms underpinning HNO anti-ischemic effects remain poorly understood. Using isolated perfused rat hearts subjected to 30 min global ischemia/1 or 2 h reperfusion, here we tested whether, in analogy to NO., HNO protection requires PKC translocation to mitochondria and KATP channels activation. To this end, we compared the benefits afforded by ischemic preconditioning (IPC; 3 cycles of I/R) with those eventually granted by the NO. donor, diethylamine/NO, DEA/NO, and two chemically unrelated HNO donors: Angeli’s salt (AS, a prototypic donor) and isopropylamine/NO (IPA/NO, a new HNO releaser). All donors were given for 19 min before I/R injury. In control I/R hearts (1 h reperfusion), infarct size (IS) measured via tetrazolium salt staining was 66 ± 5.5% of the area at risk. Both AS and IPA/NO were as effective as IPC in reducing IS [30.7 ± 2.2 (AS), 31 ± 2.9 (IPA/NO), and 31 ± 0.8 (IPC), respectively)], whereas DEA/NO was significantly less so (36.2 ± 2.6%, p < 0.001 vs. AS, IPA/NO, or IPC). IPA/NO protection was still present after 120 min of reperfusion, and the co-infusion with the PKC inhibitor (PKCV1-2500 nM) prevented it (IS = 30 ± 0.5 vs. 61 ± 1.8% with IPA/NO alone, p < 0.01). Irrespective of the donor, HNO anti-ischemic effects were insensitive to the KATP channel inhibitor, 5-OH decanoate (5HD, 100 μM), that, in contrast, abrogated DEA/NO protection. Finally, both HNO donors markedly enhanced the mitochondrial permeability transition pore (mPTP) ROS threshold over control levels (≅35–40%), an action again insensitive to 5HD. Our study shows that HNO donors inhibit mPTP opening, thus limiting myocyte loss at reperfusion, a beneficial effect that requires PKC translocation to the mitochondria but not mitochondrial K⁺ channels activation.
    Keywords infarction ; mitochondria ; myocardium ; nitric oxide ; permeability ; rats ; reperfusion injury ; risk ; tetrazolium
    Language English
    Dates of publication 2022-0214
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11020382
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: A small erythropoietin derived non-hematopoietic peptide reduces cardiac inflammation, attenuates age associated declines in heart function and prolongs healthspan.

    Winicki, Nolan M / Nanavati, Alay P / Morrell, Christopher H / Moen, Jack M / Axsom, Jessie E / Krawczyk, Melissa / Petrashevskaya, Natalia N / Beyman, Max G / Ramirez, Christopher / Alfaras, Irene / Mitchell, Sarah J / Juhaszova, Magdalena / Riordon, Daniel R / Wang, Mingyi / Zhang, Jing / Cerami, Anthony / Brines, Michael / Sollott, Steven J / de Cabo, Rafael /
    Lakatta, Edward G

    Frontiers in cardiovascular medicine

    2023  Volume 9, Page(s) 1096887

    Abstract: Background: Aging is associated with increased levels of reactive oxygen species and inflammation that disrupt proteostasis and mitochondrial function and leads to organism-wide frailty later in life. ARA290 (cibinetide), an 11-aa non-hematopoietic ... ...

    Abstract Background: Aging is associated with increased levels of reactive oxygen species and inflammation that disrupt proteostasis and mitochondrial function and leads to organism-wide frailty later in life. ARA290 (cibinetide), an 11-aa non-hematopoietic peptide sequence within the cardioprotective domain of erythropoietin, mediates tissue protection by reducing inflammation and fibrosis. Age-associated cardiac inflammation is linked to structural and functional changes in the heart, including mitochondrial dysfunction, impaired proteostasis, hypertrophic cardiac remodeling, and contractile dysfunction. Can ARA290 ameliorate these age-associated cardiac changes and the severity of frailty in advanced age?
    Methods: We conducted an integrated longitudinal (
    Results: Chronic ARA290 treatment mitigated age-related increases in the cardiac non-myocyte to myocyte ratio, infiltrating leukocytes and monocytes, pro-inflammatory cytokines, total NF-κB, and p-NF-κB. Additionally, ARA290 treatment enhanced cardiomyocyte autophagy flux and reduced cellular accumulation of lipofuscin. The cardiomyocyte mitochondrial permeability transition pore response to oxidant stress was desensitized following chronic ARA290 treatment. Concurrently, ARA290 significantly blunted the age-associated elevation in blood pressure and preserved the LV ejection fraction. Finally, ARA290 preserved body weight and significantly reduced other markers of organism-wide frailty at the end of life.
    Conclusion: Administration of ARA290 reduces cell and tissue inflammation, mitigates structural and functional changes within the cardiovascular system leading to amelioration of frailty and preserved healthspan.
    Language English
    Publishing date 2023-01-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.1096887
    Database MEDical Literature Analysis and Retrieval System OnLINE

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