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Article ; Online: Connected Health Innovation Research Program (C.H.I.R.P.): A bridge for digital health and wellness in cardiology and oncology.

Maddula, Ragasnehith / MacLeod, James / Painter, Sabrina / McLeish, Tyson / Steward, Austin / Rossman, Andrea / Hamid, Abdulaziz / Ashwath, Mahi / Martinez, Hugo R / Guha, Avirup / Patel, Brijesh / Addison, Daniel / Blaes, Anne / Choudhuri, Indrajit / Brown, Sherry-Ann

American heart journal plus : cardiology research and practice

2022 Volume 20

Abstract: ... Health Innovation Research Program (C.H.I.R.P.) to serve as a foundation for future integration and ...

Abstract	Study objective: Cancer and heart disease are leading causes of mortality, and cardio-oncology is emerging as a new field addressing the cardiovascular toxicities related to cancer and cancer therapy. Interdisciplinary research platforms that incorporate digital health to optimize cardiovascular health and wellness in cancer survivors are therefore needed as we advance in the digital era. Our goal was to develop the Connected Health Innovation Research Program (C.H.I.R.P.) to serve as a foundation for future integration and assessments of adoption and clinical efficacy of digital health tools for cardiovascular health and wellness in the general population and in oncology patients. Design/setting/participants: Partner companies were identified through the American Medical Association innovation platform, as well as LinkedIn and direct contact by our team. Company leaders met with our team to discuss features of their technology or software. Non-disclosure agreements were signed and data were discussed and obtained for descriptive or statistical analysis. Results: A suite of companies with technologies focused on wellness, biometrics tracking, audio companions, oxygen saturation, weight trends, sleep patterns, heart rate variability, electrocardiogram patterns, blood pressure patterns, real-time metabolism tracking, instructional video modules, or integration of these technologies into electronic health records was collated. We formed an interdisciplinary research team and established an academia-industry collaborative foundation for connecting patients with wellness digital health technologies. Conclusions: A suite of software and device technologies accessible to the cardiology and oncology population has been established and will facilitate retrospective, prospective, and case research studies assessing adoption and clinical efficacy of digital health tools in cardiology/oncology.
Language	English
Publishing date	2022-08-09
Publishing country	United States
Document type	Journal Article
ISSN	2666-6022
ISSN (online)	2666-6022
DOI	10.1016/j.ahjo.2022.100192
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Are Sperms Really Necessary?

Austin, C R

Development, growth & differentiation

2023 Volume 28 Suppl s1, Page(s) 1–2

Language	English
Publishing date	2023-06-06
Publishing country	Japan
Document type	Journal Article
ZDB-ID	280433-5
ISSN	1440-169X ; 0012-1592
ISSN (online)	1440-169X
ISSN	0012-1592
DOI	10.1111/j.1440-169X.1986.28s1_1.x
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Zs.A 194: Show issues

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Article ; Online: Hydrothermal Destruction and Defluorination of Trifluoroacetic Acid (TFA).

Austin, Conrad / Purohit, Anmol L / Thomsen, Cody / Pinkard, Brian R / Strathmann, Timothy J / Novosselov, Igor V

Environmental science & technology

2024

Abstract: ... at relatively mild conditions (T = 150-250 °C, ...

Abstract	Per- and polyfluoroalkyl substances (PFAS) have received increased attention due to their environmental prevalence and threat to public health. Trifluoroacetic acid (TFA) is an ultrashort-chain PFAS and the simplest perfluorocarboxylic acid (PFCA). While the US EPA does not currently regulate TFA, its chemical similarity to other PFCAs and its simple molecular structure make it a suitable model compound for studying the transformation of PFAS. We show that hydrothermal processing in compressed liquid water transforms TFA at relatively mild conditions (T = 150-250 °C,
Language	English
Publishing date	2024-04-25
Publishing country	United States
Document type	Journal Article
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.3c09404
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Article ; Online: Reduced plasma GDF10 levels are positively associated with cholesterol impairment and childhood obesity.

Yousof, Tamana R / Mejia-Benitez, Aurora / Morrison, Katherine M / Austin, Richard C

Scientific reports

2024 Volume 14, Issue 1, Page(s) 1805

Abstract: Childhood obesity is a global health concern affecting over 150 million children worldwide, with projections of a rise to 206 million by 2025. Understanding the mechanisms underlying this epidemic is crucial for developing effective interventions. In ... ...

Abstract	Childhood obesity is a global health concern affecting over 150 million children worldwide, with projections of a rise to 206 million by 2025. Understanding the mechanisms underlying this epidemic is crucial for developing effective interventions. In this study, we investigated circulating levels of Growth Differentiation Factor 10 (GDF10), a novel regulator of adipogenesis. Previous studies report diminished circulating GDF10 levels contribute to obesity and hepatic steatosis in mice. To further understand the role of plasma GDF10 in childhood obesity, a prospective case-control study was conducted. Using an enzyme-linked immunosorbent assay, plasma GDF10 levels were measured in children aged 5-17 years of age with normal (n = 36) and increased (n = 56) body mass index (BMI). Subsequently, plasma GDF10 levels were compared to various cardio-metabolic parameters. Children with increased BMI exhibit significantly lower levels of plasma GDF10 compared to children with normal BMI (p < 0.05). This study not only supports previous mouse data but is the first to report that lower levels of GDF10 is associated with childhood obesity, providing an important human connection for the relevance of GDF10 in obesity. Furthermore, this study revealed a significant correlation between low plasma GDF10 levels and elevated LDL-cholesterol and total cholesterol levels dependent on BMI (95% CI, p < 0.05). This study supports the hypothesis that children with obesity display lower plasma levels of GDF10, which correlates with elevated cholesterol levels. These insights shed light on potential mechanisms contributing to childhood obesity and may lead to future therapeutic interventions targeting GDF10 to mitigate adverse effects of adipogenesis in cardiometabolic health.
MeSH term(s)	Humans ; Child ; Animals ; Mice ; Child, Preschool ; Adolescent ; Pediatric Obesity/etiology ; Growth Differentiation Factor 10 ; Case-Control Studies ; Cholesterol ; Body Mass Index
Chemical Substances	Growth Differentiation Factor 10 ; Cholesterol (97C5T2UQ7J) ; GDF10 protein, human
Language	English
Publishing date	2024-01-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-51635-1
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Article ; Online: Expression of TRPM8 in sheep reproductive tissues and brain areas important for the expression of reproductive behavior.

Sutton, C M / Ziegler, R L / Austin, K J / Alexander, B M

Physiology & behavior

2023 Volume 270, Page(s) 114304

Abstract: The Transient Receptor Potential Melastatin 8 (TRPM8) channel is a temperature-sensitive, calcium permeable ion channel and purported testosterone receptor. To determine how the hormone environment influences the expression of TRPM8 in gonadal tissue and ...

Abstract	The Transient Receptor Potential Melastatin 8 (TRPM8) channel is a temperature-sensitive, calcium permeable ion channel and purported testosterone receptor. To determine how the hormone environment influences the expression of TRPM8 in gonadal tissue and areas of the brain important for reproduction, tissue from western white-faced cross-bred ewes, rams, and gonadectomized males (wethers; n = 6 per group) approximately 6 mo of age were collected. TRPM8 mRNA expression was greater (P = 0.01) in prostate of rams than wethers. Testes had greater (P = 0.004) expression of TRPM8 mRNA than the ovary. Differences in protein expression was similar with the testes having greater (P = 0.007) TRPM8 protein than the ovary. Protein expression did not differ (P = 0.6) in the prostate due to presence (ram) or absence (wether) of the testes. In the brain, TRPM8 varied in the amygdala with rams tending (P = 0.07) to express more mRNA which was reflected in greater (P = 0.04) number of neurons staining positive for TRPM8 in the central amygdala. Differences among ewes and wethers were not detected. This pattern was not observed (P ≥ 0.16) in the hypothalamus or olfactory bulb. To determine if TRPM8 was associated with the expression of ram sexual behavior, brains from rams categorized as high (n = 4) or low (n = 3) sexual activity were collected and blocked. Presence of TRPM8 channels was verified in the amygdala and hypothalamus of rams but was absent in the ventral tegmental area. Numbers of neurons staining positive for TRPM8 did not differ by expression of sexual behavior (P ≥ 0.2) in any area quantified. While expression of TRPM8 is more robust in tissues from intact males, expression of the channel does not appear to be important in the expression of sexual behavior.
MeSH term(s)	Animals ; Male ; Sheep ; Female ; Sexual Behavior, Animal/physiology ; Reproduction ; Brain ; Sheep, Domestic ; Testosterone
Chemical Substances	Testosterone (3XMK78S47O)
Language	English
Publishing date	2023-07-22
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	3907-x
ISSN	1873-507X ; 0031-9384
ISSN (online)	1873-507X
ISSN	0031-9384
DOI	10.1016/j.physbeh.2023.114304
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Zs.A 747: Show issues

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Article ; Online: Factors contributing to level and type of child welfare involvement following prenatal substance exposure: A scoping review.

Peddireddy, Snigdha R / Austin, Anna E / Gottfredson, Nisha C

Child abuse & neglect

2022 Volume 125, Page(s) 105484

Abstract: Background: An understanding of factors contributing to variation in child welfare outcomes in cases of prenatal substance exposure (PSE) can help identify gaps in research and practice and guide state and agency policy.: Objective: To summarize the ... ...

Abstract	Background: An understanding of factors contributing to variation in child welfare outcomes in cases of prenatal substance exposure (PSE) can help identify gaps in research and practice and guide state and agency policy. Objective: To summarize the evidence base and identify critical gaps in the literature, we conducted a scoping review regarding individual- and institutional-level factors associated with child welfare decision-marking across the service continuum and caregivers' perceptions of child welfare involvement in cases of PSE. Participants and setting: The sample included peer-reviewed studies based in the United States. Methods: We conducted a comprehensive search of four databases for studies investigating 1) sociodemographic, behavioral, policy, or other factors contributing to variation in child welfare outcomes and 2) maternal, family, or provider perceptions of the child welfare process in cases of PSE. We followed an established methodological framework for conducting scoping reviews. Results: Of the 23 articles included in the review, 20 explored variation in decision-making across the child welfare services continuum and three examined caregivers' perceptions of child welfare involvement. At the institutional level, provider characteristics, such as agency capacity, were linked to specific child welfare outcomes including reports and removals. At the individual level, factors such as socioeconomic status, race, and substance type were also associated with outcomes across the service continuum. Conclusions: Child welfare agencies use an unsystematic approach in addressing PSE, contributing to a variation in child welfare outcomes and potentially allowing for bias. This review highlights a need for increased resources and guidance for caseworkers.
MeSH term(s)	Caregivers ; Child ; Child Protective Services ; Child Welfare ; Family ; Female ; Humans ; Pregnancy ; United States/epidemiology
Language	English
Publishing date	2022-01-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	799143-5
ISSN	1873-7757 ; 0145-2134
ISSN (online)	1873-7757
ISSN	0145-2134
DOI	10.1016/j.chiabu.2022.105484
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Zs.A 1437: Show issues

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Article ; Online: Review article: Non-penetrating neck artery dissection in young adults: Not to be missed!

Deen, Raeed / Austin, Calyb / Bullen, Andrew

Emergency medicine Australasia : EMA

2023 Volume 35, Issue 3, Page(s) 384–389

Abstract: Young adults who present to the ED with neck pain following non-penetrating, seemingly trivial trauma to the neck, are at risk of neck artery dissection and subsequent stroke. Sport-related neck injury is the chief cause. Physical examination may often ... ...

Abstract	Young adults who present to the ED with neck pain following non-penetrating, seemingly trivial trauma to the neck, are at risk of neck artery dissection and subsequent stroke. Sport-related neck injury is the chief cause. Physical examination may often be unremarkable, and although there may be reluctance to expose young patients to radiation, radiological imaging is central to making a diagnosis of arterial wall disruption. A comprehensive literature search was performed in relation to neck artery dissection, and the evidence was scrutinised. We discuss the typical mechanism of injury, symptoms, anatomical considerations and clinical aids in diagnosis of neck artery dissection. Although the incidence is low, neck artery dissection has a mortality of 7%. As such, it is important for front-line physicians to have a high suspicion of the diagnosis and a low threshold to organise radiological examinations, specifically computerised tomography. Early detection of neck artery dissection will trigger clinical protocols that call for multi-disciplinary team management of this condition. In general, guideline-based recommendation for the management of neck artery dissection involving an intimal flap is by anti-platelet therapy while treatment of neck artery dissection that results in a pseudo-aneurysm or thrombosis is managed by surgical intervention or endovascular techniques. Close follow up combined with antithrombotic treatment is recommended in these individuals, the goal being prevention of stroke.
MeSH term(s)	Humans ; Young Adult ; Arteries ; Stroke/etiology ; Tomography, X-Ray Computed ; Neck Injuries/diagnosis ; Neck Injuries/therapy ; Neck Injuries/complications ; Radiography
Language	English
Publishing date	2023-03-22
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	2161824-0
ISSN	1742-6723 ; 1742-6731 ; 1035-6851
ISSN (online)	1742-6723
ISSN	1742-6731 ; 1035-6851
DOI	10.1111/1742-6723.14202
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Zs.A 5940: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Ankylosis of a knee joint from Medieval London: Trauma, congenital anomaly or osteoarthritis?

Redfern, R C / Austin, A

International journal of paleopathology

2020 Volume 28, Page(s) 69–87

Abstract: Objective: To explore the differential diagnoses of a fused left knee joint and the subsequent impairment.: Materials: An adult female skeleton from the Medieval cemetery of St Mary Spital (London, England).: Methods: We employed digital ... ...

Abstract	Objective: To explore the differential diagnoses of a fused left knee joint and the subsequent impairment. Materials: An adult female skeleton from the Medieval cemetery of St Mary Spital (London, England). Methods: We employed digital radiography and macroscopic observation to record the changes observed throughout the skeleton. We also used the Index of Care to explore the subsequent impairment. Results: A range of congenital and developmental conditions were identified throughout the axial skeleton, with changes to the spine, pelvis, arms and leg bones reflecting adaptation to the mobility impairment. Conclusions: In all probability, the left knee reflects a case of congenital ankylosis with a differential diagnosis of subadult trauma. The female's skeleton had adapted to the impairment. Their risk is likely to have been elevated because of climatic and pandemic events during this period. Significance: First reported case of congenital knee ankylosis. Limitations: The left knee joint was damaged during excavation. Suggestions for further research: Additional imaging is advised.
MeSH term(s)	Adult ; Ankylosis/history ; Ankylosis/pathology ; Female ; History, Medieval ; Humans ; Knee Joint/pathology ; London
Language	English
Publishing date	2020-01-23
Publishing country	Netherlands
Document type	Historical Article ; Journal Article
ZDB-ID	2606330-X
ISSN	1879-9825 ; 1879-9817
ISSN (online)	1879-9825
ISSN	1879-9817
DOI	10.1016/j.ijpp.2019.10.002
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Article ; Online: Iron-Mediated C-H Functionalization of Unactivated Alkynes for the Synthesis of Derivatized Dihydropyrrolones: Regioselectivity Under Thermodynamic Control.

Durham, Austin C / Liu, Cindy R / Wang, Yi-Ming

Chemistry (Weinheim an der Bergstrasse, Germany)

2023 Volume 29, Issue 45, Page(s) e202301195

Abstract: ... disconnections in synthesis. Access to challenging dihydropyrrolone products is achieved by propargylic C-H ...

Abstract	Cyclopentadienyliron dicarbonyl-based complexes present opportunities for underexplored disconnections in synthesis. Access to challenging dihydropyrrolone products is achieved by propargylic C-H functionalization of alkynes for the formation of cyclic organoiron species. Excellent regioselectivity for unsymmetrical alkynes is observed in many cases. Notably, regioselectivity under these stoichiometric conditions diverges from those observed previously under catalysis, occurring at the more-substituted terminus of the alkyne, allowing for methine functionalization and the formation of quaternary centers. Divergent demetallation of the intermediate organoiron complexes gives access to chemically diverse products which are amenable to further functionalization.
Language	English
Publishing date	2023-07-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202301195
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Article ; Online: Derivation and internal validation of the multivariate toxigenic

Davies, Sarah / Zhang, Jimmy / Yi, Yongjun / Burge, Eric R / Desjardins, Marc / Austin, Peter C / van Walraven, Carl

Antimicrobial stewardship & healthcare epidemiology : ASHE

2024 Volume 4, Issue 1, Page(s) e66

Abstract: Background: Many factors have been associated with the risk of toxigenic : Methods: A random sample of 3,050 symptomatic emergency department or hospitalized patients undergoing testing for toxigenic : Results: 8.1% of patients were TCdD positive. ...

Abstract	Background: Many factors have been associated with the risk of toxigenic Methods: A random sample of 3,050 symptomatic emergency department or hospitalized patients undergoing testing for toxigenic Results: 8.1% of patients were TCdD positive. TCdD risk increased with abdominal pain (adjusted odds ratio 1.3; 95% CI, 1.0-1.8), previous Conclusions: TCdD risk can be predicted using readily available clinical risk factors with modest accuracy.
Language	English
Publishing date	2024-04-29
Publishing country	England
Document type	Journal Article
ISSN	2732-494X
ISSN (online)	2732-494X
DOI	10.1017/ash.2024.58
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