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  1. Article: Expression of fatty acid sensing G-protein coupled receptors in peripartal Holstein cows.

    Agrawal, Alea / Alharthi, Abdulrahman / Vailati-Riboni, Mario / Zhou, Zheng / Loor, Juan J

    Journal of animal science and biotechnology

    2017  Volume 8, Page(s) 20

    Abstract: Background: G-protein coupled receptors (GPCR), also referred as Free Fatty Acid Receptors (FFAR ...

    Abstract Background: G-protein coupled receptors (GPCR), also referred as Free Fatty Acid Receptors (FFAR), are widely studied within human medicine as drug targets for metabolic disorders. To combat metabolic disorders prevalent in dairy cows during the transition period, which co-occur with negative energy balance and changes to lipid and glucose metabolism, it may be helpful to identify locations and roles of FFAR and other members of the GPCR family in bovine tissues.
    Results: Quantitative RT-PCR (qPCR) of subcutaneous adipose, liver, and PMNL samples during the transition period (-10, +7, and +20 or +30 d) were used for expression profiling of medium- (MCFA) and long-chain fatty acid (LCFA) receptors
    Conclusions: The data indicate that there is likely not a direct role in liver for the selected GPCR during the transition period, but they do play variable roles in adipose and PMN. In future, these receptors may prove useful targets and/or markers for peripartal metabolism and immunity.
    Language English
    Publishing date 2017-03-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2630162-3
    ISSN 2049-1891 ; 1674-9782
    ISSN (online) 2049-1891
    ISSN 1674-9782
    DOI 10.1186/s40104-017-0150-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: B AND T CELLS IN IMMUNE RECOGNITION. EDITED BY F. LOOR AND G.E. ROELANTS

    LOOR, F / ROELANTS, G E.

    1977  

    Title variant B AND T CELLS IN IMMUNE RECOGNITION
    Keywords B-LYMPHOCYTES / IMMUNOLOGY ; IMMUNITY, CELLULAR ; T-LYMPHOCYTES / IMMUNOLOGY
    Size XVIII,504P,14P OF PLATES,LEAF OF PLATE
    Publisher WILEY
    Publishing place LONDON ETC
    Document type Book
    Note 'A WILEY-INTERSCIENCE PUBLICATION'
    HBZ-ID HT000017350
    ISBN 0-471-99438-3 ; 978-0-471-99438-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1977 A 1569 order for loan Magazin

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  3. Article: Expression of fatty acid sensing G-protein coupled receptors in peripartal Holstein cows

    Agrawal, Alea / Abdulrahman Alharthi / Mario Vailati-Riboni / Zheng Zhou / Juan J. Loor

    Journal of animal science and biotechnology. 2017 Dec., v. 8, no. 1

    2017  

    Abstract: BACKGROUND: G-protein coupled receptors (GPCR), also referred as Free Fatty Acid Receptors (FFAR ...

    Abstract BACKGROUND: G-protein coupled receptors (GPCR), also referred as Free Fatty Acid Receptors (FFAR), are widely studied within human medicine as drug targets for metabolic disorders. To combat metabolic disorders prevalent in dairy cows during the transition period, which co-occur with negative energy balance and changes to lipid and glucose metabolism, it may be helpful to identify locations and roles of FFAR and other members of the GPCR family in bovine tissues. RESULTS: Quantitative RT-PCR (qPCR) of subcutaneous adipose, liver, and PMNL samples during the transition period (-10, +7, and +20 or +30 d) were used for expression profiling of medium- (MCFA) and long-chain fatty acid (LCFA) receptors GPR120 and GPR40, MCFA receptor GPR84, and niacin receptor HCAR2/3. Adipose samples were obtained from cows with either high (HI; BCS ≥ 3.75) or low (LO; BCS ≤ 3.25) body condition score (BCS) to examine whether FFAR expression is correlated with this indicator of health and body reserves. Supplementation of rumen-protected methionine (MET), which may improve immune function and production postpartum, was also compared with unsupplemented control (CON) cows for liver and blood polymorphonuclear leukocytes (PMNL) samples. In adipose tissue, GPR84 and GPR120 were differentially expressed over time, while GPR40 was not expressed; in PMNL, GPR40 was differentially expressed over time and between MET vs. CON, GPR84 expression differed only between dietary groups, and GPR120 was not expressed; in liver, GPCR were either not expressed or barely detectable. CONCLUSIONS: The data indicate that there is likely not a direct role in liver for the selected GPCR during the transition period, but they do play variable roles in adipose and PMN. In future, these receptors may prove useful targets and/or markers for peripartal metabolism and immunity.
    Keywords G-protein coupled receptors ; Holstein ; adipose tissue ; body condition ; dairy cows ; drugs ; energy balance ; free fatty acids ; gene expression regulation ; glucose ; immune response ; liver ; long chain fatty acids ; medicine ; metabolic diseases ; metabolism ; methionine ; neutrophils ; niacin ; quantitative polymerase chain reaction ; reverse transcriptase polymerase chain reaction
    Language English
    Dates of publication 2017-12
    Size p. 20.
    Publishing place BioMed Central
    Document type Article
    ZDB-ID 2630162-3
    ISSN 2049-1891 ; 1674-9782
    ISSN (online) 2049-1891
    ISSN 1674-9782
    DOI 10.1186/s40104-017-0150-z
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Surgical Considerations for Left Ventricular Assist Device Implantation.

    Peer, Syed B / Loor, Gabriel

    Texas Heart Institute journal

    2023  Volume 50, Issue 4

    MeSH term(s) Humans ; Heart-Assist Devices ; Thoracic Surgical Procedures
    Language English
    Publishing date 2023-08-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604761-0
    ISSN 1526-6702 ; 0730-2347
    ISSN (online) 1526-6702
    ISSN 0730-2347
    DOI 10.14503/THIJ-23-8226
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1452: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 484: Show issues

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  5. Article ; Online: A Closer Look at Donor Lung Expansion With Different Static Ex Vivo Lung Perfusion Systems: Invited Commentary.

    Loor, Gabriel

    Transplantation

    2019  Volume 103, Issue 9, Page(s) 1754–1755

    MeSH term(s) Cold Ischemia ; Extracorporeal Circulation ; Humans ; Lung ; Tissue Donors
    Language English
    Publishing date 2019-02-21
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000002668
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 488: Show issues Location:
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    Zs.MO 509: Show issues

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  6. Article ; Online: EVLP: Ready for Prime Time?

    Loor, Gabriel

    Seminars in thoracic and cardiovascular surgery

    2018  Volume 31, Issue 1, Page(s) 1–6

    Abstract: Ex vivo lung perfusion implies perfusion and ventilation of a donor lung outside of the human body. The 2 most clinically relevant and commercially available devices currently in clinical trials are XVIVO Perfusion System (XPS Perfusion, Goteborg, Sweden) ...

    Abstract Ex vivo lung perfusion implies perfusion and ventilation of a donor lung outside of the human body. The 2 most clinically relevant and commercially available devices currently in clinical trials are XVIVO Perfusion System (XPS Perfusion, Goteborg, Sweden) and Organ Care System (Transmedics, Andover, MA). Our review focuses on the needs met by ex vivo lung perfusion, and the clinical literature on both devices.
    MeSH term(s) Donor Selection ; Equipment Design ; Graft Survival ; Humans ; Lung Transplantation/adverse effects ; Lung Transplantation/instrumentation ; Lung Transplantation/methods ; Lung Transplantation/mortality ; Organ Preservation/adverse effects ; Organ Preservation/instrumentation ; Organ Preservation/methods ; Organ Preservation/mortality ; Perfusion/adverse effects ; Perfusion/instrumentation ; Perfusion/methods ; Perfusion/mortality ; Pneumonectomy/adverse effects ; Primary Graft Dysfunction/etiology ; Primary Graft Dysfunction/physiopathology ; Primary Graft Dysfunction/prevention & control ; Respiration, Artificial/adverse effects ; Respiration, Artificial/instrumentation ; Respiration, Artificial/methods ; Respiration, Artificial/mortality ; Risk Factors ; Temperature ; Time Factors ; Tissue and Organ Harvesting/adverse effects ; Treatment Outcome ; Ventilators, Mechanical
    Language English
    Publishing date 2018-06-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1038278-1
    ISSN 1532-9488 ; 1043-0679
    ISSN (online) 1532-9488
    ISSN 1043-0679
    DOI 10.1053/j.semtcvs.2018.05.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2747: Show issues Location:
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  7. Article: Extracorporeal life support during lung transplantation.

    Coster, Jenalee Nicole / Loor, Gabriel

    Indian journal of thoracic and cardiovascular surgery

    2021  Volume 37, Issue Suppl 3, Page(s) 476–483

    Abstract: Lung transplantation surgeries are performed without extracorporeal life support (ECLS) by using an off-pump technique; however, in cases of hypoxemia or hemodynamic instability, intraoperative ECLS may be required. Cardiopulmonary bypass (CPB) has ... ...

    Abstract Lung transplantation surgeries are performed without extracorporeal life support (ECLS) by using an off-pump technique; however, in cases of hypoxemia or hemodynamic instability, intraoperative ECLS may be required. Cardiopulmonary bypass (CPB) has traditionally been the standard practice for ECLS but has been associated with an increased risk of bleeding in the perioperative period, increased transfusion requirements, prolonged postoperative intubation, and possibly primary graft dysfunction. More recently, because of the flexibility of using extracorporeal membrane oxygenation (ECMO) in bridging to transplantation and during postoperative recovery, its use has increased. CPB and ECMO each has advantages and disadvantages; however, because comparisons of CPB and ECMO have been limited to small retrospective observational and single-institution studies, more research is required to determine the superiority of one modality. In this review, we critically examine the pros and cons of performing lung transplantation surgery off-pump or by using the ECLS modalities of ECMO and CPB support during lung transplantation surgery.
    Language English
    Publishing date 2021-04-27
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2164386-6
    ISSN 0973-7723 ; 0970-9134
    ISSN (online) 0973-7723
    ISSN 0970-9134
    DOI 10.1007/s12055-021-01175-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Oxidation Treatments Using Hydrogen Peroxide to Convert Paper-Grade Eucalyptus Kraft Pulp into Dissolving-Grade Pulp.

    Vera-Loor, Andrea / Rigou, Panagiota / Mortha, Gérard / Marlin, Nathalie

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 23

    Abstract: Converting paper-grade bleached Kraft pulp into dissolving pulp using eco-friendly chemicals on-site at the mill is a challenge for the pulp industry. In this study, two oxidation systems are evaluated: the first one is based on the use of hydrogen ... ...

    Abstract Converting paper-grade bleached Kraft pulp into dissolving pulp using eco-friendly chemicals on-site at the mill is a challenge for the pulp industry. In this study, two oxidation systems are evaluated: the first one is based on the use of hydrogen peroxide at various levels of alkalinity; the second one investigates the use of sodium periodate followed by hydrogen peroxide to convert aldehydes into carboxyls and enhance their hemicelluloses removal. Our results have shown that when using only peroxide, the removal of hemicelluloses was not sufficient to improve the pulp's dissolving ability. Conversely, the periodate-peroxide system proved to be more efficient. Results regarding the pulp purity, solubility, degradation (pulp viscosity and cellulose molecular mass distribution), brightness, and its potential applications were discussed.
    Language English
    Publishing date 2023-12-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28237927
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 81: Show issues

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  9. Article ; Online: Surgical right pulmonary artery to left atrial shunt for severe pulmonary hypertension and bridge to lung transplantation.

    Peer, Syed B / Loor, Gabriel / Han, Jeong W / Shafii, Alexis E

    JTCVS techniques

    2023  Volume 23, Page(s) 178–181

    Language English
    Publishing date 2023-12-09
    Publishing country United States
    Document type Journal Article
    ISSN 2666-2507
    ISSN (online) 2666-2507
    DOI 10.1016/j.xjtc.2023.12.001
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  10. Article ; Online: Feeding a Saccharomyces cerevisiae fermentation product during a gut barrier challenge in lactating Holstein cows impacts the ruminal microbiota and metabolome.

    Jiang, Qianming / Sherlock, Danielle N / Elolimy, Ahmed A / Yoon, Ilkyu / Loor, Juan J

    Journal of dairy science

    2024  

    Abstract: ... in knowledge, multiparous Holstein cows (97.1 ± 7.6 DIM; n = 8/group) fed a control diet (CON) or CON plus 19 g ...

    Abstract Through its influence on the gut microbiota, feeding of Saccharomyces cerevisiae fermentation products (SCFP) has been a successful strategy to enhance the health of dairy cows during periods of physiological stresses. Although production and metabolic outcomes from feeding SCFP are well-known, combined impacts on the ruminal microbiota and metabolome during gut barrier challenges remain unclear. To address this gap in knowledge, multiparous Holstein cows (97.1 ± 7.6 DIM; n = 8/group) fed a control diet (CON) or CON plus 19 g/d SCFP for 9 wk were subjected to a feed restriction (FR) challenge for 5 d, during which they were fed 40% of their ad-libitum intake from the 7 d before FR. DNA extracted from ruminal fluid was subjected to PacBio Full-Length 16S rRNA gene sequencing, RT-PCR of 12 major ruminal bacteria, and metabolomics analysis of up to 189 metabolites via GC-MS. High-quality amplicon sequence analyses were performed with Targeted Amplicon Diversity Analysis (TADA), MicrobiomeAnalyst, PICRUSt2, and STAMP software, while metabolomics data were analyzed via MetaboAnalyst 5.0. Ruminal fluid metabolites from the SCFP group exhibited a greater α diversity Chao 1 (P = 0.03) and Shannon indices (P = 0.05), and the PLS-DA analysis clearly discriminated metabolite profiles between dietary groups. The abundance of CPla_4_termite_group, Candidatus_Saccharimonas, Oribacterium, and Pirellula genus in cows fed SCFP was greater. In the SCFP group, concentrations of ethanolamine, 2-amino-4,6-dihydroxypyrimidine, glyoxylic acid, serine, threonine, cytosine, stearic acid, and pyrrole-2-carboxylic acid were greater in ruminal fluid. Both Fretibacterium and Succinivibrio abundance were positively correlated with metabolites across various biological processes: gamma-aminobutyric acid, galactose, butane-2,3-diol, fructose, 5-amino pentanoic acid, β-aminoisobutyric acid, ornithine, malonic acid, 3-hydroxy-3-methylbutyric acid, hexanoic acid, heptanoic acid, cadaverine, glycolic acid, β-alanine, 2-hydroxybutyric acid, methyl alanine, and alanine. In the SCFP group, compared with CON, the mean proportion of 14 predicted pathways based on metabolomics data was greater, while 10 predicted pathways were lower. Integrating metabolites and upregulated predicted enzymes (NADP+-dependent glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, serine: glyoxylate aminotransferase, and D-glycerate 3-kinase) indicated that the pentose phosphate pathway and photorespiration pathway were most upregulated by SCFP. Overall, SCFP during FR led to alterations in ruminal microbiota composition and key metabolic pathways. Among those, there was a shift from the tricarboxylic acid (TCA) cycle to the glyoxylate cycle and nitrogenous base production was enhanced.
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 242499-x
    ISSN 1525-3198 ; 0022-0302
    ISSN (online) 1525-3198
    ISSN 0022-0302
    DOI 10.3168/jds.2023-24147
    Database MEDical Literature Analysis and Retrieval System OnLINE

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