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  1. Article: PI4K2A

    Baldavira, Camila Machado / Prieto, Tabatha Gutierrez / Nagai, Maria Aparecida / Capelozzi, Vera Luiza

    Translational lung cancer research

    2024  Volume 13, Issue 1, Page(s) 199–204

    Language English
    Publishing date 2024-01-12
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2754335-3
    ISSN 2226-4477 ; 2218-6751
    ISSN (online) 2226-4477
    ISSN 2218-6751
    DOI 10.21037/tlcr-23-734
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Editorial: Multiplexed image analysis for translational research project applications.

    Capelozzi, Vera Luiza / Parra, Edwin Roger

    Frontiers in oncology

    2022  Volume 12, Page(s) 1089265

    Language English
    Publishing date 2022-11-17
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.1089265
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  3. Article ; Online: Mesothelin expression remodeled the immune-matrix tumor microenvironment predicting the risk of death in patients with malignant pleural mesothelioma.

    Qualiotto, Aline Nery / Baldavira, Camila Machado / Balancin, Marcelo / Ab'Saber, Alexandre / Takagaki, Teresa / Capelozzi, Vera Luiza

    Frontiers in immunology

    2023  Volume 14, Page(s) 1268927

    Abstract: Background: The combination of immunobiological agents with immune checkpoint proteins is a promising treatment for malignant pleural mesothelioma (MPM). Mesothelin and anti-PD-L1 antibody-drug conjugates specifically target malignant neoplastic cells, ... ...

    Abstract Background: The combination of immunobiological agents with immune checkpoint proteins is a promising treatment for malignant pleural mesothelioma (MPM). Mesothelin and anti-PD-L1 antibody-drug conjugates specifically target malignant neoplastic cells, inhibit the migration and invasion of neoplastic cells, and restore the immune landscape. In this study, we confirmed the importance of mesothelin and examined the relationship between mesothelin and the immune landscape of the tumor microenvironment (TME) in two MPM cohorts.
    Methods: The discovery cohort included 82 MPM cases. Tissue microarray slides were generated, and samples were processed for hematoxylin & eosin staining, immunohistochemistry, and immunofluorescence assays. The relationship between mesothelin, biomarkers of histogenesis, histological aggressiveness, PD-L1, immune cells (CD4, CD8, CD20, CD68), and collagen type I and type V fibers was evaluated by quantitative digital analyses. The outcome was the survival time until death from disease recurrence. The exploratory cohort included 87 malignant mesothelioma (MESO) patients from The Cancer Genome Atlas database.
    Results: Most patients were male (70.7%) with a history of asbestos exposure (53.7%) and with the epithelioid subtype (89%). Surgical resection was performed in 85.4% of patients, and 14.6% received chemotherapy; 59.8% of patients died from disease extension to the mediastinum. Low tumor mesothelin expression was associated with tumor necrosis and nuclear grade 1, whereas high mesothelin expression was significantly associated with the epithelioid histotype and high density of T cells CD8+, macrophages CD68+, and collagen type I fibers. Cox multivariate analysis showed a high risk of death for non-operated patients [hazard ratio (HR), 3.42 (1.15-10.16)] with low tumor mesothelin levels [HR, 2.58 (1.09-6.10)] and high PD-L1 and low infiltration of T cells CD4+ [HR, 3.81 (1.58-9.18)]. In the exploratory cohort, low mesothelin and high COL1A1 and COL5A1 expression were associated with poor overall survival.
    Conclusion: Tumor mesothelin expression associated with the TME immune landscape predicts the risk of death for patients with MPM and could be a new target for immunotherapy in MPM.
    MeSH term(s) Humans ; Male ; Female ; Mesothelioma, Malignant ; B7-H1 Antigen/metabolism ; Mesothelioma/drug therapy ; Mesothelin ; Tumor Microenvironment ; Collagen Type I ; Pleural Neoplasms/drug therapy ; Lung Neoplasms/pathology ; Neoplasm Recurrence, Local ; Risk Factors
    Chemical Substances B7-H1 Antigen ; Mesothelin (J27WDC343N) ; Collagen Type I
    Language English
    Publishing date 2023-10-12
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1268927
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  4. Article: The Immunological Landscape of M1 and M2 Macrophages and Their Spatial Distribution in Patients with Malignant Pleural Mesothelioma.

    Laberiano-Fernandez, Caddie / Baldavira, Camila Machado / Machado-Rugolo, Juliana / Tamegnon, Auriole / Pandurengan, Renganayaki Krishna / Ab'Saber, Alexandre Muxfeldt / Balancin, Marcelo Luiz / Takagaki, Teresa Yae / Nagai, Maria Aparecida / Capelozzi, Vera Luiza / Parra, Edwin Roger

    Cancers

    2023  Volume 15, Issue 21

    Abstract: Background: Several tumor-associated macrophages (TAMs) have shown promise as prognosticators in cancer. Our aim was to validate the importance of TAMs in malignant pleural mesothelioma (MPM) using a two-stage design.: Methods: We explored The Cancer ...

    Abstract Background: Several tumor-associated macrophages (TAMs) have shown promise as prognosticators in cancer. Our aim was to validate the importance of TAMs in malignant pleural mesothelioma (MPM) using a two-stage design.
    Methods: We explored The Cancer Genome Atlas (TCGA-MESO) to select immune-relevant macrophage genes in MPM, including M1/M2 markers, as a discovery cohort. This computational cohort was used to create a multiplex immunofluorescence panel. Moreover, a cohort of 68 samples of MPM in paraffin blocks was used to validate the macrophage phenotypes and the co-localization and spatial distribution of these immune cells within the TME and the stromal or tumor compartments.
    Results: The discovery cohort revealed six immune-relevant macrophage genes (
    Conclusions: The interactions between TAMs in situ and, particularly, CD206
    Language English
    Publishing date 2023-10-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15215116
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  5. Article ; Online: Water-Related Mechanisms Proposed for Storing and Transmitting Homeopathic Information: Putative Links with Biological Responses.

    Guedes, José Roberto Pereira / Bonamin, Leoni Villano / Capelozzi, Vera Luiza

    Homeopathy : the journal of the Faculty of Homeopathy

    2018  Volume 107, Issue 3, Page(s) 172–180

    Abstract: Introduction: There are two critical pillars of homeopathy that contrast with the dominant scientific approach: the similitude principle and the potentization of serial dilutions. Three main hypotheses about the mechanisms of action are in discussion: ... ...

    Abstract Introduction: There are two critical pillars of homeopathy that contrast with the dominant scientific approach: the similitude principle and the potentization of serial dilutions. Three main hypotheses about the mechanisms of action are in discussion: nanobubbles-related hormesis; vehicle-related electric resonance; and quantum non-locality.
    Objectives: The aim of this paper is to review and discuss some key points of such properties: the imprint of supramolecular structures based on the nanoparticle-allostatic, cross-adaptation-sensitization (NPCAS) model; the theory of non-molecular electromagnetic transfer of information, based on the coherent water domains model, and relying (like the NPCAS model) on the idea of local interactions; and the hypothesis of quantum entanglement, based on the concept of non-locality.
    Results and discussion: The nanoparticles hypothesis has been considered since 2010, after the demonstration of suspended metal nanoparticles even in very highly diluted remedies: their actual action on biological structures is still under scrutiny. The second hypothesis considers the idea of electric resonance mechanisms between living systems (including intracellular water) and homeopathic medicines: recent findings about potency-related physical properties corroborate it. Finally, quantum theory of 'non-local' phenomena inspires the idea of an 'entanglement' process among patient, practitioner and the remedy: that quantic phenomena could occur in supra-atomic structures remains speculative however.
    Conclusion: Further studies are needed to ascertain whether and which of these hypotheses may be related to potential cellular effects of homeopathic preparations, such as organization of metabolic pathways or selective gene expression.
    MeSH term(s) Allostasis ; Homeopathy/methods ; Humans ; Materia Medica/chemistry ; Models, Theoretical ; Nanoparticles/chemistry ; Plant Extracts/chemistry ; Quantum Theory
    Chemical Substances Materia Medica ; Plant Extracts
    Language English
    Publishing date 2018-05-16
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2073322-7
    ISSN 1476-4245 ; 1475-4916
    ISSN (online) 1476-4245
    ISSN 1475-4916
    DOI 10.1055/s-0038-1642055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Cyclic ACTH-secreting thymic carcinoid: a case report and review of the literature.

    Lamback, Elisa B / de Almeida, Sérgio Altino / Terra, Ricardo / Ferreira, Carlos Gil / Capelozzi, Vera Luiza / Haddad, Rui / Gadelha, Mônica R

    Archives of endocrinology and metabolism

    2021  Volume 65, Issue 4, Page(s) 512–516

    Abstract: Cyclic Cushing's syndrome (CS) due to thymic carcinoid is a rare disorder. We report a case of cyclic CS due to ectopic adrenocorticotropic hormone (ACTH)-secreting atypical thymic carcinoid tumor and reviewed similar cases published in the literature. ... ...

    Abstract Cyclic Cushing's syndrome (CS) due to thymic carcinoid is a rare disorder. We report a case of cyclic CS due to ectopic adrenocorticotropic hormone (ACTH)-secreting atypical thymic carcinoid tumor and reviewed similar cases published in the literature. Our patient had hypercortisolemia lasting approximately one month, followed by normal cortisol secretion, with relapse one year later. Histopathology revealed an atypical ACTH-positive thymic carcinoid. Ectopic CS can be derived from atypical thymic carcinoids, which can be aggressive tumors with early relapse, suggesting that this type of tumor probably needs aggressive treatment.
    MeSH term(s) ACTH Syndrome, Ectopic ; Adrenocorticotropic Hormone ; Carcinoid Tumor ; Cushing Syndrome/etiology ; Humans ; Neoplasm Recurrence, Local ; Thymus Neoplasms/diagnostic imaging
    Chemical Substances Adrenocorticotropic Hormone (9002-60-2)
    Language English
    Publishing date 2021-04-12
    Publishing country Brazil
    Document type Case Reports ; Review
    ISSN 2359-4292
    ISSN (online) 2359-4292
    DOI 10.20945/2359-3997000000346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The Fibrosis-Targeted Collagen/Integrins Gene Profile Predicts Risk of Metastasis in Pulmonary Neuroendocrine Neoplasms.

    Prieto, Tabatha Gutierrez / Machado-Rugolo, Juliana / Baldavira, Camila Machado / Velosa, Ana Paula Pereira / Teodoro, Walcy Rosolia / Saber, Alexandre Muxfeldt Ab / Capelozzi, Vera Luiza

    Frontiers in oncology

    2021  Volume 11, Page(s) 706141

    Abstract: Recently, collagen/integrin genes have shown promise as predictors of metastasis mainly in non-small cell lung cancer and breast cancer. However, it is unknown if these gene expression profiling differ in metastatic potential of pulmonary neuroendocrine ... ...

    Abstract Recently, collagen/integrin genes have shown promise as predictors of metastasis mainly in non-small cell lung cancer and breast cancer. However, it is unknown if these gene expression profiling differ in metastatic potential of pulmonary neuroendocrine neoplasms (PNENs). In this study, we sought to identify differentially expressed collagen/integrin genes in PNENs in order to understand the molecular mechanisms underlying the development of stroma-associated fibrosis for invasion and metastasis. We compared collagen/integrin gene expression profiling between PNE tumors (PNETs) and PNE carcinomas (PNECs) using a two-stage design. First, we used PCR Array System for 84 ECM-related genes, and among them, we found
    Language English
    Publishing date 2021-08-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.706141
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  8. Article ; Online: Role of immunohistochemistry in the diagnosis of lung cancer.

    Capelozzi, Vera Luiza

    Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia

    2009  Volume 35, Issue 4, Page(s) 375–382

    Abstract: The role of immunohistochemistry is to recognize antigens and, consequently, to identify and classify specific cells within a cell population whose morphology is heterogenous or apparently homogenous. The visualization of the antigen-antibody complex is ... ...

    Abstract The role of immunohistochemistry is to recognize antigens and, consequently, to identify and classify specific cells within a cell population whose morphology is heterogenous or apparently homogenous. The visualization of the antigen-antibody complex is made possible through the addition of either a fluorochrome conjugate or an enzyme to the antibody, which is then viewed under microscopy. Immunohistochemistry can be used in the routine diagnosis of lung cancer, in order to identify biological markers (diagnostic and prognostic). The essential immunohistochemistry panels will be discussed in this review.
    MeSH term(s) Biomarkers, Tumor/analysis ; Carcinoma, Non-Small-Cell Lung/immunology ; Carcinoma, Non-Small-Cell Lung/pathology ; Genes, erbB-1/immunology ; Genes, erbB-2/immunology ; Humans ; Immunohistochemistry ; Lung Neoplasms/immunology ; Lung Neoplasms/pathology ; Matrix Metalloproteinase 9/analysis ; Tumor Suppressor Protein p53/analysis ; Vascular Endothelial Growth Factor A/analysis
    Chemical Substances Biomarkers, Tumor ; Tumor Suppressor Protein p53 ; Vascular Endothelial Growth Factor A ; Matrix Metalloproteinase 9 (EC 3.4.24.35)
    Language Portuguese
    Publishing date 2009-05-22
    Publishing country Brazil
    Document type Journal Article ; Review
    ZDB-ID 2223157-2
    ISSN 1806-3756 ; 1806-3713
    ISSN (online) 1806-3756
    ISSN 1806-3713
    DOI 10.1590/s1806-37132009000400012
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  9. Article: Modeling extracellular matrix through histo-molecular gradient in NSCLC for clinical decisions.

    Baldavira, Camila Machado / Prieto, Tabatha Gutierrez / Machado-Rugolo, Juliana / de Miranda, Jurandir Tomaz / de Oliveira, Lizandre Keren Ramos / Velosa, Ana Paula Pereira / Teodoro, Walcy Rosolia / Ab'Saber, Alexandre / Takagaki, Teresa / Capelozzi, Vera Luiza

    Frontiers in oncology

    2022  Volume 12, Page(s) 1042766

    Abstract: Lung cancer still represents a global health problem, being the main type of tumor responsible for cancer deaths. In this context, the tumor microenvironment, and the extracellular matrix (ECM) pose as extremely relevant. Thus, this study aimed to ... ...

    Abstract Lung cancer still represents a global health problem, being the main type of tumor responsible for cancer deaths. In this context, the tumor microenvironment, and the extracellular matrix (ECM) pose as extremely relevant. Thus, this study aimed to explore the prognostic value of epithelial-to-mesenchymal transition (EMT), Wnt signaling, and ECM proteins expression in patients with non-small-cell lung carcinoma (NSCLC) with clinical stages I-IIIA. For that, we used 120 tissue sections from patients and evaluated the immunohistochemical, immunofluorescence, and transmission electron microscopy (TEM) to each of these markers. We also used
    Language English
    Publishing date 2022-11-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.1042766
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  10. Article ; Online: Cyclic ACTH-secreting thymic carcinoid

    Elisa B. Lamback / Sérgio Altino de Almeida / Ricardo Terra / Carlos Gil Ferreira / Vera Luiza Capelozzi / Rui Haddad / Mônica R. Gadelha

    Archives of Endocrinology and Metabolism, Vol 65, Iss 4, Pp 512-

    a case report and review of the literature

    2021  Volume 516

    Abstract: SUMMARY Cyclic Cushing's syndrome (CS) due to thymic carcinoid is a rare disorder. We report a case of cyclic CS due to ectopic adrenocorticotropic hormone (ACTH)-secreting atypical thymic carcinoid tumor and reviewed similar cases published in the ... ...

    Abstract SUMMARY Cyclic Cushing's syndrome (CS) due to thymic carcinoid is a rare disorder. We report a case of cyclic CS due to ectopic adrenocorticotropic hormone (ACTH)-secreting atypical thymic carcinoid tumor and reviewed similar cases published in the literature. Our patient had hypercortisolemia lasting approximately one month, followed by normal cortisol secretion, with relapse one year later. Histopathology revealed an atypical ACTH-positive thymic carcinoid. Ectopic CS can be derived from atypical thymic carcinoids, which can be aggressive tumors with early relapse, suggesting that this type of tumor probably needs aggressive treatment.
    Keywords Medicine ; R ; Diseases of the endocrine glands. Clinical endocrinology ; RC648-665
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher Brazilian Society of Endocrinology and Metabolism
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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