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  1. Article ; Online: Empagliflozin in Patients with Chronic Kidney Disease. Reply.

    Herrington, William G / Baigent, Colin / Haynes, Richard

    The New England journal of medicine

    2023  Volume 388, Issue 24, Page(s) 2301–2302

    MeSH term(s) Humans ; Benzhydryl Compounds/therapeutic use ; Glucosides/therapeutic use ; Patients ; Renal Insufficiency, Chronic/complications
    Chemical Substances empagliflozin (HDC1R2M35U) ; Benzhydryl Compounds ; Glucosides
    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2301923
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  2. Article ; Online: Sacubitril/valsartan in peritoneal dialysis-lessons from a pharmacokinetic study.

    Judge, Parminder K / Herrington, William G / Haynes, Richard

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2023  Volume 38, Issue 8, Page(s) 1780–1781

    MeSH term(s) Humans ; Valsartan ; Aminobutyrates/therapeutic use ; Biphenyl Compounds ; Drug Combinations ; Peritoneal Dialysis
    Chemical Substances sacubitril (17ERJ0MKGI) ; Valsartan (80M03YXJ7I) ; Aminobutyrates ; Biphenyl Compounds ; Drug Combinations
    Language English
    Publishing date 2023-04-10
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfad066
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    Zs.A 2198: Show issues Location:
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  3. Article ; Online: The authors reply.

    Chapman, Daniel / Judge, Parminder K / Arnold, Thomas / Staplin, Natalie / Clark, Sarah / Haynes, Richard / Moffat, Stewart / Herrington, William G / Hill, Michael

    Kidney international

    2023  Volume 104, Issue 1, Page(s) 201–202

    Language English
    Publishing date 2023-06-21
    Publishing country United States
    Document type Letter
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2023.03.032
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    Zs.A 797: Show issues Location:
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  4. Article ; Online: Haemodialysis, blood pressure and risk: at the limit of non-randomized evidence.

    Ng, Sarah Y A / Haynes, Richard / Herrington, William G

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2020  Volume 35, Issue 9, Page(s) 1465–1468

    MeSH term(s) Blood Pressure ; Blood Pressure Determination ; Dialysis ; Humans ; Renal Dialysis/adverse effects
    Language English
    Publishing date 2020-03-14
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfaa043
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  5. Article ; Online: Blood pressure and kidney disease: chicken or egg (or both)?

    Staplin, Natalie / Haynes, Richard / Herrington, William G

    Kidney international

    2020  Volume 98, Issue 3, Page(s) 547–549

    Abstract: A recent study supports the concept that reduced kidney function causes higher blood pressure, but it found no evidence of causality in the opposite direction. We describe the method of bidirectional Mendelian randomization that was used to explore the ... ...

    Abstract A recent study supports the concept that reduced kidney function causes higher blood pressure, but it found no evidence of causality in the opposite direction. We describe the method of bidirectional Mendelian randomization that was used to explore the direction of the causal relationship between kidney function and blood pressure, and examine the assumptions required for these analyses to give valid results.
    MeSH term(s) Blood Pressure ; Causality ; Humans ; Kidney Diseases ; Mendelian Randomization Analysis
    Language English
    Publishing date 2020-08-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2020.05.048
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  6. Article ; Online: In high-risk T2DM, canagliflozin reduced CV events regardless of baseline renal function.

    Herrington, William G / Zhu, Doreen / Haynes, Richard

    Annals of internal medicine

    2019  Volume 170, Issue 4, Page(s) JC15

    MeSH term(s) Canagliflozin ; Diabetes Mellitus, Type 2 ; Humans ; Hypoglycemic Agents ; Kidney ; Sodium-Glucose Transporter 2 Inhibitors
    Chemical Substances Hypoglycemic Agents ; Sodium-Glucose Transporter 2 Inhibitors ; Canagliflozin (0SAC974Z85)
    Language English
    Publishing date 2019-02-18
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/ACPJ201902190-015
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  7. Article ; Online: Results of a National Survey of Program Directors' Perspectives on a Pass/Fail US Medical Licensing Examination Step 1.

    Patel, Om U / Haynes, William K / Burge, Kaitlin G / Yadav, Ishant S / Peterson, Todd / Camino, Andres / Van Wagoner, Nicholas J

    JAMA network open

    2022  Volume 5, Issue 6, Page(s) e2219212

    MeSH term(s) Educational Measurement ; Humans ; Licensure
    Language English
    Publishing date 2022-06-01
    Publishing country United States
    Document type Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2022.19212
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  8. Article ; Online: Kidney disease trials for the 21st century: innovations in design and conduct.

    Herrington, William G / Staplin, Natalie / Haynes, Richard

    Nature reviews. Nephrology

    2019  Volume 16, Issue 3, Page(s) 173–185

    Abstract: Compared to other specialties, nephrology has reported relatively few clinical trials, and most of these are too small to detect moderate treatment effects. Consequently, interventions that are commonly used by nephrologists have not been adequately ... ...

    Abstract Compared to other specialties, nephrology has reported relatively few clinical trials, and most of these are too small to detect moderate treatment effects. Consequently, interventions that are commonly used by nephrologists have not been adequately tested and some may be ineffective or harmful. More randomized trials are urgently needed to address important clinical questions in patients with kidney disease. The use of robust surrogate markers may accelerate early-phase drug development. However, scientific innovations in trial conduct developed by other specialties should also be adopted to improve trial quality and enable more, larger trials in kidney disease to be completed in the current era of burdensome regulation and escalating research costs. Examples of such innovations include utilizing routinely collected health-care data and disease-specific registries to identify and invite potential trial participants, and for long-term follow-up; use of prescreening to facilitate rapid recruitment of participants; use of pre-randomization run-in periods to improve participant adherence and assess responses to study interventions prior to randomization; and appropriate use of statistics to monitor studies and analyse their results. Nephrology is well positioned to harness such innovations due to its advanced use of electronic health-care records and the development of disease-specific registries. Adopting a population approach and efficient trial conduct along with challenging unscientific regulation may increase the number of definitive clinical trials in nephrology and improve the care of current and future patients.
    MeSH term(s) Clinical Trials as Topic/organization & administration ; Female ; Forecasting ; Humans ; Kidney Diseases/diagnosis ; Kidney Diseases/drug therapy ; Kidney Diseases/epidemiology ; Male ; Needs Assessment ; Nephrology/organization & administration ; Patient Selection ; Program Development ; Program Evaluation
    Language English
    Publishing date 2019-10-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-019-0212-x
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    Zs.A 6334: Show issues Location:
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  9. Article: Cholesterol, mood, and vascular health: Untangling the relationship: Does low cholesterol predispose to depression and suicide, or vice versa?

    Fiedorowicz, Jess G / Haynes, William G

    Current psychiatry

    2014  Volume 9, Issue 7, Page(s) 17–A

    Language English
    Publishing date 2014-10-21
    Publishing country United States
    Document type Journal Article
    ISSN 1537-8276
    ISSN 1537-8276
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  10. Article ; Online: Effects of empagliflozin in patients with chronic kidney disease from Japan: exploratory analyses from EMPA-KIDNEY.

    Nangaku, Masaomi / Herrington, William G / Goto, Shinya / Maruyama, Shoichi / Kashihara, Naoki / Ueki, Kohjiro / Wada, Jun / Watada, Hirotaka / Nakashima, Eitaro / Lee, Ryonfa / Massey, Dan / Mayne, Kaitlin J / Tomita, Aiko / Haynes, Richard / Hauske, Sibylle J / Kadowaki, Takashi

    Clinical and experimental nephrology

    2024  

    Abstract: Background: EMPA-KIDNEY assessed the effects of empagliflozin 10 mg once daily vs. placebo in 6609 patients with chronic kidney disease (CKD) at risk of progression, including 612 participants from Japan.: Methods: Eligibility required an estimated ... ...

    Abstract Background: EMPA-KIDNEY assessed the effects of empagliflozin 10 mg once daily vs. placebo in 6609 patients with chronic kidney disease (CKD) at risk of progression, including 612 participants from Japan.
    Methods: Eligibility required an estimated glomerular filtration rate (eGFR) of ≥ 20 < 45; or ≥ 45 < 90 ml/min/1.73m
    Results: Japanese participants had higher levels of albuminuria and eGFR than those from non-Japan regions. During a median of 2.0 year follow-up, a primary outcome occurred in 432 patients (13.1%) in the empagliflozin group and in 558 patients (16.9%) in the placebo group (hazard ratio [HR], 0.72, 95% confidence interval [95%CI] 0.64-0.82; P < 0.0001). Among the participants from non-Japan regions, there were 399 vs. 494 primary outcomes (0.75, 0.66-0.86), and 33 vs. 64 (0.49, 0.32-0.75; heterogeneity p = 0.06) in Japan. Results were similar when models explicitly considered treatment interactions with diabetes status, categories of eGFR/uACR, and recruitment in Japan (heterogeneity p = 0.08). Safety outcomes were broadly comparable between the two groups, and by Japanese status.
    Conclusions: Empagliflozin safely reduced the risk of "kidney disease progression or cardiovascular death" in patients with CKD, with consistent effects in participants from Japan.
    Language English
    Publishing date 2024-04-20
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1338768-6
    ISSN 1437-7799 ; 1342-1751
    ISSN (online) 1437-7799
    ISSN 1342-1751
    DOI 10.1007/s10157-024-02489-4
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