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Article ; Online: Nutrition and Healthy Ageing in Asia: A Systematic Review.

Zhou, Yan-Feng / Song, Xing-Yue / Pan, An / Koh, Woon-Puay

2023 Volume 15, Issue 14

Abstract: Background: Nutrition plays a key role in modulating the likelihood of healthy ageing. In the present study, we aimed to conduct a systematic review to assess the impact of nutrition on healthy ageing in Asia.: Methods: The systematic review was ... ...

Abstract	Background: Nutrition plays a key role in modulating the likelihood of healthy ageing. In the present study, we aimed to conduct a systematic review to assess the impact of nutrition on healthy ageing in Asia. Methods: The systematic review was registered in the International Prospective Register of Systematic Reviews database (CRD42023408936) and conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The PubMed, Web of Science, and Embase databases were searched up to February 2023 without language restrictions. We included prospective cohort studies that evaluated the associations of intake of a single food or consumption of a single nutrient at midlife; adherence to various dietary patterns at midlife; and improved adherence to dietary patterns from mid- to late life with the likelihood of healthy ageing and its components. Results: Out of 16,373 records, we included 71 papers comprising 24 cohorts from Singapore, China, Japan, and Thailand. The healthy ageing components included cognitive function, physical function, and depression. The majority of studies supported the observation that the likelihood of healthy ageing and its components in late life was positively increased by a higher consumption of healthy foods, such as vegetables, fruits, fish, nuts, legumes, tea, milk, and dairy, at midlife, and also by greater adherence to dietary patterns with high diversity scores or high total antioxidant capacities. Furthermore, improved adherence to healthy dietary patterns from mid- to late life also increased the likelihood of healthy ageing in late life. Conclusion: Consuming healthy foods and adhering to healthy dietary patterns at midlife can promote the likelihood of healthy ageing. Moreover, improving diet quality from mid- to late life can still be beneficial.
MeSH term(s)	Animals ; Healthy Aging ; Prospective Studies ; Nutritional Status ; Diet ; Vegetables ; Thailand
Language	English
Publishing date	2023-07-14
Publishing country	Switzerland
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15143153
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Article ; Online: Nonlinear relationship between high-density lipoprotein cholesterol and cardiovascular disease: an observational and Mendelian randomization analysis.

Chen, Jun-Xiang / Li, Yue / Zhang, Yan-Bo / Wang, Yi / Zhou, Yan-Feng / Geng, Tingting / Liu, Gang / Pan, An / Liao, Yun-Fei

Metabolism: clinical and experimental

2024 Volume 154, Page(s) 155817

Abstract: Background: Clinical trials and Mendelian randomization (MR) studies reported null effects of high-density lipoprotein cholesterol (HDL-C) on risk of cardiovascular disease (CVD), which might have overlooked a nonlinear causal association. We aimed to ... ...

Abstract	Background: Clinical trials and Mendelian randomization (MR) studies reported null effects of high-density lipoprotein cholesterol (HDL-C) on risk of cardiovascular disease (CVD), which might have overlooked a nonlinear causal association. We aimed to investigate the dose-response relationship between circulating HDL-C concentrations and CVD in observational and MR frameworks. Methods: We included 348,636 participants (52,919 CVD cases and 295,717 non-cases) of European ancestry with genetic data from the UK Biobank (UKB) and acquired genome-wide association summary data for HDL-C of Europeans from the Global Lipids Genetics Consortium (GLGC). Observational analyses were conducted in the UKB. Stratified MR analyses were conducted combing genetic data for CVD from UKB and lipids from GLGC. Results: Observational analyses showed L-shaped associations of HDL-C with CVD, with no further risk reduction when HDL-C levels exceeded 70 mg/dL. Multivariable MR analyses across entire distribution of HDL-C found no association of HDL-C with CVD, after control of the pleiotropic effect on other lipids and unmeasured pleiotropism. However, in stratified MR analyses, significant inverse associations of HDL-C with CVD were observed in the stratum of participants with HDL-C ≤ 50 mg/dL (odds ratio per unit increase, 0.86; 95 % confidence interval, 0.79-0.94), while null associations were observed in any stratum above 50 mg/dL. Conclusions: Our data suggest a potentially causal inverse association of HDL-C at low levels with CVD risks. These findings advance our knowledge about the role of HDL as a potential target in CVD prevention and therapy.
MeSH term(s)	Humans ; Cholesterol, HDL ; Triglycerides ; Mendelian Randomization Analysis ; Genome-Wide Association Study ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/genetics ; Cholesterol, LDL ; Polymorphism, Single Nucleotide ; Risk Factors
Chemical Substances	Cholesterol, HDL ; Triglycerides ; Cholesterol, LDL
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	80230-x
ISSN	1532-8600 ; 0026-0495
ISSN (online)	1532-8600
ISSN	0026-0495
DOI	10.1016/j.metabol.2024.155817
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Article ; Online: Cost-Effectiveness of a Workplace-Based Hypertension Management Program in Real-World Practice in the Kailuan Study.

Zhou, Yan-Feng / Chen, Shuohua / Chen, Jun-Xiang / Chen, Simiao / Wang, Guodong / Pan, Xiong-Fei / Wu, Shouling / Pan, An

Journal of the American Heart Association

2024 Volume 13, Issue 8, Page(s) e031578

Abstract: Background: In 2009, a workplace-based hypertension management program was launched among men with hypertension in the Kailuan study. This program involved monitoring blood pressure semimonthly, providing free antihypertensive medications, and offering ... ...

Abstract	Background: In 2009, a workplace-based hypertension management program was launched among men with hypertension in the Kailuan study. This program involved monitoring blood pressure semimonthly, providing free antihypertensive medications, and offering personalized health consultations. However, the cost-effectiveness of this program remains unclear. Methods and results: This analysis included 12 240 participants, with 6120 in each of the management and control groups. Using a microsimulation model derived from 10-year follow-up data, we estimated costs, quality-adjusted life years (QALYs), life-years, and incremental cost-effectiveness ratios (ICERs) for workplace-based management compared with routine care in both the study period and over a lifetime. Analyses are conducted from the societal perspective. Over the 10-year follow-up, patients in the management group experienced an average gain of 0.06 QALYs with associated incremental costs of $633.17 (4366.85 RMB). Projecting over a lifetime, the management group was estimated to increase by 0.88 QALYs or 0.92 life-years compared with the control group, with an incremental cost of $1638.64 (11 301.37 RMB). This results in an incremental cost-effectiveness ratio of $1855.47 per QALY gained and $1780.27 per life-year gained, respectively, when comparing workplace-based management with routine care. In probabilistic sensitivity analyses, with a threshold willingness-to-pay of $30 765 per QALY (3 times 2019 gross domestic product per capita), the management group showed a 100% likelihood of being cost-effective in 10 000 samples. Conclusions: Workplace-based management, compared with routine care for Chinese men with hypertension, could be cost-effective both during the study period and over a lifetime, and might be considered in working populations in China and elsewhere.
MeSH term(s)	Male ; Humans ; Cost-Benefit Analysis ; Hypertension/drug therapy ; Antihypertensive Agents/therapeutic use ; Workplace ; China/epidemiology ; Quality-Adjusted Life Years
Chemical Substances	Antihypertensive Agents
Language	English
Publishing date	2024-04-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.123.031578
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Article: Safety and Efficacy of Transarterial Chemoembolization Combined with Tyrosine Kinase Inhibitor and Immune Checkpoint Inhibitors for Unresectable Hepatocellular Carcinoma: A Single Center Experience.

Pan, Xian / Wu, Shao-Jie / Tang, Yi / Zhou, Yan-Feng / Luo, Jie-Wei / Fang, Zhu-Ting

Journal of hepatocellular carcinoma

2023 Volume 10, Page(s) 883–892

Abstract: Purpose: In China, many patients with hepatocellular carcinoma (HCC) are diagnosed at an advanced stage. Several studies have shown that triple therapy [transarterial chemoembolization (TACE) combined with tyrosine kinase inhibitors (TKIs) and immune ... ...

Abstract	Purpose: In China, many patients with hepatocellular carcinoma (HCC) are diagnosed at an advanced stage. Several studies have shown that triple therapy [transarterial chemoembolization (TACE) combined with tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs)] is beneficial for patient survival. In this study, we aimed to evaluate the efficacy of triple therapy (TACE + TKIs + ICIs) for unresectable HCC (uHCC) and the conversion rate of surgical resection (SR). The primary endpoints were objective response rate (ORR) and disease control rate (DCR) based on the modified Response Evaluation Criteria in Solid Tumors (mRECIST) and RECIST v1.1 and adverse events (AEs), while the secondary endpoint was the conversion rate of patients with uHCC treated with triple therapy followed by SR. Patients and methods: Forty-nine patients with uHCC who received triple therapy at Fujian Provincial Hospital between January 2020 and June 2022 were retrospectively included. The treatment efficacy, SR conversion rate, and associated AEs were recorded. Results: Among the 49 patients enrolled, the ORRs assessed by mRECIST and RECIST v1.1 were 57.1% (24/42) and 14.3% (6/42), respectively, and the DCRs were 92.9% (39/42) and 88.1% (37/42), respectively. Seventeen (34.7%) patients met the criteria for resectable HCC and underwent resection. The median interval between the start of triple therapy and resection was 113.5 days (range 94.75 to 182 d), and the median number of TACE was 2 (range 1 to 2.5). The patients did not achieve median overall survival or median progression-free survival. Treatment-related AEs occurred in 48 (98%) patients, and 18 (36.7%) patients had grade ≥3 AEs. Conclusion: Triple combination therapy resulted in a relatively high ORR and conversion resection rate following uHCC treatment.
Language	English
Publishing date	2023-06-09
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2780784-8
ISSN	2253-5969
ISSN	2253-5969
DOI	10.2147/JHC.S404500
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Article ; Online: Integrated Passive Sensing Chip for Highly Sensitive and Reusable Detection of Differential-Charged Nanoplastics Concentration.

Wang, Yan-Xiong / Fu, Shan-Fei / Xu, Meng-Xin / Tang, Pan / Liang, Jun-Ge / Jiang, Yan-Feng / Qiang, Tian

ACS sensors

2023 Volume 8, Issue 10, Page(s) 3862–3872

Abstract: In this work, a new type, highly sensitive, and reusable nanoplastics (NPs) microwave detection method is proposed, which can be used to rapidly analyze NPs with different surface charges and sizes. The effective dielectric constant of NPs varies ... ...

Abstract	In this work, a new type, highly sensitive, and reusable nanoplastics (NPs) microwave detection method is proposed, which can be used to rapidly analyze NPs with different surface charges and sizes. The effective dielectric constant of NPs varies according to the different concentrations, particle sizes, and surface charges of NPs in aqueous solution. The feasibility of the microwave method for differential-charged NPs detection is verified using a complementary split ring resonator sensor manufactured on a cost-effective printed circuit board, which shows a high sensitivity only for positively charged NPs (PS-NH
MeSH term(s)	Microplastics ; Microwaves
Chemical Substances	Microplastics
Language	English
Publishing date	2023-09-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2379-3694
ISSN (online)	2379-3694
DOI	10.1021/acssensors.3c01406
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Article ; Online: METTL3 enhances the effect of YTHDF1 on NEDD1 mRNA stability by m6A modification in diffuse large B-cell lymphoma cells.

Feng, Lili / Yan, Qinying / Pan, Hui / Shi, Wodong

publication RETRACTED

Immunity, inflammation and disease

2023 Volume 11, Issue 2, Page(s) e789

Abstract: Aim: Diffuse large B-cell lymphoma (DLBCL) remains the most frequent subpopulation of lymphoma, and N6-methyladenosine (m6A) was implicated in the DLBCL progression. Herein, we sought to decipher the m6A-asociated mechanism of NEDD1 in DLBCL development. ...

Abstract	Aim: Diffuse large B-cell lymphoma (DLBCL) remains the most frequent subpopulation of lymphoma, and N6-methyladenosine (m6A) was implicated in the DLBCL progression. Herein, we sought to decipher the m6A-asociated mechanism of NEDD1 in DLBCL development. Methods: The NEDD1 expression profile in DLBCL was assessed by quantitative real-time polymerase chain reaction (RT-qPCR) and Western blot. NEDD1 was artificially downregulated or upregulated in DLBCL cells, followed by EdU, Transwell assays and flow cytometry. The Hedgehog pathway activity was assayed by a dual-luciferase assay. The m6A methylation of NEDD1 in DLBCL was assessed by meRIP-qPCR, and the regulatory mechanism of METTL3 on NEDD1 was validated. The LDH assay was conducted to examine the impact of CD8 Results: NEDD1 was overexpressed in DLBCL. Depletion of NEDD1 inhibited the aggressiveness of SU-DHL-8 and OCI-LY1 cells, whereas overexpression of NEDD1 expedited the aggressiveness of SU-DHL-8 and OCI-LY1 cells. METTL3 promoted NEDD1 translation in an m6A-dependent manner via YTHDF1. Depletion of METTL3 inhibited SU-DHL-8 and OCI-LY1 cell activity through regulation of NEDD1. NEDD1 reversed the repressive effect of METTL3 loss on the aggressiveness of SU-DHL-8 and OCI-LY1 cells. NEDD1 activated the Hedgehog signaling to promote immune escape of DLBCL. Conclusions: METTL3 promotes translation of NEDD1 via YTHDF1-depedndent m6A modification, thereby activating the Hedgehog signaling pathway to promote immune escape of DLBCL cells.
MeSH term(s)	Animals ; Mice ; CD8-Positive T-Lymphocytes/metabolism ; Hedgehog Proteins/metabolism ; Lymphoma, Large B-Cell, Diffuse/genetics ; Lymphoma, Large B-Cell, Diffuse/metabolism ; Methylation ; Methyltransferases/metabolism ; Signal Transduction ; Humans ; Microtubule-Associated Proteins/metabolism ; RNA-Binding Proteins/metabolism
Chemical Substances	Hedgehog Proteins ; Methyltransferases (EC 2.1.1.-) ; METTL3 protein, human (EC 2.1.1.62) ; NEDD1 protein, human ; YTHDF1 protein, human ; Microtubule-Associated Proteins ; RNA-Binding Proteins
Language	English
Publishing date	2023-02-25
Publishing country	England
Document type	Journal Article ; Retracted Publication
ZDB-ID	2740382-8
ISSN	2050-4527 ; 2050-4527
ISSN (online)	2050-4527
ISSN	2050-4527
DOI	10.1002/iid3.789
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Article ; Online: Establishment of a TaqMan probe-based qPCR assay for detecting microsporidia Enterospora epinepheli in grouper.

Liu, Quan-Lin / Wang, Yuan / Chen, Jie / Pan, Guo-Qing / Yue, Yan-Feng / Zhou, Ze-Yang / Fang, Wen-Hong

Journal of fish diseases

2023 Volume 47, Issue 3, Page(s) e13893

Abstract: Enterospora epinepheli is an intranuclear microsporidian parasite causing serious emaciative disease in hatchery-bred juvenile groupers (Epinephelus spp.). Rapid and sensitive detection is urgently needed as its chronic infection tends to cause ... ...

Abstract	Enterospora epinepheli is an intranuclear microsporidian parasite causing serious emaciative disease in hatchery-bred juvenile groupers (Epinephelus spp.). Rapid and sensitive detection is urgently needed as its chronic infection tends to cause emaciation as well as white faeces syndrome and results in fry mortality. This study established a TaqMan probe-based real-time quantitative PCR assays targeting the small subunit rRNA (SSU) gene of E. epinepheli. The relationship between the standard curve of cycle threshold (Ct) and the logarithmic starting quantity (SQ) was determined as Ct = -3.177 lg (SQ) + 38.397. The correlation coefficient (R
MeSH term(s)	Animals ; Bass/genetics ; Reproducibility of Results ; Fish Diseases/diagnosis ; Plant Breeding ; Microsporidia/genetics ; Apansporoblastina ; Real-Time Polymerase Chain Reaction/veterinary ; Real-Time Polymerase Chain Reaction/methods ; Sensitivity and Specificity
Language	English
Publishing date	2023-12-07
Publishing country	England
Document type	Journal Article
ZDB-ID	432109-1
ISSN	1365-2761 ; 0140-7775
ISSN (online)	1365-2761
ISSN	0140-7775
DOI	10.1111/jfd.13893
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Article: Resolving vertebrate brain evolution through salamander brain development and regeneration.

Pan, Xiang-Yu / Zeng, Yan-Yun / Liu, Yan-Mei / Fei, Ji-Feng

Zoological research

2023 Volume 44, Issue 1, Page(s) 219–222

MeSH term(s)	Animals ; Urodela ; Vertebrates ; Brain ; Regeneration
Language	English
Publishing date	2023-01-03
Publishing country	China
Document type	Editorial
ISSN	2095-8137
ISSN	2095-8137
DOI	10.24272/j.issn.2095-8137.2022.527
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Article ; Online: High-Toughness CO

Ou, Xu / Pan, Ji / Liu, Qinbo / Niu, Yajuan / Zhou, Yingjie / Yan, Feng

Advanced materials (Deerfield Beach, Fla.)

2024 Volume 36, Issue 16, Page(s) e2312906

Abstract: Polyurea (PUa) adhesives are renowned for their exceptional adhesion to diverse substrates even in harsh environments. However, the presence of quadruple bidentate intermolecular hydrogen bonds in the polymer chains creates a trade-off between cohesive ... ...

Abstract	Polyurea (PUa) adhesives are renowned for their exceptional adhesion to diverse substrates even in harsh environments. However, the presence of quadruple bidentate intermolecular hydrogen bonds in the polymer chains creates a trade-off between cohesive energy and interfacial adhesive energy. To overcome this challenge, a series of CO
Language	English
Publishing date	2024-01-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1474949-X
ISSN	1521-4095 ; 0935-9648
ISSN (online)	1521-4095
ISSN	0935-9648
DOI	10.1002/adma.202312906
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Article ; Online: Leg disorders in broiler chickens: a review of current knowledge.

Liu, Kai-Li / He, Yan-Feng / Xu, Bo-Wen / Lin, Lu-Xi / Chen, Pan / Iqbal, Muhammad Kashif / Mehmood, Khalid / Huang, Shu-Cheng

Animal biotechnology

2023 Volume 34, Issue 9, Page(s) 5124–5138

Abstract: Ensuring improved leg health is an important prerequisite for broilers to achieve optimal production performance and welfare status. Broiler leg disease is characterized by leg muscle weakness, leg bone deformation, joint cysts, arthritis, femoral head ... ...

Abstract	Ensuring improved leg health is an important prerequisite for broilers to achieve optimal production performance and welfare status. Broiler leg disease is characterized by leg muscle weakness, leg bone deformation, joint cysts, arthritis, femoral head necrosis, and other symptoms that result in lameness or paralysis. These conditions significantly affect movement, feeding and broiler growth performance. Nowadays, the high incidence of leg abnormalities in broiler chickens has become an important issue that hampers the development of broiler farming. Therefore, it is imperative to prevent leg diseases and improve the health of broiler legs. This review mainly discusses the current prevalence of broiler leg diseases and describes the risk factors, diagnosis, and prevention of leg diseases to provide a scientific basis for addressing broiler leg health problems.
MeSH term(s)	Animals ; Chickens ; Poultry Diseases/epidemiology ; Poultry Diseases/etiology ; Poultry Diseases/prevention & control ; Gait/physiology
Language	English
Publishing date	2023-10-18
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2043243-4
ISSN	1532-2378 ; 1049-5398
ISSN (online)	1532-2378
ISSN	1049-5398
DOI	10.1080/10495398.2023.2270000
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