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  1. Article ; Online: Stimulation of anti-tumor immunity by photodynamic therapy.

    Mroz, Pawel / Hashmi, Javad T / Huang, Ying-Ying / Lange, Norbert / Hamblin, Michael R

    Expert review of clinical immunology

    2010  Volume 7, Issue 1, Page(s) 75–91

    Abstract: ... T lymphocytes that have the ability to recognize and destroy distant tumor cells and, in addition, lead ...

    Abstract Photodynamic therapy (PDT) is a rapidly developing cancer treatment that utilizes the combination of nontoxic dyes and harmless visible light to destroy tumors by generating reactive oxygen species. PDT produces tumor-cell destruction in the context of acute inflammation that acts as a 'danger signal' to the innate immune system. Activation of the innate immune system increases the priming of tumor-specific T lymphocytes that have the ability to recognize and destroy distant tumor cells and, in addition, lead to the development of an immune memory that can combat recurrence of the cancer at a later point in time. PDT may be also successfully combined with immunomodulating strategies that are capable of overcoming or bypassing the escape mechanisms employed by the progressing tumor to evade immune attack. This article will cover the role of the immune response in PDT anti-tumor effectiveness. It will highlight the milestones in the development of PDT-mediated anti-tumor immunity and emphasize the combination strategies that may improve this therapy.
    MeSH term(s) Animals ; Cell Line ; Humans ; Immunity, Innate ; Mice ; Mice, Inbred BALB C ; Mice, SCID ; Neoplasms/drug therapy ; Neoplasms/immunology ; Photochemotherapy/methods ; Photosensitizing Agents/chemistry ; Photosensitizing Agents/therapeutic use ; T-Lymphocytes/immunology ; Treatment Outcome
    Chemical Substances Photosensitizing Agents
    Language English
    Publishing date 2010-12-16
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2274260-8
    ISSN 1744-8409 ; 1744-666X
    ISSN (online) 1744-8409
    ISSN 1744-666X
    DOI 10.1586/eci.10.81
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6661: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Effect of pulsing in low-level light therapy.

    Hashmi, Javad T / Huang, Ying-Ying / Sharma, Sulbha K / Kurup, Divya Balachandran / De Taboada, Luis / Carroll, James D / Hamblin, Michael R

    Lasers in surgery and medicine

    2010  Volume 42, Issue 6, Page(s) 450–466

    Abstract: Background and objective: Low level light (or laser) therapy (LLLT) is a rapidly growing modality used in physical therapy, chiropractic, sports medicine and increasingly in mainstream medicine. LLLT is used to increase wound healing and tissue ... ...

    Abstract Background and objective: Low level light (or laser) therapy (LLLT) is a rapidly growing modality used in physical therapy, chiropractic, sports medicine and increasingly in mainstream medicine. LLLT is used to increase wound healing and tissue regeneration, to relieve pain and inflammation, to prevent tissue death, to mitigate degeneration in many neurological indications. While some agreement has emerged on the best wavelengths of light and a range of acceptable dosages to be used (irradiance and fluence), there is no agreement on whether continuous wave or pulsed light is best and on what factors govern the pulse parameters to be chosen.
    Study design/materials and methods: The published peer-reviewed literature was reviewed between 1970 and 2010.
    Results: The basic molecular and cellular mechanisms of LLLT are discussed. The type of pulsed light sources available and the parameters that govern their pulse structure are outlined. Studies that have compared continuous wave and pulsed light in both animals and patients are reviewed. Frequencies used in other pulsed modalities used in physical therapy and biomedicine are compared to those used in LLLT.
    Conclusion: There is some evidence that pulsed light does have effects that are different from those of continuous wave light. However further work is needed to define these effects for different disease conditions and pulse structures.
    MeSH term(s) Adenosine Triphosphate/metabolism ; Animals ; Brain Ischemia/therapy ; Cerebral Cortex/metabolism ; Humans ; Lasers ; Low-Level Light Therapy/methods ; Nerve Regeneration/radiation effects ; Neural Conduction ; Pain Management ; Stroke/therapy ; Wound Healing/radiation effects
    Chemical Substances Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2010-05-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 604493-1
    ISSN 1096-9101 ; 0196-8092
    ISSN (online) 1096-9101
    ISSN 0196-8092
    DOI 10.1002/lsm.20950
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1603: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Role of low-level laser therapy in neurorehabilitation.

    Hashmi, Javad T / Huang, Ying-Ying / Osmani, Bushra Z / Sharma, Sulbha K / Naeser, Margaret A / Hamblin, Michael R

    PM & R : the journal of injury, function, and rehabilitation

    2010  Volume 2, Issue 12 Suppl 2, Page(s) S292–305

    Abstract: This year marks the 50th anniversary of the discovery of the laser. The development of lasers for medical use, which became known as low-level laser therapy (LLLT) or photobiomodulation, followed in 1967. In recent years, LLLT has become an increasingly ... ...

    Abstract This year marks the 50th anniversary of the discovery of the laser. The development of lasers for medical use, which became known as low-level laser therapy (LLLT) or photobiomodulation, followed in 1967. In recent years, LLLT has become an increasingly mainstream modality, especially in the areas of physical medicine and rehabilitation. At first used mainly for wound healing and pain relief, the medical applications of LLLT have broadened to include diseases such as stroke, myocardial infarction, and degenerative or traumatic brain disorders. This review will cover the mechanisms of LLLT that operate both on a cellular and a tissue level. Mitochondria are thought to be the principal photoreceptors, and increased adenosine triphosphate, reactive oxygen species, intracellular calcium, and release of nitric oxide are the initial events. Activation of transcription factors then leads to expression of many protective, anti-apoptotic, anti-oxidant, and pro-proliferation gene products. Animal studies and human clinical trials of LLLT for indications with relevance to neurology, such as stroke, traumatic brain injury, degenerative brain disease, spinal cord injury, and peripheral nerve regeneration, will be covered.
    MeSH term(s) Brain Injuries/physiopathology ; Brain Injuries/radiotherapy ; Electron Transport Complex IV/physiology ; Humans ; Low-Level Light Therapy ; Nervous System Diseases/physiopathology ; Nervous System Diseases/radiotherapy ; Nervous System Diseases/therapy ; Stroke Rehabilitation ; Transcription Factors/physiology
    Chemical Substances Transcription Factors ; Electron Transport Complex IV (EC 1.9.3.1)
    Language English
    Publishing date 2010-10-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2608988-9
    ISSN 1934-1563 ; 1934-1482
    ISSN (online) 1934-1563
    ISSN 1934-1482
    DOI 10.1016/j.pmrj.2010.10.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6951: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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