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Article ; Online: Construction of single-molecule counting-based biosensors for DNA-modifying enzymes: A review.

Zhang, Qian / Hu, Juan / Li, Dong-Ling / Qiu, Jian-Ge / Jiang, Bing-Hua / Zhang, Chun-Yang

2024 Volume 1298, Page(s) 342395

Abstract: DNA-modifying enzymes act as critical regulators in a wide range of genetic functions (e.g., DNA damage & repair, DNA replication), and their aberrant expression may interfere with regular genetic functions and induce various malignant diseases including ...

Abstract	DNA-modifying enzymes act as critical regulators in a wide range of genetic functions (e.g., DNA damage & repair, DNA replication), and their aberrant expression may interfere with regular genetic functions and induce various malignant diseases including cancers. DNA-modifying enzymes have emerged as the potential biomarkers in early diagnosis of diseases and new therapeutic targets in genomic research. Consequently, the development of highly specific and sensitive biosensors for the detection of DNA-modifying enzymes is of great importance for basic biomedical research, disease diagnosis, and drug discovery. Single-molecule fluorescence detection has been widely implemented in the field of molecular diagnosis due to its simplicity, high sensitivity, visualization capability, and low sample consumption. In this paper, we summarize the recent advances in single-molecule counting-based biosensors for DNA-modifying enzyme (i.e, alkaline phosphatase, DNA methyltransferase, DNA glycosylase, flap endonuclease 1, and telomerase) assays in the past four years (2019 - 2023). We highlight the principles and applications of these biosensors, and give new insight into the future challenges and perspectives in the development of single-molecule counting-based biosensors.
MeSH term(s)	DNA ; Biomarkers ; Biosensing Techniques
Chemical Substances	DNA (9007-49-2) ; Biomarkers
Language	English
Publishing date	2024-02-21
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1483436-4
ISSN	1873-4324 ; 0003-2670
ISSN (online)	1873-4324
ISSN	0003-2670
DOI	10.1016/j.aca.2024.342395
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Construction of a label-free fluorescent biosensor for homogeneous detection of m

Liu, Ming-Hao / Zhao, Ning-Ning / Yu, Wan-Tong / Qiu, Jian-Ge / Jiang, Bing-Hua / Zhang, Yan / Zhang, Chun-Yang

Talanta

2024 Volume 272, Page(s) 125784

Abstract: Fat mass and obesity-associated protein (FTO) is a crucial eraser of RNA ... ...

Abstract	Fat mass and obesity-associated protein (FTO) is a crucial eraser of RNA N
MeSH term(s)	Humans ; Female ; Breast Neoplasms/genetics ; DNA ; DNA, Single-Stranded/genetics ; RNA ; Biosensing Techniques ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO/genetics
Chemical Substances	DNA (9007-49-2) ; DNA, Single-Stranded ; RNA (63231-63-0) ; FTO protein, human (EC 1.14.11.33) ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO (EC 1.14.11.33)
Language	English
Publishing date	2024-02-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500969-5
ISSN	1873-3573 ; 0039-9140
ISSN (online)	1873-3573
ISSN	0039-9140
DOI	10.1016/j.talanta.2024.125784
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Article ; Online: Green autofluorescence of the skin and fingernails is a novel biomarker for evaluating the risk for developing acute ischemic stroke.

Tao, Yue / Yu, Haibo / Zhang, Mingchao / Zou, Xiaofeng / Li, Peilu / Qiu, Jian-Ge / Jiang, Bing-Hua / Ying, Weihai

Journal of biophotonics

2024 Volume 17, Issue 4, Page(s) e202300473

Abstract: The only existing approach for assessing the risk of developing acute ischemic stroke (AIS) necessitates that individuals possess a strong understanding of their health status. Our research gathered compelling evidence in favor of our hypothesis, ... ...

Abstract	The only existing approach for assessing the risk of developing acute ischemic stroke (AIS) necessitates that individuals possess a strong understanding of their health status. Our research gathered compelling evidence in favor of our hypothesis, suggesting that the likelihood of developing AIS can be assessed by analyzing the green autofluorescence (AF) of the skin and fingernails. Utilizing machine learning-based analyses of AF images, we found that the area under the curve (AUC) for distinguishing subjects with three risk factors from those with zero, one, or two risk factors was 0.79, 0.76, and 0.75, respectively. Our research has revealed that green AF serves as an innovative biomarker for assessing the risk of developing AIS. Our method is objective, non-invasive, efficient, and economic, which shows great promise to boost a technology for screening natural populations for risk of developing AIS.
MeSH term(s)	Humans ; Ischemic Stroke/complications ; Stroke/diagnostic imaging ; Nails ; Risk Factors ; Biomarkers
Chemical Substances	Biomarkers
Language	English
Publishing date	2024-01-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2390063-5
ISSN	1864-0648 ; 1864-063X
ISSN (online)	1864-0648
ISSN	1864-063X
DOI	10.1002/jbio.202300473
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Article ; Online: Dysregulation of microRNAs in metal-induced angiogenesis and carcinogenesis.

Wang, Lin / Liu, Ling-Zhi / Jiang, Bing-Hua

Seminars in cancer biology

2021 Volume 76, Page(s) 279–286

Abstract: MicroRNAs (miRNAs) are small endogenous non-coding RNAs that regulate cancer initiation, development, angiogenesis, and therapeutic resistance. Metal exposure widely occurs through air, water, soil, food, and industrial contaminants. Hundreds of millions ...

Abstract	MicroRNAs (miRNAs) are small endogenous non-coding RNAs that regulate cancer initiation, development, angiogenesis, and therapeutic resistance. Metal exposure widely occurs through air, water, soil, food, and industrial contaminants. Hundreds of millions of people may have metal exposure associated with toxicity, serious health problems, and cancer occurrence. Metal exposure is found to induce oxidative stress, DNA damage and repair, and activation of multiple signaling pathways. However, molecular mechanisms of metal-induced carcinogenesis remain to be elucidated. Recent studies demonstrated that the exposure of metals such as arsenic, hexavalent chromium, cadmium, and nickel caused dysregulation of microRNAs that are implicated to play an important role in cell transformation, tumor growth and angiogenesis. This review focuses on the recent studies that show metal-induced miRNA dysregulation and underlined mechanisms in cell malignant transformation, angiogenesis and tumor growth.
MeSH term(s)	Animals ; Cell Transformation, Neoplastic/chemically induced ; Humans ; Metals/adverse effects ; MicroRNAs ; Neovascularization, Pathologic/chemically induced
Chemical Substances	Metals ; MicroRNAs
Language	English
Publishing date	2021-08-21
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1033980-2
ISSN	1096-3650 ; 1044-579X
ISSN (online)	1096-3650
ISSN	1044-579X
DOI	10.1016/j.semcancer.2021.08.009
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Zs.A 2922: Show issues

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Article ; Online: ROS and miRNA Dysregulation in Ovarian Cancer Development, Angiogenesis and Therapeutic Resistance.

Stieg, David C / Wang, Yifang / Liu, Ling-Zhi / Jiang, Bing-Hua

International journal of molecular sciences

2022 Volume 23, Issue 12

Abstract: The diverse repertoires of cellular mechanisms that progress certain cancer types are being uncovered by recent research and leading to more effective treatment options. Ovarian cancer (OC) is among the most difficult cancers to treat. OC has limited ... ...

Abstract	The diverse repertoires of cellular mechanisms that progress certain cancer types are being uncovered by recent research and leading to more effective treatment options. Ovarian cancer (OC) is among the most difficult cancers to treat. OC has limited treatment options, especially for patients diagnosed with late-stage OC. The dysregulation of miRNAs in OC plays a significant role in tumorigenesis through the alteration of a multitude of molecular processes. The development of OC can also be due to the utilization of endogenously derived reactive oxygen species (ROS) by activating signaling pathways such as PI3K/AKT and MAPK. Both miRNAs and ROS are involved in regulating OC angiogenesis through mediating multiple angiogenic factors such as hypoxia-induced factor (HIF-1) and vascular endothelial growth factor (VEGF). The NAPDH oxidase subunit NOX4 plays an important role in inducing endogenous ROS production in OC. This review will discuss several important miRNAs, NOX4, and ROS, which contribute to therapeutic resistance in OC, highlighting the effective therapeutic potential of OC through these mechanisms.
MeSH term(s)	Carcinoma, Ovarian Epithelial ; Drug Resistance, Neoplasm/genetics ; Female ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit ; MicroRNAs/genetics ; NADPH Oxidases/metabolism ; Neovascularization, Pathologic/genetics ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/genetics ; Phosphatidylinositol 3-Kinases ; Reactive Oxygen Species/metabolism ; Vascular Endothelial Growth Factor A/metabolism
Chemical Substances	Hypoxia-Inducible Factor 1, alpha Subunit ; MicroRNAs ; Reactive Oxygen Species ; Vascular Endothelial Growth Factor A ; NADPH Oxidases (EC 1.6.3.-)
Language	English
Publishing date	2022-06-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23126702
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Article ; Online: Development of a N

Liu, Ming-Hao / Yu, Wan-Tong / Zhao, Ning-Ning / Qiu, Jian-Ge / Jiang, Bing-Hua / Zhang, Yan / Zhang, Chun-Yang

Analytica chimica acta

2023 Volume 1279, Page(s) 341796

Abstract: The METTL3/14 complex is an important RNA ... ...

Abstract	The METTL3/14 complex is an important RNA N
MeSH term(s)	Humans ; Female ; Quantum Dots/chemistry ; Breast Neoplasms/diagnosis ; DNA/chemistry ; Methyltransferases ; Biosensing Techniques ; RNA
Chemical Substances	cyanine dye 5 ; N-methyladenosine (CLE6G00625) ; DNA (9007-49-2) ; Methyltransferases (EC 2.1.1.-) ; RNA (63231-63-0) ; METTL3 protein, human (EC 2.1.1.62)
Language	English
Publishing date	2023-09-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1483436-4
ISSN	1873-4324 ; 0003-2670
ISSN (online)	1873-4324
ISSN	0003-2670
DOI	10.1016/j.aca.2023.341796
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Article ; Online: ROS and miRNA Dysregulation in Ovarian Cancer Development, Angiogenesis and Therapeutic Resistance

David C. Stieg / Yifang Wang / Ling-Zhi Liu / Bing-Hua Jiang

International Journal of Molecular Sciences, Vol 23, Iss 6702, p

2022 Volume 6702

Abstract	The diverse repertoires of cellular mechanisms that progress certain cancer types are being uncovered by recent research and leading to more effective treatment options. Ovarian cancer (OC) is among the most difficult cancers to treat. OC has limited treatment options, especially for patients diagnosed with late-stage OC. The dysregulation of miRNAs in OC plays a significant role in tumorigenesis through the alteration of a multitude of molecular processes. The development of OC can also be due to the utilization of endogenously derived reactive oxygen species (ROS) by activating signaling pathways such as PI3K/AKT and MAPK. Both miRNAs and ROS are involved in regulating OC angiogenesis through mediating multiple angiogenic factors such as hypoxia-induced factor (HIF-1) and vascular endothelial growth factor (VEGF). The NAPDH oxidase subunit NOX4 plays an important role in inducing endogenous ROS production in OC. This review will discuss several important miRNAs, NOX4, and ROS, which contribute to therapeutic resistance in OC, highlighting the effective therapeutic potential of OC through these mechanisms.
Keywords	ovarian cancer ; miRNA dysregulation ; ROS ; NOX4 ; HIF1-α ; VEGF ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	616
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: MKRN2 knockout causes male infertility through decreasing STAT1, SIX4, and TNC expression.

Wang, Lin / Yong, Yan-Ling / Wang, Kun-Kun / Xie, Yun-Xia / Qian, Ying-Chen / Zhou, Feng-Mei / Qiu, Jian-Ge / Jiang, Bing-Hua

Frontiers in endocrinology

2023 Volume 14, Page(s) 1138096

Abstract: ... Makorin- ... ...

Abstract	Makorin-2
MeSH term(s)	Animals ; Humans ; Male ; Mice ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Homeodomain Proteins/metabolism ; Infertility, Male/genetics ; Ribonucleoproteins/genetics ; Ribonucleoproteins/metabolism ; STAT1 Transcription Factor/metabolism ; Tenascin/metabolism ; Trans-Activators/metabolism
Chemical Substances	Basic Helix-Loop-Helix Transcription Factors ; Ebf2 protein, mouse ; Homeodomain Proteins ; Mkrn2 protein, mouse ; Ribonucleoproteins ; SIX4 protein, human ; Stat1 protein, mouse ; STAT1 Transcription Factor ; Tenascin ; Trans-Activators
Language	English
Publishing date	2023-03-10
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1138096
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Article ; Online: Human endothelial cells promote arsenic-transformed lung epithelial cells to induce tumor growth and angiogenesis through interleukin-8 induction.

Zhao, Lei / Wang, Yi-Fang / Liu, Jie / Jiang, Bing-Hua / Liu, Ling-Zhi

Aging

2022 Volume 14, Issue 5, Page(s) 2113–2130

Abstract: Arsenic exposure is associated with lung cancer. Angiogenesis is essential for tumor development. However, the role and mechanism of human vascular endothelial cells in tumor growth and angiogenesis induced by arsenic-transformed bronchial epithelial (As- ...

Abstract	Arsenic exposure is associated with lung cancer. Angiogenesis is essential for tumor development. However, the role and mechanism of human vascular endothelial cells in tumor growth and angiogenesis induced by arsenic-transformed bronchial epithelial (As-T) cells remain to be elucidated. In this study, we found that endothelial cells significantly increased As-T cell-induced tumor growth compared to those induced by As-T cells alone. To understand the molecular mechanism, we found that endothelial cells co-cultured with As-T cells or cultured in conditioned medium (CM) prepared from As-T cells showed much higher cell migration, proliferation, and tube formation compared to those co-cultured with BEAS-2B (B2B) cells or cultured in CM from B2B. We identified that higher levels of intracellular interleukin 8 (IL-8) were secreted by As-T cells, which activated IL-8/IL-8R signaling to promote endothelial cells migration and tube formation. IL-8 silencing and knockout (KO) in As-T cells, or IL-8 neutralizing antibody dramatically suppressed endothelial cell proliferation, migration, tube formation
MeSH term(s)	Arsenic/metabolism ; Arsenic/toxicity ; Bronchi/metabolism ; Cell Movement ; Cell Proliferation ; Culture Media, Conditioned/metabolism ; Culture Media, Conditioned/pharmacology ; Endothelial Cells/metabolism ; Epithelial Cells/metabolism ; Humans ; Interleukin-8/metabolism ; Neoplasms/metabolism ; Neovascularization, Pathologic/metabolism ; Receptors, Interleukin-8A/metabolism
Chemical Substances	Culture Media, Conditioned ; Interleukin-8 ; Receptors, Interleukin-8A ; Arsenic (N712M78A8G)
Language	English
Publishing date	2022-03-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.203930
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Article ; Online: PI3K/AKT and mTOR/p70S6K1 signaling pathways in human cancer.

Jiang, Bing-Hua

Current cancer drug targets

2013 Volume 13, Issue 3, Page(s) 233

MeSH term(s)	Humans ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Mutation ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Neoplasms/genetics ; Neoplasms/metabolism ; Phosphatidylinositol 3-Kinase/genetics ; Phosphatidylinositol 3-Kinase/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Ribosomal Protein S6 Kinases, 70-kDa/genetics ; Ribosomal Protein S6 Kinases, 70-kDa/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism
Chemical Substances	Isoenzymes ; Neoplasm Proteins ; MTOR protein, human (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; Phosphatidylinositol 3-Kinase (EC 2.7.1.137) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Ribosomal Protein S6 Kinases, 70-kDa (EC 2.7.11.1) ; ribosomal protein S6 kinase, 70kD, polypeptide 1 (EC 2.7.11.1)
Language	English
Publishing date	2013-01-01
Publishing country	Netherlands
Document type	Editorial ; Introductory Journal Article
ZDB-ID	2064824-8
ISSN	1873-5576 ; 1568-0096
ISSN (online)	1873-5576
ISSN	1568-0096
DOI	10.2174/1568009611313030001
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