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Article ; Online: Successful treatment of paediatric refractory Hodgkin lymphoma with immunotherapy - A case report and literature review.

Mogensen, Nina / Cananau, Carmen / Ranta, Susanna / Karlén, Jonas / Kwiecinska, Anna / Baecklund, Fredrik

Acta paediatrica (Oslo, Norway : 1992)

2024

Abstract: Aim: To describe a rare case of primary refractory Hodgkin lymphoma nodular sclerosis syncytial variant in a child and review immunotherapy in relapsed/refractory Hodgkin lymphoma.: Methods: We described the treatment course of a child with primary ... ...

Abstract	Aim: To describe a rare case of primary refractory Hodgkin lymphoma nodular sclerosis syncytial variant in a child and review immunotherapy in relapsed/refractory Hodgkin lymphoma. Methods: We described the treatment course of a child with primary refractory classic Hodgkin lymphoma and discussed different options for salvage therapy, with an emphasis on immunotherapy. We searched PubMed for all published clinical trials investigating immunotherapy in classic Hodgkin lymphoma written in English until 31 June, 2023. The reference list of each identified paper was searched for additional publications. Results: Our patient was salvaged with anti-programmed cell death 1 (PD-1) antibody therapy followed by high-dose chemotherapy with autologous stem cell rescue. Radiotherapy was avoided. We identified five one-armed phase II trials investigating anti-PD-1 therapy in first relapse/refractory disease in a total of 254 patients aged 9-71 years, of which one included 31 children. The complete remission rate before high-dose chemotherapy was 59%-95% overall and 67%-89% among those with refractory disease. Conclusion: Although it remains to be proven in randomised trials, anti-PD-1 therapy may provide higher complete response rates than traditional chemotherapy. Anti-PD-1 therapy has the potential to increase the chance of cure while decreasing the risk of late effects from chemotherapy and radiotherapy.
Language	English
Publishing date	2024-04-10
Publishing country	Norway
Document type	Journal Article ; Review
ZDB-ID	203487-6
ISSN	1651-2227 ; 0365-1436 ; 0803-5253
ISSN (online)	1651-2227
ISSN	0365-1436 ; 0803-5253
DOI	10.1111/apa.17235
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Article ; Online: "You're actually part of the team": a qualitative study of a novel transitional role from medical student to doctor.

Edmiston, Natalie / Hu, Wendy / Tobin, Stephen / Bailey, Jannine / Joyce, Caroline / Reed, Krista / Mogensen, Lise

BMC medical education

2023 Volume 23, Issue 1, Page(s) 112

Abstract: Background: Optimizing transitions from final year of medical school and into first post graduate year has important implications for students, patients and the health care system. Student experiences during novel transitional roles can provide insights ...

Abstract	Background: Optimizing transitions from final year of medical school and into first post graduate year has important implications for students, patients and the health care system. Student experiences during novel transitional roles can provide insights into potential opportunities for final year curricula. We explored the experiences of medical students in a novel transitional role and their ability to continue learning whilst working as part of a medical team. Methods: Novel transitional role for final year medical students were created in partnership by medical schools and state health departments in 2020 in response to the COVID-19 pandemic and the need for a medical surge workforce. Final year medical students from an undergraduate entry medical school were employed as Assistants in Medicine (AiMs) in urban and regional hospitals. A qualitative study with semi-structured interviews at two time points was used to obtain experiences of the role from 26 AiMs. Transcripts were analyzed using deductive thematic analysis with Activity theory as a conceptual lens. Results: This unique role was defined by the objective of supporting the hospital team. Experiential learning opportunities in patient management were optimized when AiMs had opportunities to contribute meaningfully. Team structure and access to the key instrument, the electronic medical record, enabled participants to contribute meaningfully, whilst contractual arrangements and payments formalized the obligations to contribute. Conclusions: The experiential nature of the role was facilitated by organizational factors. Structuring teams to involve a dedicated medical assistant position with specific duties and access to the electronic medical record sufficient to complete duties are key to successful transitional roles. Both should be considered when designing transitional roles as placements for final year medical students.
MeSH term(s)	Humans ; Students, Medical ; Pandemics ; COVID-19/epidemiology ; Physicians ; Qualitative Research ; Curriculum ; Education, Medical, Undergraduate
Language	English
Publishing date	2023-02-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2044473-4
ISSN	1472-6920 ; 1472-6920
ISSN (online)	1472-6920
ISSN	1472-6920
DOI	10.1186/s12909-023-04084-9
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Article ; Online: Correction: "You're actually part of the team": a qualitative study of a novel transitional role from medical student to doctor.

Edmiston, Natalie / Hu, Wendy / Tobin, Stephen / Bailey, Jannine / Joyce, Caroline / Reed, Krista / Mogensen, Lise

BMC medical education

2023 Volume 23, Issue 1, Page(s) 165

Language	English
Publishing date	2023-03-15
Publishing country	England
Document type	Published Erratum
ZDB-ID	2044473-4
ISSN	1472-6920 ; 1472-6920
ISSN (online)	1472-6920
ISSN	1472-6920
DOI	10.1186/s12909-023-04127-1
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Article ; Online: Childhood atopic dermatitis is associated with cardiovascular risk factors in young adulthood-A population-based cohort study.

Lundin, S / Wahlgren, C F / Johansson, E K / Andersson, N / Mogensen, I / Ekstrom, S / Jonsson, M / Melen, E / Ljungman, P L S / Bergstrom, A / Kull, I

Journal of the European Academy of Dermatology and Venereology : JEADV

2023 Volume 37, Issue 9, Page(s) 1854–1862

Abstract: Background: Studies have indicated that atopic dermatitis (AD) is associated with an increased risk of cardiovascular disease (CVD). However, data are conflicting. Furthermore, the longitudinal effect of childhood AD on cardiovascular risk factors in ... ...

Abstract	Background: Studies have indicated that atopic dermatitis (AD) is associated with an increased risk of cardiovascular disease (CVD). However, data are conflicting. Furthermore, the longitudinal effect of childhood AD on cardiovascular risk factors in young adulthood is less investigated. Objectives: To assess associations between AD in childhood and CVD risk factors in young adulthood. Methods: The study encompasses longitudinal data from a population-based birth cohort. Participants with data up to age 24 years were included (n = 2270). The primary outcomes were body mass index (BMI), waist circumference (WC), body fat per cent (BF%) and blood pressure (BP) at 24 years. The secondary outcome was blood lipids. Severe AD was defined as AD in combination with sleep disturbance due to itching. Results: In total, 18.6% (n = 420) had AD at 24 years. Males with AD had higher BMI (β Conclusion: AD in males appears to be associated with CVD risk factors in young adulthood. The duration and severity of AD seem to be of importance in both sexes.
MeSH term(s)	Male ; Female ; Humans ; Young Adult ; Adult ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/complications ; Dermatitis, Atopic/complications ; Dermatitis, Atopic/epidemiology ; Cohort Studies ; Risk Factors ; Body Mass Index ; Blood Pressure/physiology ; Waist Circumference ; Heart Disease Risk Factors
Language	English
Publishing date	2023-05-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1128828-0
ISSN	1468-3083 ; 0926-9959
ISSN (online)	1468-3083
ISSN	0926-9959
DOI	10.1111/jdv.19190
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Zs.A 3492: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 413: Show issues

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Article ; Online: The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation.

Farahani, Ensieh / Reinert, Line S / Narita, Ryo / Serrero, Manutea C / Skouboe, Morten Kelder / van der Horst, Demi / Assil, Sonia / Zhang, Baocun / Iversen, Marie B / Gutierrez, Eugenio / Hazrati, Hossein / Johannsen, Mogens / Olagnier, David / Kunze, Reiner / Denham, Mark / Mogensen, Trine H / Lappe, Michael / Paludan, Søren R

Cell reports

2024 Volume 43, Issue 2, Page(s) 113792

Abstract: Pattern recognition receptors (PRRs) induce host defense but can also induce exacerbated inflammatory responses. This raises the question of whether other mechanisms are also involved in early host defense. Using transcriptome analysis of disrupted ... ...

Abstract	Pattern recognition receptors (PRRs) induce host defense but can also induce exacerbated inflammatory responses. This raises the question of whether other mechanisms are also involved in early host defense. Using transcriptome analysis of disrupted transcripts in herpes simplex virus (HSV)-infected cells, we find that HSV infection disrupts the hypoxia-inducible factor (HIF) transcription network in neurons and epithelial cells. Importantly, HIF activation leads to control of HSV replication. Mechanistically, HIF activation induces autophagy, which is essential for antiviral activity. HSV-2 infection in vivo leads to hypoxia in CNS neurons, and mice with neuron-specific HIF1/2α deficiency exhibit elevated viral load and augmented PRR signaling and inflammatory gene expression in the CNS after HSV-2 infection. Data from human stem cell-derived neuron and microglia cultures show that HIF also exerts antiviral and inflammation-restricting activity in human CNS cells. Collectively, the HIF transcription factor system senses virus-induced hypoxic stress to induce cell-intrinsic antiviral responses and limit inflammation.
MeSH term(s)	Humans ; Animals ; Mice ; Encephalitis ; Inflammation ; Neurons ; Herpes Simplex ; Hypoxia ; Antiviral Agents/pharmacology
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2024.113792
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Article: Urine Flow Cytometry and Dipstick Analysis in Diagnosing Bacteriuria and Urinary Tract Infections among Adults in the Emergency Department-A Diagnostic Accuracy Trial.

Hertz, Mathias Amdi / Johansen, Isik Somuncu / Rosenvinge, Flemming S / Brasen, Claus Lohman / Andersen, Eline Sandvig / Østergaard, Claus / Skovsted, Thor Aage / Petersen, Eva Rabing Brix / Nielsen, Stig Lønberg / Mogensen, Christian Backer / Skjøt-Arkil, Helene

Diagnostics (Basel, Switzerland)

2024 Volume 14, Issue 4

Abstract: Urinary tract infections (UTIs) are a leading infectious cause of emergency department admission. Early UTI diagnosis is challenging, and a faster, preferably point-of-care urine analysis is necessary. We aimed to evaluate the diagnostic accuracy of ... ...

Abstract	Urinary tract infections (UTIs) are a leading infectious cause of emergency department admission. Early UTI diagnosis is challenging, and a faster, preferably point-of-care urine analysis is necessary. We aimed to evaluate the diagnostic accuracy of urine flow cytometry (UFC) and urine dipstick analysis (UDA) in identifying bacteriuria and UTIs. This study included adults suspected of an infection admitted to three Danish emergency departments. UFC and UDA were the index tests, and urine culture and an expert panel diagnosis were the reference tests. We used logistic regression and receiver operator characteristics curves to find each test's optimal model and cut-off. We enrolled 966 patients and performed urine cultures on 786. Urine culture was positive in 337, and 200 patients were diagnosed with a UTI. The UFC model ruled out bacteriuria in 10.9% with a negative predictive value (NPV) of 94.6% and ruled out UTI in 38.6% with an NPV of 97.0%. UDA ruled out bacteriuria in 52.1% with an NPV of 79.2% and UTI in 52.8% with an NPV of 93.9%. Neither UFC nor UDA performed well in ruling out bacteriuria in our population. In contrast, both tests ruled out UTI safely and in clinically relevant numbers.
Language	English
Publishing date	2024-02-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics14040412
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Article ; Online: Patients With Hypertrophic Cardiomyopathy and Normal Genetic Investigations Have Few Affected Relatives.

Nielsen, Søren K / Hansen, Frederikke G / Rasmussen, Torsten B / Fischer, Thomas / Lassen, Jens F / Madsen, Trine / Møller, Dorthe S / Klausen, Ib C / Brodersen, John B / Jensen, Morten S K / Mogensen, Jens

Journal of the American College of Cardiology

2023 Volume 82, Issue 18, Page(s) 1751–1761

Abstract: Background: Current guidelines recommend that relatives of index patients with hypertrophic cardiomyopathy (HCM) are offered clinical investigations to identify individuals at risk of adverse disease complications and sudden cardiac death. However, the ... ...

Abstract	Background: Current guidelines recommend that relatives of index patients with hypertrophic cardiomyopathy (HCM) are offered clinical investigations to identify individuals at risk of adverse disease complications and sudden cardiac death. However, the value of family screening in relatives of index patients with a normal genetic investigation of recognized HCM genes is largely unknown. Objectives: The purpose of this study was to perform family screening among relatives of HCM index patients with a normal genetic investigation to establish the frequency of familial disease and the clinical characteristics of affected individuals. Methods: Clinical and genetic investigations were performed in consecutive and unrelated HCM index patients. Relatives of index patients who did not carry pathogenic/likely pathogenic variants in recognized HCM genes were invited for clinical investigations. Results: In total, 60% (270 of 453) of HCM index patients had a normal genetic investigation. A total of 80% of their relatives (751 of 938, median age 44 years) participated in the study. Of these, 5% (34 of 751) were diagnosed with HCM at baseline, whereas 0.3% (2 of 717 [751-34]) developed the condition during 5 years of follow-up. Their median age at diagnosis was 57 years (IQR: 51-70 years). Two-thirds (22 of 36) were diagnosed following family screening, whereas one-third (14 of 36) had been diagnosed previously because of cardiac symptoms, a murmur, or an abnormal electrocardiogram. None of the affected relatives experienced adverse disease complications. The risk of SCD was low. Conclusions: Systematic family screening of index patients with HCM and normal genetic investigations was associated with a low frequency of affected relatives who appeared to have a favorable prognosis.
MeSH term(s)	Humans ; Adult ; Middle Aged ; Aged ; Genetic Testing ; Cardiomyopathy, Hypertrophic/diagnosis ; Cardiomyopathy, Hypertrophic/epidemiology ; Cardiomyopathy, Hypertrophic/genetics ; Death, Sudden, Cardiac/epidemiology ; Death, Sudden, Cardiac/etiology ; Death, Sudden, Cardiac/prevention & control ; Prognosis
Language	English
Publishing date	2023-10-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2023.08.041
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Zs.MO 196: Show issues

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Article: The Diagnostic Accuracy of Procalcitonin, Soluble Urokinase-Type Plasminogen Activator Receptors, and C-Reactive Protein in Diagnosing Urinary Tract Infections in the Emergency Department-A Diagnostic Accuracy Study.

Hertz, Mathias Amdi / Johansen, Isik Somuncu / Rosenvinge, Flemming S / Brasen, Claus Lohman / Andersen, Eline Sandvig / Heltborg, Anne / Skovsted, Thor Aage / Petersen, Eva Rabing Brix / Cartuliares, Mariana Bichuette / Nielsen, Stig Lønberg / Mogensen, Christian Backer / Skjøt-Arkil, Helene

Journal of clinical medicine

2024 Volume 13, Issue 6

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2024-03-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13061776
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Article ; Online: Assessment of the effectiveness of the EUROFORGEN NAME and Precision ID Ancestry panel markers for ancestry investigations.

Truelsen, D / Tvedebrink, T / Mogensen, H S / Farzad, M S / Shan, M A / Morling, N / Pereira, V / Børsting, C

Scientific reports

2021 Volume 11, Issue 1, Page(s) 18595

Abstract: The EUROFORGEN NAME panel is a regional ancestry panel designed to differentiate individuals from the Middle East, North Africa, and Europe. The first version of the panel was developed for the MassARRAY system and included 111 SNPs. Here, a custom ... ...

Abstract	The EUROFORGEN NAME panel is a regional ancestry panel designed to differentiate individuals from the Middle East, North Africa, and Europe. The first version of the panel was developed for the MassARRAY system and included 111 SNPs. Here, a custom AmpliSeq EUROFORGEN NAME panel with 102 of the original 111 loci was used to sequence 1098 individuals from 14 populations from Europe, the Middle East, North Africa, North-East Africa, and South-Central Asia. These samples were also sequenced with a global ancestry panel, the Precision ID Ancestry Panel. The GenoGeographer software was used to assign the AIM profiles to reference populations and calculate the weight of the evidence as likelihood ratios. The combination of the EUROFORGEN NAME and Precision ID Ancestry panels led to fewer ambiguous assignments, especially for individuals from the Middle East and South-Central Asia. The likelihood ratios showed that North African individuals could be separated from European and Middle Eastern individuals using the Precision ID Ancestry Panel. The separation improved with the addition of the EUROFORGEN NAME panel. The analyses also showed that the separation of Middle Eastern populations from European and South-Central Asian populations was challenging even when both panels were applied.
MeSH term(s)	DNA Fingerprinting ; Ethnicity/genetics ; Gene Frequency ; Genetics, Population ; Humans
Language	English
Publishing date	2021-09-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-97654-0
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Article ; Online: A Novel CDC42 Variant with Impaired Thymopoiesis, IL-7R Signaling, PAK1 Binding, and TCR Repertoire Diversity.

Assing, Kristian / Jørgensen, Sofie E / Sandgaard, Katrine S / De Keukeleere, Kerstin / B-Hansen, Marie / Petersen, Mikkel S / Hartling, Ulla B / Vaal, Thanis M K-de / Nielsen, Christian / Jakobsen, Marianne A / Watt, Eleanor / Adams, Stuart / Hao, Qin / Fagerberg, Christina / Mogensen, Trine H

Journal of clinical immunology

2023 Volume 43, Issue 8, Page(s) 1927–1940

Abstract: ... a rare disease manifestation. We report a novel CDC42 missense variant (c.46A > G, p.Lys16Glu) resulting ...

Abstract	Genetic variants in cell division cycle 42 (CDC42) can manifest with dysmorphic features, autoinflammation, hemophagocytic lymphohistiocytosis, and thrombocytopenia, whereas defective thymopoiesis is a rare disease manifestation. We report a novel CDC42 missense variant (c.46A > G, p.Lys16Glu) resulting in infection and HPV-driven carcinogenesis in the mosaic mother and impaired thymopoiesis and profound T cell lymphopenia in the heterozygous daughter identified through newborn screening for SCID. We found that surface expression of IL-7Rα (CD127) was decreased, consistent with reduced IL-7-induced STAT5 phosphorylation and accelerated apoptotic T cell death. Consistent with the vital role of IL-7 in regulating thymopoiesis, both patients displayed reduced T cell receptor CDR3 repertoires. Moreover, the CDC42 variant prevented binding to the downstream effector, p21-activated kinase (PAK)1, suggesting this impaired interaction to underlie reduced IL-7Rα expression and signaling. Here, we provide the first report of severely compromised thymopoiesis and perturbed IL-7Rα signaling caused by a novel CDC42 variant and presenting with diverging clinical and immunological phenotypes in patients.
MeSH term(s)	Humans ; Infant, Newborn ; Apoptosis ; Interleukin-7/genetics ; p21-Activated Kinases ; Receptors, Antigen, T-Cell/genetics ; Signal Transduction
Chemical Substances	Interleukin-7 ; p21-Activated Kinases (EC 2.7.11.1) ; PAK1 protein, human (EC 2.7.11.1) ; Receptors, Antigen, T-Cell ; CDC42 protein, human (EC 3.6.5.2)
Language	English
Publishing date	2023-08-15
Publishing country	Netherlands
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	779361-3
ISSN	1573-2592 ; 0271-9142
ISSN (online)	1573-2592
ISSN	0271-9142
DOI	10.1007/s10875-023-01561-0
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