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Book ; Online: The Objectionable Li Zhi

Handler-Spitz, Rivi / Lee, Pauline C / Saussy, Haun

Fiction, Criticism, and Dissent in Late Ming China

2021

Keywords	Literature: history & criticism ; Asian history ; dissent in China ; Ming dynasty intellectual history ; Li Zhi ; cultural history ; print culture ; Buddhism ; Confucianism
Language	English
Size	1 electronic resource (296 pages)
Publisher	University of Washington Press
Publishing place	Seattle
Document type	Book ; Online
Note	English
HBZ-ID	HT030613646
ISBN	9780295748375 ; 0295748370
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Rapid and Deep Response to Lorlatinib in Pancreatic High-Grade Neuroendocrine Carcinoma With a Treatment Emergent Novel KANK1-ALK Fusion.

Dayyani, Farshid / Lee, Whayoung / Houshyar, Roozbeh / Fontaine, Pauline

JCO precision oncology

2023 Volume 7, Page(s) e2200230

MeSH term(s)	Humans ; Adaptor Proteins, Signal Transducing ; Carcinoma, Neuroendocrine/drug therapy ; Carcinoma, Neuroendocrine/genetics ; Cytoskeletal Proteins ; Lactams ; Lactams, Macrocyclic ; Receptor Protein-Tyrosine Kinases
Chemical Substances	Adaptor Proteins, Signal Transducing ; Cytoskeletal Proteins ; KANK1 protein, human ; Lactams ; Lactams, Macrocyclic ; lorlatinib (OSP71S83EU) ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1)
Language	English
Publishing date	2023-01-09
Publishing country	United States
Document type	Case Reports ; Journal Article
ISSN	2473-4284
ISSN (online)	2473-4284
DOI	10.1200/PO.22.00230
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: From One Bilingual to the Next: An Iterated Learning Study on Language Evolution in Bilingual Societies.

Palma, Pauline / Lee, Sarah / Hodgins, Vegas / Titone, Debra

Cognitive science

2023 Volume 47, Issue 5, Page(s) e13289

Abstract: Studies of language evolution in the lab have used the iterated learning paradigm to show how linguistic structure emerges through cultural transmission-repeated cycles of learning and use across generations of speakers . However, agent-based simulations ...

Abstract	Studies of language evolution in the lab have used the iterated learning paradigm to show how linguistic structure emerges through cultural transmission-repeated cycles of learning and use across generations of speakers . However, agent-based simulations suggest that prior biases crucially impact the outcome of cultural transmission. Here, we explored this notion through an iterated learning study of English-French bilingual adults (mostly sequential bilinguals dominant in English). Each participant learned two unstructured artificial languages in a counterbalanced fashion, one resembling English, another resembling French at the phono-orthographic level. The output of each participant was passed down to the next participant, forming diffusion chains of 10 generations per language. We hypothesized that artificial languages would become easier to learn and exhibit greater structure when they were aligned with participants' bilingual experience (i.e., English languages being easier to learn overall), or as a function of practice (i.e., languages learned second being easier to learn overall). Instead, we found that English-like languages became more structured over generations, but only when they were learned first. In contrast, French-like languages became more structured regardless of the order of learning, suggesting the presence of an asymmetric switch cost during artificial language learning. Moreover, individual differences in language usage modulated the amount of structure produced by the participants. Overall, these data suggest that bilingual experience impacts how novel languages are learned at an individual level, which can then scale up to cultural transmission of novel language at a group level.
MeSH term(s)	Adult ; Humans ; Language ; Learning ; Language Development ; Linguistics ; Multilingualism
Language	English
Publishing date	2023-05-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2002940-8
ISSN	1551-6709 ; 0364-0213
ISSN (online)	1551-6709
ISSN	0364-0213
DOI	10.1111/cogs.13289
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Article: A Rare Case of Late- Onset Task-Specific Jaw Tremor.

Lau, Yue Hui / Ong, Tien Lee / Joseph, Joyce Pauline / Mawardi, Ahmad Shahir

Journal of clinical neurology (Seoul, Korea)

2023 Volume 19, Issue 4, Page(s) 416–418

Language	English
Publishing date	2023-07-07
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2500489-X
ISSN	2005-5013 ; 1738-6586
ISSN (online)	2005-5013
ISSN	1738-6586
DOI	10.3988/jcn.2022.0202
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Article ; Online: Correction: Amelioration of non-alcoholic fatty liver disease by targeting adhesion G protein-coupled receptor F1 (Adgrf1).

Wu, Mengyao / Lo, Tak-Ho / Li, Liping / Sun, Jia / Deng, Chujun / Chan, Ka-Ying / Li, Xiang / Yeh, Steve Ting-Yuan / Lee, Jimmy Tsz Hang / Lui, Pauline Po Yee / Xu, Aimin / Wong, Chi-Ming

eLife

2024 Volume 13

Language	English
Publishing date	2024-01-22
Publishing country	England
Document type	Published Erratum
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.96183
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Primary Prevention of Allergy - Is It Feasible?

Ng, Pauline Poh-Lin Chan / Tham, Elizabeth Huiwen / Lee, Bee-Wah

Allergy, asthma & immunology research

2023 Volume 15, Issue 4, Page(s) 419–436

Abstract: The allergy epidemic has been attributed to environmental influences related to urbanization and the modern lifestyle. In this regard, various theories exploring the role of microbes (hygiene, old friends, microbiota, and biodiversity hypotheses), and ... ...

Abstract	The allergy epidemic has been attributed to environmental influences related to urbanization and the modern lifestyle. In this regard, various theories exploring the role of microbes (hygiene, old friends, microbiota, and biodiversity hypotheses), and the epithelial barrier (epithelial, dual allergen exposure and vitamin D hypotheses) have been proposed. These hypotheses have guided clinical studies that led to the formulation of intervention strategies during the proposed window of opportunity dubbed as the "first thousand days." The most significant intervention is a paradigm shift from allergen avoidance to early introduction of allergenic foods, particularly egg and peanut, around 6 months of age for the prevention of food allergy. This recommendation has been adopted globally and included in allergy prevention guidelines. Other strategies with less robust clinical evidence include: encouraging a healthy balanced diet, rich in fish, during pregnancy; continuing allergenic food intake during pregnancy and lactation; vitamin D supplementation in pregnant women with asthma; discouraging social indications for caesarean section delivery; judicious use of antibiotics in early childhood; daily emollient use from birth in high risk babies; and avoiding cow's milk formula use in the first week of life. However, if early supplementation with cow's milk formula is required, continuing at least 10 mL of formula daily until age 2 months may be considered. Translating these strategies to public health and clinical practice is still a work in progress. Long-term population studies are crucial to assess the feasibility of these measures on allergy prevention.
Language	English
Publishing date	2023-07-19
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2545725-1
ISSN	2092-7363 ; 2092-7355
ISSN (online)	2092-7363
ISSN	2092-7355
DOI	10.4168/aair.2023.15.4.419
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Article ; Online: Controlling the selectivity of the hydrogenolysis of polyamides catalysed by ceria-supported metal nanoparticles.

Wu, XinBang / Lee, Wei-Tse / Turnell-Ritson, Roland C / Delannoi, Pauline C L / Lin, Kun-Han / Dyson, Paul J

Nature communications

2023 Volume 14, Issue 1, Page(s) 6524

Abstract: Catalytic hydrogenolysis is a promising approach to transform waste plastic into valuable chemicals. However, the transformation of N-containing polymers, such as polyamides (i.e. nylon), remains under-investigated, particularly by heterogeneous ... ...

Abstract	Catalytic hydrogenolysis is a promising approach to transform waste plastic into valuable chemicals. However, the transformation of N-containing polymers, such as polyamides (i.e. nylon), remains under-investigated, particularly by heterogeneous catalysis. Here, we demonstrate the hydrogenolysis of various polyamides catalysed by platinum-group metal nanoparticles supported on CeO
Language	English
Publishing date	2023-10-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-42246-x
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Article ; Online: Risk Factors for Infection Recurrence After Surgical Resection of Advanced Stage Osteonecrosis of the Mandible.

Doub, James B / Kang, Allison / Lee, Cameron / Dyalram, Donita / Shih, Pauline / Twaddell, William S / Lubek, Joshua E

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

2024 Volume 82, Issue 3, Page(s) 332–340

Abstract: Background: Advanced stage osteoradionecrosis (ORN) and medication-related osteonecrosis of the jaw (MRONJ) are challenging disease entities requiring multimodal therapy including surgical resection. However, risk factors associated with infection ... ...

Abstract	Background: Advanced stage osteoradionecrosis (ORN) and medication-related osteonecrosis of the jaw (MRONJ) are challenging disease entities requiring multimodal therapy including surgical resection. However, risk factors associated with infection recurrence are poorly understood. Purpose: The purpose of this study was to identify risk factors associated with infection recurrence following resection of advanced stage ORN or MRONJ of the mandible. Study design, setting, sample: This was a retrospective cohort study including patients who underwent segmental mandibulectomy for management of ORN or MRONJ between 2016 and 2021 at the authors' institution. Subjects who did not have margin viability data were excluded. Predictor/exposure/independent variable: The primary predictor variable was viability of resection margins on histopathologic analysis (viable or nonviable). Secondarily, other risk factors categorized as demographic (age, sex, race), medical (comorbidities), and perioperative (reconstructive modality, antibiotic duration, microbiological growth) were evaluated. Main outcome variable: The primary outcome variable was time to infection recurrence defined as time from surgical resection to clinical diagnosis of a fistula tract, abscess, or persistent inflammatory symptoms necessitating surgical intervention. Covariates: Not applicable. Analyses: Descriptive and bivariate statistics were used to identify associations between risk factors and time to infection recurrence. A significance level of P ≤ .05 was considered significant. Results: The cohort consisted of 57 subjects with a mean age of 63.3 ± 10.0 years (71.9% Male, 75.4% White) treated for ORN (47.4%) or MRONJ (52.6%). A total of 19/57 (33%) subjects developed a recurrence of infection with 1 and 2 year survival of 75.8 and 66.2%, respectively. Nonviable resection margins were associated with earlier time to infection recurrence (P ≤ .001, hazard ratio (HR) = 11.9, 95% confidence interval (CI) = 3.84 to 36.7) as was younger age (P = .005, HR = 0.921, 95% CI = 0.869 to 0.976) and atypical pathogen growth on culture (P = .002, HR = 8.58, 95% CI = 2.24 to 32.8). Conclusions and relevance: Histopathologic margin viability was associated with earlier time to infection recurrence following resection of advanced stage ORN or MRONJ of the mandible. Additional studies are needed to identify interventions that may improve outcomes in this demographic.
MeSH term(s)	Humans ; Male ; Middle Aged ; Aged ; Female ; Retrospective Studies ; Margins of Excision ; Osteonecrosis ; Osteoradionecrosis/surgery ; Mandible/surgery ; Risk Factors ; Bisphosphonate-Associated Osteonecrosis of the Jaw/surgery ; Bisphosphonate-Associated Osteonecrosis of the Jaw/drug therapy
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	392404-x
ISSN	1531-5053 ; 0278-2391
ISSN (online)	1531-5053
ISSN	0278-2391
DOI	10.1016/j.joms.2024.01.001
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Connecting the Dots of Care: A pilot study linking Aboriginal and/or Torres Strait Islander peoples with diabetes care in hospital, using hospital pharmacists.

Welch, Susan / Moles, Rebekah / Viardot, Alexander / Deweerd, Pauline / Daly, Scott / Lee, Kylie

Exploratory research in clinical and social pharmacy

2023 Volume 12, Page(s) 100351

Abstract: Background: Diabetes is common among Aboriginal and/or Torres Strait Islander peoples, yet often undetected in hospital.: Objective: To identify how urban hospital pharmacists can detect if Aboriginal and/or Torres Strait Islander patients have ... ...

Abstract	Background: Diabetes is common among Aboriginal and/or Torres Strait Islander peoples, yet often undetected in hospital. Objective: To identify how urban hospital pharmacists can detect if Aboriginal and/or Torres Strait Islander patients have diabetes or a higher chance of getting diabetes. Methods: A multi-methods study used data from patients, and researcher field notes. Aboriginal and/or Torres Strait Islander peoples admitted to hospital over 12-weeks (July-October 2021) were prospectively identified from admissions lists. A hospital pharmacist-researcher visited eligible patients. Consenting participants had their blood glucose and HbA1c checked. Participants with HbA1c > 6.5% (no known diabetes) or 7% (known diabetes) were referred for endocrinology review during their stay. Test results and resultant diabetes plan were shared with their general practitioner. Two days after discharge, participants were called to gauge views on their hospital-based diabetes care. Barcode technology recorded pharmacist time. Voice-recorded field notes were thematically analysed. Ethics approval was obtained. Results: Seventy-two patients were eligible for inclusion, 67/72 (93%) consented to take part. Sixty-one (91%) patients returned a HbA1c < 6.5, of which, 4/61 (6.5%) returned a HbA1c, 6-6.4. They were contacted to yarn about diabetes prevention. Six of the 67 (9%) qualified for endocrine review, 5 had known diabetes, one newly diagnosed. None were known to endocrinology. All participants telephoned were satisfied with their hospital-based diabetes care. Pharmacist time for initial introductory yarn, consenting process, organisation of HbA1c and results discussion was 20 min or 40 min if referred for endocrine review. Field notes guided understanding of service implementation. Conclusion: This novel pharmacist-led diabetes screening service for Aboriginal and/or Torres Strait Islander peoples appeared to provide a unique opportunity for screening and referral links in a holistic way. Future research is required to test this model by upscaling to include more pharmacists and other chronic disease screening and referral pathways.
Language	English
Publishing date	2023-10-14
Publishing country	United States
Document type	Journal Article
ISSN	2667-2766
ISSN (online)	2667-2766
DOI	10.1016/j.rcsop.2023.100351
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Article ; Online: Bioactive Decellularized Tendon-Derived Stem Cell Sheet for Promoting Graft Healing After Anterior Cruciate Ligament Reconstruction.

Yao, Shiyi / Liang, Zuru / Lee, Yuk Wa / Yung, Patrick Shu Hang / Lui, Pauline Po Yee

The American journal of sports medicine

2023 Volume 51, Issue 1, Page(s) 66–80

Abstract: Background: Stem cell sheets provide a scaffold-free option for the promotion of graft healing after anterior cruciate ligament reconstruction (ACLR). However, cell viability, stability, and potential uncontrolled actions create challenges for clinical ... ...

Abstract	Background: Stem cell sheets provide a scaffold-free option for the promotion of graft healing after anterior cruciate ligament reconstruction (ACLR). However, cell viability, stability, and potential uncontrolled actions create challenges for clinical translation. The decellularization of cell sheets may overcome these problems as studies have shown that the natural extracellular matrix of stem cells is bioactive and can promote tissue repair. Hypothesis: The decellularized tendon-derived stem cell (dTDSC) sheet can promote graft healing after ACLR. Study design: Controlled laboratory study. Methods: An optimized decellularization protocol was developed to decellularize the TDSC sheets. A total of 64 Sprague-Dawley rats underwent ACLR with or without the dTDSC sheet wrapping the tendon graft (n = 32/group). At 2 and 6 weeks after surgery, graft healing was assessed by micro-computed tomography, histology, and biomechanical testing. The accumulation of iNOS Results: The decellularization was successful, with the removal of 98.4% nucleic acid while preserving the collagenous proteins and bioactive factors. The expression of bone morphogenetic protein 2 (BMP-2) and VEGF in the dTDSC sheet was comparable with the TDSC sheet ( Conclusion: An optimized decellularization protocol for producing bioactive dTDSC sheets was developed. Wrapping tendon graft with a dTDSC sheet promoted graft healing after ACLR, likely via enhancing bone formation and angiogenesis by BMP-2 and VEGF, modulating macrophage polarization and MMP/TIMP expression, and physically protecting the tendon graft. Clinical relevance: dTDSC sheets alleviate the quality control and safety concerns of cell transplantation and can be used as a cell-free alternative for the promotion of graft healing in ACLR.
MeSH term(s)	Rats ; Animals ; Anterior Cruciate Ligament/surgery ; Matrix Metalloproteinase 13 ; Rats, Sprague-Dawley ; X-Ray Microtomography ; Matrix Metalloproteinase 1 ; Tissue Inhibitor of Metalloproteinase-1 ; Vascular Endothelial Growth Factor A ; Tendons/surgery ; Stem Cells ; Anterior Cruciate Ligament Reconstruction/methods
Chemical Substances	Matrix Metalloproteinase 13 (EC 3.4.24.-) ; Matrix Metalloproteinase 1 (EC 3.4.24.7) ; Tissue Inhibitor of Metalloproteinase-1 ; Vascular Endothelial Growth Factor A
Language	English
Publishing date	2023-01-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	197482-8
ISSN	1552-3365 ; 0363-5465
ISSN (online)	1552-3365
ISSN	0363-5465
DOI	10.1177/03635465221135770
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