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  1. Book ; Online ; E-Book: COVID-19 in Alzheimer's Disease and Dementia

    Reddy, P. Hemachandra / John, Albin

    2023  

    Author's details P. Hemachandra Reddy, Albin John
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xvi, 334 Seiten), Illustrationen, Diagramme
    Publisher Elsevier Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030003666
    ISBN 978-0-443-15257-3 ; 9780443152566 ; 0-443-15257-8 ; 044315256X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Molecular biology of aging

    Reddy, P. Hemachandra

    (Progress in molecular biology and translational science ; volume 146)

    2017  

    Author's details edited by P. Hemachandra Reddy
    Series title Progress in molecular biology and translational science ; volume 146
    Collection
    Language English
    Size xx, 372 Seiten, Illustrationen
    Publisher Elsevier Academic Press
    Publishing place Cambride, MA
    Publishing country United States
    Document type Book
    HBZ-ID HT019294390
    ISBN 978-0-12-811532-9 ; 0-12-811532-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uc I Zs 357 -146- verfügbar in Königswinter Königswinter

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  3. Book ; Online: Interphase Between Aging and Neurodegenerative Diseases

    Müller, Walter E. / Eckert, Anne / Hemachandra Reddy, P.

    2020  

    Keywords Science: general issues ; Neurosciences ; neurodegenerative diseases ; aging ; Parkinson's disease ; Alzheimer's disease ; neurodegeneration ; β-amyloid ; Aβ
    Size 1 electronic resource (129 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230581
    ISBN 9782889634569 ; 2889634566
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Unveiling the Role of Novel miRNA PC-5P-12969 in Alleviating Alzheimer's Disease.

    Vijayan, Murali / Reddy, P Hemachandra

    Journal of Alzheimer's disease : JAD

    2024  Volume 98, Issue 4, Page(s) 1329–1348

    Abstract: Background: The intricate and complex molecular mechanisms that underlie the progression of Alzheimer's disease (AD) have prompted a concerted and vigorous research endeavor aimed at uncovering potential avenues for therapeutic intervention.: ... ...

    Abstract Background: The intricate and complex molecular mechanisms that underlie the progression of Alzheimer's disease (AD) have prompted a concerted and vigorous research endeavor aimed at uncovering potential avenues for therapeutic intervention.
    Objective: This study aims to elucidate the role of miRNA PC-5P-12969 in the pathogenesis of AD.
    Methods: We assessed the differential expression of miRNA PC-5P-12969 in postmortem AD brains, AD animal and cell models using real-time reverse-transcriptase RT-PCR, we also checked the gene and protein expression of GSK3α and APP.
    Results: Our investigation revealed a notable upregulation of miRNA PC-5P-12969 in postmortem brains of AD patients, in transgenic mouse models of AD, and in mutant APP overexpressing-HT22 cells. Additionally, our findings indicate that overexpression of miRNA PC-5P-12969 exerts a protective effect on cell survival, while concurrently mitigating apoptotic cell death. Further-more, we established a robust and specific interaction between miRNA PC-5P-12969 and GSK3α. Our luciferase reporter assays provided confirmation of the binding between miRNA PC-5P-12969 and the 3'-UTR of the GSK3α gene. Manipulation of miRNA PC-5P-12969 levels in cellular models of AD yielded noteworthy alterations in the gene and protein expression levels of both GSK3α and APP. Remarkably, the manipulation of miRNA PC-5P-12969 levels yielded significant enhancements in mitochondrial respiration and ATP production, concurrently with a reduction in mitochondrial fragmentation, thus unveiling a potential regulatory role of miRNA PC-5P-12969 in these vital cellular processes.
    Conclusions: In summary, this study sheds light on the crucial role of miRNA PC-5P-12969 and its direct interaction with GSK3α in the context of AD.
    MeSH term(s) Mice ; Animals ; Humans ; Alzheimer Disease/pathology ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Mice, Transgenic ; Brain/pathology ; Up-Regulation
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2024-03-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-231281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6084: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Corrigendum to 'Mitophagy enhancers against phosphorylated Tau-induced mitochondrial and synaptic toxicities in Alzheimer disease' [Pharmacol Res. 174 (2021) 105973].

    Kshirsagar, Sudhir / Sawant, Neha / Morton, Hallie / Reddy, Arubala P / Reddy, P Hemachandra

    Pharmacological research

    2024  Volume 202, Page(s) 107134

    Language English
    Publishing date 2024-03-08
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2024.107134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: A Combinational Therapy for Preventing and Delaying the Onset of Alzheimer's Disease: A Focus on Probiotic and Vitamin Co-Supplementation.

    Sultana, Omme Fatema / Hia, Raksa Andalib / Reddy, P Hemachandra

    Antioxidants (Basel, Switzerland)

    2024  Volume 13, Issue 2

    Abstract: Alzheimer's disease is a progressive neurodegenerative disorder with a complex etiology, and effective interventions to prevent or delay its onset remain a global health challenge. In recent years, there has been growing interest in the potential role of ...

    Abstract Alzheimer's disease is a progressive neurodegenerative disorder with a complex etiology, and effective interventions to prevent or delay its onset remain a global health challenge. In recent years, there has been growing interest in the potential role of probiotic and vitamin supplementation as complementary strategies for Alzheimer's disease prevention. This review paper explores the current scientific literature on the use of probiotics and vitamins, particularly vitamin A, D, E, K, and B-complex vitamins, in the context of Alzheimer's disease prevention and management. We delve into the mechanisms through which probiotics may modulate gut-brain interactions and neuroinflammation while vitamins play crucial roles in neuronal health and cognitive function. The paper also examines the collective impact of this combinational therapy on reducing the risk factors associated with Alzheimer's disease, such as oxidative stress, inflammation, and gut dysbiosis. By providing a comprehensive overview of the existing evidence and potential mechanisms, this review aims to shed light on the promise of probiotic and vitamin co-supplementation as a multifaceted approach to combat Alzheimer's disease, offering insights into possible avenues for future research and clinical application.
    Language English
    Publishing date 2024-02-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox13020202
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Structural and physiological changes of the kidney with age and its impact on chronic conditions and COVID-19.

    Ray, Nandini / Reddy, P Hemachandra

    Ageing research reviews

    2023  Volume 88, Page(s) 101932

    Abstract: The kidney is an essential organ that removes waste products, balances the body's fluids, releases hormones that regulate blood pressure, produces an active form of vitamin D, promotes healthy bones, and controls the production of red blood cells. ... ...

    Abstract The kidney is an essential organ that removes waste products, balances the body's fluids, releases hormones that regulate blood pressure, produces an active form of vitamin D, promotes healthy bones, and controls the production of red blood cells. Structural and functional abnormalities occur in kidney with age. Alterations in kidney structure are based on physiological functions and environmental pressures. Variations in its structure across vertebrates are primarily due to the nature of alterations in number, complexity, arrangement, and location of the kidney tubules. Globally, individuals aged 65 and older are part of the fastest expanding population demographic, and as a result, a greater number of older patients are receiving a diagnosis of impaired renal function. The purpose of our mini-review is to summarize recent findings of the structural and functional differences between the normal and aging kidney, examine the evolutionary biology of the kidney across species, and demonstrate the role of aging in conditions such as diabetes, chronic kidney disease, and hypertension, along with their impact on SARS-CoV-2. Additional aims include discussing the potential therapeutic strategies to treat aged individuals with kidney health issues and how the impact of a healthy lifestyle, diet, and exercise can improve health conditions with aged kidneys.
    MeSH term(s) Animals ; Humans ; COVID-19 ; SARS-CoV-2 ; Kidney/physiology ; Hypertension ; Kidney Diseases ; Chronic Disease
    Language English
    Publishing date 2023-04-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2075672-0
    ISSN 1872-9649 ; 1568-1637
    ISSN (online) 1872-9649
    ISSN 1568-1637
    DOI 10.1016/j.arr.2023.101932
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5579: Show issues Location:
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  8. Article ; Online: Downregulation of StAR driven neurosteroid biosynthesis as a distinctive feature in the brains of Alzheimer's disease patients.

    Manna, Pulak R / Bose, Chhanda / Reddy, P Hemachandra

    Biochimica et biophysica acta. Molecular basis of disease

    2023  Volume 1869, Issue 6, Page(s) 166757

    MeSH term(s) Humans ; Alzheimer Disease/genetics ; Brain/metabolism ; Down-Regulation ; Neurosteroids ; tau Proteins/metabolism
    Chemical Substances Neurosteroids ; tau Proteins ; steroidogenic acute regulatory protein
    Language English
    Publishing date 2023-05-19
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 60-7
    ISSN 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbadis.2023.166757
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.247: Show issues Location:
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  9. Article ; Online: Is Effective Recruitment Strategy Critical to Assess Brain Cognitive Function of Super Agers in Rural West Texas.

    Brownell, Malcolm / Sehar, Ujala / Kshirsagar, Sudhir / Reddy, P Hemachandra

    Journal of Alzheimer's disease reports

    2024  Volume 8, Issue 1, Page(s) 555–559

    Abstract: Our commentary aims to elucidate the importance of participant recruitment strategy in healthy brain aging study, particularly in rural West Texas, where more than 50% of the population are Hispanics and Latinos. The objective of our health aging study ... ...

    Abstract Our commentary aims to elucidate the importance of participant recruitment strategy in healthy brain aging study, particularly in rural West Texas, where more than 50% of the population are Hispanics and Latinos. The objective of our health aging study is to investigate the possible influence of biological, sociodemographic, and lifestyle factors on the occurrence of chronic diseases and dementia in the aging populations of West Texas. The success of this initiative is, in large part, reliant on high-quality, effective recruitment of participants. To that end, we propose an increase in our strategic recruitment efforts for both healthy, cognitively superior agers as well as those with mild cognitive impairment and patients with Alzheimer's disease in rural west Texas. We discussed, multi-advertising approaches, including ads in the local newspapers, local TV Channels and poster boards in senior centers.
    Language English
    Publishing date 2024-03-19
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2542-4823
    ISSN (online) 2542-4823
    DOI 10.3233/ADR-240009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Mechanisms of pain in aging and age-related conditions: Focus on caregivers.

    Presto, Peyton / Sehar, Ujala / Kopel, Jonathan / Reddy, P Hemachandra

    Ageing research reviews

    2024  Volume 95, Page(s) 102249

    Abstract: Pain is a complex, subjective experience that can significantly impact quality of life, particularly in aging individuals, by adversely affecting physical and emotional well-being. Whereas acute pain usually serves a protective function, chronic pain is ... ...

    Abstract Pain is a complex, subjective experience that can significantly impact quality of life, particularly in aging individuals, by adversely affecting physical and emotional well-being. Whereas acute pain usually serves a protective function, chronic pain is a persistent pathological condition that contributes to functional deficits, cognitive decline, and emotional disturbances in the elderly. Despite substantial progress that has been made in characterizing age-related changes in pain, complete mechanistic details of pain processing mechanisms in the aging patient remain unknown. Pain is particularly under-recognized and under-managed in the elderly, especially among patients with Alzheimer's disease (AD), Alzheimer's disease-related dementias (ADRD), and other age-related conditions. Furthermore, difficulties in assessing pain in patients with AD/ADRD and other age-related conditions may contribute to the familial caregiver burden. The purpose of this article is to discuss the mechanisms and risk factors for chronic pain development and persistence, with a particular focus on age-related changes. Our article also highlights the importance of caregivers working with aging chronic pain patients, and emphasizes the urgent need for increased legislative awareness and improved pain management in these populations to substantially alleviate caregiver burden.
    MeSH term(s) Humans ; Aged ; Alzheimer Disease/psychology ; Caregivers/psychology ; Quality of Life/psychology ; Chronic Pain ; Aging
    Language English
    Publishing date 2024-02-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2075672-0
    ISSN 1872-9649 ; 1568-1637
    ISSN (online) 1872-9649
    ISSN 1568-1637
    DOI 10.1016/j.arr.2024.102249
    Database MEDical Literature Analysis and Retrieval System OnLINE

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