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Article ; Online: Recent advances in improving intranasal allergen-specific immunotherapy; focus on delivery systems and adjuvants.

Sadeghi, Mahvash / Asadirad, Ali / Koushki, Khadijeh / Keshavarz Shahbaz, Sanaz / Dehnavi, Sajad

2022 Volume 113, Issue Pt A, Page(s) 109327

Abstract: Allergen-specific Immunotherapy (AIT) is the main therapeutic strategy to control and treat allergic disorders. Intranasal Immunotherapy (INIT) was introduced as a needle-free, noninvasive, and efficient approach among various routes of allergen ... ...

Abstract	Allergen-specific Immunotherapy (AIT) is the main therapeutic strategy to control and treat allergic disorders. Intranasal Immunotherapy (INIT) was introduced as a needle-free, noninvasive, and efficient approach among various routes of allergen administration. Since direct exposure of nasal mucosa to allergen extracts could induce local and systemic reactions, recent studies focus on establishing novel formulations using various delivery systems and adjuvants to improve INIT efficacy. This review categorizes and describes natural and synthetic micro/nanoparticles such as chitosan, PLGA, liposome, exosome, and nano-emulation droplets used as delivery systems or immunomodulatory and immune-regulatory agents. Also, multiple microbial agents, including probiotics, mycobacterial and viral components, TLR ligands, and biologic agents, i.e., antibody fragments, recombinant cytokines, vitamin A, and pulsed dendritic cells (DCs), are other platforms that are discussed. In addition, future perspectives and proposed strategies to help INIT were provided.
MeSH term(s)	Humans ; Desensitization, Immunologic ; Allergens ; Adjuvants, Immunologic/therapeutic use ; Adjuvants, Immunologic/pharmacology ; Hypersensitivity/drug therapy ; Administration, Intranasal ; Immunotherapy ; Adjuvants, Pharmaceutic
Chemical Substances	Allergens ; Adjuvants, Immunologic ; Adjuvants, Pharmaceutic
Language	English
Publishing date	2022-10-17
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2022.109327
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Article ; Online: Gold Nanoparticles: Multifaceted Roles in the Management of Autoimmune Disorders.

Koushki, Khadijeh / Keshavarz Shahbaz, Sanaz / Keshavarz, Mohsen / Bezsonov, Evgeny E / Sathyapalan, Thozhukat / Sahebkar, Amirhossein

Biomolecules

2021 Volume 11, Issue 9

Abstract: Gold nanoparticles (GNPs) have been recently applied for various diagnostic and therapeutic purposes. The unique properties of these nanoparticles (NPs), such as relative ease of synthesis in various sizes, shapes and charges, stability, high drug- ... ...

Abstract	Gold nanoparticles (GNPs) have been recently applied for various diagnostic and therapeutic purposes. The unique properties of these nanoparticles (NPs), such as relative ease of synthesis in various sizes, shapes and charges, stability, high drug-loading capacity and relative availability for modification accompanied by non-cytotoxicity and biocompatibility, make them an ideal field of research in bio-nanotechnology. Moreover, their potential to alleviate various inflammatory factors, nitrite species, and reactive oxygen production and the capacity to deliver therapeutic agents has attracted attention for further studies in inflammatory and autoimmune disorders. Furthermore, the characteristics of GNPs and surface modification can modulate their toxicity, biodistribution, biocompatibility, and effects. This review discusses in vitro and in vivo effects of GNPs and their functionalized forms in managing various autoimmune disorders (Ads) such as rheumatoid arthritis, type 1 diabetes, and multiple sclerosis.
MeSH term(s)	Animals ; Autoimmune Diseases/therapy ; Cytokines/metabolism ; Gold/therapeutic use ; Humans ; Metal Nanoparticles/therapeutic use ; Nanotechnology
Chemical Substances	Cytokines ; Gold (7440-57-5)
Language	English
Publishing date	2021-08-30
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom11091289
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Article ; Online: PLGA-Based Curcumin Delivery System: An Interesting Therapeutic Approach in the Treatment of Alzheimer's Disease.

Shahbaz, Sanaz Keshavarz / Koushki, Khadijeh / Sathyapalan, Thozhukat / Majeed, Muhammed / Sahebkar, Amirhossein

Current neuropharmacology

2021 Volume 20, Issue 2, Page(s) 309–323

Abstract: Progressive degeneration and dysfunction of the nervous system because of oxidative stress, aggregations of misfolded proteins, and neuroinflammation are the key pathological features of neurodegenerative diseases. Alzheimer's disease is a chronic ... ...

Abstract	Progressive degeneration and dysfunction of the nervous system because of oxidative stress, aggregations of misfolded proteins, and neuroinflammation are the key pathological features of neurodegenerative diseases. Alzheimer's disease is a chronic neurodegenerative disorder driven by uncontrolled extracellular deposition of β-amyloid (Aβ) in the amyloid plaques and intracellular accumulation of hyperphosphorylated tau protein. Curcumin is a hydrophobic polyphenol with noticeable neuroprotective and anti-inflammatory effects that can cross the blood-brain barrier. Therefore, it is widely studied for the alleviation of inflammatory and neurological disorders. However, the clinical application of curcumin is limited due to its low aqueous solubility and bioavailability. Recently, nano-based curcumin delivery systems are developed to overcome these limitations effectively. This review article discusses the effects and potential mechanisms of curcumin-loaded PLGA nanoparticles in Alzheimer's disease.
MeSH term(s)	Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides ; Curcumin/therapeutic use ; Humans ; Neuroprotective Agents/therapeutic use ; Plaque, Amyloid
Chemical Substances	Amyloid beta-Peptides ; Neuroprotective Agents ; Curcumin (IT942ZTH98)
Language	English
Publishing date	2021-06-14
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	2192352-8
ISSN	1875-6190 ; 1570-159X
ISSN (online)	1875-6190
ISSN	1570-159X
DOI	10.2174/1570159X19666210823103020
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Article ; Online: Role of myeloid-derived suppressor cells in viral respiratory infections; Hints for discovering therapeutic targets for COVID-19.

Koushki, Khadijeh / Salemi, Maryam / Miri, Seyed Mohammad / Arjeini, Yaser / Keshavarz, Mohsen / Ghaemi, Amir

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2021 Volume 144, Page(s) 112346

Abstract: The expansion of myeloid-derived suppressor cells (MDSCs), known as heterogeneous population of immature myeloid cells, is enhanced during several pathological conditions such as inflammatory or viral respiratory infections. It seems that the way MDSCs ... ...

Abstract	The expansion of myeloid-derived suppressor cells (MDSCs), known as heterogeneous population of immature myeloid cells, is enhanced during several pathological conditions such as inflammatory or viral respiratory infections. It seems that the way MDSCs behave in infection depends on the type and the virulence mechanisms of the invader pathogen, the disease stage, and the infection-related pathology. Increasing evidence showing that in correlation with the severity of the disease, MDSCs are accumulated in COVID-19 patients, in particular in those at severe stages of the disease or ICU patients, contributing to pathogenesis of SARS-CoV2 infection. Based on the involved subsets, MDSCs delay the clearance of the virus through inhibiting T-cell proliferation and responses by employing various mechanisms such as inducing the secretion of anti-inflammatory cytokines, inducible nitric oxide synthase (iNOS)-mediated hampering of IFN-γ production, or forcing arginine shortage. While the immunosuppressive characteristic of MDSCs may help to preserve the tissue homeostasis and prevent hyperinflammation at early stages of the infection, hampering of efficient immune responses proved to exert significant pathogenic effects on severe forms of COVID-19, suggesting the targeting of MDSCs as a potential intervention to reactivate T-cell immunity and thereby prevent the infection from developing into severe stages of the disease. This review tried to compile evidence on the roles of different subsets of MDSCs during viral respiratory infections, which is far from being totally understood, and introduce the promising potential of MDSCs for developing novel diagnostic and therapeutic approaches, especially against COVID-19 disease.
MeSH term(s)	Antiviral Agents/pharmacology ; COVID-19/immunology ; COVID-19/virology ; Drug Discovery ; Humans ; Immune Tolerance ; Immunity, Innate ; Myeloid-Derived Suppressor Cells/drug effects ; Myeloid-Derived Suppressor Cells/physiology ; SARS-CoV-2 ; COVID-19 Drug Treatment
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2021-10-15
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2021.112346
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Article ; Online: Current possibilities and future perspectives for improving efficacy of allergen-specific sublingual immunotherapy.

Sadeghi, Mahvash / Keshavarz Shahbaz, Sanaz / Dehnavi, Sajad / Koushki, Khadijeh / Sankian, Mojtaba

International immunopharmacology

2021 Volume 101, Issue Pt B, Page(s) 108350

Abstract: Allergen-specific sublingual immunotherapy (SLIT), a safe and efficient route for treating type I hypersensitivity disorders, requires high doses of allergens. SLIT is generally performed without adjuvants and delivery systems. Therefore, allergen ... ...

Abstract	Allergen-specific sublingual immunotherapy (SLIT), a safe and efficient route for treating type I hypersensitivity disorders, requires high doses of allergens. SLIT is generally performed without adjuvants and delivery systems. Therefore, allergen formulation with appropriate presentation platforms results in improved allergen availability, targeting the immune cells, inducing regulatory immune responses, and enhancing immunotherapy's efficacy while decreasing the dose of the allergen. In this review, we discuss the adjuvants and delivery systems that have been applied as allergen-presentation platforms for SLIT. These adjuvants include TLRs ligands, 1α, 25-dihydroxy vitamin D3, galectin-9, probiotic and bacterial components that provoke allergen-specific helper type-1 T lymphocytes (TH1), and regulatory T cells (Tregs). Another approach is encapsulation or adsorption of the allergens into a particulate vector system to facilitate allergen capture by tolerogenic dendritic cells. Also, we proposed strategies to increasing the efficacy of SLIT via new immunopotentiators and carrier systems in the future.
MeSH term(s)	Adjuvants, Immunologic ; Allergens/immunology ; Animals ; Drug Delivery Systems ; Humans ; Hypersensitivity/immunology ; Hypersensitivity/therapy ; Immune Tolerance ; Probiotics ; Sublingual Immunotherapy/methods ; T-Lymphocytes, Regulatory/immunology
Chemical Substances	Adjuvants, Immunologic ; Allergens
Language	English
Publishing date	2021-11-12
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2021.108350
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Zs.A 5408: Show issues

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Article ; Online: Confirmed non-invasive prenatal testing for foetal Rh blood group genotyping along with bi-allelic short insertion/deletion polymorphisms as a positive internal control.

Armstrong-Fisher, Sylvia / Koushki, Khadijeh / Mashayekhi, Kazem / Urbaniak, Stanislaw J / van der Schoot, Ellen / Varzi, Ali Mohammad

Transfusion medicine (Oxford, England)

2022 Volume 32, Issue 2, Page(s) 141–152

Abstract: Background: Determination of foetus rhesus blood group at risk of hemolytic disease has potential application for early non-invasive prenatal testing (NIPT). There are several challenges in developing NIPT rhesus blood group genotyping assays by using ... ...

Abstract	Background: Determination of foetus rhesus blood group at risk of hemolytic disease has potential application for early non-invasive prenatal testing (NIPT). There are several challenges in developing NIPT rhesus blood group genotyping assays by using cell-free foetal DNA (cff-DNA) in plasma of RhD-negative pregnant women. So, the aim of this study was optimization of Real-time PCR assay for NIPT rhesus genotyping and development of Bi-allelic short insertion/deletion polymorphisms (INDELs) as internal control to optimise and validate rhesus genotyping based on Real-time PCR to avoid false or negative results. Material and methods: NIPT Rhesus genotyping including RHD (exon 7), RHCc, and RHEe genes were performed by TaqMan Real-time PCR on 104 maternal samples at different gestation ages (12 to ≥40 weeks) from 51 alloimmunized pregnant women. The sensitivity protocol was confirmed with standard DNA samples. Eight selected INDELs were designed and used to detectable cff-DNA in maternal plasma. INDELs frequency and inheritance were determined on 6 family and 61 unrelated individuals. Finally, multiplex Real-time PCR was performed for each sample with INDELs pairs and Rh probes. Results: The results showed 100% accuracy rhesus typing for RHD, RHC and RHE assays and 95.7% accuracy for RHc. Also, eight selected INDELs as internal control for NIPT were 100% concordance for typed samples. Conclusion: The Real-time PCR assay is a suitable method with high sensitivity and specificity for rhesus typing as NIPT for prediction of hemolytic disease in foetuses. The INDELs described here are suitable internal control for confirmation of NIPT on cff-DNA.
MeSH term(s)	Cell-Free Nucleic Acids ; DNA/genetics ; Female ; Fetus ; Genotype ; Humans ; Pregnancy ; Prenatal Diagnosis/methods ; Rh-Hr Blood-Group System
Chemical Substances	Cell-Free Nucleic Acids ; Rh-Hr Blood-Group System ; DNA (9007-49-2)
Language	English
Publishing date	2022-03-09
Publishing country	England
Document type	Journal Article
ZDB-ID	1067989-3
ISSN	1365-3148 ; 0958-7578
ISSN (online)	1365-3148
ISSN	0958-7578
DOI	10.1111/tme.12858
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Article ; Online: Epigenetic reprogramming mechanisms of immunity during influenza A virus infection.

Keshavarz, Mohsen / Sabbaghi, Ailar / Koushki, Khadijeh / Miri, Seyed Mohammad / Sarshari, Behrang / Vahdat, Katayoun / Ghaemi, Amir

Microbes and infection

2021 Volume 23, Issue 8, Page(s) 104831

Abstract: This paper reviews epigenetic mechanisms by which influenza viruses affect cellular gene activity to control their life cycles, aiming to provide new insights into the complexity of functional interactions between viral and cellular factors, as well as ... ...

Abstract	This paper reviews epigenetic mechanisms by which influenza viruses affect cellular gene activity to control their life cycles, aiming to provide new insights into the complexity of functional interactions between viral and cellular factors, as well as to introduce novel targets for therapeutic intervention and vaccine development against influenza infections.
MeSH term(s)	Epigenesis, Genetic ; Humans ; Influenza A virus/genetics ; Influenza Vaccines/genetics ; Influenza, Human ; Orthomyxoviridae ; Orthomyxoviridae Infections
Chemical Substances	Influenza Vaccines
Language	English
Publishing date	2021-04-18
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	1465093-9
ISSN	1769-714X ; 1286-4579
ISSN (online)	1769-714X
ISSN	1286-4579
DOI	10.1016/j.micinf.2021.104831
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Article ; Online: Comparison of Spirometry Values Measured in Healthy Adults with International Standards

Siavash EtemadiNezhad / Khadijeh Gheysar Koushki / Jamshid Yazdani Charati / Seyed Ehsan Samaei

تحقیقات سلامت در جامعه, Vol 7, Iss 2, Pp 1-

(A Case Study of Esfarayen)

2021 Volume 8

Abstract: Introduction and purpose: One of the most valuable and widely used methods in screening and evaluating respiratory diseases and diagnosing lung disorders is spirometry and comparing its value with standard references. Therefore, the present study aimed ... ...

Abstract	Introduction and purpose: One of the most valuable and widely used methods in screening and evaluating respiratory diseases and diagnosing lung disorders is spirometry and comparing its value with standard references. Therefore, the present study aimed to measure and compare spirometric values among adults in Esfarayen (northeastern Iran). Methods: In this cross-sectional study, demographic, anthropometric, and spirometry data (based on American Thoracic Society criteria) were obtained from 317 normal adults in the summer of 2019. Thereafter, the Forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), forced expiratory flow at 25-75% of the pulmonary volume (FEF25-75), and peak expiratory flow (PEF) values in Iranian adult population were compared with predictions from Economic Community for Coal and Steel ( ECCS), Knudson, Morris, and Pereira standardized references Data was analyzed in SPSS (version 18) using descriptive and analytical statistics (Kolmogorov-Smirnov, Pearson correlation and Paired sample t-test). Results: The mean scores of age and Body Mass Index (BMI) of subjects were reported as 29.63±0.38 years and 23.87±0.19 kg/m2, respectively. Statistical analysis demonstrated that the measured values of FVC, FEV1، FEF25-75, and PEF were significantly correlated with Knudson, Morris, ECCS, and Pereira references (P<0.05). Conclusion: The comparison of the measured spirometric values with the international standards revealed that the Morris standard had a very high correlation with all the measured spirometric values. Therefore, this standard was identified as a suitable (consistent) and applicable reference in the study population.
Keywords	adult ; pulmonary function tests ; reference standards ; spirometry ; Medicine ; R ; Public aspects of medicine ; RA1-1270
Subject code	310
Language	Persian
Publishing date	2021-07-01T00:00:00Z
Publisher	Mazandaran University of Medical Sciences
Document type	Article ; Online
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Article ; Online: Inflammasomes and Colorectal Cancer.

Keshavarz Shahbaz, Sanaz / Koushki, Khadijeh / Ayati, Seyed Hassan / Bland, Abigail R / Bezsonov, Evgeny E / Sahebkar, Amirhossein

Cells

2021 Volume 10, Issue 9

Abstract: Inflammasomes are important intracellular multiprotein signaling complexes that modulate the activation of caspase-1 and induce levels of the proinflammatory cytokines interleukin-1β (IL-1β) and IL-18 in response to pathogenic microorganisms and ... ...

Abstract	Inflammasomes are important intracellular multiprotein signaling complexes that modulate the activation of caspase-1 and induce levels of the proinflammatory cytokines interleukin-1β (IL-1β) and IL-18 in response to pathogenic microorganisms and molecules that originated from host proteins. Inflammasomes play contradictory roles in the development of inflammation-induced cancers. Based on several findings, inflammasomes can initiate and promote carcinogenesis. On the contrary, inflammasomes also exhibit anticancer effects by triggering pyroptosis and immunoregulatory functions. Herein, we review extant studies delving into different functions of inflammasomes in colorectal cancer development.
MeSH term(s)	Animals ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Cytokines/metabolism ; Humans ; Inflammasomes/metabolism ; Inflammation/metabolism ; Inflammation/pathology
Chemical Substances	Cytokines ; Inflammasomes
Language	English
Publishing date	2021-08-24
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells10092172
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Article ; Online: Dc-specific aptamer decorated gold nanoparticles: A new attractive insight into the nanocarriers for allergy epicutaneous immunotherapy.

Koushki, Khadijeh / Varasteh, Abdol-Reza / Shahbaz, Sanaz Keshavarz / Sadeghi, Mahvash / Mashayekhi, Kazem / Ayati, Seyed Hasan / Moghadam, Malihe / Sankian, Mojtaba

International journal of pharmaceutics

2020 Volume 584, Page(s) 119403

Abstract: Recently, the main goal of many allergy epicutaneous immunotherapy (EPIT) studies is to enhance the allergen delivery through the intact skin. Therefore, applying new strategies for tackling this issue are inevitable. For this purpose, ten groups of Che ... ...

Abstract	Recently, the main goal of many allergy epicutaneous immunotherapy (EPIT) studies is to enhance the allergen delivery through the intact skin. Therefore, applying new strategies for tackling this issue are inevitable. For this purpose, ten groups of Che a 2-sensitized BALB/c mice were epicutaneously treated for a 6-week period with the rChe a 2-GNPs-Aptamer, rChe a 2-GNPs-Aptamer + skin-penetrating peptides (SPPs), rChe a 2-GNPs, rChe a 2, GNPs, and PBS. Afterward, the serum IgE and IFN-γ, TGF-β, IL-10, IL-4, IL-17a cytokine production, NALF analysis, and lung/nasal histological examinations were performed. The present study results demonstrate that, EPIT in aptamer treated groups had a significant increase of IFN-γ, TGF-β, and IL-10 concentrations and a significant decrease of IgE, IL-4, and IL-17a concentrations as well as NALF infiltrated immune cell count compared to the non-targeted ones. In addition, SPPs led to more significant improvement of immunoregulatory parameters, especially IL-10 cytokine. Accordingly, the targeted-GNPs with DC-specific aptamers could act as an efficient approach for the improvement of EPIT efficacy compared to the free allergen. Moreover, the application of SPPs might be considered as a useful tool in achieving a successful EPIT with lower doses of allergen at a shorter duration of the treatment.
MeSH term(s)	Administration, Cutaneous ; Animals ; Aptamers, Nucleotide/administration & dosage ; Aptamers, Nucleotide/pharmacology ; Cytokines/biosynthesis ; Dendritic Cells ; Desensitization, Immunologic ; Female ; Gold/chemistry ; Immunoglobulin E/blood ; Inflammation Mediators/metabolism ; Metal Nanoparticles/chemistry ; Mice ; Mice, Inbred BALB C ; Rhinitis, Allergic/therapy
Chemical Substances	Aptamers, Nucleotide ; Cytokines ; Inflammation Mediators ; Immunoglobulin E (37341-29-0) ; Gold (7440-57-5)
Language	English
Publishing date	2020-05-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2020.119403
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