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Article ; Online: Editorial Expression of Concern: The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system.

Lu, Xiaowei / le Noble, Ferdinand / Yuan, Li / Jiang, Quingjan / de Lafarge, Benjamin / Sugiyama, Daisuke / Bréant, Christiane / Claes, Filip / De Smet, Frederik / Thomas, Jean- Léon / Autiero, Monica / Carmeliet, Peter / Tessier-Lavigne, Marc / Eichmann, Anne

Nature

2023 Volume 625, Issue 7994, Page(s) E12

Language	English
Publishing date	2023-12-18
Publishing country	England
Document type	Expression of Concern
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-023-06944-2
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Article ; Online: A droplet reactor on a super-hydrophobic surface allows control and characterization of amyloid fibril growth.

Zhang, Peng / Moretti, Manola / Allione, Marco / Tian, Yuansi / Ordonez-Loza, Javier / Altamura, Davide / Giannini, Cinzia / Torre, Bruno / Das, Gobind / Li, Erqiang / Thoroddsen, Sigurdur T / Sarathy, S Mani / Autiero, Ida / Giugni, Andrea / Gentile, Francesco / Malara, Natalia / Marini, Monica / Di Fabrizio, Enzo

Communications biology

2020 Volume 3, Issue 1, Page(s) 457

Abstract: Methods to produce protein amyloid fibrils, in vitro, and in situ structure characterization, are of primary importance in biology, medicine, and pharmacology. We first demonstrated the droplet on a super-hydrophobic substrate as the reactor to produce ... ...

Abstract	Methods to produce protein amyloid fibrils, in vitro, and in situ structure characterization, are of primary importance in biology, medicine, and pharmacology. We first demonstrated the droplet on a super-hydrophobic substrate as the reactor to produce protein amyloid fibrils with real-time monitoring of the growth process by using combined light-sheet microscopy and thermal imaging. The molecular structures were characterized by Raman spectroscopy, X-ray diffraction and X-ray scattering. We demonstrated that the convective flow induced by the temperature gradient of the sample is the main driving force in the growth of well-ordered protein fibrils. Particular attention was devoted to PHF6 peptide and full-length Tau441 protein to form amyloid fibrils. By a combined experimental with the molecular dynamics simulations, the conformational polymorphism of these amyloid fibrils were characterized. The study provided a feasible procedure to optimize the amyloid fibrils formation and characterizations of other types of proteins in future studies.
MeSH term(s)	Amyloid/chemistry ; Amyloid/ultrastructure ; Hydrophobic and Hydrophilic Interactions ; Microscopy, Atomic Force ; Molecular Dynamics Simulation ; Protein Aggregates ; Protein Folding ; Spectrum Analysis ; Structure-Activity Relationship ; X-Ray Diffraction
Chemical Substances	Amyloid ; Protein Aggregates
Language	English
Publishing date	2020-08-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-020-01187-7
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Article ; Online: Apixaban Interacts with Haemoglobin: Effects on Its Plasma Levels.

Sacco, Monica / Lancellotti, Stefano / Berruti, Federico / Arcovito, Alessandro / Bellelli, Andrea / Ricciardelli, Tiziana / Autiero, Ida / Cavallo, Luigi / Oliva, Romina / De Cristofaro, Raimondo

Thrombosis and haemostasis

2018 Volume 118, Issue 10, Page(s) 1701–1712

Abstract: The direct oral anticoagulant apixaban (APX), a strong factor Xa inhibitor, binds also to plasma proteins, especially albumin, and minimally to ... ...

Abstract	The direct oral anticoagulant apixaban (APX), a strong factor Xa inhibitor, binds also to plasma proteins, especially albumin, and minimally to α
MeSH term(s)	Aged ; Aged, 80 and over ; Anticoagulants/metabolism ; Anticoagulants/pharmacokinetics ; Blood Proteins/metabolism ; Cells, Cultured ; Cohort Studies ; Erythrocytes/physiology ; Factor Xa Inhibitors/metabolism ; Factor Xa Inhibitors/pharmacokinetics ; Female ; Hemoglobins/metabolism ; Humans ; Male ; Molecular Docking Simulation ; Protein Binding ; Pyrazoles/metabolism ; Pyrazoles/pharmacokinetics ; Pyridones/metabolism ; Pyridones/pharmacokinetics
Chemical Substances	Anticoagulants ; Blood Proteins ; Factor Xa Inhibitors ; Hemoglobins ; Pyrazoles ; Pyridones ; apixaban (3Z9Y7UWC1J)
Language	English
Publishing date	2018-09-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	518294-3
ISSN	2567-689X ; 0340-6245
ISSN (online)	2567-689X
ISSN	0340-6245
DOI	10.1055/s-0038-1669920
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Article: Fishing and frogging for anti-angiogenic drugs.

De Smet, Frederik / Carmeliet, Peter / Autiero, Monica

Nature chemical biology

2006 Volume 2, Issue 5, Page(s) 228–229

MeSH term(s)	Angiogenesis Inhibitors/pharmacology ; Angiogenesis Inhibitors/therapeutic use ; Animals ; Animals, Genetically Modified ; Clinical Trials as Topic ; Drug Evaluation, Preclinical ; Humans ; Mice ; Neovascularization, Pathologic/drug therapy ; Xenopus laevis ; Zebrafish
Chemical Substances	Angiogenesis Inhibitors
Language	English
Publishing date	2006-05
Publishing country	United States
Document type	Comment ; News
ZDB-ID	2202962-X
ISSN	1552-4469 ; 1552-4450
ISSN (online)	1552-4469
ISSN	1552-4450
DOI	10.1038/nchembio0506-228
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Zs.A 6251: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article: Zebrafish and Xenopus tadpoles: small animal models to study angiogenesis and lymphangiogenesis.

Ny, Annelii / Autiero, Monica / Carmeliet, Peter

Experimental cell research

2006 Volume 312, Issue 5, Page(s) 684–693

Abstract: Small vertebrate organisms have emerged as key players in the post-genomic era for the functional characterization of novel genes on a high-throughput scale. In this context, the zebrafish embryos and Xenopus tadpoles represent attractive and valuable ... ...

Abstract	Small vertebrate organisms have emerged as key players in the post-genomic era for the functional characterization of novel genes on a high-throughput scale. In this context, the zebrafish embryos and Xenopus tadpoles represent attractive and valuable models to rapidly identify and characterize novel genes involved in angiogenesis and lymphangiogenesis-a significant task with a consequent impact on the design of more effective therapeutic strategies. The advantages of these two models will be discussed in the present review.
MeSH term(s)	Animals ; Embryo, Nonmammalian/physiology ; Humans ; Lymphangiogenesis/physiology ; Models, Animal ; Neovascularization, Physiologic/physiology ; Research/trends ; Xenopus/embryology ; Xenopus/genetics ; Xenopus/physiology ; Zebrafish/embryology ; Zebrafish/genetics ; Zebrafish/physiology
Language	English
Publishing date	2006-03-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1493-x
ISSN	1090-2422 ; 0014-4827
ISSN (online)	1090-2422
ISSN	0014-4827
DOI	10.1016/j.yexcr.2005.10.018
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Article: Genetic dissection of tumor angiogenesis: are PlGF and VEGFR-1 novel anti-cancer targets?

Luttun, Aernout / Autiero, Monica / Tjwa, Marc / Carmeliet, Peter

Biochimica et biophysica acta

2004 Volume 1654, Issue 1, Page(s) 79–94

Abstract: Many proliferative diseases, most typically cancer, are driven by uncontrolled blood vessel growth. Genetic studies have been very helpful in unraveling the cellular and molecular players in pathological blood vessel formation and have provided ... ...

Abstract	Many proliferative diseases, most typically cancer, are driven by uncontrolled blood vessel growth. Genetic studies have been very helpful in unraveling the cellular and molecular players in pathological blood vessel formation and have provided opportunities to reduce tumor growth and metastasis. The fact that tumor vessels and normal blood vessels have distinct properties may help in designing more specific--and therefore safer--anti-angiogenic strategies. Such strategies may interfere with angiogenesis at the cellular or molecular level. Possible molecular targets include angiogenic growth factors and their receptors, proteinases, coagulation factors, junctional/adhesion molecules and extracellular matrix (ECM) components. Some anti-angiogenic drugs, i.e., vascular endothelial growth factor (VEGF) antibodies and VEGF receptor-2 (VEGFR-2) inhibitors, have progressed into clinical cancer trials. While the results of these trials support the potential of anti-angiogenic therapy to treat cancer, they also demonstrate the need for more effective and safer alternatives. Targeting placental growth factor (PlGF) or VEGFR-1 may constitute such an alternative since animal studies have proven their pleiotropic working mechanism and attractive safety profile. Together, these insights may bring anti-angiogenic drugs closer from bench to bedside.
MeSH term(s)	Angiogenesis Inducing Agents/metabolism ; Animals ; Blood Coagulation Factors/metabolism ; Drug Delivery Systems ; Extracellular Matrix Proteins/metabolism ; Growth Substances/metabolism ; Humans ; Lymphatic Vessels/metabolism ; Neoplasms/blood supply ; Neovascularization, Pathologic/metabolism ; Placenta Growth Factor ; Pregnancy Proteins/chemistry ; Pregnancy Proteins/metabolism ; Vascular Endothelial Growth Factor Receptor-1/chemistry ; Vascular Endothelial Growth Factor Receptor-1/drug effects ; Vascular Endothelial Growth Factor Receptor-1/metabolism
Chemical Substances	Angiogenesis Inducing Agents ; Blood Coagulation Factors ; Extracellular Matrix Proteins ; Growth Substances ; PGF protein, human ; Pregnancy Proteins ; Placenta Growth Factor (144589-93-5) ; Vascular Endothelial Growth Factor Receptor-1 (EC 2.7.10.1)
Language	English
Publishing date	2004-03-04
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	60-7
ISSN	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbcan.2003.09.002
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Article: VEGF and PlGF: two pleiotropic growth factors with distinct roles in development and homeostasis.

Tjwa, Marc / Luttun, Aernout / Autiero, Monica / Carmeliet, Peter

Cell and tissue research

2003 Volume 314, Issue 1, Page(s) 5–14

Abstract: Blood vessels are crucial for normal development and growth by providing oxygen and nutrients. As shown by genetic targeting studies in mice, zebrafish and Xenopus blood vessel formation (or angiogenesis) is a multistep process, which is highly dependent ...

Abstract	Blood vessels are crucial for normal development and growth by providing oxygen and nutrients. As shown by genetic targeting studies in mice, zebrafish and Xenopus blood vessel formation (or angiogenesis) is a multistep process, which is highly dependent on angiogenic growth factors such as VEGF, the founding member of the VEGF family. VEGF binds to the tyrosine kinase receptors VEGFR-1 and VEGFR-2, and loss of VEGF or its receptors results in abnormal angiogenesis and lethality during development. In contrast, PlGF, another member of this family, binds only to VEGFR-1, and appears to be crucial exclusively for pathological angiogenesis in the adult. However, the expression of VEGFR-1 and VEGFR-2 on non-vascular cells suggests additional biological properties for these growth factors. Indeed, the VEGF family and its receptors determine development and homeostasis of many organs, including the respiratory, skeletal, hematopoietic, nervous, renal and reproductive system, independent of their vascular role. These new insights broaden the activity spectrum of these "angiogenic" growth factors, and may have therapeutic implications when using these growth factors for vascular and/or non-vascular purposes.
MeSH term(s)	Animals ; Endothelial Growth Factors/metabolism ; Homeostasis ; Humans ; Models, Biological ; Neovascularization, Pathologic/metabolism ; Neovascularization, Physiologic ; Placenta Growth Factor ; Pregnancy Proteins/genetics ; Pregnancy Proteins/metabolism ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism ; Vascular Endothelial Growth Factors/metabolism
Chemical Substances	Endothelial Growth Factors ; PGF protein, human ; Pgf protein, mouse ; Pregnancy Proteins ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factors ; Placenta Growth Factor (144589-93-5)
Language	English
Publishing date	2003-10
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	125067-x
ISSN	1432-0878 ; 0302-766X
ISSN (online)	1432-0878
ISSN	0302-766X
DOI	10.1007/s00441-003-0776-3
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Article: Apixaban Interacts with Haemoglobin: Effects on Its Plasma Levels

Sacco, Monica / Lancellotti, Stefano / Berruti, Federico / Arcovito, Alessandro / Bellelli, Andrea / Ricciardelli, Tiziana / Autiero, Ida / Cavallo, Luigi / Oliva, Romina / De Cristofaro, Raimondo

Thrombosis and Haemostasis

2018 Volume 118, Issue 10, Page(s) 1701–1712

Abstract: The direct oral anticoagulant apixaban (APX), a strong factor Xa inhibitor, binds also to plasma proteins, especially albumin, and minimally to α 1 -acid glycoprotein. Although APX can cross the red cell membrane, due to its chemical structure, and could ...

Abstract	The direct oral anticoagulant apixaban (APX), a strong factor Xa inhibitor, binds also to plasma proteins, especially albumin, and minimally to α 1 -acid glycoprotein. Although APX can cross the red cell membrane, due to its chemical structure, and could bind to haemoglobin (Hb), no investigation was performed on this possible phenomenon that could affect the APX plasma concentration and thus its pharmacokinetics and pharmacodynamics. We addressed this issue by (1) measuring the levels of APX and haematological/biochemical parameters in 90 patients on APX therapy; (2) assessing the effect of APX on oxygen saturation curves of Hb; (3) testing the direct APX binding to Hb by fluorescence spectroscopy and a zinc-induced precipitation of Hb coupled to a reversed-phase high-performance liquid chromatography (HPLC)-based method; and (4) simulating in silico by molecular docking the APX interaction with human Hb. In a multivariable analysis, Hb was the only independent variable significantly and inversely associated in 90 patients with APX peak plasma level, at variance with patients treated with rivaroxaban ( n = 86) and dabigatran ( n = 34) therapy. APX causes a progressive left-shift of the oxygen dissociation curve of purified Hb solution, with a K d ≅300 µM. Fluorescence- and HPLC-based assays concordantly showed that APX binds to Hb with a K d ≅350 µM. Finally, docking simulations showed that APX can fit into in the central cavity of Hb. These findings support the hypothesis that APX does bind to Hb, which, due to its millimolar concentration in blood, can act as ‘buffer’ for the drug and consequently affect its free plasma level.
Keywords	anticoagulants ; apixaban ; erythrocytes ; haemoglobin ; molecular docking simulation ; individualized therapy
Language	English
Publishing date	2018-09-20
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	518294-3
ISSN	2567-689X ; 0340-6245
ISSN (online)	2567-689X
ISSN	0340-6245
DOI	10.1055/s-0038-1669920
Database	Thieme publisher's database

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Uh III Zs.192: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article: Guidance of vascular and neural network formation.

Eichmann, Anne / Le Noble, Ferdinand / Autiero, Monica / Carmeliet, Peter

Current opinion in neurobiology

2005 Volume 15, Issue 1, Page(s) 108–115

Abstract: Blood vessels and nerves are structurally similar complex branched systems. Their guidance must be exquisitely regulated to ensure proper wiring of both networks. Recent results showed that specialized endothelial cells, resembling axonal growth cones, ... ...

Abstract	Blood vessels and nerves are structurally similar complex branched systems. Their guidance must be exquisitely regulated to ensure proper wiring of both networks. Recent results showed that specialized endothelial cells, resembling axonal growth cones, form the tips of growing capillaries. These endothelial tip cells guide outgrowing capillaries in response to gradients of extracellular matrix-bound vascular endothelial growth factor. Several axon guidance molecules, including Semaphorins, Netrins, Ephrins and Slits, have also been implicated in vessel pathfinding and network formation. In particular, Semaphorin3E and its receptor plexinD1 in addition to the Netrin receptor UNC5B have recently been shown to direct endothelial tip cell navigation.
MeSH term(s)	Animals ; Endothelium, Vascular/embryology ; Endothelium, Vascular/growth & development ; Endothelium, Vascular/innervation ; Endothelium, Vascular/physiology ; Growth Cones/physiology ; Humans ; Neovascularization, Physiologic/physiology ; Nerve Net/embryology ; Nerve Net/growth & development ; Nerve Net/physiology
Language	English
Publishing date	2005-02
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1078046-4
ISSN	1873-6882 ; 0959-4388
ISSN (online)	1873-6882
ISSN	0959-4388
DOI	10.1016/j.conb.2005.01.008
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Article: Role of neural guidance signals in blood vessel navigation.

Autiero, Monica / De Smet, Frederik / Claes, Filip / Carmeliet, Peter

Cardiovascular research

2005 Volume 65, Issue 3, Page(s) 629–638

Abstract: Despite the tremendous progress achieved in both vasculogenesis and angiogenesis in the last decade, little is still known about the molecular mechanisms underlying the pathfinding of blood vessels during their formation. However, emerging evidence shows ...

Abstract	Despite the tremendous progress achieved in both vasculogenesis and angiogenesis in the last decade, little is still known about the molecular mechanisms underlying the pathfinding of blood vessels during their formation. However, emerging evidence shows that different axonal guidance cues, including members of the Slit and semaphorin families, are also involved in the blood vessel guidance, suggesting that blood vessels and nerves share common mechanisms in choosing and following specific paths to reach their respective targets. These promising findings open novel avenues not only in vascular biology but also in therapeutic angiogenesis. Indeed, the identification of new molecules involved in the guidance of blood vessels may be helpful in designing angiogenic strategies, which would insure both the formation of new blood vessels and their guidance into an organized and coordinated network.
MeSH term(s)	Animals ; Axons/physiology ; Blood Vessels/innervation ; Humans ; Neovascularization, Physiologic ; Nerve Growth Factors/physiology ; Signal Transduction/physiology ; Vascular Endothelial Growth Factor A/physiology
Chemical Substances	Nerve Growth Factors ; Vascular Endothelial Growth Factor A
Language	English
Publishing date	2005-02-15
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	80340-6
ISSN	1755-3245 ; 0008-6363
ISSN (online)	1755-3245
ISSN	0008-6363
DOI	10.1016/j.cardiores.2004.09.013
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