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  1. Article ; Online: Remembering Jane Cooke Wright, M.D., a Black Woman, Who was Among Seven Founders of the American Society of Clinical.

    Mitchell, Edith Peterson

    Journal of the National Medical Association

    2021  Volume 113, Issue 2, Page(s) 121–123

    MeSH term(s) African Americans ; Female ; History, 20th Century ; History, 21st Century ; Humans ; Medical Oncology/history ; Societies, Medical/history ; United States
    Language English
    Publishing date 2021-04-12
    Publishing country United States
    Document type Biography ; Editorial ; Historical Article
    ZDB-ID 419737-9
    ISSN 1943-4693 ; 0027-9684
    ISSN (online) 1943-4693
    ISSN 0027-9684
    DOI 10.1016/j.jnma.2021.02.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Representing women and female desire from Arcadia to Jane Eyre

    Mitchell, Marea / Osland, Dianne

    2005  

    Abstract: This book examines continuities and changes in narrative strategies deployed to deal with female desire in a broad range of fiction from the late sixteenth-century to the early nineteenth-century. By focussing on 'designing women' and the lengths to ... ...

    Institution ebrary, Inc
    Author's details Marea Mitchell and Dianne Osland
    Abstract This book examines continuities and changes in narrative strategies deployed to deal with female desire in a broad range of fiction from the late sixteenth-century to the early nineteenth-century. By focussing on 'designing women' and the lengths to which they can and should go as agents of their desires, this book investigates the way generic and moral or social issues intersect in the depiction of female subjectivity. The book examines narrative strategies deployed in the representation of female desire in a broad range of fiction from the late sixteenth-century to the early-nineteenth centu
    Keywords Desire in literature ; English literature/History and criticism ; Women and literature ; Women in literature
    Language English
    Size Online-Ressource (viii, 247 p), 23 cm
    Publisher Palgrave Macmillan
    Publishing place Houndmills, Basingstoke, Hampshire ;New York, N.Y
    Document type Book ; Online
    Note Includes bibliographical references (p. 232-242) and index
    ISBN 1403943311 ; 9781403943316
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  3. Book: Ham's primary care geriatrics

    Ham, Richard J. / Warshaw, Gregg A. / Potter, Jane F. / Flaherty, Ellen / Heflin, Mitchell T. / McNabney, Matthew K.

    a case-based approach

    2022  

    Title variant Primary care geriatrics
    Author's details edited by Gregg A. Warshaw [and five others]
    Keywords Geriatrics
    Subject code 618.97
    Language English
    Size xviii, 570 Seiten, 28 cm
    Edition Seventh edition
    Publisher Elsevier
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book
    Note Previous edition: Philadelphia: Elsevier/Saunders, 2014 ; Includes bibliographical references and index ; Zugang zu Online-Ausgabe über Code
    HBZ-ID HT021073370
    ISBN 978-0-323-72168-4 ; 9780323721691 ; 0-323-72168-0 ; 0323721699
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2022 A 169 available for loan (reading room) Lesesaal EG
    Zugang zu Online-Ausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  4. Article ; Online: Increased Osteoblast Gα

    Lee, Kathy K / Changoor, Adele / Grynpas, Marc D / Mitchell, Jane

    JBMR plus

    2023  Volume 7, Issue 12, Page(s) e10841

    Abstract: ... ...

    Abstract Gα
    Language English
    Publishing date 2023-11-15
    Publishing country England
    Document type Journal Article
    ISSN 2473-4039
    ISSN (online) 2473-4039
    DOI 10.1002/jbm4.10841
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Beyond epithelial damage: vascular and endothelial contributions to idiopathic pulmonary fibrosis.

    May, James / Mitchell, Jane A / Jenkins, R Gisli

    The Journal of clinical investigation

    2023  Volume 133, Issue 18

    Abstract: Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease of the lung with poor survival. The incidence and mortality of IPF are rising, but treatment remains limited. Currently, two drugs can slow the scarring process but often at the ... ...

    Abstract Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease of the lung with poor survival. The incidence and mortality of IPF are rising, but treatment remains limited. Currently, two drugs can slow the scarring process but often at the expense of intolerable side effects, and without substantially changing overall survival. A better understanding of mechanisms underlying IPF is likely to lead to improved therapies. The current paradigm proposes that repetitive alveolar epithelial injury from noxious stimuli in a genetically primed individual is followed by abnormal wound healing, including aberrant activity of extracellular matrix-secreting cells, with resultant tissue fibrosis and parenchymal damage. However, this may underplay the importance of the vascular contribution to fibrogenesis. The lungs receive 100% of the cardiac output, and vascular abnormalities in IPF include (a) heterogeneous vessel formation throughout fibrotic lung, including the development of abnormal dilated vessels and anastomoses; (b) abnormal spatially distributed populations of endothelial cells (ECs); (c) dysregulation of endothelial protective pathways such as prostacyclin signaling; and (d) an increased frequency of common vascular and metabolic comorbidities. Here, we propose that vascular and EC abnormalities are both causal and consequential in the pathobiology of IPF and that fuller evaluation of dysregulated pathways may lead to effective therapies and a cure for this devastating disease.
    MeSH term(s) Humans ; Endothelial Cells ; Cicatrix ; Idiopathic Pulmonary Fibrosis ; Drug-Related Side Effects and Adverse Reactions ; Epoprostenol
    Chemical Substances Epoprostenol (DCR9Z582X0)
    Language English
    Publishing date 2023-09-15
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI172058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Beyond epithelial damage

    James May / Jane A. Mitchell / R. Gisli Jenkins

    The Journal of Clinical Investigation, Vol 133, Iss

    vascular and endothelial contributions to idiopathic pulmonary fibrosis

    2023  Volume 18

    Abstract: Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease of the lung with poor survival. The incidence and mortality of IPF are rising, but treatment remains limited. Currently, two drugs can slow the scarring process but often at the ... ...

    Abstract Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease of the lung with poor survival. The incidence and mortality of IPF are rising, but treatment remains limited. Currently, two drugs can slow the scarring process but often at the expense of intolerable side effects, and without substantially changing overall survival. A better understanding of mechanisms underlying IPF is likely to lead to improved therapies. The current paradigm proposes that repetitive alveolar epithelial injury from noxious stimuli in a genetically primed individual is followed by abnormal wound healing, including aberrant activity of extracellular matrix–secreting cells, with resultant tissue fibrosis and parenchymal damage. However, this may underplay the importance of the vascular contribution to fibrogenesis. The lungs receive 100% of the cardiac output, and vascular abnormalities in IPF include (a) heterogeneous vessel formation throughout fibrotic lung, including the development of abnormal dilated vessels and anastomoses; (b) abnormal spatially distributed populations of endothelial cells (ECs); (c) dysregulation of endothelial protective pathways such as prostacyclin signaling; and (d) an increased frequency of common vascular and metabolic comorbidities. Here, we propose that vascular and EC abnormalities are both causal and consequential in the pathobiology of IPF and that fuller evaluation of dysregulated pathways may lead to effective therapies and a cure for this devastating disease.
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher American Society for Clinical Investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article ; Online: L-arginine supplementation protects against thrombosis and renal dysfunction in mice treated with the cyclooxygenase-2 inhibitor parecoxib.

    Vaja, Ricky / Lopes-Pires, Maria / Shala, Fisnik / Cypaite, Neringa / Vinokurova, Maria / Ferreira, Plinio / Mitchell, Jane A / Kirkby, Nicholas S

    Journal of thrombosis and haemostasis : JTH

    2024  

    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Letter
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1016/j.jtha.2024.03.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Discussion of "Forecasting macroeconomic variables using collapsed dynamic factor analysis" by Falk Bräuning and Siem Jan Koopman

    Mitchell, James / Bräuning, Falk / Koopman, Siem Jan

    International journal of forecasting Vol. 30, No. 3 , p. 585-588

    2014  Volume 30, Issue 3, Page(s) 585–588

    Author's details James Mitchell
    Language English
    Size graph. Darst.
    Publisher Elsevier
    Publishing place Amsterdam [u.a.]
    Document type Article
    ZDB-ID 283943x
    ISSN 0169-2070
    Database ECONomics Information System

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  9. Article ; Online: Defining a pathological role for the vasculature in the development of fibrosis and pulmonary hypertension in interstitial lung disease.

    George, Peter M / Mitchell, Jane A

    American journal of physiology. Lung cellular and molecular physiology

    2019  Volume 317, Issue 4, Page(s) L431–L433

    MeSH term(s) Chemokines ; Fibrosis ; Humans ; Hypertension, Pulmonary ; Hypoxia ; Lung Diseases, Interstitial ; Myeloid Cells ; Pulmonary Fibrosis
    Chemical Substances Chemokines
    Language English
    Publishing date 2019-08-21
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1013184-x
    ISSN 1522-1504 ; 1040-0605
    ISSN (online) 1522-1504
    ISSN 1040-0605
    DOI 10.1152/ajplung.00330.2019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A fast machine-learning-guided primer design pipeline for selective whole genome amplification.

    Dwivedi-Yu, Jane A / Oppler, Zachary J / Mitchell, Matthew W / Song, Yun S / Brisson, Dustin

    PLoS computational biology

    2023  Volume 19, Issue 4, Page(s) e1010137

    Abstract: Addressing many of the major outstanding questions in the fields of microbial evolution and pathogenesis will require analyses of populations of microbial genomes. Although population genomic studies provide the analytical resolution to investigate ... ...

    Abstract Addressing many of the major outstanding questions in the fields of microbial evolution and pathogenesis will require analyses of populations of microbial genomes. Although population genomic studies provide the analytical resolution to investigate evolutionary and mechanistic processes at fine spatial and temporal scales-precisely the scales at which these processes occur-microbial population genomic research is currently hindered by the practicalities of obtaining sufficient quantities of the relatively pure microbial genomic DNA necessary for next-generation sequencing. Here we present swga2.0, an optimized and parallelized pipeline to design selective whole genome amplification (SWGA) primer sets. Unlike previous methods, swga2.0 incorporates active and machine learning methods to evaluate the amplification efficacy of individual primers and primer sets. Additionally, swga2.0 optimizes primer set search and evaluation strategies, including parallelization at each stage of the pipeline, to dramatically decrease program runtime. Here we describe the swga2.0 pipeline, including the empirical data used to identify primer and primer set characteristics, that improve amplification performance. Additionally, we evaluate the novel swga2.0 pipeline by designing primer sets that successfully amplify Prevotella melaninogenica, an important component of the lung microbiome in cystic fibrosis patients, from samples dominated by human DNA.
    MeSH term(s) Humans ; Genomics ; Sequence Analysis, DNA/methods ; Genome ; DNA
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2023-04-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2193340-6
    ISSN 1553-7358 ; 1553-734X
    ISSN (online) 1553-7358
    ISSN 1553-734X
    DOI 10.1371/journal.pcbi.1010137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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