LIVIVO - Search results -

Search results

Result 1 - 10 of total 23

Search options

Article ; Online: Prior access to a sweet is more protective against cocaine self-administration in female rats than in male rats.

Cason, Angie M / Grigson, Patricia S

2013 Volume 112-113, Page(s) 96–103

Abstract: It is well established that female rats are more sensitive than male rats to the reinforcing effects of cocaine (Lynch, 2008 [42] for review). We hypothesized that greater preference for cocaine would support greater avoidance of a cocaine-paired taste ... ...

Abstract	It is well established that female rats are more sensitive than male rats to the reinforcing effects of cocaine (Lynch, 2008 [42] for review). We hypothesized that greater preference for cocaine would support greater avoidance of a cocaine-paired taste cue in female vs. male rats. Moreover, at least in male rats, greater avoidance of the taste cue is associated with greater cocaine self-administration (Grigson and Twining, 2002 [3]). Thus, we anticipated that female rats would not only demonstrate greater avoidance of the drug-paired taste cue, but greater drug-taking as well. We tested these hypotheses by examining avoidance of a saccharin cue in male and female rats following several pairings with self-administered saline or cocaine (0.16, 0.33, or 0.66 mg/infusion). Contrary to expectations, the results showed that female rats exhibited less avoidance of the cocaine-associated saccharin cue than male rats and self-administered less, rather than more, cocaine, Thus, while female rats reportedly take more drug than male rats when the drug is presented in the absence of an alternative reward, they take less drug than male rats when the opportunity to self-administer cocaine is preceded by access to a palatable sweet. Females, then, may not simply be more sensitive to the rewarding properties of drug, but also to the reinforcing properties of natural rewards and this increase in sensitivity to sweets may serve to protect against drug-taking behavior.
MeSH term(s)	Animals ; Cocaine/toxicity ; Cocaine-Related Disorders/prevention & control ; Conditioning, Operant/drug effects ; Disease Models, Animal ; Drug Administration Schedule ; Female ; Male ; Rats ; Rats, Sprague-Dawley ; Reinforcement Schedule ; Reinforcement, Psychology ; Saccharin/administration & dosage ; Self Administration ; Sex Characteristics ; Statistics as Topic ; Sweetening Agents/administration & dosage ; Taste/drug effects ; Water Deprivation/physiology
Chemical Substances	Sweetening Agents ; Saccharin (FST467XS7D) ; Cocaine (I5Y540LHVR)
Language	English
Publishing date	2013-03-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	3907-x
ISSN	1873-507X ; 0031-9384
ISSN (online)	1873-507X
ISSN	0031-9384
DOI	10.1016/j.physbeh.2013.02.017
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 747: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Role of Corticotropin Releasing Factor 1 Signaling in Cocaine Seeking during Early Extinction in Female and Male Rats.

Cason, Angie M / Kohtz, Amy / Aston-Jones, Gary

PloS one

2016 Volume 11, Issue 6, Page(s) e0158577

Abstract: Locus coeruleus norepinephrine (LC-NE) and corticotropin releasing factor (CRF) neurons are involved in stress responses, including stress's ability to drive drug relapse. Previous animal studies indicate that female rats exhibit greater drug seeking ... ...

Abstract	Locus coeruleus norepinephrine (LC-NE) and corticotropin releasing factor (CRF) neurons are involved in stress responses, including stress's ability to drive drug relapse. Previous animal studies indicate that female rats exhibit greater drug seeking than male rats during initial drug abstinence. Moreover, females are more sensitive to the effect of stress to drive drug seeking than males. Finally, LC-NE neurons are more sensitive to CRF in females compared to males. We hypothesized that increased drug seeking in females on extinction day one (ED1) is due to increased response to the stress of early withdrawal and is dependent upon the increased response of LC in females to CRF. We predicted that LC-NE neurons would exhibit Fos activation on ED1, and that blocking CRF1 signaling would decrease drug seeking on ED1 measured by responding on an active lever previously associated with cocaine self- administration. After chronic cocaine self-administration, female and male rats underwent a test for initial extinction responding by measuring lever pressing in the absence of cocaine. Prior to this Extinction Day 1 (ED1) session, rats were injected with vehicle or the selective CRF1 antagonist (CP) to measure effects of CRF antagonism on drug seeking during early abstinence. ED1 increased corticosterone in female rats, in proportion to lever responding in male and female, indicating that ED1 was stressful. Pretreatment with CP decreased cocaine seeking on ED1 more effectively in female compared to male rats. This increase in responding was associated with an increase in activation of LC NE neurons. Together, these findings indicate that stress, and signaling at CRF receptors in LC, may be involved in the increased drug seeking during initial abstinence.
MeSH term(s)	Animals ; Cocaine/administration & dosage ; Dopamine Uptake Inhibitors/administration & dosage ; Drug-Seeking Behavior/drug effects ; Extinction, Psychological/drug effects ; Female ; Male ; Pyrimidines/pharmacology ; Pyrroles/pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptors, Corticotropin-Releasing Hormone/antagonists & inhibitors ; Self Administration ; Signal Transduction/drug effects
Chemical Substances	CP 154526 ; Dopamine Uptake Inhibitors ; Pyrimidines ; Pyrroles ; Receptors, Corticotropin-Releasing Hormone ; CRF receptor type 1 (5CLY6W2H1M) ; Cocaine (I5Y540LHVR)
Language	English
Publishing date	2016-06-30
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0158577
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Role of Corticotropin Releasing Factor 1 Signaling in Cocaine Seeking during Early Extinction in Female and Male Rats.

Angie M Cason / Amy Kohtz / Gary Aston-Jones

PLoS ONE, Vol 11, Iss 6, p e

2016 Volume 0158577

Abstract	Locus coeruleus norepinephrine (LC-NE) and corticotropin releasing factor (CRF) neurons are involved in stress responses, including stress's ability to drive drug relapse. Previous animal studies indicate that female rats exhibit greater drug seeking than male rats during initial drug abstinence. Moreover, females are more sensitive to the effect of stress to drive drug seeking than males. Finally, LC-NE neurons are more sensitive to CRF in females compared to males. We hypothesized that increased drug seeking in females on extinction day one (ED1) is due to increased response to the stress of early withdrawal and is dependent upon the increased response of LC in females to CRF. We predicted that LC-NE neurons would exhibit Fos activation on ED1, and that blocking CRF1 signaling would decrease drug seeking on ED1 measured by responding on an active lever previously associated with cocaine self- administration. After chronic cocaine self-administration, female and male rats underwent a test for initial extinction responding by measuring lever pressing in the absence of cocaine. Prior to this Extinction Day 1 (ED1) session, rats were injected with vehicle or the selective CRF1 antagonist (CP) to measure effects of CRF antagonism on drug seeking during early abstinence. ED1 increased corticosterone in female rats, in proportion to lever responding in male and female, indicating that ED1 was stressful. Pretreatment with CP decreased cocaine seeking on ED1 more effectively in female compared to male rats. This increase in responding was associated with an increase in activation of LC NE neurons. Together, these findings indicate that stress, and signaling at CRF receptors in LC, may be involved in the increased drug seeking during initial abstinence.
Keywords	Medicine ; R ; Science ; Q
Subject code	590
Language	English
Publishing date	2016-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Role of orexin/hypocretin in conditioned sucrose-seeking in female rats.

Cason, Angie M / Aston-Jones, Gary

Neuropharmacology

2014 Volume 86, Page(s) 97–102

Abstract: The orexin/hypocretin system has recently been implicated in reward-seeking, especially for highly salient food and drug rewards. Given that eating disorders affect women more than men, we reasoned that the orexin system may be strongly engaged in female ...

Abstract	The orexin/hypocretin system has recently been implicated in reward-seeking, especially for highly salient food and drug rewards. Given that eating disorders affect women more than men, we reasoned that the orexin system may be strongly engaged in female rats, and during periods of food restriction as we recently reported in male rats. Therefore, the present study examined the involvement of the orexin system in operant responding for sucrose, and in cue-induced reinstatement of extinguished sucrose-seeking, in ad libitum fed vs. food-restricted female subjects. Female Sprague Dawley rats were trained to self-administer sucrose pellets, and we determined the effects of pretreatment with the OxR1 receptor antagonist SB 334867 (SB; 10-30 mg/kg) on fixed ratio (FR) sucrose self-administration, and on cue-induced reinstatement of extinguished sucrose-seeking. SB decreased sucrose self-administration in food-restricted but not in ad libitum-fed females. SB did not alter active lever responding during cue-induced reinstatement of sucrose-seeking in either feeding group. These results confirm our previous results in male rats that signaling at the OxR1 receptor is involved in the sucrose reinforcement and self-administration in food-restricted subjects. However, the finding that SB is ineffective at attenuating cue-induced reinstatement in females, but was effective in food-restricted males, leads us to conclude that food seeking induced by conditioned stimuli engages the orexin system differentially in males and females.
MeSH term(s)	Animals ; Appetitive Behavior/drug effects ; Appetitive Behavior/physiology ; Benzoxazoles/pharmacology ; Central Nervous System Agents/pharmacology ; Conditioning, Operant/physiology ; Cues ; Dietary Sucrose/administration & dosage ; Dose-Response Relationship, Drug ; Extinction, Psychological/drug effects ; Extinction, Psychological/physiology ; Female ; Food Deprivation/physiology ; Motivation/drug effects ; Motivation/physiology ; Naphthyridines ; Orexin Receptor Antagonists ; Orexin Receptors/metabolism ; Rats, Sprague-Dawley ; Reward ; Self Administration ; Sex Characteristics ; Spatial Behavior/drug effects ; Spatial Behavior/physiology ; Urea/analogs & derivatives ; Urea/pharmacology
Chemical Substances	1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea ; Benzoxazoles ; Central Nervous System Agents ; Dietary Sucrose ; Naphthyridines ; Orexin Receptor Antagonists ; Orexin Receptors ; Urea (8W8T17847W)
Language	English
Publishing date	2014-07-15
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	218272-5
ISSN	1873-7064 ; 0028-3908
ISSN (online)	1873-7064
ISSN	0028-3908
DOI	10.1016/j.neuropharm.2014.07.007
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui I Zs.242: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Attenuation of saccharin-seeking in rats by orexin/hypocretin receptor 1 antagonist.

Cason, Angie M / Aston-Jones, Gary

Psychopharmacology

2013 Volume 228, Issue 3, Page(s) 499–507

Abstract: Rationale: The orexin (Orx)/hypocretin system has been implicated in reward-seeking, especially for highly salient food and drug rewards. We recently demonstrated that signaling at the OxR1 receptor is involved in sucrose reinforcement and reinstatement ...

Abstract	Rationale: The orexin (Orx)/hypocretin system has been implicated in reward-seeking, especially for highly salient food and drug rewards. We recently demonstrated that signaling at the OxR1 receptor is involved in sucrose reinforcement and reinstatement of sucrose-seeking elicited by sucrose-paired cues in food-restricted rats. Because sucrose reinforcement has both a hedonic and caloric component, it remains unknown what aspect of this reward drives its reinforcing value. Objectives: The present study examined the involvement of the Orx system in operant responding for saccharin, a noncaloric, hedonic (sweet) reward, and in cue-induced reinstatement of extinguished saccharin-seeking in ad libitum-fed vs food-restricted male subjects. Methods: Male Sprague Dawley rats were fed ad libitum or food-restricted and trained to self-administer saccharin. We determined the effects of pretreatment with the OxR1 receptor antagonist SB-334867 (SB; 10-30 mg/kg) on fixed ratio (FR) saccharin self-administration and on cue-induced reinstatement of extinguished saccharin-seeking. Results: SB decreased responding and number of reinforcers earned during FR responding for saccharin and decreased cue-induced reinstatement of extinguished saccharin-seeking. All of these effects were obtained similarly in food-restricted and ad libitum-fed rats. Conclusions: These results indicate that signaling at the OxR1 receptor is involved in saccharin reinforcement and reinstatement of saccharin-seeking elicited by saccharin-paired cues regardless of food restriction. These findings lead us to conclude that the Orx system contributes to the motivational effects of hedonic food rewards, independently of caloric value and homeostatic needs.
MeSH term(s)	Animals ; Behavior, Animal/drug effects ; Benzoxazoles/pharmacology ; Dose-Response Relationship, Drug ; Drug-Seeking Behavior/drug effects ; Extinction, Psychological/drug effects ; Food Deprivation ; Male ; Naphthyridines ; Orexin Receptor Antagonists ; Rats ; Rats, Sprague-Dawley ; Reward ; Saccharin/administration & dosage ; Self Administration ; Urea/analogs & derivatives ; Urea/pharmacology
Chemical Substances	1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea ; Benzoxazoles ; Naphthyridines ; Orexin Receptor Antagonists ; Urea (8W8T17847W) ; Saccharin (FST467XS7D)
Language	English
Publishing date	2013-03-15
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	130601-7
ISSN	1432-2072 ; 0033-3158
ISSN (online)	1432-2072
ISSN	0033-3158
DOI	10.1007/s00213-013-3051-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ui I Zs.240: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Prior access to a sweet is more protective against cocaine self-administration in female rats than in male rats

Cason, Angie M / Grigson, Patricia S

Physiology & behavior. 2013 Mar. 15, v. 112-113

2013

Abstract	It is well established that female rats are more sensitive than male rats to the reinforcing effects of cocaine (Lynch, 2008 [42] for review). We hypothesized that greater preference for cocaine would support greater avoidance of a cocaine-paired taste cue in female vs. male rats. Moreover, at least in male rats, greater avoidance of the taste cue is associated with greater cocaine self-administration (Grigson and Twining, 2002 [3]). Thus, we anticipated that female rats would not only demonstrate greater avoidance of the drug-paired taste cue, but greater drug-taking as well. We tested these hypotheses by examining avoidance of a saccharin cue in male and female rats following several pairings with self-administered saline or cocaine (0.16, 0.33, or 0.66mg/infusion). Contrary to expectations, the results showed that female rats exhibited less avoidance of the cocaine-associated saccharin cue than male rats and self-administered less, rather than more, cocaine, Thus, while female rats reportedly take more drug than male rats when the drug is presented in the absence of an alternative reward, they take less drug than male rats when the opportunity to self-administer cocaine is preceded by access to a palatable sweet. Females, then, may not simply be more sensitive to the rewarding properties of drug, but also to the reinforcing properties of natural rewards and this increase in sensitivity to sweets may serve to protect against drug-taking behavior.
Keywords	cocaine ; drugs ; females ; rats ; saccharin ; sweets ; taste
Language	English
Dates of publication	2013-0315
Size	p. 96-103.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	3907-x
ISSN	1873-507X ; 0031-9384
ISSN (online)	1873-507X
ISSN	0031-9384
DOI	10.1016/j.physbeh.2013.02.017
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 74/401: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Role of orexin/hypocretin in conditioned sucrose-seeking in rats.

Cason, Angie M / Aston-Jones, Gary

Psychopharmacology

2012 Volume 226, Issue 1, Page(s) 155–165

Abstract: Rationale: The orexin/hypocretin system has recently been implicated in reward-seeking, especially for highly salient food and drug rewards. We reasoned that this system may be strongly engaged during periods of reward restriction, including food ... ...

Abstract	Rationale: The orexin/hypocretin system has recently been implicated in reward-seeking, especially for highly salient food and drug rewards. We reasoned that this system may be strongly engaged during periods of reward restriction, including food restriction. Objectives: This study examined the involvement of the orexin (Orx) system in responding for sucrose, and in cue-induced reinstatement of extinguished sucrose-seeking, in ad libitum fed versus food-restricted male subjects. Methods: Sprague-Dawley rats (n = 108) were trained to self-administer sucrose, and we determined the effects of pretreatment with the OxR1 receptor antagonist SB-334867 (SB; 10-30 mg/kg) on fixed ratio (FR) or progressive ratio (PR) sucrose self-administration, as well as on cue-induced reinstatement of sucrose-seeking. Finally, expression of the immediate early gene c-fos in Orx neurons was examined after self-administration, late extinction or cue-induced reinstatement of sucrose seeking. Results: SB decreased lever responding (by about 1/3) and the number of reinforcers earned during FR, and less so during PR, schedules and decreased cue-induced reinstatement to sucrose-seeking to extinction levels, predominately in food-restricted rats. Additionally, Fos expression in Orx neurons in perifornical and dorsomedial hypothalamus was increased during extinction. Conclusions: These results indicate that signaling at the OxR1 receptor is involved in pronounced sucrose reinforcement, and reinstatement of sucrose-seeking elicited by sucrose-paired cues, in food-restricted subjects. These findings lead us to conclude that conditioned activation of Orx neurons increases motivation for food reward during food restriction.
MeSH term(s)	Analysis of Variance ; Animals ; Behavior, Animal/drug effects ; Benzoxazoles/pharmacology ; Conditioning, Operant/drug effects ; Drug-Seeking Behavior/drug effects ; Extinction, Psychological/drug effects ; Food Deprivation ; Immunohistochemistry ; Intracellular Signaling Peptides and Proteins/metabolism ; Male ; Naphthyridines ; Neurons/drug effects ; Neurons/metabolism ; Neuropeptides/metabolism ; Orexin Receptors ; Orexins ; Rats ; Rats, Sprague-Dawley ; Receptors, G-Protein-Coupled/antagonists & inhibitors ; Receptors, Neuropeptide/antagonists & inhibitors ; Reinforcement Schedule ; Reward ; Self Administration ; Sucrose/administration & dosage ; Urea/analogs & derivatives ; Urea/pharmacology
Chemical Substances	1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea ; Benzoxazoles ; Intracellular Signaling Peptides and Proteins ; Naphthyridines ; Neuropeptides ; Orexin Receptors ; Orexins ; Receptors, G-Protein-Coupled ; Receptors, Neuropeptide ; Sucrose (57-50-1) ; Urea (8W8T17847W)
Language	English
Publishing date	2012-10-25
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	130601-7
ISSN	1432-2072 ; 0033-3158
ISSN (online)	1432-2072
ISSN	0033-3158
DOI	10.1007/s00213-012-2902-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ui I Zs.240: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Impact of gender on corticotropin-releasing factor and noradrenergic sensitivity in cocaine use disorder.

McRae-Clark, Aimee L / Cason, Angie M / Kohtz, Amy S / Moran Santa-Maria, Megan / Aston-Jones, Gary / Brady, Kathleen T

Journal of neuroscience research

2017 Volume 95, Issue 1-2, Page(s) 320–327

Abstract: Responses to stress may be important in understanding gender differences in substance use disorders and may also be a target for development of treatment interventions. A growing body of both preclinical and clinical research supports important ... ...

Abstract	Responses to stress may be important in understanding gender differences in substance use disorders and may also be a target for development of treatment interventions. A growing body of both preclinical and clinical research supports important underlying gender differences in the corticotropin-releasing factor (CRF) and noradrenergic systems, which may contribute to drug use. Preclinical models have demonstrated increased sensitivity of females to CRF and noradrenergic-induced drug reinstatement compared with males, and, consistent with these findings, human laboratory studies have demonstrated greater sensitivity to corticotropin-releasing hormone (CRH) and noradrenergic stimulation in cocaine-dependent women compared with men. Furthermore, neuroimaging studies have demonstrated increased neural response to stressful stimuli in cocaine-dependent women compared with men as well as showing significant sex differences in the sensitivity of brain regions responsible for regulating the response to CRH. Development of interventions targeting the noradrenergic system and stress response in drug-dependent individuals could have important clinical implications for both women and men. © 2016 Wiley Periodicals, Inc.
MeSH term(s)	Animals ; Brain/metabolism ; Cocaine-Related Disorders/metabolism ; Cocaine-Related Disorders/pathology ; Corticotropin-Releasing Hormone/metabolism ; Female ; Humans ; Male ; Norepinephrine/metabolism ; Sex Characteristics
Chemical Substances	Corticotropin-Releasing Hormone (9015-71-8) ; Norepinephrine (X4W3ENH1CV)
Language	English
Publishing date	2017-01-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	195324-2
ISSN	1097-4547 ; 0360-4012
ISSN (online)	1097-4547
ISSN	0360-4012
DOI	10.1002/jnr.23860
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1232: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: c-Fos induction by a 14 T magnetic field in visceral and vestibular relays of the female rat brainstem is modulated by estradiol.

Cason, Angie M / Kwon, Bumsup / Smith, James C / Houpt, Thomas A

Brain research

2010 Volume 1347, Page(s) 48–57

Abstract: There is increasing evidence that high magnetic fields interact with the vestibular system of humans and rodents. In rats, exposure to high magnetic fields of 7 T or above induces locomotor circling and leads to a conditioned taste aversion if paired ... ...

Abstract	There is increasing evidence that high magnetic fields interact with the vestibular system of humans and rodents. In rats, exposure to high magnetic fields of 7 T or above induces locomotor circling and leads to a conditioned taste aversion if paired with a novel taste. Sex differences in the behavioral responses to magnetic field exposure have been found, such that female rats show more locomotor circling and enhanced conditioned taste aversion compared to male rats. To determine if estrogen modulates the neural response to high magnetic fields, c-Fos expression after 14 T magnetic field exposure was compared in ovariectomized rats and ovariectomized rats with estradiol replacement. Compared to sham exposure, magnetic field exposure induced significantly more c-Fos positive cells in the nucleus of the solitary tract and the parabrachial, medial vestibular, prepositus, and supragenualis nuclei. Furthermore, there was a significant asymmetry in c-Fos induction between sides of the brainstem in several regions. In ovariectomized rats, there was more c-Fos expressed in the right side compared to left side in the locus coeruleus and parabrachial, superior vestibular, and supragenualis nuclei; less expression in the right compared to left side of the medial vestibular; and no asymmetry in the prepositus nucleus and the nucleus of the solitary tract. Chronic estradiol treatment modulated the neural response in some regions: less c-Fos was induced in the superior vestibular nucleus and locus coeruleus after estradiol replacement; estradiol treatment eliminated the asymmetry of c-Fos expression in the locus coeruleus and supragenualis nucleus, created an asymmetry in the prepositus nucleus and reversed the asymmetry in the parabrachial nucleus. These results suggest that ovarian steroids may mediate sex differences in the behavioral responses to magnetic field exposure at the level of visceral and vestibular nuclei of the brainstem.
MeSH term(s)	Analysis of Variance ; Animals ; Brain Stem/drug effects ; Brain Stem/metabolism ; Brain Stem/radiation effects ; Estradiol/pharmacology ; Estrogens/pharmacology ; Female ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/physiology ; Gene Expression Regulation/radiation effects ; Magnetic Resonance Spectroscopy/methods ; Magnetics/methods ; Motor Activity/drug effects ; Motor Activity/radiation effects ; Ovariectomy/methods ; Proto-Oncogene Proteins c-fos/metabolism ; Rats ; Rats, Sprague-Dawley ; Statistics as Topic ; Vestibular Nuclei/physiology ; Viscera/innervation
Chemical Substances	Estrogens ; Proto-Oncogene Proteins c-fos ; Estradiol (4TI98Z838E)
Language	English
Publishing date	2010-06-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1200-2
ISSN	1872-6240 ; 0006-8993
ISSN (online)	1872-6240
ISSN	0006-8993
DOI	10.1016/j.brainres.2010.06.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 161: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Labyrinthectomy abolishes the behavioral and neural response of rats to a high-strength static magnetic field.

Cason, Angie M / Kwon, Bumsup / Smith, James C / Houpt, Thomas A

Physiology & behavior

2009 Volume 97, Issue 1, Page(s) 36–43

Abstract: Vertigo is a commonly-reported side effect of exposure to the high magnetic fields found in magnetic resonance imaging machines. Although it has been hypothesized that high magnetic fields interact with the vestibular apparatus of the inner ear, there ... ...

Abstract	Vertigo is a commonly-reported side effect of exposure to the high magnetic fields found in magnetic resonance imaging machines. Although it has been hypothesized that high magnetic fields interact with the vestibular apparatus of the inner ear, there has been no direct evidence establishing its role in magnet-induced vertigo. Our laboratory has shown that following exposure to high magnetic fields, rats walk in circles, acquire a conditioned taste aversion (CTA), and express c-Fos in vestibular and visceral relays of the brainstem, consistent with vestibular stimulation and vertigo or motion sickness. To determine if the inner ear is required for these effects, rats were chemically labyrinthectomized with sodium arsanilate and tested for locomotor circling, CTA acquisition, and c-Fos induction after exposure within a 14.1 T magnet. Intact rats circled counterclockwise after 30-min exposure to 14.1 T, but labyrinthectomized rats showed no increase in circling after magnetic field exposure. After 3 pairings of 0.125% saccharin with 30-min exposure at 14.1 T, intact rats acquired a profound CTA that persisted for 14 days of extinction testing; labyrinthectomized rats, however, did not acquire a CTA and showed a high preference for saccharin similar to sham-exposed rats. Finally, significant c-Fos was induced in the brainstem of intact rats by 30-min exposure to 14.1 T, but magnetic field exposure did not elevate c-Fos in labyrinthectomized rats above sham-exposed levels. These results demonstrate that an intact inner ear is necessary for all the observed effects of exposure to high magnetic fields in rats.
MeSH term(s)	Animals ; Arsanilic Acid ; Brain Stem/metabolism ; Conditioning, Psychological/physiology ; Ear, Inner/physiology ; Female ; Locomotion ; Magnetics ; Neural Pathways/metabolism ; Proto-Oncogene Proteins c-fos/metabolism ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Proto-Oncogene Proteins c-fos ; Arsanilic Acid (UDX9AKS7GM)
Language	English
Publishing date	2009-01-31
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	3907-x
ISSN	1873-507X ; 0031-9384
ISSN (online)	1873-507X
ISSN	0031-9384
DOI	10.1016/j.physbeh.2009.01.018
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 747: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito