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  1. Book ; Conference proceedings: 8th International Conference on Cryptococcus and Cryptococcosis

    Del Poeta, Maurizio

    [held in Charleston, SC, from May 1 - 5, 2011]

    (Mycopathologia ; 173,5/6 = Special issue)

    2012  

    Event/congress International Conference on Cryptococcus and Cryptococcosis (8, 2011, CharlestonSC)
    Author's details guest ed.: Maurizio Del Poeta
    Series title Mycopathologia ; 173,5/6 = Special issue
    Collection
    Language English
    Size S. 283 - 471 : Ill., graph. Darst.
    Publisher Springer
    Publishing place Heidelberg u.a.
    Publishing country Germany
    Document type Book ; Conference proceedings
    HBZ-ID HT017246119
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ud II Zs 99 -173- verfügbar in Königswinter Königswinter

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  2. Book: Sphingolipids as signaling and regulatory molecules

    Del Poeta, Maurizio / Chalfant, Charles

    (Advances in experimental medicine and biology ; 688)

    2010  

    Author's details ed. by Charles Chalfant, Maurizio Del Poeta
    Series title Advances in experimental medicine and biology ; 688
    Collection
    Keywords Sphingolipids
    Language English
    Size XXIV, 291 S. : Ill., graph. Darst.
    Publisher Springer u.a.
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT016514418
    ISBN 978-1-441-96740-4 ; 1-441-96740-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 3192 -688- not available for loan Zeitschriften-Lesesaal

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  3. Article ; Online: Role of sphingolipids in the host-pathogen interaction.

    Matos, Gabriel Soares / Fernandes, Caroline Mota / Del Poeta, Maurizio

    Biochimica et biophysica acta. Molecular and cell biology of lipids

    2023  Volume 1868, Issue 11, Page(s) 159384

    Abstract: Fungal pathogens have been under the spotlight as their expanding geographic range combined with their potential harm to vulnerable populations turns them into increasingly threats to public health. Therefore, it is ultimately important to unveil the ... ...

    Abstract Fungal pathogens have been under the spotlight as their expanding geographic range combined with their potential harm to vulnerable populations turns them into increasingly threats to public health. Therefore, it is ultimately important to unveil the mechanisms associated with their infection process for further new treatment discovery. With this purpose, sphingolipid-based research has gained attention over the last years as these molecules have key properties that can regulate fungal pathogenicity. Here we discuss some of these properties as well as their role in fungal diseases, focusing on the subgroup of glycosphingolipids, as they represent promising molecules for drug discovery and for the development of fungal vaccines.
    MeSH term(s) Sphingolipids ; Glycosphingolipids ; Host-Pathogen Interactions
    Chemical Substances Sphingolipids ; Glycosphingolipids
    Language English
    Publishing date 2023-09-04
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 60-7
    ISSN 1879-2618 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2618 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbalip.2023.159384
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Host populations, challenges, and commercialization of cryptococcal vaccines.

    Del Poeta, Maurizio / Wormley, Floyd L / Lin, Xiaorong

    PLoS pathogens

    2023  Volume 19, Issue 2, Page(s) e1011115

    Abstract: Vaccines are one of the most effective public health tools to prevent and manage infectious diseases. Since the first clinical use of vaccines in the late 18th century, many vaccines have been successfully developed to combat bacterial and viral ... ...

    Abstract Vaccines are one of the most effective public health tools to prevent and manage infectious diseases. Since the first clinical use of vaccines in the late 18th century, many vaccines have been successfully developed to combat bacterial and viral infections, including the most recent Coronavirus Disease 2019 (COVID-19) pandemic. However, there remains no vaccine that is clinically available to treat or prevent invasive fungal diseases, including cryptococcal meningoencephalitis. This fungal disease is uniformly fatal without treatment and has a global mortality rate of over 70%. Despite a dire need for an effective cryptococcal vaccine, there are many scientific and economic challenges to overcome prior to making it a reality. Here, we discuss some of these challenges as well as steps that the community is taking for commercialization of effective cryptococcal vaccines.
    MeSH term(s) Humans ; COVID-19 ; Vaccines ; Communicable Diseases ; Cryptococcus neoformans ; Mycoses ; Viral Vaccines
    Chemical Substances Vaccines ; Viral Vaccines
    Language English
    Publishing date 2023-02-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1011115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Mass Spectrometric Analysis of Bioactive Sphingolipids in Fungi.

    Singh, Ashutosh / Del Poeta, Maurizio

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2306, Page(s) 239–255

    Abstract: As biomolecules, sphingolipids represent a broad spectrum of structures ranging from simple long chain bases to complex glycosphingolipids. While several different mass spectrometry based approaches have been proven to be useful in qualitative and ... ...

    Abstract As biomolecules, sphingolipids represent a broad spectrum of structures ranging from simple long chain bases to complex glycosphingolipids. While several different mass spectrometry based approaches have been proven to be useful in qualitative and quantitative analysis of sphingolipids, we find that electrospray ionization tandem mass spectrometry (ESI-MS/MS) in the multiple-reaction monitoring (MRM) mode using a triple quadrupole instrument, coupled to high-performance liquid chromatography (HPLC), is the most suitable approach for the analysis. In this chapter, we describe the method in a step-by-step manner towards the targeted analysis of sphingolipids in fungi. With optimized HPLC separation and instrument settings, this MRM approach affords detection of many sphingolipid species simultaneously with good sensitivity.
    MeSH term(s) Chromatography, High Pressure Liquid ; Fungi/chemistry ; Lipidomics/methods ; Spectrometry, Mass, Electrospray Ionization ; Sphingolipids/analysis ; Tandem Mass Spectrometry
    Chemical Substances Sphingolipids
    Language English
    Publishing date 2021-05-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1410-5_16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Three Models of Vaccination Strategies Against Cryptococcosis in Immunocompromised Hosts Using Heat-Killed

    Normile, Tyler G / Del Poeta, Maurizio

    Frontiers in immunology

    2022  Volume 13, Page(s) 868523

    Abstract: Vaccines are one of the greatest medical accomplishments to date, yet no fungal vaccines are currently available in humans mainly because opportunistic mycoses generally occur during immunodeficiencies necessary for vaccine protection. In previous ... ...

    Abstract Vaccines are one of the greatest medical accomplishments to date, yet no fungal vaccines are currently available in humans mainly because opportunistic mycoses generally occur during immunodeficiencies necessary for vaccine protection. In previous studies, a live, attenuated
    MeSH term(s) Animals ; Cryptococcosis ; Cryptococcus neoformans ; Disease Models, Animal ; Hot Temperature ; Immunocompromised Host ; Mice ; Vaccination
    Language English
    Publishing date 2022-05-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.868523
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Sterylglucosides in Fungi.

    Pereira de Sa, Nivea / Del Poeta, Maurizio

    Journal of fungi (Basel, Switzerland)

    2022  Volume 8, Issue 11

    Abstract: Sterylglucosides (SGs) are sterol conjugates widely distributed in nature. Although their universal presence in all living organisms suggests the importance of this kind of glycolipids, they are yet poorly understood. The glycosylation of sterols confers ...

    Abstract Sterylglucosides (SGs) are sterol conjugates widely distributed in nature. Although their universal presence in all living organisms suggests the importance of this kind of glycolipids, they are yet poorly understood. The glycosylation of sterols confers a more hydrophilic character, modifying biophysical properties of cell membranes and altering immunogenicity of the cells. In fungi, SGs regulate different cell pathways to help overcome oxygen and pH challenges, as well as help to accomplish cell recycling and other membrane functions. At the same time, the level of these lipids is highly controlled, especially in wild-type fungi. In addition, modulating SGs metabolism is becoming a novel tool for vaccine and antifungal development. In the present review, we bring together multiple observations to emphasize the underestimated importance of SGs for fungal cell functions.
    Language English
    Publishing date 2022-10-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof8111130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Host populations, challenges, and commercialization of cryptococcal vaccines.

    Maurizio Del Poeta / Floyd L Wormley / Xiaorong Lin

    PLoS Pathogens, Vol 19, Iss 2, p e

    2023  Volume 1011115

    Abstract: Vaccines are one of the most effective public health tools to prevent and manage infectious diseases. Since the first clinical use of vaccines in the late 18th century, many vaccines have been successfully developed to combat bacterial and viral ... ...

    Abstract Vaccines are one of the most effective public health tools to prevent and manage infectious diseases. Since the first clinical use of vaccines in the late 18th century, many vaccines have been successfully developed to combat bacterial and viral infections, including the most recent Coronavirus Disease 2019 (COVID-19) pandemic. However, there remains no vaccine that is clinically available to treat or prevent invasive fungal diseases, including cryptococcal meningoencephalitis. This fungal disease is uniformly fatal without treatment and has a global mortality rate of over 70%. Despite a dire need for an effective cryptococcal vaccine, there are many scientific and economic challenges to overcome prior to making it a reality. Here, we discuss some of these challenges as well as steps that the community is taking for commercialization of effective cryptococcal vaccines.
    Keywords Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Host populations, challenges, and commercialization of cryptococcal vaccines

    Maurizio Del Poeta / Floyd L. Wormley / Xiaorong Lin

    PLoS Pathogens, Vol 19, Iss

    2023  Volume 2

    Abstract: Vaccines are one of the most effective public health tools to prevent and manage infectious diseases. Since the first clinical use of vaccines in the late 18th century, many vaccines have been successfully developed to combat bacterial and viral ... ...

    Abstract Vaccines are one of the most effective public health tools to prevent and manage infectious diseases. Since the first clinical use of vaccines in the late 18th century, many vaccines have been successfully developed to combat bacterial and viral infections, including the most recent Coronavirus Disease 2019 (COVID-19) pandemic. However, there remains no vaccine that is clinically available to treat or prevent invasive fungal diseases, including cryptococcal meningoencephalitis. This fungal disease is uniformly fatal without treatment and has a global mortality rate of over 70%. Despite a dire need for an effective cryptococcal vaccine, there are many scientific and economic challenges to overcome prior to making it a reality. Here, we discuss some of these challenges as well as steps that the community is taking for commercialization of effective cryptococcal vaccines.
    Keywords Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Article ; Online: Cryptococcus neoformans

    Normile, Tyler G / Rella, Antonella / Del Poeta, Maurizio

    Frontiers in cellular and infection microbiology

    2021  Volume 11, Page(s) 739027

    Abstract: Cryptococcus ... ...

    Abstract Cryptococcus neoformans
    MeSH term(s) Animals ; CD4-Positive T-Lymphocytes ; CD8-Positive T-Lymphocytes ; Cryptococcosis/prevention & control ; Cryptococcus neoformans ; Lung ; Mice ; Vaccination
    Language English
    Publishing date 2021-09-08
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2021.739027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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