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  1. Article ; Online: Protective effects of a polyherbal medicine,

    Singh, Deepti / Khan, Mohammad Afsar / Akhtar, Kafil / Rehman, Sumbul / Parveen, Sabiha / Amin, K M Yusuf / Siddique, Hifzur R

    Drug and chemical toxicology

    2022  Volume 46, Issue 6, Page(s) 1057–1069

    Abstract: Bisphenol-A (BPA) is a toxic chemical largely produced and used in polycarbonate plastics worldwide. ...

    Abstract Bisphenol-A (BPA) is a toxic chemical largely produced and used in polycarbonate plastics worldwide.
    MeSH term(s) Antioxidants/pharmacology ; Oxidative Stress ; Reactive Oxygen Species ; Liver
    Chemical Substances Antioxidants ; Reactive Oxygen Species
    Language English
    Publishing date 2022-09-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 548368-2
    ISSN 1525-6014 ; 0148-0545
    ISSN (online) 1525-6014
    ISSN 0148-0545
    DOI 10.1080/01480545.2022.2124519
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  2. Article: Development of standard operating procedure and standardization of Habb-e-Banafsha Qawi-A Unani polyherbal formulation.

    Ali, Athar / Sumbul, Sabiha / Ahmad, Malik Mobeen / Ahmad, Sayeed / Kabir, Hifzul / Abdin, M Z

    Journal of pharmacy & bioallied sciences

    2015  Volume 7, Issue 4, Page(s) 250–253

    Abstract: Introduction: Herbals drugs became a boon for mankind since ancient times and still are used worldwide for the treatment of various human ailments. The safety of alternative medicinal preparations has been questioned due to reports of unwanted side ... ...

    Abstract Introduction: Herbals drugs became a boon for mankind since ancient times and still are used worldwide for the treatment of various human ailments. The safety of alternative medicinal preparations has been questioned due to reports of unwanted side effects. To maintain the quality and efficacy of these drugs, it is essential to standardize them in order to avoid the use of substandard or adulterated medicines in the market. Unani system of medicine mainly focuses on the treatment by natural drugs. Habb-e-Banafsha Qawi is useful in a cough, catarrah, and coryza.
    Materials and methods: Physiochemical constants of Habb-e-Banafsha Qawi were determined through organoleptic characters, macro- and micro-scopic characters, ash value, solubility, pH values. Chromatographic fingerprints were developed using thin layer chromatography method. Aflatoxin (AF) contamination, heavy metal, and pesticide residues were also evaluated by standard methods.
    Objectives: In the present study, an attempt has been made to develop standard operating procedure and physiochemical parameters to monitor the quality of a Unani poly-herbal formulation, Habb-e-Banafsha Qawi.
    Results: The tablets tasted sweetish bitter with a pleasant odor, water soluble and acidic in nature. R f values were almost same in all the extracts. No AF, heavy metal, and pesticide residues were observed.
    Conclusions: It may be concluded that the values and chromatographic fingerprints obtained can be used for quality evaluation and to set new pharmacopoeial standards for the preparation of Habb-e-Banafsha Qawi.
    Language English
    Publishing date 2015-12-25
    Publishing country India
    Document type Journal Article
    ZDB-ID 2573569-X
    ISSN 0975-7406 ; 0976-4879
    ISSN (online) 0975-7406
    ISSN 0976-4879
    DOI 10.4103/0975-7406.168019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Development of standard operating procedure and standardization of Habb-e-Banafsha Qawi-A Unani polyherbal formulation

    Athar Ali / Sabiha Sumbul / Malik Mobeen Ahmad / Sayeed Ahmad / Hifzul Kabir / M Z Abdin

    Journal of Pharmacy and Bioallied Sciences, Vol 7, Iss 4, Pp 250-

    2015  Volume 253

    Abstract: Introduction: Herbals drugs became a boon for mankind since ancient times and still are used worldwide for the treatment of various human ailments. The safety of alternative medicinal preparations has been questioned due to reports of unwanted side ... ...

    Abstract Introduction: Herbals drugs became a boon for mankind since ancient times and still are used worldwide for the treatment of various human ailments. The safety of alternative medicinal preparations has been questioned due to reports of unwanted side effects. To maintain the quality and efficacy of these drugs, it is essential to standardize them in order to avoid the use of substandard or adulterated medicines in the market. Unani system of medicine mainly focuses on the treatment by natural drugs. Habb-e-Banafsha Qawi is useful in a cough, catarrah, and coryza. Materials and Methods: Physiochemical constants of Habb-e-Banafsha Qawi were determined through organoleptic characters, macro- and micro-scopic characters, ash value, solubility, pH values. Chromatographic fingerprints were developed using thin layer chromatography method. Aflatoxin (AF) contamination, heavy metal, and pesticide residues were also evaluated by standard methods.Objectives: In the present study, an attempt has been made to develop standard operating procedure and physiochemical parameters to monitor the quality of a Unani poly-herbal formulation, Habb-e-Banafsha Qawi. Results: The tablets tasted sweetish bitter with a pleasant odor, water soluble and acidic in nature. Rfvalues were almost same in all the extracts. No AF, heavy metal, and pesticide residues were observed. Conclusions: It may be concluded that the values and chromatographic fingerprints obtained can be used for quality evaluation and to set new pharmacopoeial standards for the preparation of Habb-e-Banafsha Qawi.
    Keywords Habb-e-Banafsha Qawi ; herbals drug ; standard operating procedure ; Unani poly-herbal formulation ; Pharmacy and materia medica ; RS1-441 ; Analytical chemistry ; QD71-142
    Subject code 670
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
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  4. Article ; Online: Role of phenolic compounds in peptic ulcer

    Sabiha Sumbul / Mohd. Aftab Ahmad / Mohd. Asif / Mohd. Akhtar

    Journal of Pharmacy and Bioallied Sciences, Vol 3, Iss 3, Pp 361-

    An overview

    2011  Volume 367

    Abstract: Peptic ulcer is the most common gastrointestinal tract (GIT) disorder in clinical practice, which affects approximately 5-10% of the people during their life. The use of herbal drugs for the prevention and treatment of various diseases is constantly ... ...

    Abstract Peptic ulcer is the most common gastrointestinal tract (GIT) disorder in clinical practice, which affects approximately 5-10% of the people during their life. The use of herbal drugs for the prevention and treatment of various diseases is constantly developing throughout the world. This is particularly true with regard to phenolic compounds that probably constitute the largest group of plants secondary metabolites. Phenolic compounds have attracted special attention due to their health-promoting characteristics. In the past ten years a large number of the studies have been carried out on the effects of phenolic compounds on human health. Many studies have been carried out that strongly support the contribution of polyphenols to the prevention of cardiovascular diseases, cancer, osteoporosis, neurodegenerative diseases, and diabetes mellitus, and suggest a role in the prevention of peptic ulcer. Polyphenols display a number of pharmacological properties in the GIT area, acting as antisecretory, cytoprotective, and antioxidant agents. The antioxidant properties of phenolic compounds have been widely studied, but it has become clear that their mechanisms of action go beyond the modulation of oxidative stress. Various polyphenolic compounds have been reported for their anti-ulcerogenic activity with a good level of gastric protection. Besides their action as gastroprotective, these phenolic compounds can be an alternative for the treatment of gastric ulcers. Therefore, considering the important role of polyphenolic compounds in the prevention or reduction of gastric lesions induced by different ulcerogenic agents, in this review, we have summarized the literature on some potent antiulcer plants, such as, Oroxylum indicum, Zingiber officinale, Olea europaea L., Foeniculum vulgare, Alchornea glandulosa, Tephrosia purpurea, and so on, containing phenolic compounds, namely, baicalein, cinnamic acid, oleuropein, rutin, quercetin, and tephrosin, respectively, as active constituents.
    Keywords Flavonoids ; gastroprotective ; herbal drugs ; peptic ulcer ; phenolic compounds ; tannins ; Pharmacy and materia medica ; RS1-441 ; Analytical chemistry ; QD71-142
    Subject code 540
    Language English
    Publishing date 2011-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Role of phenolic compounds in peptic ulcer: An overview.

    Sumbul, Sabiha / Ahmad, Mohd Aftab / Mohd, Asif / Mohd, Akhtar

    Journal of pharmacy & bioallied sciences

    2010  Volume 3, Issue 3, Page(s) 361–367

    Abstract: Peptic ulcer is the most common gastrointestinal tract (GIT) disorder in clinical practice, which affects approximately 5-10% of the people during their life. The use of herbal drugs for the prevention and treatment of various diseases is constantly ... ...

    Abstract Peptic ulcer is the most common gastrointestinal tract (GIT) disorder in clinical practice, which affects approximately 5-10% of the people during their life. The use of herbal drugs for the prevention and treatment of various diseases is constantly developing throughout the world. This is particularly true with regard to phenolic compounds that probably constitute the largest group of plants secondary metabolites. Phenolic compounds have attracted special attention due to their health-promoting characteristics. In the past ten years a large number of the studies have been carried out on the effects of phenolic compounds on human health. Many studies have been carried out that strongly support the contribution of polyphenols to the prevention of cardiovascular diseases, cancer, osteoporosis, neurodegenerative diseases, and diabetes mellitus, and suggest a role in the prevention of peptic ulcer. Polyphenols display a number of pharmacological properties in the GIT area, acting as antisecretory, cytoprotective, and antioxidant agents. The antioxidant properties of phenolic compounds have been widely studied, but it has become clear that their mechanisms of action go beyond the modulation of oxidative stress. Various polyphenolic compounds have been reported for their anti-ulcerogenic activity with a good level of gastric protection. Besides their action as gastroprotective, these phenolic compounds can be an alternative for the treatment of gastric ulcers. Therefore, considering the important role of polyphenolic compounds in the prevention or reduction of gastric lesions induced by different ulcerogenic agents, in this review, we have summarized the literature on some potent antiulcer plants, such as, Oroxylum indicum, Zingiber officinale, Olea europaea L., Foeniculum vulgare, Alchornea glandulosa, Tephrosia purpurea, and so on, containing phenolic compounds, namely, baicalein, cinnamic acid, oleuropein, rutin, quercetin, and tephrosin, respectively, as active constituents.
    Language English
    Publishing date 2010-11-16
    Publishing country India
    Document type Journal Article
    ZDB-ID 2573569-X
    ISSN 0975-7406 ; 0975-7406
    ISSN (online) 0975-7406
    ISSN 0975-7406
    DOI 10.4103/0975-7406.84437
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  6. Article: Physicochemical and phytochemical standardization of berries of Myrtus communis Linn.

    Sumbul, Sabiha / Ahmad, M Aftab / Asif, M / Akhtar, Mohd / Saud, Ibne

    Journal of pharmacy & bioallied sciences

    2012  Volume 4, Issue 4, Page(s) 322–326

    Abstract: Purpose: Herbal medicines are gaining more and more attention all over the world due to their long historical clinical practice and less side effects. The major limitation with herbal medicines is that the lack of standardization technique. Initially, ... ...

    Abstract Purpose: Herbal medicines are gaining more and more attention all over the world due to their long historical clinical practice and less side effects. The major limitation with herbal medicines is that the lack of standardization technique. Initially, the crude drugs were identified by comparison only with the standard description available.
    Materials and methods: Standardization of drugs means confirmation of its identity and determination of its quality and purity. The quality control standards of various medicinal plants, used in indigenous system of medicine, are significant nowadays in view of commercialization of formulations based on medicinal plants. The quality of herbal drugs is the sum of all factors, which contribute directly or indirectly to the safety, effectiveness, and acceptability of the product. Lack of quality control can affect the efficacy and safety of drugs that may lead to health problems in the consumers. Standardization of drugs is needed to overcome the problems of adulteration and is most developing field of research now. Therefore, there is an urgent need of standardized drugs having consistent quality.
    Results: The drug showed the presence of phyto-chemical constituents. Powdered drug was treated with different reagents and examined under UV light. Different reagents showed different colors of the drug at 2 wavelengths. The percentage of physiological active compounds viz. total phenolics, tannins, volatile oil, fixed oil, and alkaloids were also observed.
    Conclusion: Myrtus communis L. (Family: Myrtaceae) is one of the important drug being used in Unani system of medicine for various therapeutic purposes. In this study, an attempt has been made to study berries of M. communis from physico-chemical and phytochemical standardization point of view.
    Language English
    Publishing date 2012-12-16
    Publishing country India
    Document type Journal Article
    ZDB-ID 2573569-X
    ISSN 0975-7406 ; 0976-4879
    ISSN (online) 0975-7406
    ISSN 0976-4879
    DOI 10.4103/0975-7406.103266
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Physicochemical and phytochemical standardization of berries of Myrtus communis Linn.

    Sabiha Sumbul / M Aftab Ahmad / M Asif / Mohd Akhtar / Ibne Saud

    Journal of Pharmacy and Bioallied Sciences, Vol 4, Iss 4, Pp 322-

    2012  Volume 326

    Abstract: Purpose: Herbal medicines are gaining more and more attention all over the world due to their long historical clinical practice and less side effects. The major limitation with herbal medicines is that the lack of standardization technique. Initially, ... ...

    Abstract Purpose: Herbal medicines are gaining more and more attention all over the world due to their long historical clinical practice and less side effects. The major limitation with herbal medicines is that the lack of standardization technique. Initially, the crude drugs were identified by comparison only with the standard description available. Materials and Methods: Standardization of drugs means confirmation of its identity and determination of its quality and purity. The quality control standards of various medicinal plants, used in indigenous system of medicine, are significant nowadays in view of commercialization of formulations based on medicinal plants. The quality of herbal drugs is the sum of all factors, which contribute directly or indirectly to the safety, effectiveness, and acceptability of the product. Lack of quality control can affect the efficacy and safety of drugs that may lead to health problems in the consumers. Standardization of drugs is needed to overcome the problems of adulteration and is most developing field of research now. Therefore, there is an urgent need of standardized drugs having consistent quality. Results: The drug showed the presence of phyto-chemical constituents. Powdered drug was treated with different reagents and examined under UV light. Different reagents showed different colors of the drug at 2 wavelengths. The percentage of physiological active compounds viz. total phenolics, tannins, volatile oil, fixed oil, and alkaloids were also observed. Conclusion: Myrtus communis L. (Family: Myrtaceae) is one of the important drug being used in Unani system of medicine for various therapeutic purposes. In this study, an attempt has been made to study berries of M. communis from physico-chemical and phytochemical standardization point of view.
    Keywords Physiocochemical ; phytochemical ; standardization ; Pharmacy and materia medica ; RS1-441 ; Analytical chemistry ; QD71-142
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
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  8. Article ; Online: Evaluation of Myrtus communis Linn. berries (common myrtle) in experimental ulcer models in rats.

    Sumbul, Sabiha / Ahmad, Mohd Aftab / Asif, Mohd / Saud, Ibne / Akhtar, Mohd

    Human & experimental toxicology

    2010  Volume 29, Issue 11, Page(s) 935–944

    Abstract: The present study was conducted to investigate the protective effect of the dried berries of Myrtus communis L. in gastric ulcer against ethanol, indomethacin and pyloric ligation induced models in Wistar rats. Two doses of aqueous extracts of M. ... ...

    Abstract The present study was conducted to investigate the protective effect of the dried berries of Myrtus communis L. in gastric ulcer against ethanol, indomethacin and pyloric ligation induced models in Wistar rats. Two doses of aqueous extracts of M. communis (AE( 1) and AE(2)) at the dose 105 and 175 mg/kg, respectively, and methanolic extracts (ME(1) and ME(2)) at the dose of 93 and 154 mg/kg, respectively, were administered orally to animals prior to the exposure of ulcerogens. The parameters taken to assess anti-ulcer activity were ulcer index, gastric juice volume, gastric pH, total acidity, gastric wall mucus and histopathological studies. Oral administration of AE(1) and AE(2) significantly reduced the ulcer index in all models of ulcers. Low dose of aqueous extract and high dose of methanolic extract of M. communis exhibited more significant effect in comparison to omeprazole (standard drug) in ethanol-induced ulcer model. Both the doses of aqueous and methanolic extracts also reduced the gastric juice volume, total acidity and increased the gastric pH and gastric wall mucus content in all the models of ulcers used in the present study. Histopathological examinations of gastric tissues of rats treated with the aqueous and methanolic extracts in indomethacin-induced ulcer exhibited significant ulcer-protective effect at both the dose levels.
    MeSH term(s) Animals ; Anti-Ulcer Agents/isolation & purification ; Anti-Ulcer Agents/therapeutic use ; Disease Models, Animal ; Fruit/chemistry ; Gastric Juice/chemistry ; Gastric Juice/secretion ; Hydrogen-Ion Concentration ; Myrtus/chemistry ; Plant Extracts/isolation & purification ; Plant Extracts/therapeutic use ; Rats ; Rats, Wistar ; Stomach/drug effects ; Stomach/metabolism ; Stomach/pathology ; Stomach Ulcer/chemically induced ; Stomach Ulcer/drug therapy ; Stomach Ulcer/metabolism ; Stomach Ulcer/pathology ; Treatment Outcome
    Chemical Substances Anti-Ulcer Agents ; Plant Extracts
    Language English
    Publishing date 2010-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1027454-6
    ISSN 1477-0903 ; 0144-5952 ; 0960-3271
    ISSN (online) 1477-0903
    ISSN 0144-5952 ; 0960-3271
    DOI 10.1177/0960327110364154
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1697: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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