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  1. Article ; Online: Role of Nasopharyngeal lactate dehydrogenase as a possible economical mass screening test for the detection and segregation of SARS-CoV-2 (COVID-19) cases in India

    Gharote, Mukul Arvind

    Indian J Med Sci

    Abstract: COVID-19 pandemic is affecting almost every country in the world. Every country must test all the individuals with suspected clinical presentation of COVID-19. Unfortunately, the symptoms are mild and often the incubation period is 5–7 days. Hence, the ... ...

    Abstract COVID-19 pandemic is affecting almost every country in the world. Every country must test all the individuals with suspected clinical presentation of COVID-19. Unfortunately, the symptoms are mild and often the incubation period is 5–7 days. Hence, the detection of COVID-19 takes time and is costly even, many resource-constrained nations are not testing their citizens due to cost incurred. That is why we need an economical mass screening test to detect and help the health-care system to segregate cases needing their attention. Nasopharyngeal lactate dehydrogenase (LDH) is raised in viral upper respiratory infections, it can be easily tested and raised serum LDH in addition to nasopharyngeal LDH can predict stormy outcome of disease. Such prediction will help health-care system for effective resource allocation.
    Keywords covid19
    Publisher PMC
    Document type Article ; Online
    DOI 10.25259/ijms_25_2020
    Database COVID19

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  2. Article ; Online: Role of poly (ADP) ribose polymerase-1 inhibition by nicotinamide as a possible additive treatment to modulate host immune response and prevention of cytokine storm in COVID-19

    Gharote, Mukul Arvind

    Indian J Med Sci

    Abstract: COVID-19 is rapidly spreading contagious disease spreading across the world. Patients at risk are elderly people and those with comorbidity. Early studies done on Chinese patients who suggest cytokine storm to be responsible for lung injury. We need to ... ...

    Abstract COVID-19 is rapidly spreading contagious disease spreading across the world. Patients at risk are elderly people and those with comorbidity. Early studies done on Chinese patients who suggest cytokine storm to be responsible for lung injury. We need to understand the mechanism of modulating such robust response of immunity and resultant cytokine storm. We suggest nicotinamide, a potential poly ADP ribose polymerase (PARP) inhibitor, as a supportive treatment for the prevention of cytokine storm from injuring the lung parenchyma. Nicotinamide supplementation albeit at high dose may modulate outcome in COVID-19. Nicotinamide was used previously to reduce ventilator-induced lung injury and lung injury due to hypoxia. Nicotinamide congeners are used to treat chronic lung disease like tuberculosis. Certainly, nicotinamide is effective pharmacotherapy in lung injury – whether acute or chronic. Other measures used in treating COVID-19 are focusing on targeting interleukin-6 – a cytokine responsible for mayhem, while few are targeting granulocyte-macrophage colony- stimulating factor. We suggest targeting PARP in addition to other measures to block cytokines. By inhibiting PARP course of COVID-19 may be altered. Understanding the pathophysiology of acute lung injury is crucial. PARP plays a pivotal role on cytokine release in response to any lung injury ranging from viral infection to hypoxia. Various antiviral defenses and immune response need to be studied in detail.
    Keywords covid19
    Publisher PMC
    Document type Article ; Online
    DOI 10.25259/ijms_29_2020
    Database COVID19

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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