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  1. Article: [GUIDELINE FOR ALLERGIC BRONCHOPULMONARY MYCOSIS- CURRENT EVIDENCE AND FUTURE DIRECTION].

    Oguma, Tsuyoshi

    Arerugi = [Allergy

    2022  Volume 71, Issue 3, Page(s) 181–185

    MeSH term(s) Aspergillosis, Allergic Bronchopulmonary ; Humans ; Immunoglobulin E ; Invasive Pulmonary Aspergillosis
    Chemical Substances Immunoglobulin E (37341-29-0)
    Language Japanese
    Publishing date 2022-05-13
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 974201-3
    ISSN 0021-4884
    ISSN 0021-4884
    DOI 10.15036/arerugi.71.181
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 245: Show issues Location:
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  2. Article ; Online: Reply to Correspondence to "Allergic bronchopulmonary aspergillosis with atopic, nonatopic, and sans asthma-factor analysis".

    Okada, Naoki / Oguma, Tsuyoshi / Asano, Koichiro

    Allergy

    2024  

    Language English
    Publishing date 2024-02-21
    Publishing country Denmark
    Document type Letter
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.16074
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    Zs.MO 125: Show issues

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  3. Article ; Online: Reply.

    Oguma, Tsuyoshi / Asano, Koichiro

    The Journal of allergy and clinical immunology

    2021  Volume 147, Issue 3, Page(s) 1121

    Language English
    Publishing date 2021-01-05
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2020.11.030
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    Uh III Zs.92: Show issues Location:
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  4. Article ; Online: Detrimental impact of late-onset pneumonia on long-term prognosis in oesophageal cancer survivors.

    Takiguchi, Hiroto / Koyanagi, Kazuo / Ozawa, Soji / Oguma, Tsuyoshi / Asano, Koichiro

    Respiratory investigation

    2024  Volume 62, Issue 4, Page(s) 531–537

    Abstract: Backgroud: Oesophageal cancer patients are prone to early- and late-onset pneumonia after oesophagectomy. We aimed to investigate the incidence rate and impact on the long-term prognosis of late-onset pneumonia in oesophageal cancer survivors who ... ...

    Abstract Backgroud: Oesophageal cancer patients are prone to early- and late-onset pneumonia after oesophagectomy. We aimed to investigate the incidence rate and impact on the long-term prognosis of late-onset pneumonia in oesophageal cancer survivors who survived for at least one year after oesophagectomy without cancer recurrence.
    Methods: We retrospectively reviewed 233 patients with thoracic oesophageal cancer who underwent oesophagectomy with gastric conduit reconstruction between September 2009 and June 2019 at a tertiary referral hospital in Japan. Pneumonia that occurred ≥1 year after oesophagectomy was defined as late-onset pneumonia.
    Results: Among the 185 oesophageal cancer survivors, 31 (17%) developed late-onset pneumonia. The cumulative incidence rates of late-onset pneumonia 24, 36, and 60 months after oesophagectomy were 6.4%, 10%, and 21%, respectively, whereas pneumonia recurred at 21%, 31%, and 52% within 6, 12, and 24 months, respectively, after the first pneumonia. Chronic obstructive pulmonary disease, postoperative anastomotic leakage, and loss of skeletal muscle mass were independently associated with late-onset pneumonia, and a combination of these factors further increased the risk. Late-onset pneumonia with hospitalisation had the greatest negative impact on the long-term prognosis as non-cancer deaths (HR, 21; p < 0.001), followed by recurrent late-onset pneumonia (HR, 18; p < 0.001).
    Conclusions: Late-onset pneumonia in oesophageal cancer survivors is significantly associated with an increased risk of recurrent infections and non-cancer deaths. Chronic obstructive pulmonary disease and postoperative muscle loss are risk factors for late-onset pneumonia, and more intensive pharmacological and nutritional interventions should be considered to improve long-term prognosis after oesophagectomy.
    Language English
    Publishing date 2024-04-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2660821-2
    ISSN 2212-5353 ; 2212-5345
    ISSN (online) 2212-5353
    ISSN 2212-5345
    DOI 10.1016/j.resinv.2024.04.005
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  5. Article ; Online: Importance of mucus burden and mucociliary impairment in asthma.

    Nomura, Natsuko / Matsumoto, Hisako / Sunadome, Hironobu / Oguma, Tsuyoshi / Hirai, Toyohiro

    The Journal of allergy and clinical immunology

    2023  Volume 151, Issue 5, Page(s) 1410–1411

    MeSH term(s) Humans ; Asthma ; Bronchi ; Mucus ; Mucociliary Clearance ; Cilia
    Language English
    Publishing date 2023-03-03
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2023.01.024
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  6. Article ; Online: Eosinophilic mucus diseases.

    Arima, Misaki / Ito, Keisuke / Abe, Tomoe / Oguma, Tsuyoshi / Asano, Koichiro / Mukherjee, Manali / Ueki, Shigeharu

    Allergology international : official journal of the Japanese Society of Allergology

    2024  

    Abstract: Eosinophilic inflammation is primarily characterized by type 2 immune responses against parasitic organisms. In the contemporary human being especially in developed countries, eosinophilic inflammation is strongly associated with allergic/sterile ... ...

    Abstract Eosinophilic inflammation is primarily characterized by type 2 immune responses against parasitic organisms. In the contemporary human being especially in developed countries, eosinophilic inflammation is strongly associated with allergic/sterile inflammation, and constitutes an undesired immune reaction. This situation is in stark contrast to neutrophilic inflammation, which is indispensable for the host defense against bacterial infections. Among eosinophilic inflammatory disorders, massive accumulation of eosinophils within mucus is observed in certain cases, and is often linked to the distinctive clinical finding of mucus with high viscosity. Eosinophilic mucus is found in a variety of diseases, including chronic allergic keratoconjunctivitis, chronic rhinosinusitis encompassing allergic fungal sinusitis, eosinophilic otitis media, eosinophilic sialodochitis, allergic bronchopulmonary aspergillosis/mycosis, eosinophilic plastic bronchitis, and eosinophilic asthma. In these pathological conditions, chronic inflammation and tissue remodeling coupled with irreversible organ damage due to persistent adhesion of toxic substances and luminal obstruction may impose a significant burden on the body. Eosinophils aggregate in the hyperconcentrated mucus together with cell-derived crystals, macromolecules, and polymers, thereby affecting the biophysical properties of the mucus. This review focuses on the clinically significant challenges of mucus and discusses the consequences of activated eosinophils on the mucosal surface that impact mucus and persistent inflammation.
    Language English
    Publishing date 2024-04-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1336498-4
    ISSN 1440-1592 ; 1323-8930
    ISSN (online) 1440-1592
    ISSN 1323-8930
    DOI 10.1016/j.alit.2024.03.002
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    Zs.A 5248: Show issues Location:
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  7. Article ; Online: Reply to "New aspects of fundamental pathology and environmental control: Important issues in allergic bronchopulmonary mycosis".

    Oguma, Tsuyoshi / Okada, Naoki / Asano, Koichiro

    The journal of allergy and clinical immunology. In practice

    2021  Volume 9, Issue 3, Page(s) 1420–1421

    MeSH term(s) Aspergillosis, Allergic Bronchopulmonary ; Environmental Exposure ; Humans ; Invasive Pulmonary Aspergillosis
    Language English
    Publishing date 2021-03-08
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2020.12.055
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    Zs.A 7086: Show issues Location:
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  8. Article ; Online: Bilateral Hilar and Mediastinal Lymphadenopathy as an Initial Manifestation of Amyloidosis.

    Urata, Mika / Ito, Yoko / Ogiya, Daisuke / Kutsuzawa, Naokata / Ogura, Go / Ueda, Mitsuharu / Hayama, Naoki / Oguma, Tsuyoshi / Asano, Koichiro

    The Tokai journal of experimental and clinical medicine

    2024  Volume 49, Issue 1, Page(s) 12–16

    Abstract: A 75-year-old male visited our hospital with bilateral hilar lymph node swelling detected on chest radiography during an annual medical checkup. Chest computed tomography revealed swelling of multiple hilar mediastinal lymph nodes. Histopathological and ... ...

    Abstract A 75-year-old male visited our hospital with bilateral hilar lymph node swelling detected on chest radiography during an annual medical checkup. Chest computed tomography revealed swelling of multiple hilar mediastinal lymph nodes. Histopathological and immunohistochemical examinations of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) specimens from the hilar lymph nodes revealed amyloid deposition. Bilateral hilar and mediastinal lymphadenopathies can be the first manifestations of amyloidosis diagnosed using EBUS-TBNA.
    MeSH term(s) Male ; Humans ; Aged ; Lung Neoplasms/diagnosis ; Lymphadenopathy/etiology ; Lymphadenopathy/pathology ; Mediastinum/pathology ; Lymph Nodes/pathology ; Amyloidosis/complications ; Amyloidosis/diagnosis ; Bronchoscopy/methods
    Language English
    Publishing date 2024-04-20
    Publishing country Japan
    Document type Case Reports
    ZDB-ID 431622-8
    ISSN 2185-2243 ; 0385-0005
    ISSN (online) 2185-2243
    ISSN 0385-0005
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  9. Article ; Online: Associations of fractional exhaled nitric oxide with airway dimension and mucus plugs on ultra-high-resolution computed tomography in former smokers and nonsmokers with asthma.

    Hayashi, Yusuke / Tanabe, Naoya / Matsumoto, Hisako / Shimizu, Kaoruko / Sakamoto, Ryo / Oguma, Tsuyoshi / Sunadome, Hironobu / Sato, Atsuyasu / Sato, Susumu / Hirai, Toyohiro

    Allergology international : official journal of the Japanese Society of Allergology

    2024  

    Abstract: Background: Associations of fractional exhaled nitric oxide (FeNO) with airway wall remodeling and mucus plugs remain to be explored in smokers and nonsmokers with asthma. Ultra-high-resolution computed tomography (U-HRCT), which allows accurate ... ...

    Abstract Background: Associations of fractional exhaled nitric oxide (FeNO) with airway wall remodeling and mucus plugs remain to be explored in smokers and nonsmokers with asthma. Ultra-high-resolution computed tomography (U-HRCT), which allows accurate structural quantification of airways >1 mm in diameter, was used in this study to examine whether higher FeNO was associated with thicker walls of the 3rd to 6th generation airways and mucus plugging in patients with asthma.
    Methods: The retrospective analyses included consecutive former smokers and nonsmokers with asthma who underwent U-HRCT in a hospital. The ratio of wall area to summed lumen and wall area was calculated as the wall area percent (WA%). Mucus plugging was visually scored.
    Results: Ninety-seven patients with asthma (including 59 former smokers) were classified into low (<20 ppb), middle (20-35 ppb), and high (>35 ppb) FeNO groups (n = 24, 26, and 47). In analysis including all patients and subanalysis including nonsmokers or former smokers, WA% in the 6th generation airways was consistently higher in the high FeNO group than in the low FeNO group, whereas WA% in the 3rd to 5th generation airways was not. In multivariable models, WA% in the 6th generation airways and the rate of mucus plugging were higher in the high FeNO group than in the low FeNO group after adjusting for age, sex, body mass index, smoking status, lung volume, and allergic rhinitis presence.
    Conclusions: Higher FeNO may reflect the inflammation and remodeling of relatively peripheral airways in asthma in both former smokers and nonsmokers.
    Language English
    Publishing date 2024-02-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1336498-4
    ISSN 1440-1592 ; 1323-8930
    ISSN (online) 1440-1592
    ISSN 1323-8930
    DOI 10.1016/j.alit.2024.01.013
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  10. Article ; Online: Moldy odor from air conditioners in the residences of Japanese participants with and without asthma.

    Okada, Naoki / Shiraishi, Yoshiki / Tomomatsu, Katsuyoshi / Oguma, Tsuyoshi / Asano, Koichiro

    Indoor air

    2022  Volume 32, Issue 11, Page(s) e13156

    Abstract: Fungi, a major allergen associated with asthma onset and severity, can contaminate air conditioners if not properly maintained. We surveyed the prevalence and risk factors associated with fungal contamination of air conditioners and patient behavior to ... ...

    Abstract Fungi, a major allergen associated with asthma onset and severity, can contaminate air conditioners if not properly maintained. We surveyed the prevalence and risk factors associated with fungal contamination of air conditioners and patient behavior to reduce this contamination. Japanese adults aged ≥30 years registered in the database of an Internet research company were asked to participate in an online survey. A moldy odor from the air conditioners in their residences was used as an indicator of fungal contamination. Among a total of 1006 adults, including 631 patients with asthma, 37.1% reported a moldy odor from air conditioners. The prevalence was higher in residences with indoor condensation and in air conditioners used for ≥6 years or frequently during the summer, but was lower in air conditioners with an auto-cleaning function. The risk of indoor condensation was higher in apartments, in the presence of an aquarium, and in the absence of a 24-h ventilation system. These risk factors did not differ between the residences or air conditioners of participants with and without asthma. Asthmatic patients were conscious of indoor air quality; however, do not necessarily take appropriate measures to reduce indoor mold contamination, possibly due to a lack of knowledge. In conclusion, appropriate patient education is required to reduce environmental fungal contamination and improve asthma control.
    MeSH term(s) Humans ; Air Pollution, Indoor/analysis ; Odorants ; Japan/epidemiology ; Asthma/epidemiology ; Asthma/etiology ; Fungi
    Language English
    Publishing date 2022-11-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1081722-0
    ISSN 1600-0668 ; 0905-6947
    ISSN (online) 1600-0668
    ISSN 0905-6947
    DOI 10.1111/ina.13156
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