Article ; Online: Quantitative muscle ultrasound in adult spinal muscular atrophy. A pilot study.
2023 Volume 69, Issue 3, Page(s) 349–353
Abstract: ... to-subcutaneous (M:S) thickness and echogenicity ratios were also calculated. A mean value across all muscles ... than in controls; M:S echogenicity ratio was significantly increased and M:S thickness ratio reduced ...
| Abstract | Introduction/aims: Muscle ultrasound has been investigated in children with spinal muscular atrophy (SMA) and proposed as a potential biomarker of disease severity. We studied the ultrasound properties in adults with SMA to see whether they also have potential as markers of disease severity in older patients. Methods: Thickness and quantitative echogenicity of muscle and subcutaneous tissue were compared between eight prospectively recruited adult patients with SMA and eight age, sex and body mass index-matched controls. Measurements were made in the dominant deltoid, biceps, triceps, forearm extensors, first dorsal interosseous, quadriceps, tibialis anterior, and gastrocnemius muscles. The muscle-to-subcutaneous (M:S) thickness and echogenicity ratios were also calculated. A mean value across all muscles as well as the individual values for each muscle were then calculated for each parameter in each subject and compared between the two groups. Significance was set at 0.05 after Bonferroni correction. Results: In the SMA patients, mean muscle thickness was significantly smaller (1.3 vs. 1.9 cm), muscle echogenicity higher (106 vs. 67 on the grayscale level), and subcutaneous thickness larger (0.9 vs. 0.3 cm) than in controls; M:S echogenicity ratio was significantly increased and M:S thickness ratio reduced in the patients. The most abnormal scores were found in the nonambulatory patients and the least abnormal in the ambulatory patients. Discussion: Ultrasound can detect and quantify the severity of muscle atrophy and structure in adult SMA, suggesting a potential role as a marker of disease severity, which will require validation by larger studies. |
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| MeSH term(s) | Child ; Adult ; Humans ; Aged ; Pilot Projects ; Muscular Atrophy, Spinal/diagnostic imaging ; Muscle, Skeletal/diagnostic imaging ; Ultrasonography ; Quadriceps Muscle |
| Language | English |
| Publishing date | 2023-12-29 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 438353-9 |
| ISSN | 1097-4598 ; 0148-639X |
| ISSN (online) | 1097-4598 |
| ISSN | 0148-639X |
| DOI | 10.1002/mus.28034 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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