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  1. Article ; Online: WITHDRAWN: Pegcetacoplan in the treatment of geographic atrophy.

    Kumar, Madhukar / Singh, Rishi P

    Immunotherapy

    2023  

    Abstract: Ahead of Print article withdrawn by publisher. ...

    Abstract Ahead of Print article withdrawn by publisher.
    Language English
    Publishing date 2023-06-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2495964-9
    ISSN 1750-7448 ; 1750-743X
    ISSN (online) 1750-7448
    ISSN 1750-743X
    DOI 10.2217/imt-2022-0263
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Research Developments in the Treatment of Retinal Disease: Finalists From the 4th Annual Retina Research Scholar Honoree Program.

    Singh, Rishi P

    Ophthalmic surgery, lasers & imaging retina

    2021  Volume 52, Issue S1, Page(s) 996

    MeSH term(s) Humans ; Retina ; Retinal Diseases/therapy
    Language English
    Publishing date 2021-07-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701167-7
    ISSN 2325-8179 ; 2325-8160
    ISSN (online) 2325-8179
    ISSN 2325-8160
    DOI 10.3928/23258160-20210518-01
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    Zs.A 756: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Research Developments in the Treatment of Retinal Disease: Finalists From the 3rd Annual Retina Research Scholar Honoree Program.

    Singh, Rishi P

    Ophthalmic surgery, lasers & imaging retina

    2020  Volume 51, Issue 5, Page(s) S2

    MeSH term(s) Awards and Prizes ; Biomedical Research/trends ; Humans ; Ophthalmology ; Program Development ; Retinal Diseases/therapy
    Language English
    Publishing date 2020-06-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2701167-7
    ISSN 2325-8179 ; 2325-8160
    ISSN (online) 2325-8179
    ISSN 2325-8160
    DOI 10.3928/23258160-20200113-01
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    Zs.A 756: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Award-Winning Presentations From the 2019 Retina World Congress.

    Singh, Rishi P

    Ophthalmic surgery, lasers & imaging retina

    2020  Volume 51, Issue 4, Page(s) S3

    MeSH term(s) Awards and Prizes ; Congresses as Topic ; Education, Medical, Continuing/standards ; Humans ; Ophthalmology/education ; Retina ; Retinal Diseases/therapy
    Language English
    Publishing date 2020-04-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2701167-7
    ISSN 2325-8179 ; 2325-8160
    ISSN (online) 2325-8179
    ISSN 2325-8160
    DOI 10.3928/23258160-20200402-01
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    Zs.A 756: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Risk of New Retinal Vascular Occlusion After Messenger RNA COVID-19 Vaccination Within Aggregated Electronic Health Record Data-Reply.

    Shaia, Jacqueline K / Shukla, Priya / Singh, Rishi P

    JAMA ophthalmology

    2023  Volume 141, Issue 12, Page(s) 1177–1178

    MeSH term(s) Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Electronic Health Records ; Vaccination ; Retinal Vein Occlusion/chemically induced
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-11-09
    Publishing country United States
    Document type Letter
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2023.5085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ul I Zs.26: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Research Developments in the Treatment of Retinal Disease: Finalists From the 2nd Annual Retina Research Scholar Honoree Program.

    Singh, Rishi P

    Ophthalmic surgery, lasers & imaging retina

    2019  Volume 50, Issue 5, Page(s) S2

    MeSH term(s) Biomedical Research/trends ; Education, Medical, Graduate/methods ; Humans ; Internship and Residency ; Ophthalmology/education ; Retinal Diseases/therapy
    Language English
    Publishing date 2019-05-17
    Publishing country United States
    Document type Editorial
    ZDB-ID 2701167-7
    ISSN 2325-8179 ; 2325-8160
    ISSN (online) 2325-8179
    ISSN 2325-8160
    DOI 10.3928/23258160-20190108-01
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 756: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Utilization of Crowdfunding for Medical Expenses Related to Vitrectomy.

    Gupta, Urvi / Kumar, Madhukar / Wu, Anna K / Singh, Rishi P

    Ophthalmic surgery, lasers & imaging retina

    2023  Volume 54, Issue 7, Page(s) 433–435

    MeSH term(s) Humans ; Vitrectomy/economics ; Crowdsourcing ; Health Expenditures
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Letter
    ZDB-ID 2701167-7
    ISSN 2325-8179 ; 2325-8160
    ISSN (online) 2325-8179
    ISSN 2325-8160
    DOI 10.3928/23258160-20230508-02
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 756: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Associations between lipid abnormalities and diabetic retinopathy across a large United States national database.

    Jeong, Hejin / Maatouk, Christopher M / Russell, Matthew W / Singh, Rishi P

    Eye (London, England)

    2024  

    Abstract: Background/objectives: While dyslipidaemia has been suggested as a potential risk factor for diabetic retinopathy (DR), previous studies have reported conflicting findings. This study aimed to better characterize the relationship between abnormal serum ... ...

    Abstract Background/objectives: While dyslipidaemia has been suggested as a potential risk factor for diabetic retinopathy (DR), previous studies have reported conflicting findings. This study aimed to better characterize the relationship between abnormal serum levels of various lipid markers and the risk of the development and progression of DR.
    Subjects/methods: This retrospective cohort study utilized a United States national database of electronic medical records. Adults with a history of type 2 diabetes mellitus without type 1 diabetes mellitus were divided into cohorts based on the presence of abnormal serum levels of various lipid markers. Propensity score matching was performed to match cohorts with abnormal lipid levels to those with normal lipid levels on covariates. The cohorts were then compared to evaluate the hazard ratios (HR) of receiving a new DR diagnosis, pars plana vitrectomy, panretinal photocoagulation, vitreous haemorrhage, proliferative diabetic retinopathy, diabetic macular oedema (DMO), and traction retinal detachment.
    Results: The database contained 1,126,231 eligible patients (mean age: 60.8 [14.2] years; 46.0% female). Among patients without prior DR, low HDL (HR = 0.94, CI = 0.90-0.98), total cholesterol (HR = 0.88, CI = 0.85-0.91), and high triglyceride (HR = 0.91, CI = 0.86-0.97) levels were associated with a decreased risk of receiving a DR diagnosis. Among patients with preexisting DR, high LDL levels was associated with an increased risk of DMO (HR = 1.42, CI = 1.15-1.75), whereas low HDL levels was associated with a marginally decreased risk (HR = 0.92, CI = 0.85-0.99).
    Conclusions: Elevated levels of markers of dyslipidaemia are inversely associated with the risk of receiving a DR diagnosis, but this relationship is blunted after the onset of DR.
    Language English
    Publishing date 2024-03-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-024-03022-3
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    Zs.B 3010: Show issues Location:
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    Zs.MO 603: Show issues

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  9. Article ; Online: Brolucizumab for the treatment of diabetic macular edema.

    Kuo, Blanche L / Singh, Rishi P

    Current opinion in ophthalmology

    2022  Volume 33, Issue 3, Page(s) 167–173

    Abstract: Purpose of review: To review the available data supporting the use of brolucizumab in the treatment of diabetic macular edema (DME).: Recent findings: Brolucizumab is a humanized single- chain variable antibody fragment (scFv), the smallest ... ...

    Abstract Purpose of review: To review the available data supporting the use of brolucizumab in the treatment of diabetic macular edema (DME).
    Recent findings: Brolucizumab is a humanized single- chain variable antibody fragment (scFv), the smallest functional subunit of an antibody approved for intravitreal use. Three phase III studies demonstrate that at 52 weeks, brolucizumab has statistically superior anatomical outcomes of reducing retinal thickness (54.0-57.5% of brolucizumab treated eyes achieved central subfield thickness <280 μm compared to 40.1 - 41.4% of aflibercept treated eyes) and retinal fluid (present in 54.2-60.3% of brolucizumab treated eyes compared to 72.9-78.2% of aflibercept treated eyes). Brolucizumab also demonstrated a prolonged durability up to 16 weeks, thus reducing treatment burden. The visual outcomes appear noninferior to current anti-VEGF agents with an increased risk for intraocular inflammatory events (0.3-4.7% compared to 0.6-1.7%).
    Summary: Results from recent phase III trials showing the efficacy and safety of brolucizumab presents an additional therapeutic option in the DME treatment landscape. It can reduce treatment burden in DME with increased inter-treatment intervals while conferring efficacy in both functional and anatomical outcomes. Caution should be taken regarding the risks of intraocular inflammation, retinal vasculitis, and retinal vascular occlusion.
    MeSH term(s) Angiogenesis Inhibitors/therapeutic use ; Antibodies, Monoclonal, Humanized ; Diabetes Mellitus/chemically induced ; Diabetes Mellitus/drug therapy ; Diabetic Retinopathy/drug therapy ; Humans ; Intravitreal Injections ; Macular Edema/drug therapy ; Receptors, Vascular Endothelial Growth Factor/therapeutic use ; Recombinant Fusion Proteins/therapeutic use ; Uveitis/drug therapy ; Vision Disorders ; Visual Acuity
    Chemical Substances Angiogenesis Inhibitors ; Antibodies, Monoclonal, Humanized ; Recombinant Fusion Proteins ; Receptors, Vascular Endothelial Growth Factor (EC 2.7.10.1) ; brolucizumab (XSZ53G39H5)
    Language English
    Publishing date 2022-03-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1049383-9
    ISSN 1531-7021 ; 1040-8738
    ISSN (online) 1531-7021
    ISSN 1040-8738
    DOI 10.1097/ICU.0000000000000849
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3047: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: A review of emerging tyrosine kinase inhibitors as durable treatment of neovascular age-related macular degeneration.

    Das, Nikhil / Chaurasia, Sameer / Singh, Rishi P

    Expert opinion on emerging drugs

    2023  Volume 28, Issue 3, Page(s) 203–211

    Abstract: Introduction: Current treatment for age-related macular degeneration poses a large burden on patients and the inability of patients to adhere to this immense burden can lead to worse visual outcomes. Novel treatments have been proposed to extend ... ...

    Abstract Introduction: Current treatment for age-related macular degeneration poses a large burden on patients and the inability of patients to adhere to this immense burden can lead to worse visual outcomes. Novel treatments have been proposed to extend treatment intervals and reduce visit burden.
    Areas covered: This review article summarizes phase I and phase II clinical trials of tyrosine kinase inhibitors as durable treatment options for patient with neovascular age-related macular degeneration.
    Expert opinion: Tyrosine kinase inhibitors have shown substantial promise in reducing treatment burden while maintaining visual acuity and anatomic outcomes with favorable safety profiles. Several platforms have shown positive outcomes in initial trials and are currently moving toward phase III clinical trials.
    MeSH term(s) Humans ; Intravitreal Injections ; Macular Degeneration/drug therapy ; Tyrosine Kinase Inhibitors/therapeutic use
    Chemical Substances Tyrosine Kinase Inhibitors
    Language English
    Publishing date 2023-10-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2061369-6
    ISSN 1744-7623 ; 1472-8214
    ISSN (online) 1744-7623
    ISSN 1472-8214
    DOI 10.1080/14728214.2023.2259790
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