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Article ; Online: Insurance Transitions from Employer-Based Insurance to Medicare and Waitlisting for Kidney Transplantation: Placing Marietta v. DaVita in Context.

Adler, Joel T / Kuk, Arnold E / Cron, David C / Parast, Layla / Husain, Syed Ali

Journal of the American Society of Nephrology : JASN

2024 Volume 35, Issue 4, Page(s) 495–498

MeSH term(s)	Aged ; Humans ; United States ; Medicare ; Kidney Transplantation ; Insurance ; Kidney Failure, Chronic
Language	English
Publishing date	2024-01-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1085942-1
ISSN	1533-3450 ; 1046-6673
ISSN (online)	1533-3450
ISSN	1046-6673
DOI	10.1681/ASN.0000000000000298
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Book ; Online: Lives v livelihoods, part 1

Adler, Matthew / Bradley, Richard / Ferranna, Maddalena / Fleurbaey, Marc / Hammitt, James K. / Voorhoeve, Alex

how can we measure the value of a life?

2020

Abstract: ... of two posts, Matthew Adler (Duke University/LSE), Richard Bradley (LSE), Maddalena Ferranna (Princeton ...

Abstract	Policies that suppress or control the COVID-19 pandemic prevent illness and save lives, but exact an economic toll. How should we balance lives and livelihoods to determine which policy is best? In the first of two posts, Matthew Adler (Duke University/LSE), Richard Bradley (LSE), Maddalena Ferranna (Princeton), Marc Fleurbaey (Princeton and Paris School of Economics), James Hammitt (Harvard) and Alex Voorhoeve (LSE) compare the benefit-cost and social welfare approaches to doing so.
Keywords	RA0421 Public health. Hygiene. Preventive Medicine ; HV Social pathology. Social and public welfare. Criminology ; covid19
Language	English
Publishing date	2020-08-06
Publisher	London School of Economics and Political Science
Publishing country	uk
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Lives v livelihoods, part 2

Adler, Matthew / Bradley, Richard / Ferranna, Maddalena / Fleurbaey, Hélène / Hammitt, James K. / Voorhoeve, Alex

suppression or control?

2020

Abstract: ... on livelihoods. Matthew Adler (Duke University/LSE), Richard Bradley (LSE), Maddalena Ferranna (Princeton), Marc ...

Abstract	Limiting the length of lockdown is key to minimising the damage the pandemic inflicts on livelihoods. Matthew Adler (Duke University/LSE), Richard Bradley (LSE), Maddalena Ferranna (Princeton), Marc Fleurbaey (Princeton and Paris School of Economics), James Hammitt (Harvard) and Alex Voorhoeve (LSE) compare the benefit-cost and social welfare approaches to doing so. They find early suppression is often best, if it can be ensured that those on lower incomes bear a smaller share of the economic burden of lockdown.
Keywords	RA0421 Public health. Hygiene. Preventive Medicine ; HV Social pathology. Social and public welfare. Criminology ; covid19
Language	English
Publishing date	2020-08-11
Publisher	London School of Economics and Political Science
Publishing country	uk
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: T cells specific to multiple Bet v 1 peptides are highly cross-reactive toward the corresponding peptides from the homologous group of tree pollens.

Lund, Gitte / Christensen, Lars Harder / Ihlemann, Jacob / Andersen, Peter Sejer / Wambre, Erik / Würtzen, Peter Adler / Gupta, Shashank

Frontiers in immunology

2023 Volume 14, Page(s) 1291666

Abstract: ... and some parts of Asia. The definition of the birch homologous group, which includes birch (Bet v ... specificities and cross-reactivity toward various Bet v 1 family members, (PR-10/group 1 major allergens ... individuals through stimulation of peripheral blood mononuclear cells (PBMCs) with birch/Bet v or oak/Que ...

Abstract	Background: Allergens from Fagales trees frequently cause spring allergy in Europe, North America, and some parts of Asia. The definition of the birch homologous group, which includes birch (Bet v), oak (Que a), alder (Aln g), hazel (Cor a), hornbeam (Car b), beech (Fag s), and chestnut (Cas s), is based on high allergen sequence identity and extensive IgE cross-reactivity. Clinical effect was seen during the alder/hazel, birch, and oak pollen seasons after treatment with tree SLIT-tablets containing only birch allergen extract. Here, we characterize T-cell reactivity with respect to epitope specificities and cross-reactivity toward various Bet v 1 family members, (PR-10/group 1 major allergens). This cross-reactivity may be part of the immunological basis of clinical effect or cross-protection when exposed to birch homologous tree species. Method: T-cell lines were generated from 29 birch-allergic individuals through stimulation of peripheral blood mononuclear cells (PBMCs) with birch/Bet v or oak/Que a allergen extracts. T-cell responses to allergen extracts, purified group 1 allergens, and overlapping 20-mer peptides (Bet v 1, Aln g 1, Cor a 1, and Que a 1) were investigated by T-cell proliferation and cytokine production. Cross-reactivity was evaluated based on Pearson's correlations of response strength and further investigated by flow cytometry using tetramer staining for homologous peptide pairs. Results: T-cell reactivity toward extracts and group 1 allergens from across the birch homologous group was observed for birch/Bet v as well as oak/Que a T-cell lines. T-cell lines responded to multiple Bet v 1 homologous peptides from Aln g 1 and Cor a 1 and a subset of Que a 1 peptides. Significant Pearson's correlations between frequently recognized peptides derived from Bet v 1 and the corresponding peptides derived from alder, hazel, and oak strongly supported the T-cell cross-reactivity toward these allergens. Cross-reactivity between birch and birch homologous peptides was confirmed by pMHCII tetramer staining. Conclusion: T cells from birch tree pollen allergic individuals respond to multiple trees within the birch homologous group in accordance with the level of sequence homology between Bet v 1 family members, (PR-10 allergens) from these allergen sources, confirming the basis for clinical cross-protection.
MeSH term(s)	Humans ; Trees ; T-Lymphocytes ; Leukocytes, Mononuclear ; Antigens, Plant ; Pollen ; Allergens ; Hypersensitivity ; Peptides/analysis ; Betula
Chemical Substances	Antigens, Plant ; Allergens ; Peptides
Language	English
Publishing date	2023-11-22
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1291666
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Article: Neues von der AfnP e. V.

Bundschu, Marion / Köhler, Franka / Adler, Ilona

Dialyse aktuell

2017 Volume 21, Issue 01, Page(s) 8–10

Abstract: Die Silvester-Raketen sind abgefeuert, das Konfetti ist im Staubsauger, das Geschirr gespült und die leeren Flaschen sind zum Altglas-Container gebracht. Das neue Jahr hat seinen Lauf genommen. Die AfnP möchte sich an dieser Stelle bei ihren Mitgliedern ... ...

Abstract	Die Silvester-Raketen sind abgefeuert, das Konfetti ist im Staubsauger, das Geschirr gespült und die leeren Flaschen sind zum Altglas-Container gebracht. Das neue Jahr hat seinen Lauf genommen. Die AfnP möchte sich an dieser Stelle bei ihren Mitgliedern bedanken. Sie haben uns in den vergangenen Jahren die Treue gehalten und auch nicht mit Lob und Kritik gespart. Viele haben unsere Veranstaltungen besucht und ihren Bildungsgutschein (in Höhe von 40 Euro) eingelöst.
Language	German
Publishing date	2017-02-01
Publisher	© Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2146225-2
ISSN	1860-3300 ; 1434-0704
ISSN (online)	1860-3300
ISSN	1434-0704
DOI	10.1055/s-0043-100984
Database	Thieme publisher's database

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Zs.A 6979: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.A 6979/X: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article: Priority for the worse-off and the social cost of carbon -> N&V p389

Adler, Matthew / Anthoff, David / Bosetti, Valentina / Garner, Greg / Keller, Klaus / Treich, Nicolas

Nature climate change

2017 Volume 7, Issue 6, Page(s) 443

Language	English
Document type	Article
ZDB-ID	2614383-5
ISSN	1758-678x
Database	Current Contents Nutrition, Environment, Agriculture

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Article ; Online: 'Carriers of variant luteinizing hormone (V-LH) among 1593 Baltic men have significantly higher serum LH'.

Punab, A M / Grigorova, M / Punab, M / Adler, M / Kuura, T / Poolamets, O / Vihljajev, V / Žilaitienė, B / Erenpreiss, J / Matulevičius, V / Laan, M

Andrology

2015 Volume 3, Issue 3, Page(s) 512–519

Abstract: ... reproduction. Its functional polymorphic variant (V-LH) is determined by two missense mutations (rs1800447, A/G ... Among women, V-LH has been associated with higher circulating LH and reduced fertility, but the knowledge ... the effect of V-LH on hormonal, seminal and testicular parameters in the Baltic young men cohort (n = 986 ...

Abstract	Luteinizing hormone (LH) is a pituitary heterodimeric glycoprotein essential in male and female reproduction. Its functional polymorphic variant (V-LH) is determined by two missense mutations (rs1800447, A/G, Trp8Arg; rs34349826, A/G, Ile15Thr) in the LH β-subunit encoding gene (LHB; 19q13.3; 1111 bp; 3 exons). Among women, V-LH has been associated with higher circulating LH and reduced fertility, but the knowledge of its effect on male reproductive parameters has been inconclusive. The objective of this study was to assess the effect of V-LH on hormonal, seminal and testicular parameters in the Baltic young men cohort (n = 986; age: 20.1 ± 2.1 years) and Estonian idiopathic infertility patients (n = 607; 35.1 ± 5.9 years). V-LH was detected by genotyping of the underlying DNA polymorphisms using PCR-RFLP combined with resequencing of a random subset of subjects. Genetic associations were tested using linear regression under additive model and results were combined in meta-analysis. No significant difference was detected between young men and infertility patients for the V-LH allele frequency (11.0 vs. 9.3%, respectively). V-LH was associated with higher serum LH in both, the young men cohort (p = 0.022, allelic effect = 0.26 IU/L) and the idiopathic infertility group (p = 0.008, effect = 0.59 IU/L). In meta-analysis, the statistical significance was enhanced (p = 0.0007, resistant to Bonferroni correction for multiple testing; effect = 0.33 IU/L). The detected significant association of V-LH with increased serum LH remained unchanged after additional adjustment for the SNPs previously demonstrated to affect LH levels (FSHB -211G/T, FSHR Asn680Ser, FSHR -29A/G). Additionally, a suggestive trend for association with reduced testicular volume was observed among young men, and with lower serum FSH among infertility patients. The V-LH carrier status did not affect sperm parameters and other circulating reproductive hormones. For the first time, we show a conclusive contribution of V-LH to the natural variance in male serum LH levels. Its downstream clinical consequences are still to be learned.
MeSH term(s)	Aging ; Estonia ; Female ; Follicle Stimulating Hormone/blood ; Gene Frequency/genetics ; Humans ; Luteinizing Hormone, beta Subunit/blood ; Luteinizing Hormone, beta Subunit/genetics ; Male ; Mutation/genetics ; Oligospermia/blood ; Oligospermia/genetics ; Polymorphism, Single Nucleotide ; Protein Isoforms/blood ; Protein Isoforms/genetics ; Sperm Count ; Testis/physiology ; Testosterone/blood
Chemical Substances	Luteinizing Hormone, beta Subunit ; Protein Isoforms ; Testosterone (3XMK78S47O) ; Follicle Stimulating Hormone (9002-68-0)
Language	English
Publishing date	2015-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2696108-8
ISSN	2047-2927 ; 2047-2919
ISSN (online)	2047-2927
ISSN	2047-2919
DOI	10.1111/andr.12022
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Zs.A 6983: Show issues

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Article ; Online: King v. Burwell: Desperately Seeking Ambiguity in Clear Statutory Text.

Adler, Jonathan H / Cannon, Michael F

Journal of health politics, policy and law

2015 Volume 40, Issue 3, Page(s) 577–588

Abstract: ... in Pruitt v. Burwell, Halbig v. Burwell, King v. Burwell, and Indiana v. IRS. The plaintiffs argue ...

Abstract	Does the Patient Protection and Affordable Care Act (ACA) of 2010 authorize tax credits within the thirty-six states that failed to establish health insurance exchanges? That is the question presented in Pruitt v. Burwell, Halbig v. Burwell, King v. Burwell, and Indiana v. IRS. The plaintiffs argue that the statute is clear and forecloses any possibility of tax credits in federal exchanges. The government argues that the statute plainly authorizes tax credits in federal exchanges, or is at least ambiguous on the question. Mere disagreement is not evidence of ambiguity. Reaching the truth requires wading deep into each side's arguments. Whether the relevant text is viewed in isolation or in its full statutory context, the ACA authorizes tax credits only in exchanges established by the states.
MeSH term(s)	Health Insurance Exchanges/legislation & jurisprudence ; Humans ; Patient Protection and Affordable Care Act/legislation & jurisprudence ; Supreme Court Decisions ; Taxes/legislation & jurisprudence ; United States
Language	English
Publishing date	2015-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	752966-1
ISSN	1527-1927 ; 0361-6878
ISSN (online)	1527-1927
ISSN	0361-6878
DOI	10.1215/03616878-2867869
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Article: Balans vody v organizme pri laparoskopicheskikh fundoplikatsiiakh u deteĭ.

Lazarev, V V / Adler, A V

Anesteziologiia i reanimatologiia

2004 , Issue 1, Page(s) 46–49

Title translation	Body water balance during laparoscopic fundoplications in children.
MeSH term(s)	Adolescent ; Anesthesia, General ; Blood Pressure/physiology ; Child ; Child, Preschool ; Electric Impedance ; Fundoplication ; Heart Rate/physiology ; Hemodynamics/physiology ; Humans ; Intubation, Intratracheal ; Laparoscopy ; Pneumoperitoneum, Artificial ; Water-Electrolyte Balance/physiology
Language	Russian
Publishing date	2004-01
Publishing country	Russia (Federation)
Document type	Journal Article
ZDB-ID	754946-5
ISSN	0201-7563
ISSN	0201-7563
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Zs.B 1954: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 644: Show issues

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Article ; Online: Allele frequency distribution of 1691G >A F5 (which confers Factor V Leiden) across Europe, including Slavic populations.

Clark, Jeremy S C / Adler, Grażyna / Salkic, Nermin N / Ciechanowicz, Andrzej

Journal of applied genetics

2013 Volume 54, Issue 4, Page(s) 441–446

Abstract: Unlabelled: The allele 1691A F5, conferring Factor V Leiden, is a common risk factor ...

Abstract	Unlabelled: The allele 1691A F5, conferring Factor V Leiden, is a common risk factor in venous thromboembolism. The frequency distribution for this allele in Western Europe has been well documented; but here data from Central, Eastern and South-Eastern Europe has been included. In order to assess the significance of the collated data, a chi-squared test was applied, and Tukey tests and z-tests with Bonferroni correction were compared. Results: A distribution with a North-Southeast band of high frequency of the 1691A F5 allele was discovered with a pocket including some Southern Slavic populations with low frequency. European countries/regions can be arbitrarily delimited into low (group 1, <2.8 %, mean 1.9 % 1691A F5 allele) or high (group 2, ≥2.8 %, mean 4.0 %) frequency groups, with many significant differences between groups, but only one intra-group difference (the Tukey test is suggested to be superior to the z-tests). Conclusion: In Europe a North-Southeast band of 1691A F5 high frequency has been found, clarified by inclusion of data from Central, Eastern and South-Eastern Europe, which surrounds a pocket of low frequency in the Balkans which could possibly be explained by Slavic migration. There seem to be no indications of variation in environmental selection due to geographical location.
MeSH term(s)	Alleles ; Europe ; European Continental Ancestry Group/genetics ; Factor V/genetics ; Gene Frequency ; Humans ; Phylogeography ; Risk Factors
Chemical Substances	factor V Leiden ; Factor V (9001-24-5)
Language	English
Publishing date	2013-08-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1235302-4
ISSN	2190-3883 ; 1234-1983
ISSN (online)	2190-3883
ISSN	1234-1983
DOI	10.1007/s13353-013-0166-9
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