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  1. Article ; Online: A New "Lnc" to Brake Inflammation.

    Long, Xiaochun / Miano, Joseph M / Zhou, Jiliang

    Arteriosclerosis, thrombosis, and vascular biology

    2023  Volume 43, Issue 7, Page(s) 1176–1178

    MeSH term(s) Humans ; Inflammation ; MicroRNAs ; RNA, Long Noncoding
    Chemical Substances MicroRNAs ; RNA, Long Noncoding
    Language English
    Publishing date 2023-05-25
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.123.319444
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1705: Show issues Location:
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  2. Article ; Online: Of mice and human-specific long noncoding RNAs.

    Ghanam, Amr R / Bryant, William B / Miano, Joseph M

    Mammalian genome : official journal of the International Mammalian Genome Society

    2022  Volume 33, Issue 2, Page(s) 281–292

    Abstract: The number of human LncRNAs has now exceeded all known protein-coding genes. Most studies of human LncRNAs have been conducted in cell culture systems where various mechanisms of action have been worked out. On the other hand, efforts to elucidate the ... ...

    Abstract The number of human LncRNAs has now exceeded all known protein-coding genes. Most studies of human LncRNAs have been conducted in cell culture systems where various mechanisms of action have been worked out. On the other hand, efforts to elucidate the function of human LncRNAs in an in vivo setting have been limited. In this brief review, we highlight some strengths and weaknesses of studying human LncRNAs in the mouse. Special consideration is given to bacterial artificial chromosome transgenesis and genome editing. The integration of these technical innovations offers an unprecedented opportunity to complement and extend the expansive literature of cell culture models for the study of human LncRNAs. Two different examples of how BAC transgenesis and genome editing can be leveraged to gain insight into human LncRNA regulation and function in mice are presented: the random integration of a vascular cell-enriched LncRNA and a targeted approach for a new LncRNA immediately upstream of the ACE2 gene, which encodes the receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent underlying the coronavirus disease-19 (COVID-19) pandemic.
    MeSH term(s) COVID-19 ; Humans ; RNA, Long Noncoding/genetics ; SARS-CoV-2/genetics
    Chemical Substances RNA, Long Noncoding
    Language English
    Publishing date 2022-02-01
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 1058547-3
    ISSN 1432-1777 ; 0938-8990
    ISSN (online) 1432-1777
    ISSN 0938-8990
    DOI 10.1007/s00335-022-09943-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3489: Show issues Location:
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  3. Article: Generating a CRISPR knockout mouse through a strong premature termination codon: a cautionary tale.

    Lyu, Qing Rex / Yao, Peng / Miano, Joseph M

    Journal of biomedical research

    2021  Volume 35, Issue 2, Page(s) 174–178

    Language English
    Publishing date 2021-04-02
    Publishing country China
    Document type Journal Article
    ZDB-ID 2555537-6
    ISSN 1876-4819 ; 1674-8301
    ISSN (online) 1876-4819
    ISSN 1674-8301
    DOI 10.7555/JBR.34.20200106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Fate and State of Vascular Smooth Muscle Cells in Atherosclerosis.

    Miano, Joseph M / Fisher, Edward A / Majesky, Mark W

    Circulation

    2021  Volume 143, Issue 21, Page(s) 2110–2116

    Abstract: Vascular smooth muscle cells (VSMCs) have long been associated with phenotypic modulation/plasticity or dedifferentiation. Innovative technologies in cell lineage tracing, single-cell RNA sequencing, and human genomics have been integrated to gain ... ...

    Abstract Vascular smooth muscle cells (VSMCs) have long been associated with phenotypic modulation/plasticity or dedifferentiation. Innovative technologies in cell lineage tracing, single-cell RNA sequencing, and human genomics have been integrated to gain unprecedented insights into the molecular reprogramming of VSMCs to other cell phenotypes in experimental and clinical atherosclerosis. The current thinking is that an apparently small subset of contractile VSMCs undergoes a fate switch to transitional, multipotential cells that can adopt plaque-destabilizing (inflammation, ossification) or plaque-stabilizing (collagen matrix deposition) cell states. Several candidate mediators of such VSMC fate and state changes are coming to light with intriguing implications for understanding coronary artery disease risk and the development of new treatment modalities. Here, we briefly summarize some technical and conceptual advancements derived from 2 publications in
    MeSH term(s) Atherosclerosis/physiopathology ; Cell Proliferation ; Humans ; Muscle, Smooth, Vascular/metabolism
    Language English
    Publishing date 2021-05-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.120.049922
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: CRISPR-tagging mice in aging research.

    Miano, Joseph M / Long, Xiaochun

    Aging

    2018  Volume 10, Issue 9, Page(s) 2226–2227

    MeSH term(s) Aging ; Animals ; Clustered Regularly Interspaced Short Palindromic Repeats ; Mice ; Nuclear Proteins/metabolism ; Trans-Activators/metabolism
    Chemical Substances Nuclear Proteins ; Trans-Activators ; myocardin
    Language English
    Publishing date 2018-09-22
    Publishing country United States
    Document type Editorial
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.101566
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Myocardin in biology and disease.

    Miano, Joseph M

    Journal of biomedical research

    2014  Volume 29, Issue 1, Page(s) 3–19

    Abstract: Myocardin (MYOCD) is a potent transcriptional coactivator that functions primarily in cardiac muscle and smooth muscle through direct contacts with serum response factor (SRF) over cis elements known as CArG boxes found near a number of genes encoding ... ...

    Abstract Myocardin (MYOCD) is a potent transcriptional coactivator that functions primarily in cardiac muscle and smooth muscle through direct contacts with serum response factor (SRF) over cis elements known as CArG boxes found near a number of genes encoding for contractile, ion channel, cytoskeletal, and calcium handling proteins. Since its discovery more than 10 years ago, new insights have been obtained regarding the diverse isoforms of MYOCD expressed in cells as well as the regulation of MYOCD expression and activity through transcriptional, post-transcriptional, and post-translational processes. Curiously, there are a number of functions associated with MYOCD that appear to be independent of contractile gene expression and the CArG-SRF nucleoprotein complex. Further, perturbations in MYOCD gene expression are associated with an increasing number of diseases including heart failure, cancer, acute vessel disease, and diabetes. This review summarizes the various biological and pathological processes associated with MYOCD and offers perspectives to several challenges and future directions for further study of this formidable transcriptional coactivator.
    Language English
    Publishing date 2014-12-25
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2555537-6
    ISSN 1876-4819 ; 1674-8301
    ISSN (online) 1876-4819
    ISSN 1674-8301
    DOI 10.7555/JBR.29.20140151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Vascular smooth muscle cell differentiation-2010.

    Miano, Joseph M

    Journal of biomedical research

    2013  Volume 24, Issue 3, Page(s) 169–180

    Abstract: Vascular smooth muscle cells have attracted considerable interest as a model for a flexible program of gene expression. This cell type arises throughout the embryo body plan via poorly understood signaling cascades that direct the expression of ... ...

    Abstract Vascular smooth muscle cells have attracted considerable interest as a model for a flexible program of gene expression. This cell type arises throughout the embryo body plan via poorly understood signaling cascades that direct the expression of transcription factors and microRNAs which, in turn, orchestrate the activation of contractile genes collectively defining this cell lineage. The discovery of myocardin and its close association with serum response factor has represented a major break-through for the molecular understanding of vascular smooth muscle cell differentiation. Retinoids have been shown to improve the outcome of vessel wall remodeling following injury and have provided further insights into the molecular circuitry that defines the vascular smooth muscle cell phenotype. This review summarizes the progress to date in each of these areas of vascular smooth muscle cell biology.
    Language English
    Publishing date 2013-04-01
    Publishing country China
    Document type Journal Article
    ZDB-ID 2555537-6
    ISSN 1876-4819 ; 1674-8301
    ISSN (online) 1876-4819
    ISSN 1674-8301
    DOI 10.1016/S1674-8301(10)60026-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: CRISPR links to long noncoding RNA function in mice: A practical approach.

    Miano, Joseph M / Long, Xiaochun / Lyu, Qing

    Vascular pharmacology

    2019  Volume 114, Page(s) 1–12

    Abstract: Next generation sequencing has uncovered a trove of short noncoding RNAs (e.g., microRNAs) and long noncoding RNAs (lncRNAs) that act as molecular rheostats in the control of diverse homeostatic processes. Meanwhile, the tsunamic emergence of clustered ... ...

    Abstract Next generation sequencing has uncovered a trove of short noncoding RNAs (e.g., microRNAs) and long noncoding RNAs (lncRNAs) that act as molecular rheostats in the control of diverse homeostatic processes. Meanwhile, the tsunamic emergence of clustered regularly interspaced short palindromic repeats (CRISPR) editing has transformed our influence over all DNA-carrying entities, heralding global CRISPRization. This is evident in biomedical research where the ease and low-cost of CRISPR editing has made it the preferred method of manipulating the mouse genome, facilitating rapid discovery of genome function in an in vivo context. Here, CRISPR genome editing components are updated for elucidating lncRNA function in mice. Various strategies are highlighted for understanding the function of lncRNAs residing in intergenic sequence space, as host genes that harbor microRNAs or other genes, and as natural antisense, overlapping or intronic genes. Also discussed is CRISPR editing of mice carrying human lncRNAs as well as the editing of competing endogenous RNAs. The information described herein should assist labs in the rigorous design of experiments that interrogate lncRNA function in mice where complex disease processes can be modeled thus accelerating translational discovery.
    MeSH term(s) Animals ; CRISPR-Associated Protein 9/genetics ; CRISPR-Associated Protein 9/metabolism ; CRISPR-Cas Systems ; Clustered Regularly Interspaced Short Palindromic Repeats ; Gene Editing/methods ; Gene Expression Regulation ; Humans ; Mice ; Mice, Transgenic ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism
    Chemical Substances RNA, Long Noncoding ; CRISPR-Associated Protein 9 (EC 3.1.-)
    Language English
    Publishing date 2019-02-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2082846-9
    ISSN 1879-3649 ; 1537-1891 ; 1879-3649
    ISSN (online) 1879-3649 ; 1537-1891
    ISSN 1879-3649
    DOI 10.1016/j.vph.2019.02.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 591: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Challenges and Opportunities in Linking Long Noncoding RNAs to Cardiovascular, Lung, and Blood Diseases.

    Freedman, Jane E / Miano, Joseph M

    Arteriosclerosis, thrombosis, and vascular biology

    2016  Volume 37, Issue 1, Page(s) 21–25

    Abstract: The new millennium heralds an unanticipated surge of genomic information, most notably an expansive class of long noncoding RNAs (lncRNAs). These transcripts, which now outnumber all protein-coding genes, often exhibit the same characteristics as mRNAs ( ... ...

    Abstract The new millennium heralds an unanticipated surge of genomic information, most notably an expansive class of long noncoding RNAs (lncRNAs). These transcripts, which now outnumber all protein-coding genes, often exhibit the same characteristics as mRNAs (RNA polymerase II-dependent, 5' methyl-capped, multiexonic, polyadenylated); yet, they do not encode for stable, well-conserved proteins. Elucidating the function of all relevant lncRNAs in heart, vasculature, lung, and blood is essential for generating a complete interactome in these tissues. This is particularly evident because an increasing number of investigators perform RNA-sequencing experiments where, typically, annotated lncRNAs exhibit impressive changes in gene expression. How does one go about evaluating an lncRNA when the sequence of the transcript lends no insight into how it may function within a cell type? Here, we provide a brief overview for the rational study of lncRNAs.
    MeSH term(s) Animals ; Cardiovascular Diseases/genetics ; Cardiovascular Diseases/metabolism ; Computational Biology ; Gene Expression Regulation ; Genetic Association Studies ; Genetic Markers ; Genetic Predisposition to Disease ; Genomics/methods ; Hematologic Diseases/genetics ; Hematologic Diseases/metabolism ; Humans ; Lung Diseases/genetics ; Lung Diseases/metabolism ; Phenotype ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism
    Chemical Substances Genetic Markers ; RNA, Long Noncoding
    Language English
    Publishing date 2016-11-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.116.308513
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: What is truth? Standards of scientific integrity in American Heart Association journals.

    Miano, Joseph M

    Arteriosclerosis, thrombosis, and vascular biology

    2010  Volume 30, Issue 1, Page(s) 1–4

    MeSH term(s) American Heart Association ; Humans ; Plagiarism ; Publishing/standards ; Scientific Misconduct ; United States
    Language English
    Publishing date 2010-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.109.200204
    Database MEDical Literature Analysis and Retrieval System OnLINE

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