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  1. Article ; Online: Diet in Food Insecurity: A Mediator of Metabolic Health?

    Morselli, Lisa L / Amjad, Rabia / James, Roland / Kindel, Tammy L / Kwitek, Anne E / Williams, Joni S / Grobe, Justin L / Kidambi, Srividya

    Journal of the Endocrine Society

    2024  Volume 8, Issue 6, Page(s) bvae062

    Abstract: Objective: Food insecurity (FI) is associated with poor metabolic health. It is assumed that energy intake and diet quality underlie this association. We tested the hypothesis that dietary factors (quantity and quality) mediate the association of FI ... ...

    Abstract Objective: Food insecurity (FI) is associated with poor metabolic health. It is assumed that energy intake and diet quality underlie this association. We tested the hypothesis that dietary factors (quantity and quality) mediate the association of FI with excess weight, waist circumference and glycemic control [glycohemoglobin (A1C)].
    Methods: A mediation analysis was performed on data from the National Health And Nutrition Examination Survey using FI as an independent variable; body mass index (BMI), waist circumference, and A1C as metabolic outcome variables and total energy intake, macronutrients, and diet quality measured by the Healthy Eating Index-2015 (HEI-2015) as potential mediators.
    Results: Despite a greater prevalence of obesity in participants experiencing FI, daily reported energy intake was similar in food-secure and -insecure subjects. In adjusted analyses of the overall cohort, none of the examined dietary factors mediated associations between FI and metabolic outcomes. In race-stratified analyses, total sugar consumption was a partial mediator of BMI in non-Hispanic Whites, while diet quality measures (HEI-2015 total score and added sugar subscore) were partial mediators of waist circumference and BMI, respectively, for those in the "other" ethnic group.
    Conclusion: Dietary factors are not the main factors underlying the association of FI with metabolic health. Future studies should investigate whether other social determinants of health commonly present in the context of FI play a role in this association.
    Language English
    Publishing date 2024-04-02
    Publishing country United States
    Document type Journal Article
    ISSN 2472-1972
    ISSN (online) 2472-1972
    DOI 10.1210/jendso/bvae062
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  2. Article ; Online: Recent Advances in Hypertension: Intersection of Metabolic and Blood Pressure Regulatory Circuits in the Central Nervous System.

    Oliveira, Vanessa / Kwitek, Anne E / Sigmund, Curt D / Morselli, Lisa L / Grobe, Justin L

    Hypertension (Dallas, Tex. : 1979)

    2021  Volume 77, Issue 4, Page(s) 1061–1068

    Abstract: Obesity represents the single greatest ongoing roadblock to improving cardiovascular health. Prolonged obesity is associated with fundamental changes in the integrative control of energy balance, including the development of selective leptin resistance, ... ...

    Abstract Obesity represents the single greatest ongoing roadblock to improving cardiovascular health. Prolonged obesity is associated with fundamental changes in the integrative control of energy balance, including the development of selective leptin resistance, which is thought to contribute to obesity-associated hypertension, and adaptation of resting metabolic rate (RMR) when excess weight is reduced. Leptin and the melanocortin system within the hypothalamus contribute to the control of both energy balance and blood pressure. While the development of drugs to stimulate RMR and thereby reverse obesity through activation of the melanocortin system has been pursued, most of the resulting compounds simultaneously cause hypertension. Evidence supports the concept that although feeding behaviors, RMR, and blood pressure are controlled through mechanisms that utilize similar molecular mediators, these mechanisms exist in anatomically dissociable networks. New evidence supports a major change in molecular signaling within AgRP (Agouti-related peptide) neurons of the arcuate nucleus of the hypothalamus during prolonged obesity and the existence of multiple distinct subtypes of AgRP neurons that individually contribute to control of feeding, RMR, or blood pressure. Finally, ongoing work by our laboratory and others support a unique role for AT
    MeSH term(s) Angiotensins/metabolism ; Cardiometabolic Risk Factors ; Central Nervous System/metabolism ; Central Nervous System/physiopathology ; Drug Discovery ; Humans ; Hypertension/metabolism ; Hypertension/physiopathology ; Hypertension/therapy ; Leptin/metabolism ; Metabolism/drug effects ; Metabolism/physiology ; Obesity/metabolism ; Obesity/prevention & control
    Chemical Substances Angiotensins ; Leptin
    Language English
    Publishing date 2021-02-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.120.14513
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  3. Article: Cell-specific transcriptome changes in the hypothalamic arcuate nucleus in a mouse deoxycorticosterone acetate-salt model of hypertension.

    Wagner, Valerie A / Deng, Guorui / Claflin, Kristin E / Ritter, McKenzie L / Cui, Huxing / Nakagawa, Pablo / Sigmund, Curt D / Morselli, Lisa L / Grobe, Justin L / Kwitek, Anne E

    Frontiers in cellular neuroscience

    2023  Volume 17, Page(s) 1207350

    Abstract: A common preclinical model of hypertension characterized by low circulating renin is the "deoxycorticosterone acetate (DOCA)-salt" model, which influences blood pressure and metabolism through mechanisms involving the angiotensin II type 1 receptor ( ... ...

    Abstract A common preclinical model of hypertension characterized by low circulating renin is the "deoxycorticosterone acetate (DOCA)-salt" model, which influences blood pressure and metabolism through mechanisms involving the angiotensin II type 1 receptor (AT
    Language English
    Publishing date 2023-05-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2023.1207350
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  4. Article ; Online: Krüppel-like factor 4 in transcriptional control of the three unique isoforms of Agouti-related peptide in mice.

    Ritter, McKenzie L / Wagner, Valerie A / Balapattabi, Kirthikaa / Opichka, Megan A / Lu, Ko-Ting / Wackman, Kelsey K / Reho, John J / Keen, Henry L / Kwitek, Anne E / Morselli, Lisa L / Geurts, Aron M / Sigmund, Curt D / Grobe, Justin L

    Physiological genomics

    2023  Volume 56, Issue 3, Page(s) 265–275

    Abstract: Agouti-related peptide (AgRP/ ...

    Abstract Agouti-related peptide (AgRP/
    MeSH term(s) Mice ; Animals ; Agouti-Related Protein/genetics ; Agouti-Related Protein/metabolism ; Kruppel-Like Factor 4 ; Neurons/metabolism ; Obesity/genetics ; Obesity/metabolism ; Hypothalamus/metabolism ; Protein Isoforms/genetics ; Protein Isoforms/metabolism
    Chemical Substances Agouti-Related Protein ; Kruppel-Like Factor 4 ; Protein Isoforms
    Language English
    Publishing date 2023-12-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2038823-8
    ISSN 1531-2267 ; 1094-8341
    ISSN (online) 1531-2267
    ISSN 1094-8341
    DOI 10.1152/physiolgenomics.00042.2023
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    In stock of ZB MED Cologne/Königswinter

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  5. Article: Sex Differences in the Impact of Obstructive Sleep Apnea on Glucose Metabolism.

    Temple, Karla A / Leproult, Rachel / Morselli, Lisa / Ehrmann, David A / Van Cauter, Eve / Mokhlesi, Babak

    Frontiers in endocrinology

    2018  Volume 9, Page(s) 376

    Abstract: Objectives: ...

    Abstract Objectives:
    Language English
    Publishing date 2018-07-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2018.00376
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  6. Article ; Online: Amnion responses to intrauterine inflammation and effects of inhibition of TNF signaling in preterm Rhesus macaque.

    Presicce, Pietro / Cappelletti, Monica / Morselli, Marco / Ma, Feiyang / Senthamaraikannan, Paranthaman / Protti, Giulia / Nadel, Brian B / Aryan, Laila / Eghbali, Mansoureh / Salwinski, Lukasz / Pithia, Neema / De Franco, Emily / Miller, Lisa A / Pellegrini, Matteo / Jobe, Alan H / Chougnet, Claire A / Kallapur, Suhas G

    iScience

    2023  Volume 26, Issue 11, Page(s) 108118

    Abstract: Intrauterine infection/inflammation (IUI) is a frequent complication of pregnancy leading to preterm labor and fetal inflammation. How inflammation is modulated at the maternal-fetal interface is unresolved. We compared transcriptomics of amnion (a fetal ...

    Abstract Intrauterine infection/inflammation (IUI) is a frequent complication of pregnancy leading to preterm labor and fetal inflammation. How inflammation is modulated at the maternal-fetal interface is unresolved. We compared transcriptomics of amnion (a fetal tissue in contact with amniotic fluid) in a preterm Rhesus macaque model of IUI induced by lipopolysaccharide with human cohorts of chorioamnionitis. Bulk RNA sequencing (RNA-seq) amnion transcriptomic profiles were remarkably similar in both Rhesus and human subjects and revealed that induction of key labor-mediating genes such as
    Language English
    Publishing date 2023-10-06
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.108118
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  7. Article ; Online: Angiotensin AT

    Balapattabi, Kirthikaa / Yavuz, Yavuz / Jiang, Jingwei / Deng, Guorui / Mathieu, Natalia M / Ritter, McKenzie L / Opichka, Megan A / Reho, John J / McCorvy, John D / Nakagawa, Pablo / Morselli, Lisa L / Mouradian, Gary C / Atasoy, Deniz / Cui, Huxing / Hodges, Matthew R / Sigmund, Curt D / Grobe, Justin L

    Cell reports

    2023  Volume 42, Issue 8, Page(s) 112935

    Abstract: Resting metabolic rate (RMR) adaptation occurs during obesity and is hypothesized to contribute to failed weight management. Angiotensin II (Ang-II) type 1 ( ... ...

    Abstract Resting metabolic rate (RMR) adaptation occurs during obesity and is hypothesized to contribute to failed weight management. Angiotensin II (Ang-II) type 1 (AT
    MeSH term(s) Animals ; Mice ; Agouti-Related Protein/metabolism ; Angiotensin II/metabolism ; Neurons/metabolism ; Obesity/metabolism ; Receptor, Angiotensin, Type 1/metabolism
    Chemical Substances Agouti-Related Protein ; Angiotensin II (11128-99-7) ; Agtr1a protein, mouse ; Receptor, Angiotensin, Type 1
    Language English
    Publishing date 2023-08-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.112935
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  8. Article ; Online: Control of Energy Expenditure by AgRP Neurons of the Arcuate Nucleus: Neurocircuitry, Signaling Pathways, and Angiotensin.

    Morselli, Lisa L / Claflin, Kristin E / Cui, Huxing / Grobe, Justin L

    Current hypertension reports

    2018  Volume 20, Issue 3, Page(s) 25

    Abstract: Purpose of review: Here, we review the current understanding of the functional neuroanatomy of neurons expressing Agouti-related peptide (AgRP) and the angiotensin 1A receptor (AT: Recent findings: The development and maintenance of obesity involves ... ...

    Abstract Purpose of review: Here, we review the current understanding of the functional neuroanatomy of neurons expressing Agouti-related peptide (AgRP) and the angiotensin 1A receptor (AT
    Recent findings: The development and maintenance of obesity involves suppression of resting metabolic rate (RMR). RMR control is integrated via AgRP and proopiomelanocortin neurons within the ARC. Their projections to other hypothalamic and extrahypothalamic nuclei contribute to RMR control, though relatively little is known about the contributions of individual projections and the neurotransmitters involved. Recent studies highlight a role for AT
    MeSH term(s) Agouti-Related Protein/metabolism ; Angiotensins/metabolism ; Animals ; Arcuate Nucleus of Hypothalamus/metabolism ; Arcuate Nucleus of Hypothalamus/physiology ; Energy Metabolism/physiology ; Humans ; Hypertension/metabolism ; Neurons/metabolism ; Obesity/metabolism ; Receptor, Angiotensin, Type 1/metabolism ; Signal Transduction/physiology
    Chemical Substances Agouti-Related Protein ; Angiotensins ; Receptor, Angiotensin, Type 1
    Language English
    Publishing date 2018-03-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2057367-4
    ISSN 1534-3111 ; 1522-6417
    ISSN (online) 1534-3111
    ISSN 1522-6417
    DOI 10.1007/s11906-018-0824-8
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    Zs.A 5522: Show issues Location:
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  9. Article ; Online: Cardiometabolic Consequences of Deleting the Regulator of G protein Signaling-2 (

    Ritter, McKenzie L / Deng, Guorui / Reho, John J / Deng, Yue / Sapouckey, Sarah A / Opichka, Megan A / Balapattabi, Kirthikaa / Wackman, Kelsey K / Brozoski, Daniel T / Lu, Ko-Ting / Paradee, William J / Gibson-Corley, Katherine N / Cui, Huxing / Nakagawa, Pablo / Morselli, Lisa L / Sigmund, Curt D / Grobe, Justin L

    Hypertension (Dallas, Tex. : 1979)

    2022  Volume 79, Issue 12, Page(s) 2843–2853

    Abstract: Background: RGS (regulator of G protein signaling) family members catalyze the termination of G protein signaling cascades. Single nucleotide polymorphisms in the : Methods: To study cell-specific functions of RGS2, a novel gene-targeted mouse ... ...

    Abstract Background: RGS (regulator of G protein signaling) family members catalyze the termination of G protein signaling cascades. Single nucleotide polymorphisms in the
    Methods: To study cell-specific functions of RGS2, a novel gene-targeted mouse harboring a conditional allele for the
    Results: Whereas
    Conclusions: These results demonstrate the development of a novel mouse with conditional expression of
    MeSH term(s) Animals ; Mice ; Agouti-Related Protein ; Hypertension/genetics ; Mice, Knockout ; Mice, Transgenic ; Receptor, Angiotensin, Type 1/genetics ; Recombinases ; RGS Proteins/genetics
    Chemical Substances Agouti-Related Protein ; Receptor, Angiotensin, Type 1 ; Recombinases ; RGS Proteins
    Language English
    Publishing date 2022-10-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.122.20169
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  10. Article ; Online: Amnion responses to intrauterine inflammation and effects of inhibition of TNF signaling in preterm Rhesus macaque

    Pietro Presicce / Monica Cappelletti / Marco Morselli / Feiyang Ma / Paranthaman Senthamaraikannan / Giulia Protti / Brian B. Nadel / Laila Aryan / Mansoureh Eghbali / Lukasz Salwinski / Neema Pithia / Emily De Franco / Lisa A. Miller / Matteo Pellegrini / Alan H. Jobe / Claire A. Chougnet / Suhas G. Kallapur

    iScience, Vol 26, Iss 11, Pp 108118- (2023)

    2023  

    Abstract: Summary: Intrauterine infection/inflammation (IUI) is a frequent complication of pregnancy leading to preterm labor and fetal inflammation. How inflammation is modulated at the maternal-fetal interface is unresolved. We compared transcriptomics of amnion ...

    Abstract Summary: Intrauterine infection/inflammation (IUI) is a frequent complication of pregnancy leading to preterm labor and fetal inflammation. How inflammation is modulated at the maternal-fetal interface is unresolved. We compared transcriptomics of amnion (a fetal tissue in contact with amniotic fluid) in a preterm Rhesus macaque model of IUI induced by lipopolysaccharide with human cohorts of chorioamnionitis. Bulk RNA sequencing (RNA-seq) amnion transcriptomic profiles were remarkably similar in both Rhesus and human subjects and revealed that induction of key labor-mediating genes such as IL1 and IL6 was dependent on nuclear factor κB (NF-κB) signaling and reversed by the anti-tumor necrosis factor (TNF) antibody Adalimumab. Inhibition of collagen biosynthesis by IUI was partially restored by Adalimumab. Interestingly, single-cell transcriptomics, flow cytometry, and immunohistology demonstrated that a subset of amnion mesenchymal cells (AMCs) increase CD14 and other myeloid cell markers during IUI both in the human and Rhesus macaque. Our data suggest that CD14+ AMCs represent activated AMCs at the maternal-fetal interface.
    Keywords Immunology ; Bioinformatics ; Omics ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
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