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  1. Article ; Online: Inflammation Resolution: Implications for Atherosclerosis.

    Doran, Amanda C

    Circulation research

    2022  Volume 130, Issue 1, Page(s) 130–148

    Abstract: Resolution is an active and highly coordinated process that occurs in response to inflammation to limit tissue damage and promote repair. When the resolution program fails, inflammation persists. It is now understood that failed resolution is a major ... ...

    Abstract Resolution is an active and highly coordinated process that occurs in response to inflammation to limit tissue damage and promote repair. When the resolution program fails, inflammation persists. It is now understood that failed resolution is a major underlying cause of many chronic inflammatory diseases. Here, we will review the major failures of resolution in atherosclerosis, including the imbalance of proinflammatory to pro-resolving mediator production, impaired clearance of dead cells, and functional changes in immune cells that favor ongoing inflammation. In addition, we will briefly discuss new concepts that are emerging as possible regulators of resolution and highlight the translational significance for the field.
    MeSH term(s) Animals ; Anti-Inflammatory Agents/therapeutic use ; Atherosclerosis/drug therapy ; Atherosclerosis/metabolism ; Humans ; Inflammasomes/metabolism ; Signal Transduction
    Chemical Substances Anti-Inflammatory Agents ; Inflammasomes
    Language English
    Publishing date 2022-01-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.121.319822
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Correction: Same name, different game?-How ontogeny shapes classical monocyte phenotypes.

    Pimenov, Lisabeth / Gonzalez, Azuah Lucrecia / Doran, Amanda C / Knapp, Sylvia

    Genes and immunity

    2024  

    Language English
    Publishing date 2024-04-09
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2060566-3
    ISSN 1476-5470 ; 1466-4879
    ISSN (online) 1476-5470
    ISSN 1466-4879
    DOI 10.1038/s41435-024-00269-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Same name, different game?-How ontogeny shapes classical monocyte phenotypes.

    Pimenov, Lisabeth / Gonzalez, Azuah Lucrecia / Doran, Amanda C / Knapp, Sylvia

    Genes and immunity

    2024  Volume 25, Issue 1, Page(s) 1–3

    MeSH term(s) Monocytes ; Phenotype
    Language English
    Publishing date 2024-01-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2060566-3
    ISSN 1476-5470 ; 1466-4879
    ISSN (online) 1476-5470
    ISSN 1466-4879
    DOI 10.1038/s41435-023-00248-1
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  4. Article ; Online: Harnessing prostaglandin E

    Burkett, Juliann B / Doran, Amanda C / Gannon, Maureen

    Trends in immunology

    2023  Volume 44, Issue 3, Page(s) 162–171

    Abstract: The etiology of most autoimmune diseases remains unknown; however, shared among them is a disruption of immunoregulation. Prostaglandin lipid signaling molecules possess context-dependent immunoregulatory properties, making their role in autoimmunity ... ...

    Abstract The etiology of most autoimmune diseases remains unknown; however, shared among them is a disruption of immunoregulation. Prostaglandin lipid signaling molecules possess context-dependent immunoregulatory properties, making their role in autoimmunity difficult to decipher. For example, prostaglandin E
    MeSH term(s) Humans ; Autoimmunity ; Dinoprostone/metabolism ; Signal Transduction ; Autoimmune Diseases ; T-Lymphocyte Subsets/metabolism
    Chemical Substances Dinoprostone (K7Q1JQR04M)
    Language English
    Publishing date 2023-01-25
    Publishing country England
    Document type Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2023.01.004
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  5. Article ; Online: B cells and atherosclerosis: A HIV perspective.

    Obare, Laventa M / Bonami, Rachel H / Doran, Amanda C / Wanjalla, Celestine N

    Journal of cellular physiology

    2024  

    Abstract: Atherosclerosis remains a leading cause of cardiovascular disease (CVD) globally, with the complex interplay of inflammation and lipid metabolism at its core. Recent evidence suggests a role of B cells in the pathogenesis of atherosclerosis; however, ... ...

    Abstract Atherosclerosis remains a leading cause of cardiovascular disease (CVD) globally, with the complex interplay of inflammation and lipid metabolism at its core. Recent evidence suggests a role of B cells in the pathogenesis of atherosclerosis; however, this relationship remains poorly understood, particularly in the context of HIV. We review the multifaceted functions of B cells in atherosclerosis, with a specific focus on HIV. Unique to atherosclerosis is the pivotal role of natural antibodies, particularly those targeting oxidized epitopes abundant in modified lipoproteins and cellular debris. B cells can exert control over cellular immune responses within atherosclerotic arteries through antigen presentation, chemokine production, cytokine production, and cell-cell interactions, actively participating in local and systemic immune responses. We explore how HIV, characterized by chronic immune activation and dysregulation, influences B cells in the context of atherosclerosis, potentially exacerbating CVD risk in persons with HIV. By examining the proatherogenic and antiatherogenic properties of B cells, we aim to deepen our understanding of how B cells influence atherosclerotic plaque development, especially within the framework of HIV. This research provides a foundation for novel B cell-targeted interventions, with the potential to mitigate inflammation-driven cardiovascular events, offering new perspectives on CVD risk management in PLWH.
    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3116-1
    ISSN 1097-4652 ; 0021-9541
    ISSN (online) 1097-4652
    ISSN 0021-9541
    DOI 10.1002/jcp.31270
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  6. Article ; Online: Inflammation Resolution in the Cardiovascular System: Arterial Hypertension, Atherosclerosis, and Ischemic Heart Disease.

    Gonzalez, Azuah L / Dungan, Matthew M / Smart, C Duncan / Madhur, Meena S / Doran, Amanda C

    Antioxidants & redox signaling

    2023  Volume 40, Issue 4-6, Page(s) 292–316

    Abstract: Significance: ...

    Abstract Significance:
    MeSH term(s) Humans ; Atherosclerosis/metabolism ; Inflammation/metabolism ; Myocardial Infarction/drug therapy ; Cardiovascular System/metabolism ; Hypertension/drug therapy ; Inflammation Mediators/metabolism
    Chemical Substances Inflammation Mediators
    Language English
    Publishing date 2023-08-01
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1483836-9
    ISSN 1557-7716 ; 1523-0864
    ISSN (online) 1557-7716
    ISSN 1523-0864
    DOI 10.1089/ars.2023.0284
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5488: Show issues Location:
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  7. Article ; Online: An improved method for cytochrome p450 reaction phenotyping using a sequential qualitative-then-quantitative approach.

    Doran, Angela C / Dantonio, Alyssa L / Gualtieri, Gabrielle M / Balesano, Amanda / Landers, Connor / Burchett, Woodrow / Goosen, Theunis C / Obach, R Scott

    Drug metabolism and disposition: the biological fate of chemicals

    2022  

    Abstract: Cytochrome P450 reaction phenotyping to determine the fraction of metabolism values ( ... ...

    Abstract Cytochrome P450 reaction phenotyping to determine the fraction of metabolism values (f
    Language English
    Publishing date 2022-07-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 186795-7
    ISSN 1521-009X ; 0090-9556
    ISSN (online) 1521-009X
    ISSN 0090-9556
    DOI 10.1124/dmd.122.000883
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  8. Article ; Online: Statins and Atherosclerotic Lesion Microcalcification: A New Mechanism for Plaque Stability?

    Doran, Amanda C / Terry, James G / Carr, John Jeffrey / Linton, MacRae F

    Arteriosclerosis, thrombosis, and vascular biology

    2021  Volume 41, Issue 4, Page(s) 1306–1308

    MeSH term(s) Animals ; Atherosclerosis ; Calcium ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Mice ; Plaque, Atherosclerotic ; Vascular Calcification/diagnostic imaging
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-03-24
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.121.315949
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  9. Article ; Online: Small Molecule Activation of NAPE-PLD Enhances Efferocytosis by Macrophages.

    Zarrow, Jonah E / Alli-Oluwafuyi, Abdul-Musawwir / Youwakim, Cristina M / Kim, Kwangho / Jenkins, Andrew N / Suero, Isabelle C / Jones, Margaret R / Mashhadi, Zahra / Mackie, Ken / Waterson, Alex G / Doran, Amanda C / Sulikowski, Gary A / Davies, Sean S

    ACS chemical biology

    2023  Volume 18, Issue 8, Page(s) 1891–1904

    Abstract: ... ...

    Abstract N
    MeSH term(s) Mice ; Humans ; Animals ; Phospholipase D ; Phosphatidylethanolamines/metabolism ; Brain/metabolism ; Macrophages/metabolism ; Cardiovascular Diseases/metabolism
    Chemical Substances Phospholipase D (EC 3.1.4.4) ; Phosphatidylethanolamines
    Language English
    Publishing date 2023-08-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 1554-8937
    ISSN (online) 1554-8937
    DOI 10.1021/acschembio.3c00401
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  10. Article ; Online: Efferocytosis in health and disease.

    Doran, Amanda C / Yurdagul, Arif / Tabas, Ira

    Nature reviews. Immunology

    2019  Volume 20, Issue 4, Page(s) 254–267

    Abstract: The clearance of apoptotic cells by professional and non-professional phagocytes - a process termed 'efferocytosis' - is essential for the maintenance of tissue homeostasis. Accordingly, defective efferocytosis underlies a growing list of chronic ... ...

    Abstract The clearance of apoptotic cells by professional and non-professional phagocytes - a process termed 'efferocytosis' - is essential for the maintenance of tissue homeostasis. Accordingly, defective efferocytosis underlies a growing list of chronic inflammatory diseases. Although much has been learnt about the mechanisms of apoptotic cell recognition and uptake, several key areas remain incompletely understood. This Review focuses on new discoveries related to how phagocytes process the metabolic cargo they receive during apoptotic cell uptake; the links between efferocytosis and the resolution of inflammation in health and disease; and the roles of efferocytosis in host defence. Understanding these aspects of efferocytosis sheds light on key physiological and pathophysiological processes and suggests novel therapeutic strategies for diseases driven by defective efferocytosis and impaired inflammation resolution.
    MeSH term(s) Apoptosis/physiology ; Homeostasis/physiology ; Humans ; Inflammation/physiopathology ; Phagocytes/physiology ; Phagocytosis/physiology
    Language English
    Publishing date 2019-12-10
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-019-0240-6
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