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  1. Article ; Online: Antinociceptive effect of ranolazine and trimetazidine.

    Tolunay, Hatice

    Expert review of cardiovascular therapy

    2021  Volume 19, Issue 5, Page(s) 457–464

    Abstract: ... ...

    Abstract Background
    MeSH term(s) Aged ; Aged, 80 and over ; Analgesics/therapeutic use ; Cardiovascular Agents/therapeutic use ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Quality of Life ; Ranolazine/therapeutic use ; Treatment Outcome ; Trimetazidine/therapeutic use ; Vasodilator Agents/therapeutic use
    Chemical Substances Analgesics ; Cardiovascular Agents ; Vasodilator Agents ; Ranolazine (A6IEZ5M406) ; Trimetazidine (N9A0A0R9S8)
    Language English
    Publishing date 2021-04-16
    Publishing country England
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 2192343-7
    ISSN 1744-8344 ; 1477-9072
    ISSN (online) 1744-8344
    ISSN 1477-9072
    DOI 10.1080/14779072.2021.1914589
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6107: Show issues Location:
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  2. Article ; Online: Does Ranolazine Reduce Pain Perception With Cerebral Effect?

    Tolunay, Hatice

    Clinical therapeutics

    2020  Volume 42, Issue 2, Page(s) 374–375

    MeSH term(s) Acetanilides ; Coronary Artery Disease ; Humans ; Ivabradine ; Nicorandil ; Pain Perception ; Randomized Controlled Trials as Topic ; Ranolazine
    Chemical Substances Acetanilides ; Nicorandil (260456HAM0) ; Ivabradine (3H48L0LPZQ) ; Ranolazine (A6IEZ5M406)
    Language English
    Publishing date 2020-01-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 603113-4
    ISSN 1879-114X ; 0149-2918
    ISSN (online) 1879-114X
    ISSN 0149-2918
    DOI 10.1016/j.clinthera.2019.12.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1435: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 404: Show issues

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  3. Article ; Online: Are the birth month and season predictors of coronary artery disease?

    Hatice Tolunay

    Medicine Science, Vol 10, Iss 2, Pp 474-

    2021  Volume 8

    Abstract: The month and season of birth have been found to be associated with cardiovascular mortality, but the mechanisms are not fully explained. We planned a study to examine the relationship between SYNTAX score, which shows the severity of coronary artery ... ...

    Abstract The month and season of birth have been found to be associated with cardiovascular mortality, but the mechanisms are not fully explained. We planned a study to examine the relationship between SYNTAX score, which shows the severity of coronary artery disease (CAD), and the month and season of birth. 346 patients who underwent coronary angiography between October 2019 and January 2020 were evaluated. Birth month, birth seasons and demographic data of patients were recorded. SYNTAX scores were calculated from patients' coronary angiographies. Patients with birth months September, October, November and December had the lowest SYNTAX score (6.42±8.78, 5.61±8.42, 8.93±12.07, 6.35±8.02, respectively). SYNTAX score of patients who were born in October was statistically significantly lower compared to other months (p= 0.005). Coronary artery disease was highest in those born in June (.2) and July (.6). The presence of CAD in patients born in fall was 46.5% (p [Med-Science 2021; 10(2.000): 474-8]
    Keywords birth month ; birth season ; coronary artery disease ; syntax score ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher Society of TURAZ AKADEMI
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Predictors of arrhythmia other than QT interval prolongation and the use of β-blocker therapy in the coronavirus disease 2019 pandemic.

    Tolunay, Hatice

    Kardiologia polska

    2020  Volume 78, Issue 7-8, Page(s) 796

    MeSH term(s) Anti-Inflammatory Agents ; Antiviral Agents ; Arrhythmias, Cardiac ; Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections ; Humans ; Long QT Syndrome ; Pandemics ; Pneumonia, Viral ; Poland ; SARS-CoV-2
    Chemical Substances Anti-Inflammatory Agents ; Antiviral Agents
    Keywords covid19
    Language English
    Publishing date 2020-08-25
    Publishing country Poland
    Document type Journal Article ; Comment
    ZDB-ID 411492-9
    ISSN 1897-4279 ; 0022-9032
    ISSN (online) 1897-4279
    ISSN 0022-9032
    DOI 10.33963/KP.15563
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 598: Show issues Location:
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    Zs.MO 474: Show issues

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  5. Article ; Online: Role of Striated Muscles in the Pathogenesis of COVID-19.

    Tolunay, Hatice / Tolunay, Tolga

    Cardiovascular revascularization medicine : including molecular interventions

    2021  Volume 35, Page(s) 190

    MeSH term(s) COVID-19 ; Humans ; Muscle, Skeletal ; Muscle, Striated ; SARS-CoV-2
    Language English
    Publishing date 2021-05-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2212113-4
    ISSN 1878-0938 ; 1553-8389
    ISSN (online) 1878-0938
    ISSN 1553-8389
    DOI 10.1016/j.carrev.2021.05.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5562: Show issues Location:
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  7. Article ; Online: The relationship of systemic inflammatory biomarkers and cardiac parameters with malignancy in patients with soft tissue tumors located in the extremity.

    Tolunay, Tolga / Arıkan, Şefik Murat / Öztürk, Recep / Tolunay, Hatice

    Joint diseases and related surgery

    2021  Volume 32, Issue 3, Page(s) 698–704

    Abstract: Objectives: In this study, we aimed to investigate the contribution of systemic inflammatory biomarkers to the diagnosis and to examine the relationship between cardiac parameters and malignancy in patients with extremity soft tissue sarcomas (STSs).: ...

    Abstract Objectives: In this study, we aimed to investigate the contribution of systemic inflammatory biomarkers to the diagnosis and to examine the relationship between cardiac parameters and malignancy in patients with extremity soft tissue sarcomas (STSs).
    Patients and methods: Between January 2011 and December 2020, a total of 256 patients (155 males, 101 females; median age: 50 years; range, 18 to 87 years) who were diagnosed with benign and malignant soft tissue tumors were retrospectively analyzed. The control group consisted of a total of 150 age- and sex-matched healthy individuals (83 males, 67 females; median age: 52 years; range 19 to 76 years) with complete blood count analysis and having no STS. Demographic characteristics, laboratory parameters, and echocardiographic data of the patients were obtained from the hospital database. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were calculated.
    Results: Of a total of 256 patients included, 99 were diagnosed with benign tumors and 157 with malignant tumors. Lipoma was observed with the highest frequency of 40.4% among benign tumors, while malignant mesenchymal tumor (35.0%) was the most common tumor in the malignant group. There was no significant difference between the control and benign groups (p=0.198 and p=0.553, respectively), while the NLR and PLR of the malignant group were higher than both the control and benign groups, indicating a statistical significance (p<0.001). Total cholesterol, albumin, and ejection fraction (EF) levels of patients in the malignant group were significantly lower than the benign group (p=0.01, p<0.001, and p=0.046, respectively). According to the receiver operating characteristic curve, a cut-off value of 2.17 for NLR (sensitivity=64.1%, specificity=72%) and a cut-off value of 138.2 for PLR (sensitivity=60.9%, specificity=60.7%) were determined to distinguish malignant patients from healthy individuals. To distinguish malignant patients from the benign group, the cut-off values of NLR and PLR were 2.24 (sensitivity=62.8%, specificity=67.7%) and 137.9 (sensitivity=61%, specificity= 59.6%), respectively.
    Conclusion: Our study results suggest that NLR and PLR can be used as diagnostic markers in malignant soft tissue tumors located in the extremities. In addition, total cholesterol, albumin, and EF values are lower than normal in malignant soft tissue tumors.
    MeSH term(s) Adult ; Aged ; Biomarkers ; Extremities ; Female ; Humans ; Lymphocytes ; Male ; Middle Aged ; Retrospective Studies ; Soft Tissue Neoplasms ; Young Adult
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-11-19
    Publishing country Turkey
    Document type Journal Article
    ISSN 2687-4792
    ISSN (online) 2687-4792
    DOI 10.52312/jdrs.2021.392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Incidentally Diagnosed Double Inferior Vena Cava While Being Investigated for Pulmonary Hypertension.

    Yaşar, Salim / Köksal, Ozan / Eşki, Selen / Asil, Serkan / Tolunay, Hatice / Bozlar, Uğur / Yüksel, Uygar Çağdaş / Barçın, Cem / Çelik, Murat

    Anatolian journal of cardiology

    2022  Volume 26, Issue 6, Page(s) E8–E9

    MeSH term(s) Humans ; Hypertension, Pulmonary/diagnostic imaging ; Pulmonary Embolism ; Vena Cava, Inferior/diagnostic imaging
    Language English
    Publishing date 2022-09-05
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2278670-3
    ISSN 2149-2271 ; 2149-2271
    ISSN (online) 2149-2271
    ISSN 2149-2271
    DOI 10.5152/AnatolJCardiol.2022.1305
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Comparison of coronary risk scoring systems to predict the severity of coronary artery disease using the SYNTAX score.

    Tolunay, Hatice / Kurmus, Ozge

    Cardiology journal

    2016  Volume 23, Issue 1, Page(s) 51–56

    Abstract: Background: Reliable risk scoring systems that can predict the severity of coronary artery disease (CAD) are necessary to implement effective management strategies in high-risk patients. Atherosclerotic vascular disease and with cardiovascular morbidity ...

    Abstract Background: Reliable risk scoring systems that can predict the severity of coronary artery disease (CAD) are necessary to implement effective management strategies in high-risk patients. Atherosclerotic vascular disease and with cardiovascular morbidity and mortality risk are patients who would benefit most from a change in patients at high risk factors. Framingham Risk Score, the Prospective Cardiovascular Münster (PROCAM) score and Systematic Coronary Risk Evaluation (SCORE) risk scores are used for this purpose. The severity of the CAD as detected by coronary angiography can be estimated using the SYNTAX score. In this study, it is aimed to assess the relation between SYNTAX score and the Framingham, PROCAM and SCORE scores in the context of their utility for the determination of the severity of the CAD.
    Methods: A total of 205 patients with documented CAD who underwent coronary angiography due to a diagnosis of stable angina pectoris were included in this study. Coronary risk scores were determined for each patient. The relation between the SYNTAX score and the results of coronary risk scoring systems were analyzed.
    Results: A positive relationship between the SYNTAX score, which reflects the severity of the CAD and coronary risk scores was found. However, Framingham and SCORE were superior, i.e., had more predictive value, regarding their ability to predict the SYNTAX score (p = 0.029, 0.033 and 0.002, respectively).
    Conclusions: Examination of the distribution of SYNTAX score across low, intermediate and high-risk groups showed a significantly higher predictive value of SCORE for high-risk patients (p = 0.005).
    MeSH term(s) Coronary Angiography ; Coronary Artery Disease/diagnostic imaging ; Coronary Vessels/diagnostic imaging ; Decision Support Techniques ; Female ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Prognosis ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Severity of Illness Index
    Language English
    Publishing date 2016
    Publishing country Poland
    Document type Comparative Study ; Journal Article
    ZDB-ID 2488680-4
    ISSN 1897-5593 ; 1897-5593
    ISSN (online) 1897-5593
    ISSN 1897-5593
    DOI 10.5603/CJ.a2015.0074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6770: Show issues Location:
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  10. Article ; Online: The Relationship Between Sexual Activity and Heart Rate Variability in Menopausal Women.

    Tolunay, Hatice / Yıldırım, Erkan / Gökoğlan, Yalçın / Buğan, Barış / Saatçi Yaşar, Ayşe / Çelik, Murat / Yüksel, Uygar Çağdaş / Kabul, Hasan Kutsi / Barçın, Cem

    Anatolian journal of cardiology

    2022  Volume 26, Issue 7, Page(s) 543–551

    Abstract: Background: Menopause is an important life stage for women, which can bring along sex- ual and cardiac problems. Increased heart rate variability is an indicator of parasympa- thetic activity and is associated with mental and physical health and life ... ...

    Abstract Background: Menopause is an important life stage for women, which can bring along sex- ual and cardiac problems. Increased heart rate variability is an indicator of parasympa- thetic activity and is associated with mental and physical health and life expectancy. This study aimed to evaluate the effect of sexual activity (only penile-vaginal intercourse but not masturbation or non-coital sex with a partner) on heart rate variability in healthy menopausal women.
    Methods: We evaluated 130 menopausal patients aged 45-60 years, without chronic dis- ease. The average weekly sexual activity numbers remembered in the last 1 year were questioned. The patients were divided into 2 groups according to the presence of sexual activity. The sexually active group was divided into subgroups as 1 per week and 2 or more per week. Menopause Rating Scale was applied for menopausal symptoms. Heart rate variability was analyzed from the 24-hour electrocardiography Holter recording.
    Results: Heart rate variability parameters were higher in the sexually active group than in the sexually inactive group (mean of the standard deviations of all the NN intervals for each 5 min segment of a 24-hour heart rate variability recording: P = .004; root mean square of differences between adjacent normal RR intervals, expressed in ms: P=.001; number of NN intervals exceeding 50 milliseconds: P = .011; percentage of adjacent RR intervals with a difference of duration >50 ms: P = .009; low frequency: P = .011; high fre- quency: P=.008, low frequency/high frequency: P=.018). When assessed by multiple linear regression analysis by adjusting for age, body mass index, and menopause dura- tion, the variables mean of the standard deviations of all the NN intervals for each 5 min segment of a 24-hour heart rate variability recording, root mean square of differences between adjacent normal RR intervals, expressed in ms, and low frequency were inde- pendently associated with the number of sexual activities per week (B = 2.89 ± 1.02, 95% CI = 0.866-4.91, P = .005; B = 4.57 ± 1.83, 95% CI = 0.94-8.2, P = .014; and B = 1174.9 ± 592.2, 95% CI = 2.9-2346.9, P = .049, respectively).
    Conclusion: In healthy menopausal women, continued sexual activity with penile-vagi- nal intercourse is associated with better health outcomes on cardiac autonomic function through higher heart rate variability, an index of parasympathetic activity.
    MeSH term(s) Autonomic Nervous System ; Electrocardiography ; Female ; Heart Rate/physiology ; Humans ; Menopause ; Sexual Behavior
    Language English
    Publishing date 2022-07-05
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2278670-3
    ISSN 2149-2271 ; 2149-2271
    ISSN (online) 2149-2271
    ISSN 2149-2271
    DOI 10.5152/AnatolJCardiol.2022.1180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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