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Article ; Online: Race, Affordability and Utilization of Supportive Care in Ovarian Cancer Patients.

Anyanwu, Mercy C / Ohamadike, Onyinye / Wilson, Lauren E / Meernik, Clare / Huang, Bin / Pisu, Maria / Liang, Margaret / Previs, Rebecca A / Joshi, Ashwini / Ward, Kevin C / Tucker, Tom / Schymura, Maria J / Berchuck, Andrew / Akinyemiju, Tomi

Journal of pain and symptom management

2022 Volume 64, Issue 6, Page(s) 537–545

Abstract: Objective: Lack of access to supportive care (SC) among cancer patients have been well documented. However, the role of affordability in this disparity among ovarian cancer (OC) patients remain poorly understood.: Methods: Patients with OC between ... ...

Abstract	Objective: Lack of access to supportive care (SC) among cancer patients have been well documented. However, the role of affordability in this disparity among ovarian cancer (OC) patients remain poorly understood. Methods: Patients with OC between 2008 and 2015 were identified from the SEER-Medicare dataset. Racial disparities in utilization of SC medications within the six months of OC diagnosis among patients with Medicare Part D coverage was examined. Multivariable log-binomial regression models were used to examine the associations of race, affordability and SC medications after adjusting for clinical covariates among all patients and separately among patients with advanced-stage disease. Results: The study cohort included 3697 patients: 86% non-Hispanic White (NHW), 6% non-Hispanic Black (NHB), and 8% Hispanic. In adjusted models, NHB and Hispanic patients were less likely to receive antidepressants compared to NHW patients (NHB: aOR 0.46; 95% CI 0.33-0.63 and Hispanic: aOR 0.79; 95% CI 0.63-0.99). This association persisted for NHB patients with advanced-stage disease (aOR 0.42; 95% CI 0.28-0.62). Patients dual enrolled in Medicaid were more likely to receive antidepressants (overall: aOR 1.34; 95% CI 1.17-1.53 and advanced-stage: aOR 1.29; 95% CI 1.10-1.52). However, patients residing in areas with higher vs. lower proportions of lower educated adults (overall: aOR 0.82; 95% CI 0.70-0.97 and advanced-stage: aOR 0.82; 95% CI 0.68-0.99) were less likely to receive antidepressants. Conclusion: Black OC patients and those living in lower educated areas were less likely to receive antidepressants as SC. Given the importance of post-primary treatment quality of life for cancer patients, interventions are needed to enhance equitable access to SC.
MeSH term(s)	Adult ; Humans ; Aged ; United States ; Female ; White People ; Black or African American ; Quality of Life ; Medicare ; Ovarian Neoplasms/therapy ; Costs and Cost Analysis
Language	English
Publishing date	2022-09-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	639142-4
ISSN	1873-6513 ; 0885-3924
ISSN (online)	1873-6513
ISSN	0885-3924
DOI	10.1016/j.jpainsymman.2022.08.021
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Article ; Online: Development of a diagnostic device to detect different Pseudomonas aeruginosa phenotypes in medically relevant contexts.

Ward, Andrew C / Tucker, Nicholas P / Connolly, Patricia

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2015 Volume 2014, Page(s) 2757–2760

Abstract: Pseudomonas aeruginosa, widely present in the environment, is well known for its ability to cause infection in immune compromised individuals. For example, P. aeruginosa is the leading cause of morbidity and mortality in patients with cystic fibrosis (CF) ...

Abstract	Pseudomonas aeruginosa, widely present in the environment, is well known for its ability to cause infection in immune compromised individuals. For example, P. aeruginosa is the leading cause of morbidity and mortality in patients with cystic fibrosis (CF). Here, we describe how Electrochemical Impedance Spectroscopy (EIS) can be used to detect the presence of four different strains of P. aeruginosa. Using a low cost, screen printed carbon electrode significant changes can be seen in impedance data in the presence of P. aeruginosa after 24 hours. Furthermore, through the use of a normalization technique whereby the phase angle of the impedance (a commonly used parameter) is divided by a starting measurement, it is possible to identify differences between a non-mucoid and mucoid strain of P. aeruginosa. Sensors based upon the techniques described here could be used in a number of healthcare scenarios, where there is a need for low cost, real time detection of P. aeruginosa, such as CF.
MeSH term(s)	Cystic Fibrosis/microbiology ; Electric Impedance ; Electrochemical Techniques ; Humans ; Phenotype ; Pseudomonas Infections/diagnosis ; Pseudomonas Infections/microbiology ; Pseudomonas aeruginosa/physiology
Language	English
Publishing date	2015-01-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC.2014.6944194
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Article ; Online: Pseudomonas aeruginosa can be detected in a polymicrobial competition model using impedance spectroscopy with a novel biosensor.

Ward, Andrew C / Connolly, Patricia / Tucker, Nicholas P

PloS one

2014 Volume 9, Issue 3, Page(s) e91732

Abstract: Electrochemical Impedance Spectroscopy (EIS) is a powerful technique that can be used to elicit information about an electrode interface. In this article, we highlight six principal processes by which the presence of microorganisms can affect impedance ... ...

Abstract	Electrochemical Impedance Spectroscopy (EIS) is a powerful technique that can be used to elicit information about an electrode interface. In this article, we highlight six principal processes by which the presence of microorganisms can affect impedance and show how one of these--the production of electroactive metabolites--changes the impedance signature of culture media containing Pseudomonas aeruginosa. EIS, was used in conjunction with a low cost screen printed carbon sensor to detect the presence of P. aeruginosa when grown in isolation or as part of a polymicrobial infection with Staphylococcus aureus. By comparing the electrode to a starting measurement, we were able to identify an impedance signature characteristic of P. aeruginosa. Furthermore, we are able to show that one of the changes in the impedance signature is due to pyocyanin and associated phenazine compounds. The findings of this study indicate that it might be possible to develop a low cost sensor for the detection of P. aeruginosa in important point of care diagnostic applications. In particular, we suggest that a development of the device described here could be used in a polymicrobial clinical sample such as sputum from a CF patient to detect P. aeruginosa.
MeSH term(s)	Bacterial Adhesion/drug effects ; Biosensing Techniques/methods ; Cell Count ; Coculture Techniques ; Dielectric Spectroscopy/methods ; Electrodes ; Microbial Interactions/drug effects ; Models, Biological ; Mutation/genetics ; Plankton/cytology ; Pseudomonas aeruginosa/isolation & purification ; Pyocyanine/pharmacology ; Spectrophotometry, Ultraviolet ; Staphylococcus aureus/growth & development
Chemical Substances	Pyocyanine (9OQM399341)
Language	English
Publishing date	2014-03-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0091732
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Article ; Online: Identification and characterisation of Staphylococcus aureus on low cost screen printed carbon electrodes using impedance spectroscopy.

Ward, A C / Hannah, A J / Kendrick, S L / Tucker, N P / MacGregor, G / Connolly, P

Biosensors & bioelectronics

2018 Volume 110, Page(s) 65–70

Abstract: Staphylococcus aureus infections are a cause of significant morbidity and mortality, in addition to representing a considerable economic burden. The aim of this study was to explore a low cost screen printed electrode as a sensor for the detection of S. ... ...

Abstract	Staphylococcus aureus infections are a cause of significant morbidity and mortality, in addition to representing a considerable economic burden. The aim of this study was to explore a low cost screen printed electrode as a sensor for the detection of S. aureus using impedance spectroscopy. S. aureus was incubated in chambers containing the electrodes and the results analysed using a novel normalisation approach. These results show that it is possible to detect the presence of S. aureus in LB media after 30 min incubation of a 1% growth culture, in addition to being able to see immediate cell concentration dependant changes in 0.9% NaCl. These observations imply that a number of electrochemical mechanisms cause a change in the impedance as a result of the presence of S. aureus, including adsorption to the electrode surface and the metabolism of the bacteria during growth. The study suggests that this detection approach would be useful in a number of clinical scenarios where S. aureus leads to difficult to treat infections.
MeSH term(s)	Biosensing Techniques/instrumentation ; Carbon/chemistry ; Dielectric Spectroscopy/instrumentation ; Electric Impedance ; Electrodes ; Equipment Design ; Humans ; Staphylococcal Infections/microbiology ; Staphylococcus aureus/growth & development ; Staphylococcus aureus/isolation & purification
Chemical Substances	Carbon (7440-44-0)
Language	English
Publishing date	2018-03-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2018.03.048
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Zs.A 2275: Show issues

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Article ; Online: Influence of Eat, Sleep, and Console on Infants Pharmacologically Treated for Opioid Withdrawal: A Post Hoc Subgroup Analysis of the ESC-NOW Randomized Clinical Trial.

Devlin, Lori A / Hu, Zhuopei / Merhar, Stephanie L / Ounpraseuth, Songthip T / Simon, Alan E / Lee, Jeannette Y / Das, Abhik / Crawford, Margaret M / Greenberg, Rachel G / Smith, P Brian / Higgins, Rosemary D / Walsh, Michele C / Rice, Ward / Paul, David A / Maxwell, Jessie R / Fung, Camille M / Wright, Tanner / Ross, Julie / McAllister, Jennifer M /

Crowley, Moira / Shaikh, Sophie K / Christ, Lori / Brown, Jaime / Riccio, Julie / Wong Ramsey, Kara / Braswell, Erica F / Tucker, Lauren / McAlmon, Karen / Dummula, Krishna / Weiner, Julie / White, Jessica R / Newman, Sarah / Snowden, Jessica N / Young, Leslie W

JAMA pediatrics

2024

Abstract: Importance: The function-based eat, sleep, console (ESC) care approach substantially reduces the proportion of infants who receive pharmacologic treatment for neonatal opioid withdrawal syndrome (NOWS). This reduction has led to concerns for increased ... ...

Abstract	Importance: The function-based eat, sleep, console (ESC) care approach substantially reduces the proportion of infants who receive pharmacologic treatment for neonatal opioid withdrawal syndrome (NOWS). This reduction has led to concerns for increased postnatal opioid exposure in infants who receive pharmacologic treatment. However, the effect of the ESC care approach on hospital outcomes for infants pharmacologically treated for NOWS is currently unknown. Objective: To evaluate differences in opioid exposure and total length of hospital stay (LOS) for pharmacologically treated infants managed with the ESC care approach vs usual care with the Finnegan tool. Design, setting, and participants: This post hoc subgroup analysis involved infants pharmacologically treated in ESC-NOW, a stepped-wedge cluster randomized clinical trial conducted at 26 US hospitals. Hospitals maintained pretrial practices for pharmacologic treatment, including opioid type, scheduled opioid dosing, and use of adjuvant medications. Infants were born at 36 weeks' gestation or later, had evidence of antenatal opioid exposure, and received opioid treatment for NOWS between September 2020 and March 2022. Data were analyzed from November 2022 to January 2024. Exposure: Opioid treatment for NOWS and the ESC care approach. Main outcomes and measures: For each outcome (total opioid exposure, peak opioid dose, time from birth to initiation of first opioid dose, length of opioid treatment, and LOS), we used generalized linear mixed models to adjust for the stepped-wedge design and maternal and infant characteristics. Results: In the ESC-NOW trial, 463 of 1305 infants were pharmacologically treated (143/603 [23.7%] in the ESC care approach group and 320/702 [45.6%] in the usual care group). Mean total opioid exposure was lower in the ESC care approach group with an absolute difference of 4.1 morphine milligram equivalents per kilogram (MME/kg) (95% CI, 1.3-7.0) when compared with usual care (4.8 MME/kg vs 8.9 MME/kg, respectively; P = .001). Mean time from birth to initiation of pharmacologic treatment was 22.4 hours (95% CI, 7.1-37.7) longer with the ESC care approach vs usual care (75.4 vs 53.0 hours, respectively; P = .002). No significant difference in mean peak opioid dose was observed between groups (ESC care approach, 0.147 MME/kg, vs usual care, 0.126 MME/kg). The mean length of treatment was 6.3 days shorter (95% CI, 3.0-9.6) in the ESC care approach group vs usual care group (11.8 vs 18.1 days, respectively; P < .001), and mean LOS was 6.2 days shorter (95% CI, 3.0-9.4) with the ESC care approach than with usual care (16.7 vs 22.9 days, respectively; P < .001). Conclusion and relevance: When compared with usual care, the ESC care approach was associated with less opioid exposure and shorter LOS for infants pharmacologically treated for NOWS. The ESC care approach was not associated with a higher peak opioid dose, although pharmacologic treatment was typically initiated later. Trial registration: ClinicalTrials.gov Identifier: NCT04057820.
Language	English
Publishing date	2024-04-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2701223-2
ISSN	2168-6211 ; 2168-6203
ISSN (online)	2168-6211
ISSN	2168-6203
DOI	10.1001/jamapediatrics.2024.0544
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Article ; Online: Pseudomonas aeruginosa can be detected in a polymicrobial competition model using impedance spectroscopy with a novel biosensor.

Andrew C Ward / Patricia Connolly / Nicholas P Tucker

PLoS ONE, Vol 9, Iss 3, p e

2014 Volume 91732

Abstract	Electrochemical Impedance Spectroscopy (EIS) is a powerful technique that can be used to elicit information about an electrode interface. In this article, we highlight six principal processes by which the presence of microorganisms can affect impedance and show how one of these--the production of electroactive metabolites--changes the impedance signature of culture media containing Pseudomonas aeruginosa. EIS, was used in conjunction with a low cost screen printed carbon sensor to detect the presence of P. aeruginosa when grown in isolation or as part of a polymicrobial infection with Staphylococcus aureus. By comparing the electrode to a starting measurement, we were able to identify an impedance signature characteristic of P. aeruginosa. Furthermore, we are able to show that one of the changes in the impedance signature is due to pyocyanin and associated phenazine compounds. The findings of this study indicate that it might be possible to develop a low cost sensor for the detection of P. aeruginosa in important point of care diagnostic applications. In particular, we suggest that a development of the device described here could be used in a polymicrobial clinical sample such as sputum from a CF patient to detect P. aeruginosa.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Chromosome Translocations and Cosmic Radiation Dose in Male U.S. Commercial Airline Pilots.

Grajewski, Barbara / Yong, Lee C / Bertke, Stephen J / Bhatti, Parveen / Little, Mark P / Ramsey, Marilyn J / Tucker, James D / Ward, Elizabeth M / Whelan, Elizabeth A / Sigurdson, Alice J / Waters, Martha A

Aerospace medicine and human performance

2018 Volume 89, Issue 7, Page(s) 616–625

Abstract: ... Bhatti P, Little MP, Ramsey MJ, Tucker JD, Ward EM, Whelan EA, Sigurdson AJ, Waters MA ...

Abstract	Background: Chromosome translocations are a biomarker of cumulative exposure to ionizing radiation. We examined the relation between the frequency of translocations and cosmic radiation dose in 83 male airline pilots. Methods: Translocations were scored using fluorescence in situ hybridization chromosome painting. Cumulative radiation doses were estimated from individual flight records. Excess rate and log-linear Poisson regression models were evaluated. Results: Pilots' estimated median cumulative absorbed dose was 15 mGy (range 4.5-38). No association was observed between translocation frequency and absorbed dose from all types of flying [rate ratio (RR) = 1.01 at 1 mGy, 95% confidence interval (CI) 0.97-1.04]. However, additional analyses of pilots' dose from only commercial flying suggested an association (RR = 1.04 at 1 mGy, 95% CI 0.97-1.13). Discussion: Although this is the largest cytogenetic study of male commercial airline pilots to date of which the authors are aware, future studies will need additional highly exposed pilots to better assess the translocation-cosmic radiation relation.Grajewski B, Yong LC, Bertke SJ, Bhatti P, Little MP, Ramsey MJ, Tucker JD, Ward EM, Whelan EA, Sigurdson AJ, Waters MA. Chromosome translocations and cosmic radiation dose in male U.S. commercial airline pilots. Aerosp Med Hum Perform. 2018; 89(7):616-625.
MeSH term(s)	Adult ; Aerospace Medicine ; Aged ; Circadian Rhythm ; Cosmic Radiation/adverse effects ; DNA/blood ; DNA/genetics ; Humans ; Leukocytes, Mononuclear/chemistry ; Leukocytes, Mononuclear/cytology ; Male ; Middle Aged ; Occupational Exposure/analysis ; Occupational Exposure/statistics & numerical data ; Pilots/statistics & numerical data ; Translocation, Genetic/genetics
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2018-06-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2809085-8
ISSN	2375-6322 ; 2375-6314
ISSN (online)	2375-6322
ISSN	2375-6314
DOI	10.3357/AMHP.4502.2018
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Article ; Online: Covalent Ligand Discovery against Druggable Hotspots Targeted by Anti-cancer Natural Products.

Grossman, Elizabeth A / Ward, Carl C / Spradlin, Jessica N / Bateman, Leslie A / Huffman, Tucker R / Miyamoto, David K / Kleinman, Jordan I / Nomura, Daniel K

Cell chemical biology

2017 Volume 24, Issue 11, Page(s) 1368–1376.e4

Abstract: Many natural products that show therapeutic activities are often difficult to synthesize or isolate and have unknown targets, hindering their development as drugs. Identifying druggable hotspots targeted by covalently acting anti-cancer natural products ... ...

Abstract	Many natural products that show therapeutic activities are often difficult to synthesize or isolate and have unknown targets, hindering their development as drugs. Identifying druggable hotspots targeted by covalently acting anti-cancer natural products can enable pharmacological interrogation of these sites with more synthetically tractable compounds. Here, we used chemoproteomic platforms to discover that the anti-cancer natural product withaferin A targets C377 on the regulatory subunit PPP2R1A of the tumor-suppressor protein phosphatase 2A (PP2A) complex leading to activation of PP2A activity, inactivation of AKT, and impaired breast cancer cell proliferation. We developed a more synthetically tractable cysteine-reactive covalent ligand, JNS 1-40, that selectively targets C377 of PPP2R1A to impair breast cancer signaling, proliferation, and in vivo tumor growth. Our study highlights the utility of using chemoproteomics to map druggable hotspots targeted by complex natural products and subsequently interrogating these sites with more synthetically tractable covalent ligands for cancer therapy.
MeSH term(s)	Amino Acid Sequence ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacology ; Biological Products/chemistry ; Biological Products/metabolism ; Biological Products/pharmacology ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cysteine/chemistry ; Female ; Humans ; Ligands ; MCF-7 Cells ; Protein Phosphatase 2/chemistry ; Protein Phosphatase 2/metabolism ; Proteome/drug effects ; Proteome/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/drug effects ; Withanolides/chemistry ; Withanolides/pharmacology
Chemical Substances	Antineoplastic Agents ; Biological Products ; Ligands ; Proteome ; Withanolides ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Protein Phosphatase 2 (EC 3.1.3.16) ; Cysteine (K848JZ4886) ; withaferin A (L6DO3QW4K5)
Language	English
Publishing date	2017-09-14
Publishing country	United States
Document type	Journal Article
ISSN	2451-9448
ISSN (online)	2451-9448
DOI	10.1016/j.chembiol.2017.08.013
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Article ; Online: Isolation and quantification of botulinum neurotoxin from complex matrices using the BoTest matrix assays.

Dunning, F Mark / Piazza, Timothy M / Zeytin, Füsûn N / Tucker, Ward C

Journal of visualized experiments : JoVE

2014 , Issue 85

Abstract: Accurate detection and quantification of botulinum neurotoxin (BoNT) in complex matrices is required for pharmaceutical, environmental, and food sample testing. Rapid BoNT testing of foodstuffs is needed during outbreak forensics, patient diagnosis, and ... ...

Abstract	Accurate detection and quantification of botulinum neurotoxin (BoNT) in complex matrices is required for pharmaceutical, environmental, and food sample testing. Rapid BoNT testing of foodstuffs is needed during outbreak forensics, patient diagnosis, and food safety testing while accurate potency testing is required for BoNT-based drug product manufacturing and patient safety. The widely used mouse bioassay for BoNT testing is highly sensitive but lacks the precision and throughput needed for rapid and routine BoNT testing. Furthermore, the bioassay's use of animals has resulted in calls by drug product regulatory authorities and animal-rights proponents in the US and abroad to replace the mouse bioassay for BoNT testing. Several in vitro replacement assays have been developed that work well with purified BoNT in simple buffers, but most have not been shown to be applicable to testing in highly complex matrices. Here, a protocol for the detection of BoNT in complex matrices using the BoTest Matrix assays is presented. The assay consists of three parts: The first part involves preparation of the samples for testing, the second part is an immunoprecipitation step using anti-BoNT antibody-coated paramagnetic beads to purify BoNT from the matrix, and the third part quantifies the isolated BoNT's proteolytic activity using a fluorogenic reporter. The protocol is written for high throughput testing in 96-well plates using both liquid and solid matrices and requires about 2 hr of manual preparation with total assay times of 4-26 hr depending on the sample type, toxin load, and desired sensitivity. Data are presented for BoNT/A testing with phosphate-buffered saline, a drug product, culture supernatant, 2% milk, and fresh tomatoes and includes discussion of critical parameters for assay success.
MeSH term(s)	Animals ; Botulinum Toxins/isolation & purification ; Complex Mixtures/analysis ; High-Throughput Screening Assays/methods ; Mice
Chemical Substances	Complex Mixtures ; Botulinum Toxins (EC 3.4.24.69)
Language	English
Publishing date	2014-03-03
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Video-Audio Media
ZDB-ID	2259946-0
ISSN	1940-087X ; 1940-087X
ISSN (online)	1940-087X
ISSN	1940-087X
DOI	10.3791/51170
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Article ; Online: The effect of unilateral arm swing motion on lower extremity running mechanics associated with injury risk.

Agresta, Cristine / Ward, Christian R / Wright, W Geoffrey / Tucker, Carole A

Sports biomechanics

2017 Volume 17, Issue 2, Page(s) 206–215

Abstract: Many field sports involve equipment that restricts one or both arms from moving while running. Arm swing during running has been examined from a biomechanical and physiologic perspective but not from an injury perspective. Moreover, only bilateral arm ... ...

Abstract	Many field sports involve equipment that restricts one or both arms from moving while running. Arm swing during running has been examined from a biomechanical and physiologic perspective but not from an injury perspective. Moreover, only bilateral arm swing suppression has been studied with respect to running. The purpose of this study was to determine the influence of running with one arm restrained on lower extremity mechanics associated with running or sport-related injury. Fifteen healthy participants ran at a self-selected speed with typical arm swing, with one arm restrained and with both arms restrained. Lower extremity kinematics and spatiotemporal measures were analysed for all arm swing conditions. Running with one arm restrained resulted in increased frontal plane knee and hip angles, decreased foot strike angle, and decreased centre of mass vertical displacement compared to typical arm swing or bilateral arm swing restriction. Stride length was decreased and step frequency increased when running with one or both arms restrained. Unilateral arm swing restriction induces changes in lower extremity kinematics that are not similar to running with bilateral arm swing restriction or typical arm swing motion. Running with one arm restrained increases frontal plane mechanics associated with risk of knee injury.
MeSH term(s)	Adult ; Arm/physiology ; Biomechanical Phenomena/physiology ; Female ; Foot/physiology ; Gait/physiology ; Hip/physiology ; Humans ; Knee/physiology ; Lower Extremity/injuries ; Lower Extremity/physiology ; Male ; Middle Aged ; Movement ; Risk Factors ; Running/injuries ; Running/physiology ; Time and Motion Studies ; Young Adult
Language	English
Publishing date	2017-02-28
Publishing country	England
Document type	Journal Article
ISSN	1752-6116
ISSN (online)	1752-6116
DOI	10.1080/14763141.2016.1269186
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