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  1. Article ; Online: Traitement des syndromes myélodysplasiques de bas risque.

    Park, Sophie

    Bulletin du cancer

    2023  Volume 110, Issue 11, Page(s) 1156–1161

    Abstract: For low-risk myelodysplastic syndromes, the goal of treatment is to correct cytopenias or their consequences. Erythropoiesis-stimulating agents have an important role in the management of anemia. In this chapter, we will detail the response to ESAs, the ... ...

    Title translation Treatment of lower risk myelodysplastic syndromes.
    Abstract For low-risk myelodysplastic syndromes, the goal of treatment is to correct cytopenias or their consequences. Erythropoiesis-stimulating agents have an important role in the management of anemia. In this chapter, we will detail the response to ESAs, the factors predictive of response to ESAs. However, the search for new therapeutic options for low-risk, ESA-resistant MDS remains necessary as the incidence of AML transformation of the patients is higher. We can retain luspatercept for MDS with excess ring of sideroblasts, lenalidomide, and some molecules currently being tested such as imetelstat or roxedustat. However, the search for new therapeutic options for ESA-resistant low-risk MDS remains necessary. We can use androgenotherapy or TPO agonists in limited access for symptomatic thrombocytopenia.
    MeSH term(s) Humans ; Myelodysplastic Syndromes/complications ; Myelodysplastic Syndromes/drug therapy ; Lenalidomide/therapeutic use ; Anemia/drug therapy ; Anemia/complications ; Hematinics/therapeutic use ; Risk ; Thrombocytopenia/complications
    Chemical Substances Lenalidomide (F0P408N6V4) ; Hematinics
    Language French
    Publishing date 2023-07-25
    Publishing country France
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 213270-9
    ISSN 1769-6917 ; 0007-4551
    ISSN (online) 1769-6917
    ISSN 0007-4551
    DOI 10.1016/j.bulcan.2023.02.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Flow cytometric analysis of peripheral blood neutrophil myeloperoxidase expression in myelodysplastic neoplasms.

    Raskovalova, Tatiana / Jacob, Marie-Christine / Park, Sophie

    Leukemia

    2024  Volume 38, Issue 4, Page(s) 923–924

    MeSH term(s) Humans ; Neutrophils/metabolism ; Neoplasms ; Flow Cytometry ; Myelodysplastic Syndromes/metabolism ; Peroxidase/metabolism
    Chemical Substances Peroxidase (EC 1.11.1.7)
    Language English
    Publishing date 2024-03-14
    Publishing country England
    Document type Letter
    ZDB-ID 807030-1
    ISSN 1476-5551 ; 0887-6924
    ISSN (online) 1476-5551
    ISSN 0887-6924
    DOI 10.1038/s41375-024-02223-9
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  3. Article ; Online: Lower-risk myelodysplastic syndromes: Current treatment options for anemia.

    Meunier, Mathieu / Park, Sophie

    EJHaem

    2022  Volume 3, Issue 4, Page(s) 1091–1099

    Abstract: Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematological disorders. Treatment options are classified and defined by prognostic risk based on the International Prognostic Scoring System (IPSS) and, more recently, the revised IPSS ( ...

    Abstract Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematological disorders. Treatment options are classified and defined by prognostic risk based on the International Prognostic Scoring System (IPSS) and, more recently, the revised IPSS (IPSS-R). The treatment goal for lower-risk MDS is to correct cytopenias or their consequences, with the goal of maintaining or improving quality of life. Erythropoiesis-stimulating agents (ESAs) play an important role in treating anemia. Individuals with MDS who have a 5q deletion are particularly sensitive to treatment with lenalidomide; however, this comprises the minority of patients with MDS. Luspatercept was recently approved in the United States and the European Union for the treatment of ESA-refractory MDS with ring sideroblasts. Research into new treatment options, especially after ESA failure, is needed. In this review, we will focus on the current therapeutic options for MDS-related anemia.
    Language English
    Publishing date 2022-08-12
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2688-6146
    ISSN (online) 2688-6146
    DOI 10.1002/jha2.523
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  4. Article ; Online: Integration of social determinants of health information within the primary care electronic health record: a systematic review of patient perspectives and experiences.

    Arroyave Caicedo, Nicolle Marianne / Parry, Emma / Arslan, Nazan / Park, Sophie

    BJGP open

    2024  Volume 8, Issue 1

    Abstract: Background: Social determinants of health (SDOH) are the non-medical factors that impact health. Although geographical measures of deprivation are used, individual measures of social risk could identify those most at risk and generate more personalised ... ...

    Abstract Background: Social determinants of health (SDOH) are the non-medical factors that impact health. Although geographical measures of deprivation are used, individual measures of social risk could identify those most at risk and generate more personalised care and targeted referrals to community resources. We know SDOH are important to health care, but it is not yet known whether their collection via the electronic health record (EHR) is acceptable and useful from the patient perspective.
    Aim: To synthesise relevant literature to explore patient perspectives on integrating information about SDOH into primary care EHRs, and the opportunities and challenges of its implementation in a general practice setting.
    Design & setting: Systematic review of primary care-based qualitative and mixed-method studies using thematic framework analysis.
    Method: Key databases were searched for articles reporting patient perspectives of SDOH collection within the primary care EHR. Qualitative and mixed-methods studies written in English were included. A framework analysis was conducted to identify themes.
    Results: From 14 included studies, the following five main themes were identified: rationale for SDOH screening and the anticipated outcomes; impact of the provider-patient relationship on patient perceptions; data, which included privacy concerns; screening process and referral; and recommendations for future research.
    Conclusion: Integration of information on SDOH into the EHR appears acceptable to patients. This review has added to the discussion of whether and how to implement SDOH screening and referral programmes into UK primary care systems.
    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Journal Article
    ISSN 2398-3795
    ISSN (online) 2398-3795
    DOI 10.3399/BJGPO.2023.0155
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  5. Article ; Online: Extracellular Vesicles and MicroRNA in Myelodysplastic Syndromes.

    Meunier, Mathieu / Laurin, David / Park, Sophie

    Cells

    2023  Volume 12, Issue 4

    Abstract: The bone marrow niche plays an increasing role in the pathophysiogenesis of myelodysplastic syndromes. More specifically, mesenchymal stromal cells, which can secrete extracellular vesicles and their miRNA contents, modulate the fate of hematopoietic ... ...

    Abstract The bone marrow niche plays an increasing role in the pathophysiogenesis of myelodysplastic syndromes. More specifically, mesenchymal stromal cells, which can secrete extracellular vesicles and their miRNA contents, modulate the fate of hematopoietic stem cells leading to leukemogenesis. Extracellular vesicles can mediate their miRNA and protein contents between nearby cells but also in the plasma of the patients, being potent tools for diagnosis and prognostic markers in MDS. They can be targeted by antisense miRNA or by modulators of the secretion of extracellular vesicles and could lead to future therapeutic directions in MDS.
    MeSH term(s) Humans ; MicroRNAs/genetics ; Bone Marrow/metabolism ; Myelodysplastic Syndromes/genetics ; Hematopoietic Stem Cells/metabolism ; Extracellular Vesicles/metabolism
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2023-02-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12040658
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  6. Article: Selpercatinib combination with the mitochondria-targeted antioxidant MitoQ effectively suppresses RET-mutant thyroid cancer.

    Chen, Wenjing / Dream, Sophie / Leung, Pui-Yin / Wu, Pui-Kei / Wong, Stuart / Park, Jong-In

    NPJ precision oncology

    2024  Volume 8, Issue 1, Page(s) 39

    Abstract: Genetic alternation of REarranged during Transfection (RET) that leads to constitutive RET activation is a crucial etiological factor for thyroid cancer. RET is known to regulate mitochondrial processes, although the underlying molecular mechanisms ... ...

    Abstract Genetic alternation of REarranged during Transfection (RET) that leads to constitutive RET activation is a crucial etiological factor for thyroid cancer. RET is known to regulate mitochondrial processes, although the underlying molecular mechanisms remain unclear. We previously showed that the multi-kinase inhibitors vandetanib and cabozantinib increase the mitochondrial membrane potential (Δψ
    Language English
    Publishing date 2024-02-20
    Publishing country England
    Document type Journal Article
    ISSN 2397-768X
    ISSN 2397-768X
    DOI 10.1038/s41698-024-00536-7
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  7. Article ; Online: Guidelines needed for the management of fear of cancer recurrence in adult survivors of cancer in the United States: A consensus statement.

    Hall, Daniel L / Wagner, Lynne I / Lebel, Sophie / Smith, Allan Ben / Bergerot, Cristiane D / Park, Elyse R

    Cancer

    2024  

    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/cncr.35326
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  8. Article ; Online: Commentary on the paper "The heartbeat evoked potential is a questionable biomarker in nightmare disorder: A replication study. By Bogdany, T., Perakakis, P., Bodizs, R., Simor, P., 2021. Neuroimage Clin 33, 102933".

    Perogamvros, Lampros / Park, Hyeong-Dong / Schwartz, Sophie

    NeuroImage. Clinical

    2022  Volume 36, Page(s) 103196

    Language English
    Publishing date 2022-09-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2701571-3
    ISSN 2213-1582 ; 2213-1582
    ISSN (online) 2213-1582
    ISSN 2213-1582
    DOI 10.1016/j.nicl.2022.103196
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  9. Article ; Online: Well-being, burnout and value fulfilment: Let us situate individuals within systems.

    Park, Sophie / Bansal, Aarti / Owen, Emily C

    Medical education

    2022  Volume 57, Issue 3, Page(s) 208–210

    MeSH term(s) Humans ; Burnout, Professional/prevention & control ; Burnout, Psychological ; Personal Satisfaction ; Surveys and Questionnaires
    Language English
    Publishing date 2022-12-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 195274-2
    ISSN 1365-2923 ; 0308-0110
    ISSN (online) 1365-2923
    ISSN 0308-0110
    DOI 10.1111/medu.14979
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  10. Article ; Online: Editorial: Dissecting the pathological bone marrow niche through single-cell omics and artificial intelligence.

    Park, Sophie / Hainaut, Pierre

    Current opinion in oncology

    2020  Volume 32, Issue 2, Page(s) 137–138

    MeSH term(s) Artificial Intelligence ; Bone Marrow Cells/pathology ; Humans ; Neoplasms/pathology ; Neoplastic Stem Cells/pathology ; Single-Cell Analysis/methods
    Language English
    Publishing date 2020-02-19
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1049384-0
    ISSN 1531-703X ; 1040-8746
    ISSN (online) 1531-703X
    ISSN 1040-8746
    DOI 10.1097/CCO.0000000000000604
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