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Article ; Online: Increased synthesis and intestinal expression of IL-39 in patients with inflammatory bowel disease.

Fonseca-Camarillo, Gabriela / Furuzawa-Carballeda, Janette / Barreto-Zúñiga, Rafael / Martínez-Benítez, Braulio / Yamamoto-Furusho, Jesús K

Immunologic research

2023 Volume 72, Issue 2, Page(s) 284–292

Abstract: IL-39 (Interleukin-39) is a heterodimeric cytokine composed of IL-23p19 and EBI3 (Epstein-Barr virus-induced gene 3) subunits. Despite the evidence that correlates the role of IL-39 in regulating inflammation, its expression in the intestinal ... ...

Abstract	IL-39 (Interleukin-39) is a heterodimeric cytokine composed of IL-23p19 and EBI3 (Epstein-Barr virus-induced gene 3) subunits. Despite the evidence that correlates the role of IL-39 in regulating inflammation, its expression in the intestinal microenvironment of IBD (inflammatory bowel disease) patients is still unknown. Thus, this work was focused on characterizing relative mRNA (messenger RNA) IL-39 expression and intestinal synthesis in IBD patients. This study includes 37 patients diagnosed with ulcerative colitis (UC), 15 with Chron's disease (CD), and 22 controls. Gene expression of IL-39 subunits (IL-23p19/EBI3) was measured by RT-PCR (real time polymerase chain reaction). Intestinal synthesis was evaluated by immunohistochemistry and serum levels by ELISA. Statistical analysis was done using Prism GraphPad V6. Relative mRNA IL-39 expression was increased in patients with active UC and active CD compared to the remission UC, remission CD, and control group. High levels of relative mRNA expression of IL-39 (IL-23p19 subunit) were associated with histological activity. IHQ analysis showed increased IL-39 production in mucosa, submucosa, muscular, and serosa layer of patients with active disease. IL-39 serum production was increased in patients with UC. IL-39 gene's upregulation was found in patients with active IBD and was associated with severe histological activity in UC. This is the first report regarding the role of IL-39 in patients with IBD. The findings suggest that IL-39 might play a role as an inflammatory mediator in active IBD and could be considered a new alternative in treating this condition.
MeSH term(s)	Humans ; Crohn Disease ; Interleukin-23 Subunit p19/metabolism ; Epstein-Barr Virus Infections/metabolism ; Herpesvirus 4, Human/genetics ; Inflammatory Bowel Diseases ; Colitis, Ulcerative/genetics ; RNA, Messenger/genetics ; Intestinal Mucosa/metabolism
Chemical Substances	Interleukin-23 Subunit p19 ; RNA, Messenger
Language	English
Publishing date	2023-11-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	632857-x
ISSN	1559-0755 ; 0257-277X
ISSN (online)	1559-0755
ISSN	0257-277X
DOI	10.1007/s12026-023-09432-x
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Article: Synthesis of Interleukin-10 in Patients with Ulcerative Colitis and

Yamamoto-Furusho, Jesús K / Fonseca-Camarillo, Gabriela / Barrera-Ochoa, Carlos A / Furuzawa-Carballeda, Janette

Gastroenterology research and practice

2020 Volume 2020, Page(s) 4171083

Abstract: Methods: Detection of : Results: Serological IL-10 levels in patients with UC and negative 13C-urea breath test was 10.28 pg/ml whereas in patients with UC and positive 13C-urea breath test was 5.5 pg/ml (: Conclusions: The role of IL-10 secretion ...

Abstract	Methods: Detection of Results: Serological IL-10 levels in patients with UC and negative 13C-urea breath test was 10.28 pg/ml whereas in patients with UC and positive 13C-urea breath test was 5.5 pg/ml ( Conclusions: The role of IL-10 secretion in patients with UC in determining the clinicopathological outcome of infection merits further study. This study suggests an association between serum IL-10 and disease severity in patients with UC and HP infection.
Language	English
Publishing date	2020-07-06
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2435460-0
ISSN	1687-630X ; 1687-6121
ISSN (online)	1687-630X
ISSN	1687-6121
DOI	10.1155/2020/4171083
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Article ; Online: Differential expression of TOB/BTG family members in patients with plaque psoriasis: cross-sectional study.

Barrera-Ochoa, Carlos A / Fonseca-Camarillo, Gabriela / Vega-Memije, María Elisa / Furuzawa-Carballeda, Janette / Uriarte-Ruiz, Karen / Fernández-Camargo, Dheni Aidé / Yamamoto-Furusho, Jesús K

Immunologic research

2023 Volume 72, Issue 2, Page(s) 234–241

Abstract: TOB/BTG is a family of antiproliferative proteins that play an important role in the regulation of immune responses, acting as lymphocyte activators and macrophage-mediated cytotoxicity. No previous studies have explored their role in patients with ... ...

Abstract	TOB/BTG is a family of antiproliferative proteins that play an important role in the regulation of immune responses, acting as lymphocyte activators and macrophage-mediated cytotoxicity. No previous studies have explored their role in patients with psoriasis. The aim of this study was to characterize the expression of TOB/BTG family and their co-localization in skin from patients with psoriasis. This is an exploratory, observational, and cross-sectional study that included 24 plaque psoriasis patients and 15 controls. Gene expression of TOB/BTG family was determinate by RT-PCR. Protein products of TOB/BTG were evaluated by immunohistochemistry and compared with control skin tissues. Holm-Sidak's multiple comparisons test was performed. TOB/BTG family mRNA levels and protein expression were significantly decreased in psoriatic skin tissue compared to non-inflammatory control skin tissue. Double-positive cell TOB1/2, BTG1,2 and BTG4/CD16 expressions were found in normal control skin tissues through epidermis and dermis (p < 0.001) and lesser percentage in patients with mild, almost absent in moderate-severe plaque psoriasis. This is the first report of the TOB/BTG family gene and protein expression in skin tissues by a CD16 + subpopulation in plaque psoriasis. TOB/BTG family protein might represent a new therapeutic target among immune-mediated inflammatory diseases.
MeSH term(s)	Humans ; Tumor Suppressor Proteins/genetics ; Cross-Sectional Studies ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Protein Processing, Post-Translational ; Psoriasis/genetics
Chemical Substances	Tumor Suppressor Proteins ; Cell Cycle Proteins
Language	English
Publishing date	2023-10-24
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	632857-x
ISSN	1559-0755 ; 0257-277X
ISSN (online)	1559-0755
ISSN	0257-277X
DOI	10.1007/s12026-023-09427-8
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Article ; Online: AKAP12/Gravin is over-expressed in patients with ulcerative colitis.

Fonseca-Camarillo, Gabriela / Furuzawa-Carballeda, Janette / Priego-Ranero, Ángel Alexis / Zúñiga, Rafael Barreto / Martínez-Benítez, Braulio / Yamamoto-Furusho, Jesús K

Immunologic research

2021 Volume 69, Issue 5, Page(s) 429–435

Abstract: The gene of A-kinase anchor protein 12 (AKAP12) regulates cell cycle progression, cell motility, and morphology through its multiple scaffolding domains. However, the role of AKAP12 expression in ulcerative colitis (UC) patients has not been yet ... ...

Abstract	The gene of A-kinase anchor protein 12 (AKAP12) regulates cell cycle progression, cell motility, and morphology through its multiple scaffolding domains. However, the role of AKAP12 expression in ulcerative colitis (UC) patients has not been yet described. The aim of the study was to describe the gene and protein of AKAP12 expression in patients with UC and its association regarding the disease severity. We included a total of 40 patients with confirmed diagnosis of UC and 25 controls without endoscopic evidence of colitis or neoplasia. The relative quantification of the gene expression was performed by real-time PCR for AKAP12. Kruskal-Wallis was used to test differences among groups, and Spearman correlation to assess the relationship between AKAP12 gene and clinical outcomes. The extent of disease was evaluated using total colonoscopy, and biopsies were taken from rectum segments. The AKAP12 gene expression was increased in colonic mucosa from patients with active UC when compared with UC remission and control group. The overexpression of AKAP12 in patients with UC was associated with the presence of extensive colitis (p = 0.04, RM = 12, IC = 1.29-186.37). AKAP12/CD16 double positive cells were higher in submucosa (p = 0.04), muscular (p < 0.001), and cells from serosa (p < 0.001) in patients affected by UC in comparison to controls. The overexpression of AKAP12 was associated with the extent of disease. This is the first report about the role of AKAP12 in patients with UC suggesting that this gene and its protein could be involved in the modulation of the disease.
MeSH term(s)	A Kinase Anchor Proteins/genetics ; Biomarkers ; Biopsy ; Case-Control Studies ; Cell Cycle Proteins/genetics ; Colitis, Ulcerative/diagnosis ; Colitis, Ulcerative/genetics ; Colitis, Ulcerative/metabolism ; Colonoscopy ; Disease Management ; Disease Susceptibility ; Female ; Gene Expression ; Gene Expression Profiling ; Humans ; Immunohistochemistry ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Male ; Protein Binding
Chemical Substances	A Kinase Anchor Proteins ; AKAP12 protein, human ; Biomarkers ; Cell Cycle Proteins
Language	English
Publishing date	2021-07-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632857-x
ISSN	1559-0755 ; 0257-277X
ISSN (online)	1559-0755
ISSN	0257-277X
DOI	10.1007/s12026-021-09214-3
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Article ; Online: Expression of TOB/BTG family members in patients with inflammatory bowel disease.

Fonseca-Camarillo, Gabriela / Furuzawa-Carballeda, Janette / Priego-Ranero, Ángel A / Martínez-Benítez, Braulio / Barreto-Zúñiga, Rafael / Yamamoto-Furusho, Jesús K

Scandinavian journal of immunology

2021 Volume 93, Issue 4, Page(s) e13004

Abstract: In recent years, the role of anti-proliferative TOB proteins in the regulation of immune response by inhibiting T cell activation has been demonstrated. Nevertheless, no previous studies have explored their expression in patients with IBD. The aim of the ...

Abstract	In recent years, the role of anti-proliferative TOB proteins in the regulation of immune response by inhibiting T cell activation has been demonstrated. Nevertheless, no previous studies have explored their expression in patients with IBD. The aim of the study was to characterize the gene and protein expression of the TOB/BTG family in intestinal tissue of patients with IBD. This is an observational and cross-sectional study that included 63 IBD patients. Gene expression of TOB/BTG family was measured by RT-PCR. Protein expression of TOB/CD16 and BTG/Ki-67 was evaluated by immunohistochemistry. TOB/BTG family mRNAs were detected and quantitated by RT-qPCR in rectal and ileum biopsies from UC patients and CD patients, respectively, and non-inflammatory control tissues. Results showed that TOB1 and BTG1 gene expression was decreased in the colonic mucosa from patients with UC compared with the control group. The TOB2 and BTG2 genes were over-expressed in the colonic mucosa of patients with UC in remission compared with the active UC and control group. The high TOB2 gene expression was associated with histological remission (P = .01). TOB1/CD16, TOB2/CD16, BTG1/Ki-67, BTG2/Ki-67 and BTG4/Ki-67 single and double positive cells were mostly NK, macrophages, epithelial cells, connective tissue cells and perivascular inflammatory infiltrates in tissues from patients with UC and CD. This is the first depiction of the TOB/BTG family gene and protein expression in rectal and ileum tissues by a CD16
MeSH term(s)	Adult ; Cell Proliferation/physiology ; Colitis/metabolism ; Colon/metabolism ; Cross-Sectional Studies ; Epithelial Cells/metabolism ; Female ; Gene Expression/physiology ; Humans ; Immediate-Early Proteins/metabolism ; Inflammatory Bowel Diseases/metabolism ; Intestinal Mucosa/metabolism ; Ki-67 Antigen/metabolism ; Macrophages/metabolism ; Male ; Middle Aged ; RNA, Messenger/metabolism ; Receptors, IgG/metabolism ; Tumor Suppressor Proteins/metabolism
Chemical Substances	Immediate-Early Proteins ; Ki-67 Antigen ; RNA, Messenger ; Receptors, IgG ; Tumor Suppressor Proteins
Language	English
Publishing date	2021-01-22
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	120476-2
ISSN	1365-3083 ; 0300-9475
ISSN (online)	1365-3083
ISSN	0300-9475
DOI	10.1111/sji.13004
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Article ; Online: Intestinal production of secreted protein acidic and rich in cysteine (SPARC) in patients with ulcerative colitis.

Fonseca-Camarillo, Gabriela / Furuzawa-Carballeda, Janette / Razo-López, Natalia / Barreto-Zúñiga, Rafael / Martínez-Benítez, Braulio / Yamamoto-Furusho, Jesús K

Immunobiology

2021 Volume 226, Issue 3, Page(s) 152095

Abstract: Background: Ulcerative colitis (UC) is an inflammatory disease of the intestine. The genetics factors play an important role in the pathogenesis of UC. SPARC exacerbates colonic inflammatory symptoms in dextran sodium sulphate-induced murine colitis. ... ...

Abstract	Background: Ulcerative colitis (UC) is an inflammatory disease of the intestine. The genetics factors play an important role in the pathogenesis of UC. SPARC exacerbates colonic inflammatory symptoms in dextran sodium sulphate-induced murine colitis. The aim of the study was to measure the gene expression and intestinal production of SPARC in patients with UC and controls as well as, to determine its correlation with histological activity. Methods: We included 40 patients with confirmed diagnosis of UC, and 20 controls without endoscopic evidence of any type of colitis or neoplasia. The relative quantification of the gene expression was performed by real time PCR. GAPDH was used as housekeeping gene for normalization purposes and quality controls. Protein expression was determined by immunohistochemistry. Results: The gene expression of SPARC was increased in patients with active UC vs in remission UC and vs. controls (P = 0.005). There was no significant difference between patients with remission UC and controls. The overexpression of SPARC in patients with active UC correlated significantly with mild histological activity (P = 0.06, OR = 7.77, IC = 0.77-77.9) moderate (P = 0.06, OR = 8.1, IC 95%=0.79-82.73), and severe (P = 0.03, OR = 6.5, IC 95%=1.09-38.6). Double positive SPARC+/CD16+ cells were localized mainly in submucosa, muscular layer, and adventitia, and in perivascular inflammatory infiltrates in patients with active UC. Conclusion: The gene and protein expression of SPARC is increased in active UC. SPARC could be a marker of intestinal inflammation and its expression correlates with histological activity.
MeSH term(s)	Adult ; Aged ; Biomarkers ; Colitis, Ulcerative/diagnosis ; Colitis, Ulcerative/etiology ; Colitis, Ulcerative/metabolism ; Cross-Sectional Studies ; Disease Susceptibility ; Female ; Gene Expression ; Humans ; Immunohistochemistry ; Intestinal Mucosa/immunology ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Male ; Middle Aged ; Osteonectin/biosynthesis ; Osteonectin/genetics ; Young Adult
Chemical Substances	Biomarkers ; Osteonectin ; SPARC protein, human
Language	English
Publishing date	2021-05-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	563292-4
ISSN	1878-3279 ; 0171-2985
ISSN (online)	1878-3279
ISSN	0171-2985
DOI	10.1016/j.imbio.2021.152095
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Article ; Online: Differential Expression of IL-36 Family Members and IL-38 by Immune and Nonimmune Cells in Patients with Active Inflammatory Bowel Disease.

Fonseca-Camarillo, Gabriela / Furuzawa-Carballeda, Janette / Iturriaga-Goyon, Emilio / Yamamoto-Furusho, Jesús K

BioMed research international

2018 Volume 2018, Page(s) 5140691

Abstract: IL-1 family includes IL-38 (IL-1F10) and the subfamily of IL-36 and is the central mediators of inflammatory diseases, including pustular psoriasis, atopic dermatitis, rheumatoid arthritis, and gut inflammation. The purpose of the study was to evaluate ... ...

Abstract	IL-1 family includes IL-38 (IL-1F10) and the subfamily of IL-36 and is the central mediators of inflammatory diseases, including pustular psoriasis, atopic dermatitis, rheumatoid arthritis, and gut inflammation. The purpose of the study was to evaluate on tissue of the patients with inflammatory bowel disease (IBD), the IL-36
MeSH term(s)	Adult ; Cross-Sectional Studies ; Dendritic Cells/metabolism ; Dendritic Cells/pathology ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Female ; Gene Expression Regulation ; Humans ; Immunohistochemistry ; Inflammatory Bowel Diseases/metabolism ; Inflammatory Bowel Diseases/pathology ; Interleukin-1/biosynthesis ; Interleukins/biosynthesis ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Macrophages/metabolism ; Macrophages/pathology ; Male ; Middle Aged
Chemical Substances	IL-38 protein, human ; Interleukin-1 ; Interleukins
Language	English
Publishing date	2018-12-10
Publishing country	United States
Document type	Clinical Trial ; Comparative Study ; Journal Article
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2018/5140691
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Article ; Online: Increased expression of extracellular matrix metalloproteinase inducer (EMMPRIN) and MMP10, MMP23 in inflammatory bowel disease: Cross-sectional study.

Fonseca-Camarillo, Gabriela / Furuzawa-Carballeda, Janette / Martínez-Benitez, Braulio / Barreto-Zuñiga, Rafael / Yamamoto-Furusho, Jesús K

Scandinavian journal of immunology

2020 Volume 93, Issue 1, Page(s) e12962

Abstract: It has been reported that EMMPRIN is involved in the regulation of immune response and the induction of MMPs production by fibroblasts. The aim of this study was to describe the intestinal gene expression and protein production of EMMPRIN, MMP23 and ... ...

Abstract	It has been reported that EMMPRIN is involved in the regulation of immune response and the induction of MMPs production by fibroblasts. The aim of this study was to describe the intestinal gene expression and protein production of EMMPRIN, MMP23 and MMP10 in patients with ulcerative colitis (UC) and Crohn's disease (CD) and compared them with a control group. Gene expression of EMMPRIN, MMP10 and MMP23B was measured by RT-PCR. In order to determine EMMPRIN and MMP protein expression, colonic tissues were immunostained. The results of the study showed EMMPRIN gene expression was upregulated in rectal mucosa from active (a)UC versus aCD patients (P = .045), remission (r)CD group (P = .0009) and controls (P < .0001). We detected differences between rUC and aCD (P = .004), rCD (P < .0001) or control group (P < .0001). EMMPRIN showed a higher expression in mucosa (intraepithelial lymphocytes), submucosa and adventitia (endothelial cells) from aCD patients. MMP23 levels were increased in aUC and aCD compared to rUC and rCD and the control group (P = .0001). EMMPRIN+/MMP23+─expressing cells were localized mainly in mucosa, muscular and adventitia from active UC patients. MMP10 gene expression was increased in aUC versus CD patients and the control group (P = .0001). MMP10 gene expression is associated with inflammation in UC patients (P = .0001, r
MeSH term(s)	Adult ; Aged ; Basigin/genetics ; Basigin/metabolism ; Biomarkers ; Biopsy ; Case-Control Studies ; Cross-Sectional Studies ; Disease Susceptibility ; Female ; Gene Expression ; Gene Expression Profiling ; Humans ; Immunohistochemistry ; Inflammatory Bowel Diseases/genetics ; Inflammatory Bowel Diseases/metabolism ; Inflammatory Bowel Diseases/pathology ; Inflammatory Bowel Diseases/therapy ; Male ; Matrix Metalloproteinase 10/genetics ; Matrix Metalloproteinase 10/metabolism ; Metalloendopeptidases/genetics ; Metalloendopeptidases/metabolism ; Middle Aged ; Protein Binding
Chemical Substances	BSG protein, human ; Biomarkers ; Basigin (136894-56-9) ; Metalloendopeptidases (EC 3.4.24.-) ; MMP10 protein, human (EC 3.4.24.22) ; Matrix Metalloproteinase 10 (EC 3.4.24.22)
Language	English
Publishing date	2020-10-15
Publishing country	England
Document type	Journal Article
ZDB-ID	120476-2
ISSN	1365-3083 ; 0300-9475
ISSN (online)	1365-3083
ISSN	0300-9475
DOI	10.1111/sji.12962
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Article ; Online: Immunoregulatory Pathways Involved in Inflammatory Bowel Disease.

Fonseca-Camarillo, Gabriela / Yamamoto-Furusho, Jesús K

Inflammatory bowel diseases

2015 Volume 21, Issue 9, Page(s) 2188–2193

Abstract: Inflammatory bowel diseases (IBD) include ulcerative colitis and Crohn's disease. The immune response in ulcerative colitis is different from the Crohn's disease. Accumulating evidence suggests that IBD results from an inappropriate inflammatory response ...

Abstract	Inflammatory bowel diseases (IBD) include ulcerative colitis and Crohn's disease. The immune response in ulcerative colitis is different from the Crohn's disease. Accumulating evidence suggests that IBD results from an inappropriate inflammatory response to intestinal microbes in a genetically susceptible host. Several immunoregulatory abnormalities have been reported in patients with IBD, including the ratio of proinflammatory (tumor necrosis factor alpha, IL-6, IL-1-β) to immunoregulatory cytokines (IL-10, TGF-β, IL-35) and selective activation of T-helper (Th) lymphocyte subsets (Th1, Th2, Th9, Th17, and regulatory T cells). The purpose of this review is to show the immunoregulatory pathways (regulatory cells and cytokines) involved in IBD published in recent years.
MeSH term(s)	Humans ; Inflammatory Bowel Diseases/immunology ; Inflammatory Bowel Diseases/metabolism ; Interleukin-10/metabolism ; Interleukin-1beta/metabolism ; Interleukin-6/metabolism ; Interleukins/metabolism ; Signal Transduction/immunology ; T-Lymphocytes, Helper-Inducer/metabolism ; T-Lymphocytes, Regulatory/metabolism ; Transforming Growth Factor beta/metabolism ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	IL10 protein, human ; Interleukin-1beta ; Interleukin-6 ; Interleukins ; Transforming Growth Factor beta ; Tumor Necrosis Factor-alpha ; interleukin-35, human ; Interleukin-10 (130068-27-8)
Language	English
Publishing date	2015-06-24
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1340971-2
ISSN	1536-4844 ; 1078-0998
ISSN (online)	1536-4844
ISSN	1078-0998
DOI	10.1097/MIB.0000000000000477
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Article ; Online: Genetic Markers Associated with Clinical Outcomes in Patients with Inflammatory Bowel Disease.

Yamamoto-Furusho, Jesús K / Fonseca-Camarillo, Gabriela

Inflammatory bowel diseases

2015 Volume 21, Issue 11, Page(s) 2683–2695

Abstract: Genetic factors play a significant role in determining inflammatory bowel disease (IBD) susceptibility. Epidemiologic data support genetic contribution to the pathogenesis of IBD, which include familial aggregation, twin studies, and racial and ethnic ... ...

Abstract	Genetic factors play a significant role in determining inflammatory bowel disease (IBD) susceptibility. Epidemiologic data support genetic contribution to the pathogenesis of IBD, which include familial aggregation, twin studies, and racial and ethnic differences in disease prevalence. Recently, several new genes have been identified to be involved in the genetic susceptibility to IBD. The characterization of novel genes potentially will lead to the identification of therapeutic agents and clinical assessment of phenotype and prognosis in patients with IBD. The development of genetic markers associated with clinical outcomes in patients with IBD will be very important in the future. The progress of molecular biology tools (microarrays, proteomics, and epigenetics) have progressed the field of the genetic markers discovery. The advances in bioinformatics coupled with cross-disciplinary collaborations have greatly enhanced our ability to retrieve, characterize, and analyze large amounts of data generated by the technological advances. The techniques available for markers development are genomics (single nucleotide polymorphism genotyping, pharmacogenetics, and gene expression analyses) and proteomics. This could be a potential great benefit in predicting the course of disease in individual patients and in guiding appropriate medical therapy.
MeSH term(s)	Computational Biology ; Epigenomics ; Genetic Markers ; Genetic Predisposition to Disease ; Humans ; Inflammatory Bowel Diseases/diagnosis ; Inflammatory Bowel Diseases/genetics ; Oligonucleotide Array Sequence Analysis ; Polymorphism, Single Nucleotide ; Prognosis ; Proteomics
Chemical Substances	Genetic Markers
Language	English
Publishing date	2015-07-28
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1340971-2
ISSN	1536-4844 ; 1078-0998
ISSN (online)	1536-4844
ISSN	1078-0998
DOI	10.1097/MIB.0000000000000500
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