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  1. AU=Shim Kwang Yong
  2. AU="Metzner, Frank"
  3. AU="Steenkamp, Rudolph C."
  4. AU="Yushko, L A"
  5. AU="Bolander, Emily"
  6. AU="Lesens, O"
  7. AU=Braman Sidney S
  8. AU="Shao, Yin-Qi"
  9. AU="Ham, Christopher"
  10. AU="Adnan, Saqeeb"
  11. AU="Reima Mansour"
  12. AU="Hanin, François-Xavier"
  13. AU=Dufour Alexandre C.
  14. AU="Matos, Stênio Gonçalves da Silva"
  15. AU="Robinson, James B"
  16. AU="An, Dowon"
  17. AU="Mohammad Shahrooei"
  18. AU="Brandjes, Dees P M"
  19. AU="Zou, J Z"
  20. AU="Kamal Dahan Alsultan"
  21. AU="Ayres-Silva, Jackline P"
  22. AU="Devrim, Fatma"
  23. AU="Michael J Horzewski"
  24. AU="Mumtaz, Nazia"
  25. AU="Elsa R. Treffeisen"
  26. AU="Ram, Natalie"
  27. AU="Azzaoui, Kamal"
  28. AU="Clowney, Billy"
  29. AU="Andrews, Lawrence C."
  30. AU="Arias, Andrés Hugo"
  31. AU="Yeo, B K"
  32. AU="Sultan, Mahmoud H"
  33. AU="Kou, Z Q"
  34. AU="Lamm, L"
  35. AU="Truxius, Lidia"
  36. AU="Xingyi Guo"
  37. AU="Gang Lin"
  38. AU="Oka, T"
  39. AU="Frank-Pearce, Summer G"
  40. AU="Hairi Li"
  41. AU="Park, SungHee"
  42. AU="Pascual-Carreras, Eudald"
  43. AU=Joffe Ari R
  44. AU="Buccafurri, Francesco"
  45. AU="Naomi H. Philip"
  46. AU="P. Naina"
  47. AU="Sigal, Leonard H"
  48. AU="Xu, T" AU="Xu, T"
  49. AU="Mazlout, Adam"
  50. AU="Novak, Cheryl B"
  51. AU="Ren, Zhongmin"
  52. AU="Nadhira Houhou-Fidouh"
  53. AU="Seiffert, Jacqui"
  54. AU=Zhang Zizhen
  55. AU="Bhupender Singh Negi"

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  1. Artikel ; Online: The Association Between Sputum Culture Conversion and Mortality in Cavitary Mycobacterium avium Complex Pulmonary Disease.

    Lee, Ju Kwang / Kim, Seonok / Chong, Yong Pil / Lee, Hyun Joo / Shim, Tae Sun / Jo, Kyung-Wook

    Chest

    2024  

    Abstract: Background: The association between treatment outcome and the mortality of Mycobacterium avium complex pulmonary disease (MAC-PD) with cavitary lesions is unclear. This article assessed the impact of culture conversion on mortality in patients with ... ...

    Abstract Background: The association between treatment outcome and the mortality of Mycobacterium avium complex pulmonary disease (MAC-PD) with cavitary lesions is unclear. This article assessed the impact of culture conversion on mortality in patients with cavitary MAC-PD.
    Research question: Is the achievement of sputum culture conversion in MAC-PD with cavitary lesions associated with the prognosis?
    Study design and methods: From 2002 to 2020, a total of 351 patients with cavitary MAC-PD (105 with the fibrocavitary type and 246 with the cavitary nodular bronchiectatic type), who had been treated with a ≥ 6-month macrolide-containing regimen at a tertiary referral center in the Republic of Korea, were retrospectively enrolled in this study. All-cause mortality during the follow-up period was analyzed based on culture conversion at the time of treatment completion.
    Results: The cohort had a median treatment duration of 14.7 months (interquartile range [IQR], 13.4-16.8 months). Of the 351 patients, 69.8% (245 of 351) achieved culture conversion, and 30.2% (106 of 351) did not. The median follow-up was 4.4 years (IQR, 2.3-8.3 years) in patients with culture conversion and 3.1 years (IQR, 2.1-4.8 years) in those without. For the patients with and without culture conversion, all-cause mortality was 5.3% vs 35.8% (P < .001), and the 5-year cumulative mortality was 20.0% vs 38.4%, respectively. Cox analysis found that a lack of culture conversion was significantly associated with higher mortality (adjusted hazard ratio, 5.73; 95% CI, 2.86-11.50). Moreover, the 2-year landmark analysis revealed a distinct impact of treatment outcome on mortality.
    Interpretation: The mortality rate of patients with cavitary MAC-PD who did not achieve culture conversion was significantly higher than that of those with culture conversion.
    Sprache Englisch
    Erscheinungsdatum 2024-03-18
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2024.03.027
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  2. Artikel ; Online: Proposal of New ypStage Grouping System for Esophageal Squamous Cell Carcinoma Patients who Underwent Neoadjuvant Chemoradiotherapy followed by Surgery.

    Park, Seong Yong / Park, Boram / Yun, Jae Kwang / Kim, Hyeong Ryul / Kim, Yong-Hee / Jeon, Yeong Jeong / Lee, Junghee / Cho, Jong Ho / Choi, Yong Soo / Zo, Jae Il / Shim, Young Mog / Kim, Hong Kwan

    Annals of surgery

    2024  

    Abstract: Objective: To propose a new ypTNM grouping system to address these limitations and improve prognostic relevance.: Summary background data: The current 8th edition of the American Joint Committee on Cancer (AJCC) ypStage system shows unsatisfactory ... ...

    Abstract Objective: To propose a new ypTNM grouping system to address these limitations and improve prognostic relevance.
    Summary background data: The current 8th edition of the American Joint Committee on Cancer (AJCC) ypStage system shows unsatisfactory prognostic relevance in patients with esophageal squamous cell carcinoma (ESCC) treated with neoadjuvant chemoradiotherapy (nCRT) followed by esophagectomy.
    Methods: The study cohort included 501 ESCC patients who received nCRT followed by esophagectomy at the Samsung Medical Center in Korea between 1994 and 2018 (development cohort) and 422 patients treated at Asan Medical Center (validation cohort). Recursive partitioning with a tree-structured regression model was used to develop and validate a new ypStage grouping system.
    Results: In the new ypStage grouping system, ypStage I includes ypT0N0 only; ypStage II includes ypTis-T2N0 or ypT0-T2N1; ypStage III includes ypT3N0-N1; and ypStage IV includes ypT4N0-N1 or ypTanyN2-3. This system adequately addressed the limitations of the existing AJCC classification system, including overlapping and reversal of survival rates. Moreover, the discrimination ability of the new system was higher than that of the existing system [concordance-index (C-index): 61.9%] in the development (C-index: 66.6%) and validation (C-index: 66.0%) cohorts. NRIe was 0.17 [95% confidence interval (CI): 0.09-0.26, P-<0.001) and 0.18 (95% CI: 0.10-0.27, P-<0.001)] in the development and validation cohorts, respectively.
    Conclusions: The current study proposes a clear revised version of the 8th edition of the AJCC ypStage grouping system that exhibits superior prognostic stratification in patients with ESCC treated with nCRT followed by esophagectomy.
    Sprache Englisch
    Erscheinungsdatum 2024-01-17
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000006204
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  3. Artikel ; Online: E/e' Ratio Predicts the Atrial Pacing-Induced Left Atrial Pressure Response in Patients with Preserved Ejection Fraction.

    Roh, Seung-Young / Lee, Dae-In / Lee, Kwang-No / Ahn, Jinhee / Baek, Yong-Soo / Kim, Dong-Hyeok / Shim, Jaemin / Choi, Jong-Il / Kim, Young-Hoon

    Medicina (Kaunas, Lithuania)

    2023  Band 59, Heft 2

    Abstract: Background and Objectives: ...

    Abstract Background and Objectives:
    Mesh-Begriff(e) Humans ; Male ; Adult ; Middle Aged ; Aged ; Female ; Atrial Fibrillation ; Atrial Pressure ; Stroke Volume/physiology ; Heart Atria ; Ventricular Dysfunction, Left ; Hypertension ; Ventricular Function, Left/physiology
    Sprache Englisch
    Erscheinungsdatum 2023-01-21
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59020210
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  4. Artikel: Characteristics and survival of patients with atypical chronic myeloid leukemia.

    Kong, Jee Hyun / Nam, Hohyung / Go, Tae-Hwa / Hyun, Shin Young / Shim, Kwang Yong

    Blood research

    2019  Band 54, Heft 3, Seite(n) 233–236

    Sprache Englisch
    Erscheinungsdatum 2019-09-25
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article
    ZDB-ID 2711910-5
    ISSN 2288-0011 ; 2287-979X
    ISSN (online) 2288-0011
    ISSN 2287-979X
    DOI 10.5045/br.2019.54.3.233
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  5. Artikel ; Online: A Reference-Sampling Based Calibration-Free Fractional-N PLL with a PI-Linked Sampling Clock Generator.

    Han, Jae-Soub / Eom, Tae-Hyeok / Choi, Seong-Wook / Seong, Kiho / Yoon, Dong-Hyun / Kim, Tony Tae-Hyong / Baek, Kwang-Hyun / Shim, Yong

    Sensors (Basel, Switzerland)

    2021  Band 21, Heft 20

    Abstract: Sampling-based PLLs have become a new research trend due to the possibility of removing the frequency divider (FDIV) from the feedback path, where the FDIV increases the contribution of in-band noise by the factor of dividing ratio square ( ... ...

    Abstract Sampling-based PLLs have become a new research trend due to the possibility of removing the frequency divider (FDIV) from the feedback path, where the FDIV increases the contribution of in-band noise by the factor of dividing ratio square (N
    Sprache Englisch
    Erscheinungsdatum 2021-10-14
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s21206824
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  6. Artikel ; Online: The efficacy and safety of DW1601 in patients with acute bronchitis: a multi-center, randomized, double-blind, phase III clinical trial.

    Lee, Young Seok / Lim, Seong Yong / Min, Kyung Hoon / Kim, Do Jin / Yoo, Kwang Ha / Kim, Tae-Bum / Kim, Hak-Ryul / Shim, Jae Jeong

    The Korean journal of internal medicine

    2022  Band 37, Heft 6, Seite(n) 1195–1204

    Abstract: Background/aims: DW1601, an oral fixed dose combination syrup composed of DW16011 and Pelargonium sidoides, was developed to enhance the symptom relief effect in patients with acute bronchitis. We evaluated the efficacy and safety of DW1601 compared to ... ...

    Abstract Background/aims: DW1601, an oral fixed dose combination syrup composed of DW16011 and Pelargonium sidoides, was developed to enhance the symptom relief effect in patients with acute bronchitis. We evaluated the efficacy and safety of DW1601 compared to DW16011 or P. sidoides for treatment of acute bronchitis using a randomized, double-blind, placebocontrolled, multi-centre trial design.
    Methods: A total of 204 patients with acute bronchitis was randomized 1:1:1 to receive DW1601 (n = 67), DW16011 (n = 70), or P. sidoides (n = 64) for 7 days. The primary outcome was efficacy of DW1601 compared to DW16011 or P. sidoides in reducing the total bronchitis severity score (BSS) at day 4 of treatment. Secondary endpoints were changes in total and symptomspecific BSS, response rate and patient satisfaction rate. Safety analysis was assessed at day 7.
    Results: At 4 days after medication, decrease of total BSS from baseline was significantly greater in the DW1601 group than in the DW16011 group (-3.51 ± 0.18 vs. -2.65 ± 0.18, p = 0.001) or P. sidoides group (-3.56 ± 0.18 vs. -2.64 ± 0.19, p < 0.001). In addition, the BSS total score at day 7 and the BSS cough and sputum component scores at days 4 and 7 were significantly more improved with DW1601 treatment compared with the DW16011 group or P. sidoides group. Participants treated with DW1601 showed higher rates of response and satisfaction than control groups (response rate, DW1601, 100% vs. DW16011, 85.7% vs. P. sidoides, 85.9%; satisfaction rate, DW1601, 92.6% vs. DW16011, 82.9% vs. P. sidoides, 81.2%). Significant adverse events were not observed in the DW1601 group.
    Conclusion: DW1601 is superior to DW16011 or P. sidoides in improving symptoms of acute bronchitis.
    Mesh-Begriff(e) Humans ; Phytotherapy ; Plant Extracts/adverse effects ; Treatment Outcome ; Pelargonium ; Bronchitis/diagnosis ; Bronchitis/drug therapy ; Bronchitis/chemically induced ; Acute Disease ; Double-Blind Method
    Chemische Substanzen Plant Extracts
    Sprache Englisch
    Erscheinungsdatum 2022-09-26
    Erscheinungsland Korea (South)
    Dokumenttyp Randomized Controlled Trial ; Multicenter Study ; Clinical Trial, Phase III ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639023-7
    ISSN 2005-6648 ; 1226-3303
    ISSN (online) 2005-6648
    ISSN 1226-3303
    DOI 10.3904/kjim.2022.104
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  7. Artikel: Feasibility of fast, four-dimensional computed tomography-based O-ring LINAC plans for lung stereotactic body radiotherapy in patients with poor performance status.

    Heo, Eun Jeong / Kim, Minseok / Park, Chun Gun / Chang, Kyung Hwan / Kim, Kwang Hyeon / Shim, Jang Bo / Park, Young Je / Kim, Chul Yong / Lee, Nam Kwon / Lee, Suk

    Frontiers in oncology

    2023  Band 13, Seite(n) 1270677

    Abstract: Purpose: We aimed to retrospectively analyzed the feasibility of fast four-dimensional computed tomography (4DCT)-based O-ring LINAC treatment for patients with an average respiratory amplitude was< 0.5 cm and who cannot endure long treatment times due ... ...

    Abstract Purpose: We aimed to retrospectively analyzed the feasibility of fast four-dimensional computed tomography (4DCT)-based O-ring LINAC treatment for patients with an average respiratory amplitude was< 0.5 cm and who cannot endure long treatment times due to poor performance status in lung 4D-stereotactic body radiotherapy (SBRT).
    Methods: This study included data of 38 patients who received lung 4D-SBRT and had average respiratory amplitude< 0.5 cm in the full phase. C-arm LINAC plans were based on 4DCT data obtained at phase values ranging from 20-70% using a C-arm LINAC. O-ring LINAC plans were retrospectively established based on 4DCT data obtained at phase values of 0-90% using an O-ring LINAC. The conformity index (CI), homogeneity index (HI), and gradient measurement of the planning target volumes (PTV) were analyzed to compare dosimetric data between C-arm LINAC and O-ring LINAC plans. Organs at risk were analyzed in accordance with the Radiation Therapy Oncology Group 0915 protocol. Treatment delivery time and total monitor units were analyzed to compare the efficiency of treatment delivery. Statistical comparisons were performed using the Wilcoxon signed-rank test (
    Results: For the PTV, there was no significant difference in the CI or HI between C-arm LINAC and O-ring LINAC plans. For organs-at-risk, all plans met the criteria for dose constraint. There was a significant difference between C-arm LINAC and O-ring LINAC plans except in the spinal cord. Treatment delivery time was 92% longer for C-arm LINAC plans than for O-ring LINAC plans. The total MU value for C-arm LINAC plans was 9.6% higher than that for O-ring LINAC plans.
    Conclusion: We verified the feasibility of fast 4DCT-based O-ring LINAC treatment for patients with average respiratory amplitude< 0.5 cm and who cannot endure long treatment times due to poor performance status in lung 4D-SBRT.
    Sprache Englisch
    Erscheinungsdatum 2023-11-20
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1270677
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  8. Artikel ; Online: An Experimental Study on the Relationship Between Temperature and Pressure Inside the Cup During Cupping Procedures

    Ha Lim Lee / Soo Kwang An / Jae Yong Lee / Dong Wook Shim / Byung Ryul Lee / Gi Young Yang

    Journal of Acupuncture Research, Vol 38, Iss 1, Pp 41-

    2021  Band 46

    Abstract: Background Pressure changes related to temperature variation during cupping may lead to dropout. This study aimed to investigate pressure changes related to temperature variations in the cup during the cupping procedure. Methods Changes in temperature ... ...

    Abstract Background Pressure changes related to temperature variation during cupping may lead to dropout. This study aimed to investigate pressure changes related to temperature variations in the cup during the cupping procedure. Methods Changes in temperature and pressure were measured for 15 minutes after the procedure was performed using the alcohol rub method with glass cups and with the addition of infrared irradiation. Changes in temperature and pressure were also measured for 15 minutes after pumping 3 times using the valve suction method, and with the addition of infrared irradiation. Results In a comparison between the alcohol rub method with glass cups and with the addition of infrared irradiation, the negative pressure increased over time in the absence of infrared irradiation, whereas it decreased when performed with infrared irradiation p = 0.094. However, in a comparison between pumping 3 times using the valve suction method, and with the addition of infrared irradiation, the negative pressure decreased in both cases, but this was more significant with infrared irradiation p = 0.172. There was a significantly higher temperature in the glass cups (p = 0.004) and the valve cups (p = 0.001) exposed to infrared radiation, compared with no infrared irradiation. Conclusion The reduction in negative pressure inside the cups exposed to infrared radiation was greater than without infrared irradiation. Temperature increases inside the cup can lead to the risk of dropout.
    Schlagwörter cupping therapy ; korean traditional medicine ; hyperthermia ; pressure ; temperature ; Miscellaneous systems and treatments ; RZ409.7-999 ; Therapeutics. Pharmacology ; RM1-950
    Thema/Rubrik (Code) 660
    Sprache Englisch
    Erscheinungsdatum 2021-02-01T00:00:00Z
    Verlag E-Tree Publishing
    Dokumenttyp Artikel ; Online
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  9. Artikel ; Online: Pressure Changes During Layer Cupping in a Skin Model

    Dong Wook Shim / Soo Kwang An / Ha Lim Lee / Jae Yong Lee / Byung Ryul Lee / Gi Young Yang

    Journal of Acupuncture Research, Vol 38, Iss 2, Pp 159-

    2021  Band 164

    Abstract: Background Cupping is widely used in Korean medicine, but there is a risk of bacterial infection if the suction pump (used for inducing negative pressure) and the patients’ skin are not separated. This study aimed to investigate the effect of layer ... ...

    Abstract Background Cupping is widely used in Korean medicine, but there is a risk of bacterial infection if the suction pump (used for inducing negative pressure) and the patients’ skin are not separated. This study aimed to investigate the effect of layer cupping by comparing the pressure changes between layer cupping and conventional cupping. Methods To evaluate pressure changes the study was designed with 3 types of conditions applied to a skin model: (1) a Dongbang cup with a manual or motor suction pump (conventional cupping); (2) layer cupping with 2 Dongbang cups; and (3) layer cupping with a cup made by 3D printing and a Dongbang cup. Results When a manual suction pump was used (conventional cupping), the pressure did not decrease steadily, and in 1 section there was an increase in pressure. When layer cupping was used, the pressure in the lower cup (which would be directly applied to the patient’s skin), decreased steadily. Conclusion In the pressure change graph for layer cupping in this skin model, the pressure in the lower cup (which would be placed on the patient’s skin) steadily decreased, and reached equilibrium. Therefore, the layer cupping model may help to reduce the risks of bacterial infection.
    Schlagwörter bacterial infection ; korean traditional medicine ; pressure ; skin ; Miscellaneous systems and treatments ; RZ409.7-999 ; Therapeutics. Pharmacology ; RM1-950
    Thema/Rubrik (Code) 660
    Sprache Englisch
    Erscheinungsdatum 2021-05-01T00:00:00Z
    Verlag E-Tree Publishing
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: The Impact of Personal Thoracic Impedance on Electrical Cardioversion in Patients with Atrial Arrhythmias.

    Roh, Seung-Young / Ahn, Jinhee / Lee, Kwang-No / Baek, Yong-Soo / Kim, Dong-Hyeok / Lee, Dae-In / Shim, Jaemin / Choi, Jong-Il / Kim, Young-Hoon

    Medicina (Kaunas, Lithuania)

    2021  Band 57, Heft 6

    Abstract: Background and ... ...

    Abstract Background and Objectives
    Mesh-Begriff(e) Atrial Appendage ; Atrial Fibrillation ; Electric Countershock ; Electric Impedance ; Female ; Heart Atria ; Humans ; Male
    Sprache Englisch
    Erscheinungsdatum 2021-06-13
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina57060618
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