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Article ; Online: Reply to: "Is oral collagen the elixir of youth?"

Samadi, Aniseh / Ahmad Nasrollahi, Saman / Firooz, Alireza

2023 Volume 23, Issue 3, Page(s) 1089–1090

Abstract: Following letter provides answers and explanations for the correspoundance titled "Is oral collagen the elixir of youth." They have admitted the strengths of our study and also have raised some questions about it, which we aim to provide answers and ... ...

Abstract	Following letter provides answers and explanations for the correspoundance titled "Is oral collagen the elixir of youth." They have admitted the strengths of our study and also have raised some questions about it, which we aim to provide answers and explanations.
MeSH term(s)	Humans ; Collagen/therapeutic use
Chemical Substances	Collagen (9007-34-5)
Language	English
Publishing date	2023-10-27
Publishing country	England
Document type	Letter
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.16051
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Article ; Online: Efficacy of intramuscular injections of biotin and dexpanthenol in the treatment of diffuse hair loss: A randomized, double-blind controlled study comparing two brands.

Samadi, Aniseh / Ketabi, Yasaman / Firooz, Rojin / Firooz, Alireza

Dermatologic therapy

2022 Volume 35, Issue 9, Page(s) e15695

Abstract: Combination therapy with biotin and dexpanthenol is a well-known practice in preventing and treating hair loss, however, it is not well studied. In this study, we compared the efficacy of the 6-week treatment with two brands of biotin and dexpanthenol ... ...

Abstract	Combination therapy with biotin and dexpanthenol is a well-known practice in preventing and treating hair loss, however, it is not well studied. In this study, we compared the efficacy of the 6-week treatment with two brands of biotin and dexpanthenol for the treatment of diffuse hair loss. Fifty eligible patients with diffused pattern hair loss, (41 women and 9 men) were randomized in a 1:1 ratio to receive either 6 weekly injections of dexpanthenol ampoule 250 mg/2 ml and biotin ampoule 5 mg/1 ml, manufactured by Pars Behvarzan or Bayer Company. Combing test, Standard scalp photography and trichoscan assessment were performed before the first treatment session and one and 8 weeks after the last one. Patients' satisfaction and drug adverse reactions were also recorded. One and eight weeks after the last treatment session, hair fall count and total hair density significantly improved in both groups (p-value <0.01 for hair fall count and 0.04 and 0.02, for hair density in Pars and Bayer groups, respectively). There was no significant difference between the two groups in any other trichoscan parameter, except for improvement in terminal/vellus hair ratio in the Bayer group in both follow up visits, compared to the Pars group (p-value = 0.02 and 0.033 for weeks one and eight). Six-week treatment with both brands of biotin and dexpanthenol was effective and safe in people with diffused pattern hair loss.
MeSH term(s)	Alopecia/diagnosis ; Alopecia/drug therapy ; Biotin/therapeutic use ; Double-Blind Method ; Female ; Hair ; Humans ; Injections, Intramuscular ; Male ; Pantothenic Acid/analogs & derivatives ; Pantothenic Acid/therapeutic use ; Treatment Outcome
Chemical Substances	Pantothenic Acid (19F5HK2737) ; dexpanthenol (1O6C93RI7Z) ; Biotin (6SO6U10H04)
Language	English
Publishing date	2022-07-15
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1354801-3
ISSN	1529-8019 ; 1396-0296
ISSN (online)	1529-8019
ISSN	1396-0296
DOI	10.1111/dth.15695
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Article ; Online: COVID-19 vaccines: What dermatologists should know?

Ayatollahi, Azin / Hosseini, Hamed / Firooz, Rojin / Firooz, Alireza

Dermatologic therapy

2021 Volume 34, Issue 5, Page(s) e15056

Abstract: As COVID-19 vaccination has started worldwide to control this pandemic, dermatologists may face various challenges with these new vaccines. In this manuscript, we review different types of available COVID-19 vaccines and their various production ... ...

Abstract	As COVID-19 vaccination has started worldwide to control this pandemic, dermatologists may face various challenges with these new vaccines. In this manuscript, we review different types of available COVID-19 vaccines and their various production platforms. Vaccination considerations in patients with skin diseases, especially those using immunomodulatory drugs will be presented. Finally, adverse cutaneous reactions of COVID-19 vaccines will be reviewed.
MeSH term(s)	COVID-19 ; COVID-19 Vaccines ; Dermatologists ; Humans ; SARS-CoV-2 ; Vaccines/adverse effects
Chemical Substances	COVID-19 Vaccines ; Vaccines
Language	English
Publishing date	2021-07-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1354801-3
ISSN	1529-8019 ; 1396-0296
ISSN (online)	1529-8019
ISSN	1396-0296
DOI	10.1111/dth.15056
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Article: Updates on Tinea Incognita: Literature review.

Ghaderi, Aliasghar / Tamimi, Pegah / Firooz, Alireza / Fattahi, Maryam / Ghazanfari, Mona / Fattahi, Mahsa

Current medical mycology

2024 Volume 9, Issue 2, Page(s) 52–63

Abstract: Background and purpose: Tinea incognita (TI), or the other equivalent tinea atypica, is a term used to declare the atypical presentation of dermatophyte infections caused by the administration of steroids or other immunosuppressive medications which ... ...

Abstract	Background and purpose: Tinea incognita (TI), or the other equivalent tinea atypica, is a term used to declare the atypical presentation of dermatophyte infections caused by the administration of steroids or other immunosuppressive medications which modulate the local and systemic immune response. It can mimic other dermatoses; hence making diagnostic challenges for dermatologists. Tina incognita may be misdiagnosed as many dermatoses. Based on previous studies, corticosteroids may cause different clinical manifestations of dermatophytes that might be very different from those that are commonly described. Materials and methods: This narrative review was conducted using PubMed and Scopus databases. Search terms included "Tinea incognita" and "Atypical dermatophytosis". The search strategy included meta-analyses, randomized controlled trials, clinical trials, observational studies, reviews, and case reports. The search was restricted to articles written in the English language from 2006 to Feb 01, 2023. Moreover, duplicate articles and non-available full-text articles were excluded. The extracted data of the search results were retrieved in this study. The morphological patterns, prevalence, sight of infection, and causative agents were also described. Results: Prevalence of different patterns of TI were recorded as 50% (431 out of 862 cases) for eczema-like lesions followed by psoriasis-like and 6.61% (57 out of 862) for parapsoriasis-like pattern. Moreover, each of the rosacea-like and pyoderma-like lesions equally accounted for 4.98 % of cases (43 out of 862). In addition, the prevalence of causative agents was reported as follows: Conclusion: Tinea incognita is a great mimicker; hence, dermatologists should obtain a full medical history of the patients to make correct diagnoses. It is vital to encourage an exact identification of the etiological agent according to the internal transcribed spacer sequencing in some uncertain cases. This review highlights the importance of mycological tests and fast diagnosis of TI, especially in cases of atypical skin lesions, to choose appropriate treatment and avoid the spread of drug-resistant species.
Language	English
Publishing date	2024-02-05
Publishing country	Iran
Document type	Journal Article ; Review
ZDB-ID	3015705-5
ISSN	2423-3420 ; 2423-3439
ISSN (online)	2423-3420
ISSN	2423-3439
DOI	10.22034/cmm.2023.345069.1425
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Article ; Online: Postherpetic abdominal pseudohernia: An uncommon complication of herpes zoster.

Azimi, Seyyede Zeinab / Firooz, Alireza

Dermatologic therapy

2020 Volume 33, Issue 4, Page(s) e13530

Abstract: Herpes zoster, a common inflammatory viral disease, results in several complications. Pain and sensory disorders are the main symptoms of herpes zoster. We reported a case of segmental abdominal zoster with progression to motor involvement and ... ...

Abstract	Herpes zoster, a common inflammatory viral disease, results in several complications. Pain and sensory disorders are the main symptoms of herpes zoster. We reported a case of segmental abdominal zoster with progression to motor involvement and pseudohernia.
MeSH term(s)	Abdominal Wall ; Herpes Zoster/complications ; Herpes Zoster/diagnosis ; Herpes Zoster/drug therapy ; Humans ; Neuralgia, Postherpetic/diagnosis ; Neuralgia, Postherpetic/drug therapy ; Neuralgia, Postherpetic/etiology
Language	English
Publishing date	2020-05-20
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1354801-3
ISSN	1529-8019 ; 1396-0296
ISSN (online)	1529-8019
ISSN	1396-0296
DOI	10.1111/dth.13530
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Article ; Online: Plantar herpes zoster following heterologous recombinant adenovirus-based COVID-19 vaccine.

Ayatollahi, Azin / Robati, Reza M / Firooz, Alireza

Journal of cosmetic dermatology

2021 Volume 21, Issue 1, Page(s) 34–35

MeSH term(s)	Adenoviridae ; COVID-19 ; COVID-19 Vaccines ; Herpes Zoster/prevention & control ; Humans ; SARS-CoV-2
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2021-11-10
Publishing country	England
Document type	Letter
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.14605
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Article ; Online: Assessing effectiveness of adding niosomal atorvastatin 1% ointment to topical calcineurin inhibitor treatment in non-segmental vitiligo.

Zartab, Hamed / Aflatoonian, Mahin / Shamsi-Meymandi, Simin / Pardakhty, Abbas / Isazadeh, Ahdie / Firooz, Alireza / Amiri, Rezvan

Journal of cosmetic dermatology

2024

Abstract: Background: Treatment of vitiligo is still a big challenge for dermatologists. The efficacy of statins in the treatment of vitiligo is controversial.: Aim and objective: We studied possible therapeutic effect of topical 1% niosomal atorvastatin ... ...

Abstract	Background: Treatment of vitiligo is still a big challenge for dermatologists. The efficacy of statins in the treatment of vitiligo is controversial. Aim and objective: We studied possible therapeutic effect of topical 1% niosomal atorvastatin ointment combined with topical 0.1% tacrolimus in treatment of non-segmental vitiligo. Methods: This is a triple blind, pilot, randomized placebo-controlled trial (RCT) that was performed in dermatology clinic. All the patients used topical 0.1% tacrolimus cream twice daily (BD). Moreover, the intervention group participants used topical 1% niosomal atorvastatin ointment, and control group participants were prescribed placebo ointment, BD. Patients were evaluated using vitiligo area surface index (VASI) score and patients' satisfaction at baseline and after 3 months treatment. Results: The mean patient satisfaction in the intervention and control groups were 5 ± 1.4 and 3.5 ± 1.9; the difference between groups was not statistically significant (p = 0.9). We found statistically significant difference in VASI score before and after treatment in both intervention and control groups (p = 0.01 and p = 0.03, respectively). However, comparison of the VASI score between groups was not statistically significant (p = 0.62). We also found no significant correlation between VASI score and other variables. Conclusion: The result of this study indicates that adding of niosomal atorvastatin 1% ointment to topical calcineurin inhibitor has no additional effect on non-segmental type of vitiligo. Further large studies with different combinations are recommended before any conclusive result can be concluded on efficacy of statins in vitiligo.
Language	English
Publishing date	2024-02-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.16227
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Article ; Online: The effect of an oral product containing Amla fruit (Phyllanthus emblica L.) on female androgenetic alopecia: A randomized controlled trial.

Akhbari, Marzieh / Firooz, Alireza / Rahimi, Roja / Shirzad, Meysam / Esmaealzadeh, Niusha / Shirbeigi, Laila

Journal of ethnopharmacology

2023 Volume 318, Issue Pt A, Page(s) 116958

Abstract: Ethnopharmacological relevance: Amla (Phyllanthus emblica) fruit has been emphasized as a hair tonic in Traditional Persian Medicine (TPM) and recommended for hair loss orally and topically.: Aim of the study: This study aimed to investigate the ... ...

Abstract	Ethnopharmacological relevance: Amla (Phyllanthus emblica) fruit has been emphasized as a hair tonic in Traditional Persian Medicine (TPM) and recommended for hair loss orally and topically. Aim of the study: This study aimed to investigate the effect of an oral product containing Amla fruit on Female Androgenetic Alopecia (FAGA). Materials and methods: This study was a triple-blind, randomized, controlled clinical trial. Sixty women with FAGA were randomly assigned into two groups of thirty. The intervention group received ten cc Amla syrup thrice a day for 12 weeks. The second group received a placebo with the same dose and duration. Hair growth parameters were analyzed using TrichoScan before and after 12 weeks of intervention. Physician and patient satisfaction were assessed using the CGI-I and PGI-I questionnaires, respectively. Results: Twenty-seven participants in the intervention group and 25 in the placebo group completed the trial. Based on our findings, the anagen-to-telogen ratio increased significantly in the intervention group compared with the group who received placebo (F = 10.4, P = 0.002). Physician and patient satisfaction increased in the amla group compared with placebo at 12th weeks of intervention (P<0.001), (P<0.001). The formula had no remarkable side effects. Only one case of mild constipation was reported in one of the participants after one month of consuming Amla syrup. Conclusion: The results of this study demonstrated that Amla syrup could help treat androgenic hair loss in women and increase the anagen phase. Further studies are needed to evaluate this potential treatment for FAGA.
MeSH term(s)	Humans ; Female ; Phyllanthus emblica ; Fruit ; Alopecia/drug therapy ; Medicine, Traditional ; Double-Blind Method
Language	English
Publishing date	2023-07-23
Publishing country	Ireland
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116958
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Article ; Online: Assessment of efficacy of carboxytherapy in management of skin aging through evaluation of gene expression profile: a 2-split randomized clinical trial.

Bagherani, Nooshin / Firooz, Alireza / Ghanadan, Alireza / Smoller, Bruce R / Mirmomeni, Golshan / Shojaei, Reza / Mondanizadeh, Mahdieh / Tavoosidana, Gholamreza

Archives of dermatological research

2023 Volume 315, Issue 9, Page(s) 2575–2584

Abstract: Skin aging is a continuous and irreversible process which results in impairment of the skin role as barrier against all aggressive exogenous factors. It mainly manifests by photoaging, laxity, sagging, wrinkling, and xerosis. Carboxytherapy is considered ...

Abstract	Skin aging is a continuous and irreversible process which results in impairment of the skin role as barrier against all aggressive exogenous factors. It mainly manifests by photoaging, laxity, sagging, wrinkling, and xerosis. Carboxytherapy is considered as a safe, minimally invasive modality used for rejuvenation, restoration, and recondition of the skin. In the current study, the efficacy of carboxytherapy in the treatment of skin aging was assessed through investigation of gene expression profile for Coll I, Coll III, Coll IV, elastin, FGF, TGF-β1, and VEGF. Our study is a 2-split clinical trial in which carboxytherapy was performed on one side of the abdomen in 15 cases with intrinsically skin aging manifestations weekly for 10 sessions, while the other side of the abdomen was left without treatment. Two weeks after the last session, skin biopsies were taken from both the treated and control sides of the abdomen in order to assess gene expression profile by qRT-PCR. The analysis of gene expression levels for all of Coll I, Coll III, Coll IV, elastin, TGF-β1, FGF and VEGF genes showed a statistically significant difference between the interventional and control groups. The findings for all of these seven genes showed increase in the interventional group, among which Coll IV, VEGF, FGF, and elastin showed the higher mean changes. Our study confirmed the effectiveness of carboxytherapy in treating and reversing the intrinsically aging skin.Clinical Trial Registration Code and Date of Registration: ChiCTR2200055185; 2022/1/2.
MeSH term(s)	Humans ; Skin Aging/genetics ; Elastin ; Transforming Growth Factor beta1/genetics ; Transcriptome ; Vascular Endothelial Growth Factor A/genetics ; Treatment Outcome
Chemical Substances	Elastin (9007-58-3) ; Transforming Growth Factor beta1 ; Vascular Endothelial Growth Factor A
Language	English
Publishing date	2023-07-04
Publishing country	Germany
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	130131-7
ISSN	1432-069X ; 0340-3696
ISSN (online)	1432-069X
ISSN	0340-3696
DOI	10.1007/s00403-023-02656-9
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Article ; Online: The Overlap between Genetic Susceptibility to COVID-19 and Skin Diseases.

Jabalameli, Navid / Rajabi, Fateme / Firooz, Alireza / Rezaei, Nima

Immunological investigations

2021 Volume 51, Issue 4, Page(s) 1087–1094

Abstract: Coronavirus disease 2019 (COVID-19) mainly affects the respiratory system, but the involvement of other organ systems has also been commonly reported. Acute acro-ischemia or chilblain like lesions were among the first recognized dermatological ... ...

Abstract	Coronavirus disease 2019 (COVID-19) mainly affects the respiratory system, but the involvement of other organ systems has also been commonly reported. Acute acro-ischemia or chilblain like lesions were among the first recognized dermatological presentations of COVID-19. Though the occurrence of such lesions has been attributed to the similar interferon-1 mediated immune response in both COVID-19 and systemic lupus erythematosus, we propose another possible explanation based on a common genetic background. In a recent genome-wide association study, the 3p21.31 region was found to be associated with COVID-19 severity. This region also contains the
MeSH term(s)	COVID-19/genetics ; Chromosomes, Human, Pair 3 ; Exodeoxyribonucleases/genetics ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Lupus Erythematosus, Cutaneous/genetics ; Lupus Erythematosus, Cutaneous/pathology ; Lupus Erythematosus, Systemic ; Phosphoproteins/genetics ; Severity of Illness Index
Chemical Substances	Phosphoproteins ; Exodeoxyribonucleases (EC 3.1.-) ; three prime repair exonuclease 1 (EC 3.1.16.-)
Language	English
Publishing date	2021-01-26
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	632565-8
ISSN	1532-4311 ; 0882-0139
ISSN (online)	1532-4311
ISSN	0882-0139
DOI	10.1080/08820139.2021.1876086
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