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Book: Sodium and water homeostasis

Hyndman, Kelly Anne / Pannabecker, Thomas L.

comparative, evolutionary and genetic models

(Physiology in health and disease)

2015

Author's details	Kelly Anne Hyndman ; Thomas L. Pannabecker ed
Series title	Physiology in health and disease
Keywords	Homeostasis
Subject code	612.022
Language	English
Size	VI, 325 S. : Ill., graph. Darst.
Publisher	Springer
Publishing place	New York u.a.
Publishing country	United States
Document type	Book
HBZ-ID	HT018811002
ISBN	978-1-4939-3212-2 ; 978-1-4939-3213-9 ; 1-4939-3212-8 ; 1-4939-3213-6
Database	Catalogue ZB MED Medicine, Health

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2015 A 3872	available for loan (reading room)	Lesesaal EG

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Article ; Online: Renal vascular pericytes: long overlooked and poorly understood, but clearly important, and what about those regulatory pathways?

Pannabecker, Thomas L

American journal of physiology. Renal physiology

2017 Volume 314, Issue 1, Page(s) F67–F69

MeSH term(s)	Animals ; Blood Vessels/pathology ; Humans ; Ischemia ; Kidney/blood supply ; Kidney/injuries ; Mice ; Pericytes/metabolism ; Pericytes/pathology
Language	English
Publishing date	2017-09-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	603837-2
ISSN	1522-1466 ; 0363-6127
ISSN (online)	1522-1466
ISSN	0363-6127
DOI	10.1152/ajprenal.00468.2017
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Article ; Online: Aquaporins in desert rodent physiology.

Pannabecker, Thomas L

The Biological bulletin

2015 Volume 229, Issue 1, Page(s) 120–128

Abstract: Desert rodents face a sizeable challenge in maintaining salt and water homeostasis due to their life in an arid environment. A number of their organ systems exhibit functional characteristics that limit water loss above that which occurs in non-desert ... ...

Abstract	Desert rodents face a sizeable challenge in maintaining salt and water homeostasis due to their life in an arid environment. A number of their organ systems exhibit functional characteristics that limit water loss above that which occurs in non-desert species under similar conditions. These systems include renal, pulmonary, gastrointestinal, nasal, and skin epithelia. The desert rodent kidney preserves body water by producing a highly concentrated urine that reaches a maximum osmolality nearly three times that of the common laboratory rat. The precise mechanism by which urine is concentrated in any mammal is unknown. Insights into the process may be more apparent in species that produce highly concentrated urine. Aquaporin water channels play a fundamental role in water transport in several desert rodent organ systems. The role of aquaporins in facilitating highly effective water preservation in desert rodents is only beginning to be explored. The organ systems of desert rodents and their associated AQPs are described.
MeSH term(s)	Animals ; Aquaporins/genetics ; Aquaporins/metabolism ; Desert Climate ; Gastrointestinal Tract/physiology ; Kidney/physiology ; Mice ; Rats ; Rodentia/physiology
Chemical Substances	Aquaporins
Language	English
Publishing date	2015-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	1268-3
ISSN	1939-8697 ; 0006-3185 ; 0148-9488
ISSN (online)	1939-8697
ISSN	0006-3185 ; 0148-9488
DOI	10.1086/BBLv229n1p120
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Article ; Online: Mammalian urine concentration: a review of renal medullary architecture and membrane transporters.

Nawata, C Michele / Pannabecker, Thomas L

Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology

2018 Volume 188, Issue 6, Page(s) 899–918

Abstract: Mammalian kidneys play an essential role in balancing internal water and salt concentrations. When water needs to be conserved, the renal medulla produces concentrated urine. Central to this process of urine concentration is an osmotic gradient that ... ...

Abstract	Mammalian kidneys play an essential role in balancing internal water and salt concentrations. When water needs to be conserved, the renal medulla produces concentrated urine. Central to this process of urine concentration is an osmotic gradient that increases from the corticomedullary boundary to the inner medullary tip. How this gradient is generated and maintained has been the subject of study since the 1940s. While it is generally accepted that the outer medulla contributes to the gradient by means of an active process involving countercurrent multiplication, the source of the gradient in the inner medulla is unclear. The last two decades have witnessed advances in our understanding of the urine-concentrating mechanism. Details of medullary architecture and permeability properties of the tubules and vessels suggest that the functional and anatomic relationships of these structures may contribute to the osmotic gradient necessary to concentrate urine. Additionally, we are learning more about the membrane transporters involved and their regulatory mechanisms. The role of medullary architecture and membrane transporters in the mammalian urine-concentrating mechanism are the focus of this review.
MeSH term(s)	Animals ; Humans ; Kidney Medulla/anatomy & histology ; Kidney Medulla/physiology ; Membrane Transport Proteins/physiology ; Urine
Chemical Substances	Membrane Transport Proteins
Language	English
Publishing date	2018-05-24
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	231245-1
ISSN	1432-136X ; 0174-1578
ISSN (online)	1432-136X
ISSN	0174-1578
DOI	10.1007/s00360-018-1164-3
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Article ; Online: Structure and function of the thin limbs of the loop of Henle.

Pannabecker, Thomas L

Comprehensive Physiology

2013 Volume 2, Issue 3, Page(s) 2063–2086

Abstract: The thin limbs of the loop of Henle, which comprise the intermediate segment, connect the proximal tubule to the distal tubule and lie entirely within the renal medulla. The descending thin limb consists of at least two or three morphologically and ... ...

Abstract	The thin limbs of the loop of Henle, which comprise the intermediate segment, connect the proximal tubule to the distal tubule and lie entirely within the renal medulla. The descending thin limb consists of at least two or three morphologically and functionally distinct subsegments and participates in transepithelial transport of NaCl, urea, and water. Only one functionally distinct segment is recognized for the ascending thin limb, which carries out transepithelial transport of NaCl and urea in the reabsorptive and/or secretory directions. Membrane transporters involved with passive transcellular Cl, urea, and water fluxes have been characterized for thin limbs; however, these pathways do not account for all transepithelial fluid and solute fluxes that have been measured in vivo. The paracellular pathway has been proposed to play an important role in transepithelial Na and urea fluxes in defined thin-limb subsegments. As the transport pathways become clearer, the overall function of the thin limbs is becoming better understood. Primary and secondary signaling pathways and protein-protein interactions are increasingly recognized as important modulators of thin-limb cell function and cell metabolism. These functions must be investigated under diverse extracellular conditions, particularly for those cells of the deep inner medulla that function in an environment of wide variation in hyperosmolality. Transgenic mouse models of several key water and solute transport proteins have provided significant insights into thin-limb function. An understanding of the overall architecture of the medulla, including juxtapositions of thin limbs with collecting ducts, thick ascending limbs, and vasa recta, is essential for understanding the role of the kidney in maintaining Na and water homeostasis, and for understanding the urine concentrating mechanism.
MeSH term(s)	Animals ; Chlorides/metabolism ; Cytoskeletal Proteins/metabolism ; Humans ; Ion Channels/metabolism ; Ion Pumps/metabolism ; Ion Transport ; Loop of Henle/metabolism ; Loop of Henle/ultrastructure ; Mice ; Urea/metabolism
Chemical Substances	Chlorides ; Cytoskeletal Proteins ; Ion Channels ; Ion Pumps ; Urea (8W8T17847W)
Language	English
Publishing date	2013-05-31
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ISSN	2040-4603
ISSN (online)	2040-4603
DOI	10.1002/cphy.c110019
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Article ; Online: Comparative physiology and architecture associated with the mammalian urine concentrating mechanism: role of inner medullary water and urea transport pathways in the rodent medulla.

Pannabecker, Thomas L

American journal of physiology. Regulatory, integrative and comparative physiology

2013 Volume 304, Issue 7, Page(s) R488–503

Abstract: Comparative studies of renal structure and function have potential to provide insights into the urine-concentrating mechanism of the mammalian kidney. This review focuses on the tubular transport pathways for water and urea that play key roles in fluid ... ...

Abstract	Comparative studies of renal structure and function have potential to provide insights into the urine-concentrating mechanism of the mammalian kidney. This review focuses on the tubular transport pathways for water and urea that play key roles in fluid and solute movements between various compartments of the rodent renal inner medulla. Information on aquaporin water channel and urea transporter expression has increased our understanding of functional segmentation of medullary thin limbs of Henle's loops, collecting ducts, and vasa recta. A more complete understanding of membrane transporters and medullary architecture has identified new and potentially significant interactions between these structures and the interstitium. These interactions are now being introduced into our concept of how the inner medullary urine-concentrating mechanism works. A variety of regulatory pathways lead directly or indirectly to variable patterns of fluid and solute movements among the interstitial and tissue compartments. Animals with the ability to produce highly concentrated urine, such as desert species, are considered to exemplify tubular structure and function that optimize urine concentration. These species may provide unique insights into the urine-concentrating process.(1)
MeSH term(s)	Animals ; Biological Transport/physiology ; Kidney Medulla/anatomy & histology ; Kidney Medulla/blood supply ; Kidney Medulla/physiology ; Nephrons/anatomy & histology ; Nephrons/blood supply ; Nephrons/physiology ; Rodentia/anatomy & histology ; Rodentia/physiology ; Urea/metabolism ; Water/metabolism
Chemical Substances	Water (059QF0KO0R) ; Urea (8W8T17847W)
Language	English
Publishing date	2013-01-30
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	603839-6
ISSN	1522-1490 ; 0363-6119
ISSN (online)	1522-1490
ISSN	0363-6119
DOI	10.1152/ajpregu.00456.2012
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Article ; Online: Expression of SLC4A11 protein in mouse and rat medulla: a candidate transporter involved in outer medullary ammonia recycling.

Gee, Michael T / Kurtz, Ira / Pannabecker, Thomas L

Physiological reports

2019 Volume 7, Issue 10, Page(s) e14089

Abstract: SLC4A11 is a multifunctional membrane transporter involved with ... ...

Abstract	SLC4A11 is a multifunctional membrane transporter involved with H
MeSH term(s)	Ammonia/metabolism ; Animals ; Anion Transport Proteins/metabolism ; Antiporters/metabolism ; Aquaporin 1/metabolism ; Kidney Medulla/metabolism ; Loop of Henle/metabolism ; Membrane Transport Proteins/metabolism ; Mice, Inbred ICR ; Rats, Wistar ; Renal Elimination ; Renal Reabsorption ; Species Specificity ; Symporters/metabolism ; Urea Transporters
Chemical Substances	Anion Transport Proteins ; Antiporters ; Aqp1 protein, mouse ; Aqp1 protein, rat ; Membrane Transport Proteins ; Slc4a11 protein, mouse ; Slc4a11 protein, rat ; Symporters ; urea transporter B, mouse ; Aquaporin 1 (146410-94-8) ; Ammonia (7664-41-7)
Language	English
Publishing date	2019-06-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2724325-4
ISSN	2051-817X ; 2051-817X
ISSN (online)	2051-817X
ISSN	2051-817X
DOI	10.14814/phy2.14089
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Article ; Online: Ca2+ and cAMP signaling pathways interact to increase the diuretic effect of serotonin in Malpighian tubules of the kissing bug. Focus on "Serotonin triggers cAMP- and PKA-1-mediated intracellular calcium waves in Malpighian tubules of Rhodnius prolixus".

Pannabecker, Thomas L / Beyenbach, Klaus W

American journal of physiology. Regulatory, integrative and comparative physiology

2014 Volume 307, Issue 7, Page(s) R819–21

MeSH term(s)	8-Bromo Cyclic Adenosine Monophosphate/pharmacology ; Animals ; Calcium/metabolism ; Cyclic AMP/metabolism ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Ion Transport/drug effects ; Malpighian Tubules/metabolism ; Serotonin/pharmacology
Chemical Substances	8-Bromo Cyclic Adenosine Monophosphate (23583-48-4) ; Serotonin (333DO1RDJY) ; Cyclic AMP (E0399OZS9N) ; Cyclic AMP-Dependent Protein Kinases (EC 2.7.11.11) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2014-08-20
Publishing country	United States
Document type	Editorial ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
ZDB-ID	603839-6
ISSN	1522-1490 ; 0363-6119
ISSN (online)	1522-1490
ISSN	0363-6119
DOI	10.1152/ajpregu.00336.2014
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Article ; Online: Targeted delivery of solutes and oxygen in the renal medulla: role of microvessel architecture.

Pannabecker, Thomas L / Layton, Anita T

American journal of physiology. Renal physiology

2014 Volume 307, Issue 6, Page(s) F649–55

Abstract: Renal medullary function is characterized by corticopapillary concentration gradients of various molecules. One example is the generally decreasing axial gradient in oxygen tension (Po2). Another example, found in animals in the antidiuretic state, is a ... ...

Abstract	Renal medullary function is characterized by corticopapillary concentration gradients of various molecules. One example is the generally decreasing axial gradient in oxygen tension (Po2). Another example, found in animals in the antidiuretic state, is a generally increasing axial solute gradient, consisting mostly of NaCl and urea. This osmolality gradient, which plays a principal role in the urine concentrating mechanism, is generally considered to involve countercurrent multiplication and countercurrent exchange, although the underlying mechanism is not fully understood. Radial oxygen and solute gradients in the transverse dimension of the medullary parenchyma have been hypothesized to occur, although strong experimental evidence in support of these gradients remains lacking. This review considers anatomic features of the renal medulla that may impact the formation and maintenance of oxygen and solute gradients. A better understanding of medullary architecture is essential for more clearly defining the compartment-to-compartment flows taken by fluid and molecules that are important in producing axial and radial gradients. Preferential interactions between nephron and vascular segments provide clues as to how tubular and interstitial oxygen flows contribute to safeguarding active transport pathways in renal function in health and disease.
MeSH term(s)	Animals ; Humans ; Kidney Medulla/blood supply ; Kidney Medulla/metabolism ; Microvessels/anatomy & histology ; Oxygen/metabolism
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2014-07-23
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	603837-2
ISSN	1522-1466 ; 0363-6127
ISSN (online)	1522-1466
ISSN	0363-6127
DOI	10.1152/ajprenal.00276.2014
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Article: Loop of Henle interaction with interstitial nodal spaces in the renal inner medulla.

Pannabecker, Thomas L

American journal of physiology. Renal physiology

2008 Volume 295, Issue 6, Page(s) F1744–51

Abstract: Understanding dynamics of NaCl reabsorption from loops of Henle, and cellular and physiological consequences, requires a clear understanding of the structural relationships of loops with other functional elements of the inner medulla (IM). Pathways taken ...

Abstract	Understanding dynamics of NaCl reabsorption from loops of Henle, and cellular and physiological consequences, requires a clear understanding of the structural relationships of loops with other functional elements of the inner medulla (IM). Pathways taken by ascending thin limbs (ATLs) and prebend segments along the corticopapillary axis were evaluated for the outer zone of the IM of the Munich-Wistar rat. Connectivity between these segments and microdomains of interstitium adjacent to collecting ducts (CDs) and abutting ascending vasa recta (interstitial nodal spaces) was assessed by evaluating their physical contacts. For each secondary CD cluster, the number of contacts made between the total population of ATLs and interstitial nodal spaces declines as a function of depth below the outer medulla (OM)-IM boundary at near the same exponential rate that loop number declines. The proportion of each loop that makes contact with nodal spaces is inversely related to loop length. Prebend and postbend equivalent length ATL segments lie in contact with an interstitial nodal space along nearly their entire lengths. The number of contacts made by the total population of prebend or postbend segments exhibits a marked, periodic increase and decrease as a function of depth below the OM-IM boundary; this number of contacts correlates with equivalent periodic changes in prebend number. Simulations of loop distribution indicate that small discontinuities in loop distribution contribute to periodic changes in prebend number. Convergence of IM loop bends within CD clusters likely plays an essential role in NaCl compartmentalization by promoting NaCl reabsorption near interstitial regions lying adjacent to CDs and ascending vasa recta.
MeSH term(s)	Absorption ; Animals ; Kidney Cortex/anatomy & histology ; Kidney Cortex/physiology ; Kidney Medulla/anatomy & histology ; Kidney Medulla/physiology ; Loop of Henle/anatomy & histology ; Loop of Henle/physiology ; Male ; Models, Anatomic ; Rats ; Rats, Wistar ; Sodium Chloride/metabolism
Chemical Substances	Sodium Chloride (451W47IQ8X)
Language	English
Publishing date	2008-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	603837-2
ISSN	1522-1466 ; 1931-857X ; 0363-6127
ISSN (online)	1522-1466
ISSN	1931-857X ; 0363-6127
DOI	10.1152/ajprenal.90483.2008
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