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  1. Article ; Online: Advanced practice provider-led clinic for care transitions in newly diagnosed venous thromboembolism: establishment and utilization.

    Frank, Cassiopeia / Kasthuri, Raj / Key, Nigel S / Mooberry, Micah / Wilson, Samuel R / Moll, Stephan

    Research and practice in thrombosis and haemostasis

    2023  Volume 7, Issue 4, Page(s) 100198

    Abstract: Background: Patients with suspected or newly diagnosed venous thromboembolism (VTE) are often referred to the emergency department (ED) for management, where anticoagulation is initiated. However, when the patient is judged to be suitable for outpatient ...

    Abstract Background: Patients with suspected or newly diagnosed venous thromboembolism (VTE) are often referred to the emergency department (ED) for management, where anticoagulation is initiated. However, when the patient is judged to be suitable for outpatient management, counseling and follow-up specialty care are frequently suboptimal.
    Objectives: To establish an advanced practice provider (APP)-led rapid follow-up clinic to improve transitions of care for patients with newly diagnosed deep vein thrombosis or low-risk pulmonary embolism and to provide continued specialty care and support, including management of complications and medication access issues.
    Methods: In order to address this gap in transition of care, we developed an APP-led clinic with a mandate to improve quality and safety in the outpatient setting for patients with acute VTE.
    Results: In the first 2 years, a total of 234 patients were evaluated, of whom data were standardized and reviewed for 229. Utilization steadily increased over time, with at least 10% of patients requiring financial medication assistance over both years. Seventy-two percent of patients were referred from the ED in the first year and 59% in the second year, and referrals from non-ED outpatient specialties increased. Data on deviations from standard care identified in referred patients were collected in the second year and found in 19 (12.7%) of cases. These included unnecessarily prescribed or changed anticoagulants, dosing errors, misclassification of thrombosis, and other deviations. Patient demographic data also demonstrated increasing diversity of the patient population over time, with increased utilization by Hispanic and African American patients in the second year. This highlighted the need for better patient education material translations into Spanish, which is a future aim.
    Conclusion: In summary, the APP-led VTE Transition Clinic was feasible and grew quickly in utilization, diversity of referrals, and diversity of patients served.
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Journal Article
    ISSN 2475-0379
    ISSN (online) 2475-0379
    DOI 10.1016/j.rpth.2023.100198
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hereditary hemorrhagic telangiectasia (HHT): a practical guide to management.

    Hammill, Adrienne M / Wusik, Katie / Kasthuri, Raj S

    Hematology. American Society of Hematology. Education Program

    2021  Volume 2021, Issue 1, Page(s) 469–477

    Abstract: Hereditary hemorrhagic telangiectasia (HHT), the second most common inherited bleeding disorder, is associated with the development of malformed blood vessels. Abnormal blood vessels may be small and cutaneous or mucosal (telangiectasia), with frequent ... ...

    Abstract Hereditary hemorrhagic telangiectasia (HHT), the second most common inherited bleeding disorder, is associated with the development of malformed blood vessels. Abnormal blood vessels may be small and cutaneous or mucosal (telangiectasia), with frequent complications of bleeding, or large and visceral (arteriovenous malformations [AVMs]), with additional risks that can lead to significant morbidity and even mortality. HHT can present in many different ways and can be difficult to recognize, particularly in younger patients in the absence of a known family history of disease or epistaxis, its most common manifestation. HHT is commonly diagnosed using the established Curaçao clinical criteria, which include (1) family history, (2) recurrent epistaxis, (3) telangiectasia, and (4) visceral AVMs. Fulfillment of 3 or more criteria provides a definite diagnosis of HHT, whereas 2 criteria constitute a possible diagnosis of HHT. However, these criteria are insufficient in children to rule out disease due to the age-dependent development of some of these criteria. Genetic testing, when positive, can provide definitive diagnosis of HHT in all age groups. Clinical course is often complicated by significant epistaxis and/or gastrointestinal bleeding, leading to anemia in half of adult patients with HHT. The management paradigm has recently shifted from surgical approaches to medical treatments aimed at control of chronic bleeding, such as antifibrinolytic and antiangiogenic agents, combined with aggressive iron replacement with intravenous iron. Guidelines for management of HHT, including screening and treatment, were determined by expert consensus and originally published in 2009 with updates and new guidelines in 2020.
    MeSH term(s) Adolescent ; Anemia/complications ; Anemia/diagnosis ; Anemia/therapy ; Disease Management ; Epistaxis/complications ; Epistaxis/diagnosis ; Epistaxis/therapy ; Female ; Gastrointestinal Hemorrhage/complications ; Gastrointestinal Hemorrhage/diagnosis ; Gastrointestinal Hemorrhage/therapy ; Humans ; Pregnancy ; Pregnancy Complications, Hematologic/diagnosis ; Pregnancy Complications, Hematologic/therapy ; Telangiectasia, Hereditary Hemorrhagic/complications ; Telangiectasia, Hereditary Hemorrhagic/diagnosis ; Telangiectasia, Hereditary Hemorrhagic/therapy
    Language English
    Publishing date 2021-12-18
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2084287-9
    ISSN 1520-4383 ; 1520-4391
    ISSN (online) 1520-4383
    ISSN 1520-4391
    DOI 10.1182/hematology.2021000281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Platelet transfusion for patients with platelet dysfunction: effectiveness, mechanisms, and unanswered questions.

    Lee, Robert H / Kasthuri, Raj S / Bergmeier, Wolfgang

    Current opinion in hematology

    2020  Volume 27, Issue 6, Page(s) 378–385

    Abstract: Purpose of review: In this review, we discuss current clinical guidelines and potential underlying mechanisms regarding platelet transfusion therapy in patients at risk of bleeding, comparing management of patients with thrombocytopenia versus those ... ...

    Abstract Purpose of review: In this review, we discuss current clinical guidelines and potential underlying mechanisms regarding platelet transfusion therapy in patients at risk of bleeding, comparing management of patients with thrombocytopenia versus those with qualitative platelet disorders.
    Recent findings: Platelet transfusion therapy is highly effective in managing bleeding in patients with hypoproliferative thrombocytopenia. Clinical trials have demonstrated that platelet transfusion can be used at a lower trigger threshold and reduced platelet doses, and may be used therapeutically rather than prophylactically in some situations, although additional data are needed. In patients with inherited platelet disorders such as Glanzmann's Thrombasthenia or those with RASGRP2 mutations, platelet transfusion may be ineffective because of competition between transfused and endogenous platelets at the site of vascular injury. Successful management of these patients may require transfusion of additional platelet units, or mechanism-driven combination therapy with other pro-hemostatic agents. In patients on antiplatelet therapy, timing of transfusion and inhibitor mechanism-of-action are key in determining therapeutic success.
    Summary: Expanding our understanding of the mechanisms by which transfused platelets exert their pro-hemostatic function in various bleeding disorders will improve the appropriate use of platelet transfusion.
    MeSH term(s) Animals ; Blood Platelet Disorders/blood ; Blood Platelet Disorders/therapy ; Hemorrhage/blood ; Hemorrhage/therapy ; Hemostasis/drug effects ; Hemostatics/therapeutic use ; Humans ; Platelet Aggregation Inhibitors/therapeutic use ; Platelet Transfusion/methods
    Chemical Substances Hemostatics ; Platelet Aggregation Inhibitors
    Language English
    Publishing date 2020-08-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1153887-9
    ISSN 1531-7048 ; 1065-6251
    ISSN (online) 1531-7048
    ISSN 1065-6251
    DOI 10.1097/MOH.0000000000000608
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Emicizumab reduces re-hospitalization for bleeding in acquired haemophilia A.

    Chen, Sheh-Li / Ellsworth, Patrick / Kasthuri, Raj S / Moll, Stephan / Ma, Alice D / Key, Nigel S

    Haemophilia : the official journal of the World Federation of Hemophilia

    2021  Volume 27, Issue 4, Page(s) e585–e588

    MeSH term(s) Antibodies, Bispecific ; Antibodies, Monoclonal, Humanized/therapeutic use ; Hemophilia A/complications ; Hemophilia A/drug therapy ; Hospitalization ; Humans
    Chemical Substances Antibodies, Bispecific ; Antibodies, Monoclonal, Humanized ; emicizumab (7NL2E3F6K3)
    Language English
    Publishing date 2021-05-29
    Publishing country England
    Document type Letter
    ZDB-ID 1229713-6
    ISSN 1365-2516 ; 1351-8216 ; 1355-0691
    ISSN (online) 1365-2516
    ISSN 1351-8216 ; 1355-0691
    DOI 10.1111/hae.14335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Initiating and Managing Patients with Venous Thromboembolism on Anticoagulant Drugs: A Practical Overview.

    Kasthuri, Raj S / Moll, Stephan

    Seminars in interventional radiology

    2017  Volume 34, Issue 1, Page(s) 3–10

    Abstract: Several new oral anticoagulants have recently been approved for the treatment of venous thromboembolism (VTE). In this review, we discuss the currently approved drugs and the factors that influence the choice of anticoagulant in a given patient. Once ... ...

    Abstract Several new oral anticoagulants have recently been approved for the treatment of venous thromboembolism (VTE). In this review, we discuss the currently approved drugs and the factors that influence the choice of anticoagulant in a given patient. Once anticoagulation is initiated, periodic monitoring of adequacy of anticoagulation may be necessary depending on the choice of anticoagulant and patient-related factors, such as renal function. Situations that may warrant need for monitoring and the tests available for this purpose are discussed. We review reversal of anticoagulation in urgent/emergent situations as well as perioperative anticoagulation interruption in the elective setting. The data on use of direct oral anticoagulants in patients with compromised renal function, obesity and bariatric surgery, and in the treatment of cancer-associated thrombosis are discussed. The review aims to provide the clinician with the essential information to allow effective and safe use of anticoagulants for the treatment of VTE.
    Language English
    Publishing date 2017-03-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 848341-3
    ISSN 1098-8963 ; 0739-9529
    ISSN (online) 1098-8963
    ISSN 0739-9529
    DOI 10.1055/s-0036-1597758
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Cancer Therapy-Associated Thrombosis.

    Grover, Steven P / Hisada, Yohei M / Kasthuri, Raj S / Reeves, Brandi N / Mackman, Nigel

    Arteriosclerosis, thrombosis, and vascular biology

    2021  Volume 41, Issue 4, Page(s) 1291–1305

    Abstract: Figure: see text]. ...

    Abstract [Figure: see text].
    MeSH term(s) Animals ; Antineoplastic Agents/adverse effects ; Arterial Occlusive Diseases/blood ; Arterial Occlusive Diseases/chemically induced ; Arterial Occlusive Diseases/prevention & control ; Blood Coagulation/drug effects ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/metabolism ; Humans ; Molecular Targeted Therapy/adverse effects ; Neoplasms/blood ; Neoplasms/drug therapy ; Platelet Activation/drug effects ; Risk Assessment ; Risk Factors ; Signal Transduction ; Thrombosis/blood ; Thrombosis/chemically induced ; Thrombosis/prevention & control ; Venous Thrombosis/blood ; Venous Thrombosis/chemically induced ; Venous Thrombosis/prevention & control
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2021-02-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.120.314378
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Accuracy of a modified 4Ts score in predicting heparin-induced thrombocytopenia in critically ill patients: A pilot study.

    Powell, Brandon D / Lin, Feng-Chang / Beach, Katherine F / Kasthuri, Raj S / Northam, Kalynn A

    Journal of critical care

    2021  Volume 67, Page(s) 88–94

    Abstract: Purpose: Thrombocytopenia is common among critically ill patients and heparin-induced thrombocytopenia (HIT) is often on the differential. Professional guidelines recommend calculating a pre-test probability score before performing HIT testing. The 4Ts ... ...

    Abstract Purpose: Thrombocytopenia is common among critically ill patients and heparin-induced thrombocytopenia (HIT) is often on the differential. Professional guidelines recommend calculating a pre-test probability score before performing HIT testing. The 4Ts score is widely utilized but accuracy has been questioned in critically ill patients. The HIT Expert Probability (HEP) score is available, but complexity limits use. Our objective was to compare a modified intensive care unit (ICU)-4Ts score to available scoring tools.
    Materials and methods: This was a single-center retrospective pilot study. Adult ICU patients that were tested for HIT and had a documented 4Ts score were included. A blinded investigator retrospectively calculated the HEP and ICU-4Ts score. Receiver operating characteristics (ROC) area under the curve (AUC), sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were compared.
    Results: In 194 included patients, ROC AUC was significantly higher for the ICU-4Ts compared to the 4Ts score (0.80 versus 0.66, respectively; p = 0.044). The ICU-4Ts score had the highest specificity, PPV, and NPV. The sensitivity was similar between the HEP and ICU-4Ts score.
    Conclusions: The ICU-4Ts score better predicted the diagnosis of HIT compared to the 4Ts score. Prospective validation studies are needed to confirm these results.
    MeSH term(s) Adult ; Anticoagulants/adverse effects ; Critical Illness ; Heparin/adverse effects ; Humans ; Pilot Projects ; Retrospective Studies ; Thrombocytopenia/chemically induced ; Thrombocytopenia/diagnosis
    Chemical Substances Anticoagulants ; Heparin (9005-49-6)
    Language English
    Publishing date 2021-11-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 632818-0
    ISSN 1557-8615 ; 0883-9441
    ISSN (online) 1557-8615
    ISSN 0883-9441
    DOI 10.1016/j.jcrc.2021.09.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Secondary Immune Thrombocytopenia in Metastatic Renal Cell Carcinoma: A Case Report and Discussion of the Literature.

    Cockrell, Dillon C / Kasthuri, Raj S / Altun, Ersan / Rose, Tracy L / Milowsky, Matthew I

    Case reports in oncology

    2020  Volume 13, Issue 3, Page(s) 1349–1356

    Abstract: Immune thrombocytopenia (ITP) is a rare paraneoplastic syndrome of solid tumor malignancies. In previously described cases of renal cell carcinoma (RCC) associated with secondary ITP, treatment has consisted of nephrectomy, splenectomy, and ... ...

    Abstract Immune thrombocytopenia (ITP) is a rare paraneoplastic syndrome of solid tumor malignancies. In previously described cases of renal cell carcinoma (RCC) associated with secondary ITP, treatment has consisted of nephrectomy, splenectomy, and corticosteroids. Here, we describe a case of metastatic RCC presenting with a right ventricular mass and subsequent development of secondary ITP. The clinical course was complicated by recurrent severe thrombocytopenia despite treatment with corticosteroids, rituximab, and thrombopoietin receptor agonists, precluding cancer-directed therapy and anticoagulation. Further study is needed to determine the optimal management strategy for malignancy-associated ITP.
    Language English
    Publishing date 2020-11-25
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2458961-5
    ISSN 1662-6575
    ISSN 1662-6575
    DOI 10.1159/000511067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Coagulation Abnormalities and Thrombosis in Patients Infected With SARS-CoV-2 and Other Pandemic Viruses.

    Mackman, Nigel / Antoniak, Silvio / Wolberg, Alisa S / Kasthuri, Raj / Key, Nigel S

    Arteriosclerosis, thrombosis, and vascular biology

    2020  Volume 40, Issue 9, Page(s) 2033–2044

    Abstract: The world is amid a pandemic caused by severe acute respiratory syndrome-coronavirus 2. Severe acute respiratory syndrome-coronavirus causes serious respiratory tract infections that can lead to viral pneumonia, acute respiratory distress syndrome, and ... ...

    Abstract The world is amid a pandemic caused by severe acute respiratory syndrome-coronavirus 2. Severe acute respiratory syndrome-coronavirus causes serious respiratory tract infections that can lead to viral pneumonia, acute respiratory distress syndrome, and death. Some patients with coronavirus disease 2019 (COVID-19) have an activated coagulation system characterized by elevated plasma levels of d-dimer-a biomarker of fibrin degradation. Importantly, high levels of D-dimer on hospital admission are associated with increased risk of mortality. Venous thromboembolism is more common than arterial thromboembolism in hospitalized COVID-19 patients. Pulmonary thrombosis and microvascular thrombosis are observed in autopsy studies, and this may contribute to the severe hypoxia observed in COVID-19 patients. It is likely that multiple systems contribute to thrombosis in COVID-19 patients, such as activation of coagulation, platelet activation, hypofibrinolysis, endothelial cell dysfunction, inflammation, neutrophil extracellular traps, and complement. Targeting these different pathways may reduce thrombosis and improve lung function in COVID-19 patients.
    MeSH term(s) Betacoronavirus ; Blood Coagulation ; Blood Coagulation Disorders/blood ; Blood Coagulation Disorders/complications ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Humans ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Thrombosis/blood ; Thrombosis/etiology
    Keywords covid19
    Language English
    Publishing date 2020-07-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.120.314514
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Effect of chemotherapy and longitudinal analysis of circulating extracellular vesicle tissue factor activity in patients with pancreatic and colorectal cancer.

    Kasthuri, Raj S / Hisada, Yohei / Ilich, Anton / Key, Nigel S / Mackman, Nigel

    Research and practice in thrombosis and haemostasis

    2020  Volume 4, Issue 4, Page(s) 636–643

    Abstract: Introduction: We conducted a longitudinal study in patients with pancreatic and colorectal cancer. We determined the effect of chemotherapy on extracellular vesicle tissue factor (EVTF) activity and the association of plasma EVTF activity with venous ... ...

    Abstract Introduction: We conducted a longitudinal study in patients with pancreatic and colorectal cancer. We determined the effect of chemotherapy on extracellular vesicle tissue factor (EVTF) activity and the association of plasma EVTF activity with venous thromboembolism (VTE) and survival.
    Material and methods: We enrolled 13 patients with pancreatic and 22 patients with colorectal cancer. Plasma samples were collected during the 85-day study period. Patients were followed for 3 months after the study period. We recorded symptomatic VTE during the study period (3 months) or asymptomatic deep vein thrombosis detected by ultrasound at day 85. We measured EVTF activity before and after chemotherapy.
    Results and conclusions: In the pancreatic cancer group, 2 patients had elevated levels of EVTF activity. One of these patients developed symptomatic VTE and died, and the second patient did not have a VTE but died. Chemotherapy decreased EVTF activity in 2 pancreatic patients with high levels. In the colorectal cancer group, 4 patients developed VTE, but EVTF activity was not elevated in any patient and no patient died. We observed a borderline significant correlation between EVTF activity and D-dimer in the patients with pancreatic but not colorectal cancer. In this small descriptive study, 2 patients with pancreatic cancer had an elevated level of EVTF activity. Both patients died during the study period, and one had a VTE. Chemotherapy decreased EVTF activity in these patients. In contrast, elevated levels of EVTF activity were not observed in patients with colorectal cancer with or without VTE.
    Language English
    Publishing date 2020-03-09
    Publishing country United States
    Document type Journal Article
    ISSN 2475-0379
    ISSN (online) 2475-0379
    DOI 10.1002/rth2.12317
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