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Article ; Online: Effect of Moderate-Intense Training and Detraining on Glucose Metabolism, Lipid Profile, and Liver Enzymes in Male Wistar Rats: A Preclinical Randomized Study.

Shakoor, Hira / Kizhakkayil, Jaleel / Khalid, Mariyam / Mahgoub, Amar / Platat, Carine

2023 Volume 15, Issue 17

Abstract: Exercise training positively regulates glucose metabolism. This study investigated the impact of training and detraining on glucose metabolism, lipid profiles, and liver enzymes. Twenty-six rats completed an initial 4-week moderate-intense training (T0- ... ...

Abstract	Exercise training positively regulates glucose metabolism. This study investigated the impact of training and detraining on glucose metabolism, lipid profiles, and liver enzymes. Twenty-six rats completed an initial 4-week moderate-intense training (T0-T4). Then, the animals were randomly assigned to two groups at the end of week 4: AT4: detraining for 8 weeks; AT8: training for 8 weeks and 4-week detraining. Six animals were sacrificed at T0 and T4, four animals/group at T8, and three/group at T12. The study continued for 12 weeks, and all parameters were assessed at T0, T4, T8, and T12. IPGTT significantly improved after 4 weeks of training (
MeSH term(s)	Animals ; Male ; Rats ; Glucose ; Liver ; Pyruvic Acid ; Rats, Wistar ; Triglycerides
Chemical Substances	Glucose (IY9XDZ35W2) ; Pyruvic Acid (8558G7RUTR) ; Triglycerides
Language	English
Publishing date	2023-08-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15173820
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Reduction in Average Length-of-Stay in Emergency Department of a Low-Income Country's Cancer Hospital.

Shakoor, Qurratulain / Hafeez, Haroon / Saleem, Atif / Khanzada, Zubair Shabbir / Safir, Hira / Ajmal, Zainab / Sajjad, Kashif

Journal of cancer & allied specialties

2024 Volume 10, Issue 1, Page(s) 537

Abstract: Introduction: Prolonged length of stay (LOS) in emergency departments (ED) is a widespread problem in every hospital around the globe. Multiple factors cause it and can have a negative impact on the quality of care provided to the patients and the ... ...

Abstract	Introduction: Prolonged length of stay (LOS) in emergency departments (ED) is a widespread problem in every hospital around the globe. Multiple factors cause it and can have a negative impact on the quality of care provided to the patients and the patient satisfaction rates. This project aimed to ensure that the average LOS of patients in a tertiary care cancer hospital stays below 3 hours. Materials and methods: The Six Sigma DMAIC (Define, Measure, Analyze, Improve, Control) approach was followed. Results: The average LOS was 166 minutes before implementing interventions. The two primary reasons for the increased length of stay were delays secondary to physician assessment and diagnostic lab reports. Strategies were defined to control these factors, which helped reduce the average length of stay to 142 minutes, a 30% reduction. Conclusion: A process improvement model similar to this project is recommended to enhance the quality of hospital services. It will provide valuable insights into the process flow and assist in gathering precise data on the various steps involved. The data collected can then be analyzed to identify potential causes and make informed decisions that can significantly improve hospital processes.
Language	English
Publishing date	2024-01-22
Publishing country	Pakistan
Document type	Journal Article
ISSN	2411-989X
ISSN (online)	2411-989X
DOI	10.37029/jcas.v10i1.537
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Muscle-Conditioned Medium Containing Protocatechuic Acid Improves Insulin Resistance by Modulating Muscle Communication with Liver and Adipose Tissue.

Shakoor, Hira / Hussein, Haneen / Al-Hassan, Nour / Alketbi, Mouza / Kizhakkayil, Jaleel / Platat, Carine

International journal of molecular sciences

2023 Volume 24, Issue 11

Abstract: Diabetes mellitus is a public health concern, affecting 10.5% of the population. Protocatechuic acid (PCA), a polyphenol, exerts beneficial effects on insulin resistance and diabetes. This study investigated the role of PCA in improving insulin ... ...

Abstract	Diabetes mellitus is a public health concern, affecting 10.5% of the population. Protocatechuic acid (PCA), a polyphenol, exerts beneficial effects on insulin resistance and diabetes. This study investigated the role of PCA in improving insulin resistance and the crosstalk between muscle with liver and adipose tissue. C2C12 myotubes received four treatments: Control, PCA, insulin resistance (IR), and IR-PCA. Conditioned media from C2C12 was used to incubate HepG2 and 3T3-L1 adipocytes. The impact of PCA was analyzed on glucose uptake and signaling pathways. PCA (80 µM) significantly enhanced glucose uptake in C2C12, HepG2, and 3T3-L1 adipocytes (
MeSH term(s)	Mice ; Animals ; Insulin Resistance ; Culture Media, Conditioned/pharmacology ; Culture Media, Conditioned/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; AMP-Activated Protein Kinases/metabolism ; Peroxisome Proliferator-Activated Receptors/metabolism ; Adipose Tissue/metabolism ; Insulin/metabolism ; Muscle Fibers, Skeletal/metabolism ; Liver/metabolism ; Glucose/metabolism ; 3T3-L1 Cells
Chemical Substances	Culture Media, Conditioned ; protocatechuic acid (36R5QJ8L4B) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; Peroxisome Proliferator-Activated Receptors ; Insulin ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2023-05-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24119490
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Article ; Online: The Muscle-Conditioned Medium Containing Protocatechuic Acid Improves Insulin Resistance by Modulating Muscle Communication with Liver and Adipose Tissue

Hira Shakoor / Haneen Hussein / Nour Al-Hassan / Mouza Alketbi / Jaleel Kizhakkayil / Carine Platat

International Journal of Molecular Sciences, Vol 24, Iss 9490, p

2023 Volume 9490

Abstract	Diabetes mellitus is a public health concern, affecting 10.5% of the population. Protocatechuic acid (PCA), a polyphenol, exerts beneficial effects on insulin resistance and diabetes. This study investigated the role of PCA in improving insulin resistance and the crosstalk between muscle with liver and adipose tissue. C2C12 myotubes received four treatments: Control, PCA, insulin resistance (IR), and IR-PCA. Conditioned media from C2C12 was used to incubate HepG2 and 3T3-L1 adipocytes. The impact of PCA was analyzed on glucose uptake and signaling pathways. PCA (80 µM) significantly enhanced glucose uptake in C2C12, HepG2, and 3T3-L1 adipocytes ( p < 0.05). In C2C12, PCA significantly elevated GLUT-4, IRS-1, IRS-2, PPAR-γ, P-AMPK, and P-Akt vs. Control ( p ≤ 0.05), and modulated pathways in IR-PCA. In HepG2, PPAR-γ and P-Akt increased significantly in Control (CM) vs. No CM, and PCA dose upregulated PPAR-γ, P-AMPK, and P-AKT ( p < 0.05). In the 3T3-L1 adipocytes, PI3K and GLUT-4 expression was elevated in PCA (CM) vs. No CM. A significant elevation of IRS-1, GLUT-4, and P-AMPK was observed in IR-PCA vs. IR ( p ≤ 0.001). Herein, PCA strengthens insulin signaling by activating key proteins of that pathway and regulating glucose uptake. Further, conditioned media modulated crosstalk between muscle with liver and adipose tissue, thus regulating glucose metabolism.
Keywords	diabetes mellitus ; protocatechuic acid ; insulin resistance ; glucose uptake ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	571
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Alert! Does Prolonged Temporary Support Induce an Immunological Response?

Shakoor, Hira / Abdelrehim, Ahmad / Maliakkal, Neville / McKean, Staci / Harrison, Caroline / Van Zyl, Johanna / Patel, Raksha / Hall, Shelley / Alam, Amit

JACC. Case reports

2023 Volume 16, Page(s) 101877

Abstract: Little is known about the development of human leukocyte antigen antibodies with use of the temporary transvalvular pump 5.5 mechanical circulatory support device. This case reports a patient who developed de novo antibodies prior to his heart ... ...

Abstract	Little is known about the development of human leukocyte antigen antibodies with use of the temporary transvalvular pump 5.5 mechanical circulatory support device. This case reports a patient who developed de novo antibodies prior to his heart transplantation and remains free of any episodes of rejection post transplantation to date. (
Language	English
Publishing date	2023-05-17
Publishing country	Netherlands
Document type	Case Reports
ISSN	2666-0849
ISSN (online)	2666-0849
DOI	10.1016/j.jaccas.2023.101877
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Antioxidant Potential of Cookies Formulated with Date Seed Powder.

Najjar, Zein / Kizhakkayil, Jaleel / Shakoor, Hira / Platat, Carine / Stathopoulos, Constantinos / Ranasinghe, Meththa

Foods (Basel, Switzerland)

2022 Volume 11, Issue 3

Abstract: Utilising major waste products from the food industry can have both a great environmental impact and be a means to improve consumer health. Date seed is a food industry byproduct that has been proven to have high nutritional value. The aim of this work ... ...

Abstract	Utilising major waste products from the food industry can have both a great environmental impact and be a means to improve consumer health. Date seed is a food industry byproduct that has been proven to have high nutritional value. The aim of this work was to measure the total polyphenolic content (TPC), flavonoids, and antioxidant activity of the seeds of six date fruit varieties,
Language	English
Publishing date	2022-02-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods11030448
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Article: Cancer Patients during COVID-19 Pandemic: A Mini-Review.

Linjawi, Maryam / Shakoor, Hira / Hilary, Serene / Ali, Habiba I / Al-Dhaheri, Ayesha S / Ismail, Leila Cheikh / Apostolopoulos, Vasso / Stojanovska, Lily

Healthcare (Basel, Switzerland)

2023 Volume 11, Issue 2

Abstract: Since its emergence, coronavirus disease 2019 (COVID-19) has affected the entire world and all commerce and industries, including healthcare systems. COVID-19 adversely affects cancer patients because they are immunocompromised. Increased COVID-19 ... ...

Abstract	Since its emergence, coronavirus disease 2019 (COVID-19) has affected the entire world and all commerce and industries, including healthcare systems. COVID-19 adversely affects cancer patients because they are immunocompromised. Increased COVID-19 infection and shortage of medical supplies, beds and healthcare workers in hospitals affect cancer care. This paper includes a description of the existing research that shows the impact of COVID-19 on the management of cancer patients. Aged people with various chronic conditions such as cancer and comorbidities face more challenges as they have a greater risk of disease severity. COVID-19 has affected care delivery, including patient management, and has been responsible for increased mortality among cancer patients. Cancer patients with severe symptoms require regular therapies and treatment; therefore, they have a higher risk of exposure. Due to the risk of transmission, various steps were taken to combat this disease; however, they have affected the existing operational efficiency. Herein, we present the changing priorities during COVID-19, which also affected cancer care, including delayed diagnosis, treatment, and surgeries.
Language	English
Publishing date	2023-01-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare11020248
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Article ; Online: The impact of active cytomegalovirus infection on donor-derived cell-free DNA testing in heart transplant recipients.

Alam, Amit H / Van Zyl, Johanna / Shakoor, Hira I / Farsakh, Dana / Abdelrehim, Ahmad B / Maliakkal, Neville / Jamil, Aayla K / Patel, Raksha / Felius, Joost / McKean, Staci / Hall, Shelley A

Clinical transplantation

2024 Volume 38, Issue 3, Page(s) e15287

Abstract: Background: Little is known about the relationship between cytomegalovirus (CMV) infections and donor-derived cell-free DNA (dd-cfDNA) in heart transplant recipients.: Methods: In our study, CMV and dd-cfDNA results were prospectively collected on ... ...

Abstract	Background: Little is known about the relationship between cytomegalovirus (CMV) infections and donor-derived cell-free DNA (dd-cfDNA) in heart transplant recipients. Methods: In our study, CMV and dd-cfDNA results were prospectively collected on single-organ heart transplant recipients. If the CMV study was positive, a CMV study with dd-cfDNA was repeated 1-3 months later. The primary aim was to compare dd-cfDNA between patients with positive and negative CMV results. Results: Of 44 patients enrolled between August 2022 and April 2023, 12 tested positive for CMV infections, 25 were included as controls, and seven patients with a viral infection without CMV were excluded. Baseline characteristics did not differ significantly between CMV-positive and CMV-negative patients with the exception of a later median time post-transplant in the CMV-positive group (253 days vs. 120 days, p = .03). Dd-cfDNA levels were significantly higher in patients with CMV infections compared to those without (p < .001) with more patients in the CMV positive group showing dd-cfDNA results ≥.12% (75% vs. 8%, p < .001) and ≥.20% (58% vs. 8%, p = .002). Each 1 log Conclusion: Our findings suggest that active CMV infections may raise dd-cfDNA levels in patients following heart transplantation. Larger studies are needed to validate these preliminary findings.
MeSH term(s)	Humans ; Cell-Free Nucleic Acids ; Cytomegalovirus Infections ; Cytomegalovirus/genetics ; Tissue Donors ; Heart Transplantation ; Transplant Recipients ; Graft Rejection
Chemical Substances	Cell-Free Nucleic Acids
Language	English
Publishing date	2024-03-13
Publishing country	Denmark
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639001-8
ISSN	1399-0012 ; 0902-0063
ISSN (online)	1399-0012
ISSN	0902-0063
DOI	10.1111/ctr.15287
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Article ; Online: Effectiveness of Single Dose Premedication of Piroxicam and Prednisolone on Post Endodontic Pain in One Visit Root Canal Treatment: A Randomized Clinical Trial.

Tanwir, Anum / Ahmed, Shahbaz / Akhtar, Hira / Wahid, Umair / Shakoor Abbasi, Maria / Ahmed, Naseer

European endodontic journal

2022 Volume 7, Issue 3, Page(s) 187–192

Abstract: Objective: The objective of this study was to compare the effectiveness of premedication drugs including single dose Piroxicam and Prednisolone in regard to post endodontic pain at different time intervals (24, 48, 72 and 96 hours) after single visit ... ...

Abstract	Objective: The objective of this study was to compare the effectiveness of premedication drugs including single dose Piroxicam and Prednisolone in regard to post endodontic pain at different time intervals (24, 48, 72 and 96 hours) after single visit root canal treatment. Methods: This randomized clinical trial (registration no. NCT04124822) was performed in operative dentistry department of a private clinical institute. One hundred twenty patients identified with symptomatic irreversible pulpitis were included in the study. The pain intensity levels were marked through the use of visual analog scale (VAS) before the commencement of treatment. The participants were randomly allocated in three groups, Group I (n=40) received no medication (control), Group II (n=40) received Piroxicam (20 mg) and Group III (n=40) received Prednisolone (20 mg). The drugs were administered thirty minutes before the endodontic procedure was initiated. Root canal treatmentwas carried out followed by placement of provisional restoration in a single appointment. The patients were instructed to continue marking their pain intensity levels after 24, 48, 72 and 96 hours using VAS. All patients were called for follow up after 4 days for clinical evaluation and the placement of permanent restoration. The effectiveness of each drug over different time interval was studied employing ANOVA test. The significance level was set at P≤0.05. Results: The results of the present study revealed that a higher percentage of patients in all 3 groups, reported no post-operative pain at all evaluated time durations (24, 48, 72, and 96 hours). However, the long term effectiveness (96 hours) of both drugs to reduce post-endodontic pain was observed to be statistically insignificant. There was no significant difference in demographic data in terms of age (P=0.14), gender (P=0.12), whilst tooth type (P≤0.05) showed statistically significant value. Conclusion: Pre-medication with either single dose piroxicam or prednisolone was able to prevent post-endodontic pain in patients with symptomatic irreversible pulpitis.
MeSH term(s)	Dental Pulp Cavity ; Humans ; Pain, Postoperative/drug therapy ; Pain, Postoperative/prevention & control ; Piroxicam/therapeutic use ; Prednisolone/therapeutic use ; Premedication ; Pulpitis/therapy
Chemical Substances	Piroxicam (13T4O6VMAM) ; Prednisolone (9PHQ9Y1OLM)
Language	English
Publishing date	2022-10-10
Publishing country	Turkey
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ISSN	2548-0839
ISSN (online)	2548-0839
DOI	10.14744/eej.2022.24119
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Antioxidant Potential of Cookies Formulated with Date Seed Powder

Najjar, Zein / Kizhakkayil, Jaleel / Shakoor, Hira / Platat, Carine / Stathopoulos, Constantinos / Ranasinghe, Meththa

Foods. 2022 Feb. 03, v. 11, no. 3

2022

Abstract	Utilising major waste products from the food industry can have both a great environmental impact and be a means to improve consumer health. Date seed is a food industry byproduct that has been proven to have high nutritional value. The aim of this work was to measure the total polyphenolic content (TPC), flavonoids, and antioxidant activity of the seeds of six date fruit varieties, Fard, Khalas, Khinaizi, Sukkary, Shaham, and Zahidi, and to use those seeds to enhance the antioxidant value of cookies by partially substituting flour with ground date seed. Date seed powder (DSP) was extracted at three levels of sample to solvent ratio (5:1, 10:1 and 15:1 mg/mL). Cookies were prepared using three substitution levels of wheat flour (2.5, 5.0, and 7.5%, w/w) by DSP and two types of flour (white and whole wheat), and were baked at two different temperatures, 180 and 200 °C. The composite cookies were found to contain a significant amount of TPC and flavonoids, and showed increased antioxidant activity compared with the control samples.
Keywords	antioxidant activity ; antioxidants ; dates (fruit) ; environmental impact ; flavonoids ; food industry ; industrial byproducts ; nutritive value ; solvents ; wheat ; wheat flour
Language	English
Dates of publication	2022-0203
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods11030448
Database	NAL-Catalogue (AGRICOLA)

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