LIVIVO - Search results -

Search results

Result 1 - 10 of total 371

Search options

Article ; Online: Self-healing codes: How stable neural populations can track continually reconfiguring neural representations.

Rule, Michael E / O'Leary, Timothy

Proceedings of the National Academy of Sciences of the United States of America

2022 Volume 119, Issue 7

Abstract: As an adaptive system, the brain must retain a faithful representation of the world while continuously integrating new information. Recent experiments have measured population activity in cortical and hippocampal circuits over many days and found that ... ...

Abstract	As an adaptive system, the brain must retain a faithful representation of the world while continuously integrating new information. Recent experiments have measured population activity in cortical and hippocampal circuits over many days and found that patterns of neural activity associated with fixed behavioral variables and percepts change dramatically over time. Such "representational drift" raises the question of how malleable population codes can interact coherently with stable long-term representations that are found in other circuits and with relatively rigid topographic mappings of peripheral sensory and motor signals. We explore how known plasticity mechanisms can allow single neurons to reliably read out an evolving population code without external error feedback. We find that interactions between Hebbian learning and single-cell homeostasis can exploit redundancy in a distributed population code to compensate for gradual changes in tuning. Recurrent feedback of partially stabilized readouts could allow a pool of readout cells to further correct inconsistencies introduced by representational drift. This shows how relatively simple, known mechanisms can stabilize neural tuning in the short term and provides a plausible explanation for how plastic neural codes remain integrated with consolidated, long-term representations.
MeSH term(s)	Animals ; Homeostasis ; Models, Neurological ; Nerve Net ; Neuronal Plasticity/physiology ; Neurons/physiology
Language	English
Publishing date	2022-02-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2106692119
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1148: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Adjuvant Radiotherapy for Surgically Resected Stage III Merkel Cell Carcinoma.

Pairawan, Seyed Saeed / Dominguez, Chloe E / Solomon, Naveenraj / Caba-Molina, David / O'Leary, Michael / Reeves, Mark E / Namm, Jukes P

JAMA surgery

2024 Volume 159, Issue 3, Page(s) 347–349

MeSH term(s)	Humans ; Carcinoma, Merkel Cell/pathology ; Carcinoma, Merkel Cell/radiotherapy ; Radiotherapy, Adjuvant ; Skin Neoplasms/pathology ; Disease-Free Survival ; Neoplasm Staging ; Retrospective Studies
Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2701841-6
ISSN	2168-6262 ; 2168-6254
ISSN (online)	2168-6262
ISSN	2168-6254
DOI	10.1001/jamasurg.2023.7016
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uk I Zs.72: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Organ donation by children in Australia, 2000-2019: impact of the 2009 National Reform Program. A population-based registry data study.

Klein, Tal T / O'Leary, Michael J / Staub, Lukas / Cavazzoni, Elena

The Medical journal of Australia

2023 Volume 218, Issue 11, Page(s) 520–525

Abstract: Objectives: To assess the impact of the 2009 National Reform Program for organ donation in Australia on the number and characteristics of organ donors under 16 years of age.: Design, setting, participants: Retrospective observational time series ... ...

Abstract	Objectives: To assess the impact of the 2009 National Reform Program for organ donation in Australia on the number and characteristics of organ donors under 16 years of age. Design, setting, participants: Retrospective observational time series study; analysis of Australia and New Zealand Organ Donation (ANZOD) registry data for all consented potential deceased organ donors under 16 years of age during 2000-2019, and of numbers of donors aged 16 years or more reported in ANZOD annual reports. Main outcome measures: Difference between 2000-2008 (pre-reform) and 2009-2019 (reform period) in annual organ donor rates (donors per million population), by age group (under 16 years, 16 years or more), reported as incidence rate ratio (IRR). Secondary outcomes: Differences in child donor characteristics during 2000-2008 and 2009-2019. Results: During 2000-2019, 400 children under 16 years of age were consented potential deceased organ donors, of whom 374 were actual deceased donors (94%): 146 during 2000-2008, 228 during 2009-2019. The median annual rate was 3.3 (interquartile range [IQR], 3.0-4.3) actual donors per million population during 2000-2008 and 4.2 (IQR, 3.6-5.2) donors per million population during 2009-2019 (IRR, 1.15; 95% confidence interval [CI], 0.93-1.42). In contrast, the difference between the two periods was statistically significant for donors aged 16 years or more, rising from 11.7 (IQR, 11.2-11.8) to 19.9 (IQR, 18.3-24.4) actual donors per million population (IRR, 1.75; 95% CI, 1.66-1.85). The median age of actual organ donors under 16 was similar during 2000-2008 (11 years; IQR, 7-14 years) and 2009-2019 (10 years; IQR, 4-14 years), as was the proportion of donors in this age group under 10 kg (2000-2008: four of 146, 3%; 2009-2019: 14 of 228, 6%). Conclusions: Despite its overall effect on organ donation rates, the National Reform Program was not effective in increasing the numbers of donors under 16 years of age. Relying on broad initiatives for adult donors may not be appropriate for achieving this aim.
MeSH term(s)	Adolescent ; Humans ; Australia ; Organ Transplantation ; Retrospective Studies ; Routinely Collected Health Data ; Tissue and Organ Procurement ; Tissue Donors ; Child
Language	English
Publishing date	2023-05-29
Publishing country	Australia
Document type	Journal Article ; Observational Study
ZDB-ID	186082-3
ISSN	1326-5377 ; 0025-729X
ISSN (online)	1326-5377
ISSN	0025-729X
DOI	10.5694/mja2.51978
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.398: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Inducing expression of ICOS-L by oncolytic adenovirus to enhance tumor-specific bi-specific antibody efficacy.

Saffarzadeh, Neshat / Foord, Emelie / O'Leary, Eoghan / Mahmoun, Rand / Birkballe Hansen, Thomas / Levitsky, Victor / Poiret, Thomas / Uhlin, Michael

Journal of translational medicine

2024 Volume 22, Issue 1, Page(s) 250

Abstract: Background: Intratumoral injection of oncolytic viruses (OVs) shows promise in immunotherapy: ONCOS-102, a genetically engineered OV that encodes Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) demonstrated efficacy in early clinical trials, ... ...

Abstract	Background: Intratumoral injection of oncolytic viruses (OVs) shows promise in immunotherapy: ONCOS-102, a genetically engineered OV that encodes Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) demonstrated efficacy in early clinical trials, enhancing T cell infiltration in tumors. This suggests OVs may boost various forms of immunotherapy, including tumor-specific bi-specific antibodies (BsAbs). Methods: Our study investigated in vitro, how ONCOS-204, a variant of ONCOS-virus expressing the ligand of inducible T-cell co-stimulator (ICOSL), modulates the process of T cell activation induced by a BsAb. ONCOS-102 was used for comparison. Phenotypic and functional changes induced by combination of different OVs, and BsAb in T cell subsets were assessed by flow cytometry, viability, and proliferation assays. Results: Degranulation and IFNγ and TNF production of T cells, especially CD4 + T cells was the most increased upon target cell exposure to ONCOS-204. Unexpectedly, ONCOS-204 profoundly affected CD8 + T cell proliferation and function through ICOS-L/ICOS interaction. The effect solely depended on cell surface expression of ICOS-L as soluble ICOSL did not induce notable T cell activity. Conclusions: Together, our data suggests that oncolytic adenoviruses encoding ICOSL may enhance functional activity of tumor-specific BsAbs thereby opening a novel avenue for clinical development in immunotherapeutics.
MeSH term(s)	Humans ; Adenoviridae ; Oncolytic Viruses ; Neoplasms/therapy ; CD8-Positive T-Lymphocytes ; CD4-Positive T-Lymphocytes ; Inducible T-Cell Co-Stimulator Protein ; Antibodies ; Oncolytic Virotherapy
Chemical Substances	Inducible T-Cell Co-Stimulator Protein ; Antibodies ; ICOS protein, human
Language	English
Publishing date	2024-03-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-024-05049-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Obstetric rectal buttonhole tears: A case series and literature review.

Tunney, Elizabeth / O'Leary, Bobby / Malone, Fergal / Geary, Michael

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

2022 Volume 161, Issue 2, Page(s) 455–461

Abstract: Introduction: Isolated rectal buttonhole tears are a rare obstetric complication and so there is a lack of consensus for their management. The current case series reviews the published literature on obstetric rectal buttonhole injuries and provides ... ...

Abstract	Introduction: Isolated rectal buttonhole tears are a rare obstetric complication and so there is a lack of consensus for their management. The current case series reviews the published literature on obstetric rectal buttonhole injuries and provides further cases from our institution. Methods: A literature review was performed and all results were reviewed. Rectal buttonhole tears following vaginal delivery between 2012 and 2022 in our institution were identified. Repair technique and postoperative management were recorded. Results: There were 14 published case reports. Seven case reports described a two-layer closure, and seven reports described a three-layer closure. Four cases were repaired in collaboration with colorectal surgeons. Twelve cases were asymptomatic after 6 weeks. One woman had a defunctioning stoma following a wound breakdown and one woman was readmitted with a rectal hemorrhage. We identified two women in our institution with buttonhole tears. Three-layer repairs were performed in both cases and each woman made an uneventful recovery. Conclusion: Repair techniques of rectal buttonhole tears vary among institutions. Despite this variance, most women experience no short-term morbidity following these injuries. This review adds to the current literature with examples of different repair techniques and outcomes.
MeSH term(s)	Pregnancy ; Female ; Humans ; Anal Canal/injuries ; Rectum/surgery ; Delivery, Obstetric/adverse effects ; Lacerations/etiology ; Lacerations/surgery ; Risk Factors ; Obstetric Labor Complications/surgery ; Fecal Incontinence/etiology
Language	English
Publishing date	2022-10-31
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	80149-5
ISSN	1879-3479 ; 0020-7292
ISSN (online)	1879-3479
ISSN	0020-7292
DOI	10.1002/ijgo.14513
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 355: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 183: Show issues

Order via subito

Details ▾

Article ; Online: Causes and consequences of representational drift.

Rule, Michael E / O'Leary, Timothy / Harvey, Christopher D

Current opinion in neurobiology

2019 Volume 58, Page(s) 141–147

Abstract: The nervous system learns new associations while maintaining memories over long periods, exhibiting a balance between flexibility and stability. Recent experiments reveal that neuronal representations of learned sensorimotor tasks continually change over ...

Abstract	The nervous system learns new associations while maintaining memories over long periods, exhibiting a balance between flexibility and stability. Recent experiments reveal that neuronal representations of learned sensorimotor tasks continually change over days and weeks, even after animals have achieved expert behavioral performance. How is learned information stored to allow consistent behavior despite ongoing changes in neuronal activity? What functions could ongoing reconfiguration serve? We highlight recent experimental evidence for such representational drift in sensorimotor systems, and discuss how this fits into a framework of distributed population codes. We identify recent theoretical work that suggests computational roles for drift and argue that the recurrent and distributed nature of sensorimotor representations permits drift while limiting disruptive effects. We propose that representational drift may create error signals between interconnected brain regions that can be used to keep neural codes consistent in the presence of continual change. These concepts suggest experimental and theoretical approaches to studying both learning and maintenance of distributed and adaptive population codes.
MeSH term(s)	Brain ; Learning ; Memory ; Neurons
Language	English
Publishing date	2019-09-27
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1078046-4
ISSN	1873-6882 ; 0959-4388
ISSN (online)	1873-6882
ISSN	0959-4388
DOI	10.1016/j.conb.2019.08.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3260: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Translation initiation factor eIF1.2 promotes

Wang, Fengrong / Holmes, Michael J / Hong, Hea Jin / Thaprawat, Pariyamon / Kannan, Geetha / Huynh, My-Hang / Schultz, Tracey L / Licon, M Haley / Lourido, Sebastian / Sullivan, William J / O'Leary, Seán E / Carruthers, Vern B

bioRxiv : the preprint server for biology

2023

Abstract: ... The ... ...

Abstract	The parasite
Language	English
Publishing date	2023-11-03
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.11.03.565545
Database	MEDical Literature Analysis and Retrieval System OnLINE

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Combined data analysis of fossil and living mammals: a Paleogene sister taxon of Placentalia and the antiquity of Marsupialia.

Velazco, Paúl M / Buczek, Alexandra J / Hoffman, Eva / Hoffman, Devin K / O'Leary, Maureen A / Novacek, Michael J

Cladistics : the international journal of the Willi Hennig Society

2022 Volume 38, Issue 3, Page(s) 359–373

Abstract: ... of North America have important fossil mammals occurring just before and after the KPg boundary (e.g. Prodiacodon ...

Abstract	The Cretaceous-Paleogene (KPg) boundary, one of Earth's five major extinction events, occurred just before the appearance of Placentalia in the fossil record. The Gobi Desert, Mongolia and the Western Interior of North America have important fossil mammals occurring just before and after the KPg boundary (e.g. Prodiacodon, Deltatheridium) that have yet to be phylogenetically tested in a character-rich context with molecular data. We present here phylogenetic analyses of >6000 newly scored anatomical observations drawn from six untested fossils and added to the largest existing morphological matrix for mammals. These data are combined with sequence data from 27 nuclear genes. Results show the existence of a new eutherian sister clade to Placentalia, which we name and characterize. The extinct clade Leptictidae is part of this placental sister clade, indicating that the sister clade survived the KPg event to co-exist in ancient ecosystems during the Paleogene radiation of placentals. Analysing the Cretaceous metatherian Deltatheridium in this character-rich context reveals it is a member of Marsupialia, a finding that extends the minimum age of Marsupialia before the KPg boundary. Numerous shared-derived features from multiple anatomical systems support the assignment of Deltatheridium to Marsupialia. Computed tomography scans of exquisite new specimens better document the marsupial-like dental replacement pattern of Deltatheridium. The new placental sister clade has both Asian and North American species, and is ancestrally characterized by shared derived features such as a hind limb modified for saltatorial locomotion.
MeSH term(s)	Animals ; Biological Evolution ; Data Analysis ; Ecosystem ; Female ; Fossils ; Mammals/genetics ; Marsupialia/genetics ; Phylogeny ; Placenta ; Pregnancy
Language	English
Publishing date	2022-01-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1462608-1
ISSN	1096-0031 ; 0748-3007
ISSN (online)	1096-0031
ISSN	0748-3007
DOI	10.1111/cla.12499
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: The Contribution of Declines in Blood Lead Levels to Reductions in Blood Pressure Levels: Longitudinal Evidence in the Strong Heart Family Study.

Lieberman-Cribbin, Wil / Li, Zheng / Lewin, Michael / Ruiz, Patricia / Jarrett, Jeffery M / Cole, Shelley A / Kupsco, Allison / O'Leary, Marcia / Pichler, Gernot / Shimbo, Daichi / Devereux, Richard B / Umans, Jason G / Navas-Acien, Ana / Nigra, Anne E

Journal of the American Heart Association

2024 Volume 13, Issue 2, Page(s) e031256

Abstract: Background: Chronic lead exposure is associated with both subclinical and clinical cardiovascular disease. We evaluated whether declines in blood lead were associated with changes in systolic and diastolic blood pressure in adult American Indian ... ...

Abstract	Background: Chronic lead exposure is associated with both subclinical and clinical cardiovascular disease. We evaluated whether declines in blood lead were associated with changes in systolic and diastolic blood pressure in adult American Indian participants from the SHFS (Strong Heart Family Study). Methods and results: Lead in whole blood was measured in 285 SHFS participants in 1997 to 1999 and 2006 to 2009. Blood pressure and measures of cardiac geometry and function were obtained in 2001 to 2003 and 2006 to 2009. We used generalized estimating equations to evaluate the association of declines in blood lead with changes in blood pressure; cardiac function and geometry measures were considered secondary. Mean blood lead was 2.04 μg/dL at baseline. After ≈10 years, mean decline in blood lead was 0.67 μg/dL. In fully adjusted models, the mean difference in systolic blood pressure comparing the highest to lowest tertile of decline (>0.91 versus <0.27 μg/dL) in blood lead was -7.08 mm Hg (95% CI, -13.16 to -1.00). A significant nonlinear association between declines in blood lead and declines in systolic blood pressure was detected, with significant linear associations where blood lead decline was 0.1 μg/dL or higher. Declines in blood lead were nonsignificantly associated with declines in diastolic blood pressure and significantly associated with declines in interventricular septum thickness. Conclusions: Declines in blood lead levels in American Indian adults, even when small (0.1-1.0 μg/dL), were associated with reductions in systolic blood pressure. These findings suggest the need to further study the cardiovascular impacts of reducing lead exposures and the importance of lead exposure prevention.
MeSH term(s)	Adult ; Humans ; American Indian or Alaska Native ; Blood Pressure ; Cardiovascular Diseases/complications ; Hypertension/diagnosis ; Hypertension/epidemiology ; Lead/blood
Chemical Substances	Lead (2P299V784P)
Language	English
Publishing date	2024-01-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.123.031256
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Reach and effectiveness of a centralized navigation program for patients with positive fecal immunochemical tests requiring follow-up colonoscopy.

O'Leary, Meghan C / Reuland, Daniel S / Randolph, Connor / Ferrari, Renée M / Brenner, Alison T / Wheeler, Stephanie B / Farr, Deeonna E / Newcomer, Michael K / Crockett, Seth D

Preventive medicine reports

2023 Volume 34, Page(s) 102211

Abstract: ... timeliness of follow-up colonoscopy (i.e., within 9 months), and bowel prep adequacy ...

Abstract	Completion rates for follow-up colonoscopies after an abnormal fecal immunochemical test (FIT) are suboptimal in federally qualified health center (FQHC) settings. We implemented a screening intervention that included mailed FIT outreach to North Carolina FQHC patients from June 2020 to September 2021 and centralized patient navigation to support patients with abnormal FITs in completing follow-up colonoscopy. We evaluated the reach and effectiveness of navigation using electronic medical record data and navigator call logs detailing interactions with patients. Reach assessments included the proportion of patients successfully contacted by phone and who agreed to participate in navigation, intensity of navigation provided (including types of barriers to colonoscopy identified and total navigation time), and differences in these measures by socio-demographic characteristics. Effectiveness outcomes included colonoscopy completion, timeliness of follow-up colonoscopy (i.e., within 9 months), and bowel prep adequacy
Language	English
Publishing date	2023-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2785569-7
ISSN	2211-3355
ISSN	2211-3355
DOI	10.1016/j.pmedr.2023.102211
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito