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  1. Article ; Online: Reply to "Comment on 'Efficacy of ginseng and its ingredients as adjuvants to chemotherapy in non-small cell lung cancer'" by H. W. Lee, L. Ang and M. S. Lee,

    Zhu, He / Liu, Hui / Zhu, Jin-Hao / Wang, Si-Yu / Zhou, Shan-Shan / Kong, Ming / Mao, Qian / Long, Fang / Fang, Zhi-Jun / Li, Song-Lin

    Food & function

    2022  Volume 13, Issue 15, Page(s) 8332–8333

    MeSH term(s) Adjuvants, Immunologic ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Humans ; Lung Neoplasms/drug therapy ; Panax
    Chemical Substances Adjuvants, Immunologic
    Language English
    Publishing date 2022-08-01
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d2fo00744d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7872: Show issues

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  2. Article: Effect of extraction on the acoustic vibrational properties of Picea jezoensis var. microsperma (Lindl.) W.C.Cheng & L.K.Fu

    Miao, Yuanyuan / Li, Rui / Qian, Xiaodong / Yin, Yuxue / Yang, Yang / Jin, Xianglong / Lin, Bin / Liu, Yixing / Liu, Zhenbo

    Annals of forest science. 2021 Mar., v. 78, no. 1

    2021  

    Abstract: ... Lindl.) W.C.Cheng & L.K.Fu) were improved by extraction treatment with deionized water, dichloromethane ...

    Abstract • KEY MESSAGE : The specific dynamic elastic modulus, acoustic radiation, logarithmic decrement, sound transmission parameter, and acoustic conversion efficiency of spruce wood (Picea jezoensis var. microsperma (Lindl.) W.C.Cheng & L.K.Fu) were improved by extraction treatment with deionized water, dichloromethane, benzyl alcohol, and ethanol. A larger improvement was achieved after extraction with benzoyl alcohol and dichloromethane extraction than by using ethanol and deionized water. • CONTEXT : It is necessary to improve the acoustic vibrational properties of wood to solve the problem of resource shortage of wood with excellent acoustic vibrational properties for the soundboards of musical instruments and to improve the use value of wood. • AIMS : The effects of extraction treatment with deionized water, dichloromethane, benzyl alcohol, and ethanol on the acoustic vibrational properties of spruce wood were evaluated. • METHODS : After the acoustic vibrational properties of untreated wood samples were measured using the free-free flexural vibration test method with a fast Fourier transform spectrum analyzer (FFT, CF-5220Z), extraction treatment of the wood samples was separately performed with deionized water, dichloromethane, benzyl alcohol, and ethanol for 15 days at room temperature and pressure, followed by drying. The acoustic vibrational properties of the treated wood samples were then measured, and the effect of extraction treatment on the acoustic vibrational properties was analyzed. • RESULTS : The increase in the specific dynamic elastic modulus was highest (14.5%) after the benzyl alcohol treatment. The acoustic radiation clearly improved after the ethanol treatment (18.1%). The acoustic impedance of the wood treated by dichloromethane extraction decreased significantly (−4.35%), while the logarithmic decrement was significantly reduced (−52.0%) by benzyl alcohol treatment. From the viewpoint of energy utilization, with benzyl alcohol treatment, the acoustic conversion efficiency and transmission parameter increased by 124% and 125%, respectively. • CONCLUSION : The degree of improvement in the acoustic vibrational properties of wood differed depending on the solvent used. Greater improvement was observed after extraction with benzoyl alcohol and dichloromethane as compared to ethanol and deionized water.
    Keywords Picea jezoensis ; acoustic impedance ; ambient temperature ; benzyl alcohol ; energy ; ethanol ; forests ; methylene chloride ; modulus of elasticity ; solvents ; vibration ; wood
    Language English
    Dates of publication 2021-03
    Size p. 24.
    Publishing place Springer Paris
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 1464978-0
    ISSN 1297-966X ; 1286-4560
    ISSN (online) 1297-966X
    ISSN 1286-4560
    DOI 10.1007/s13595-021-01048-1
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    Z 2166: Show issues

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  3. Article ; Online: The Bcl-2/Bcl-X(L)/Bcl-w inhibitor, navitoclax, enhances the activity of chemotherapeutic agents in vitro and in vivo.

    Chen, Jun / Jin, Sha / Abraham, Vivek / Huang, Xiaoli / Liu, Bernard / Mitten, Michael J / Nimmer, Paul / Lin, Xiaoyu / Smith, Morey / Shen, Yu / Shoemaker, Alexander R / Tahir, Stephen K / Zhang, Haichao / Ackler, Scott L / Rosenberg, Saul H / Maecker, Heather / Sampath, Deepak / Leverson, Joel D / Tse, Chris /
    Elmore, Steven W

    Molecular cancer therapeutics

    2011  Volume 10, Issue 12, Page(s) 2340–2349

    Abstract: ... to chemoresistance. The Bcl-2 family of prosurvival proteins (Bcl-2, Bcl-X(L), Bcl-w, Mcl-1, and A1) plays a key role ... of Bcl-2, Bcl-X(L), and Bcl-w. While navitoclax exhibits single-agent activity in tumors dependent on Bcl ... 2 or Bcl-X(L) for survival, the expression of Mcl-1 has been shown to confer resistance ...

    Abstract The ability of a cancer cell to avoid apoptosis is crucial to tumorigenesis and can also contribute to chemoresistance. The Bcl-2 family of prosurvival proteins (Bcl-2, Bcl-X(L), Bcl-w, Mcl-1, and A1) plays a key role in these processes. We previously reported the discovery of ABT-263 (navitoclax), a potent small-molecule inhibitor of Bcl-2, Bcl-X(L), and Bcl-w. While navitoclax exhibits single-agent activity in tumors dependent on Bcl-2 or Bcl-X(L) for survival, the expression of Mcl-1 has been shown to confer resistance to navitoclax, most notably in solid tumors. Thus, therapeutic agents that can downregulate or neutralize Mcl-1 are predicted to synergize potently with navitoclax. Here, we report the activity of navitoclax in combination with 19 clinically relevant agents across a panel of 46 human solid tumor cell lines. Navitoclax broadly enhanced the activity of multiple therapeutic agents in vitro and enhanced efficacy of both docetaxel and erlotinib in xenograft models. The ability of navitoclax to synergize with docetaxel or erlotinib corresponded to an altered sensitivity of the mitochondria toward navitoclax, which was associated with the downmodulation of Mcl-1 and/or upregulation of Bim. These data provide a rationale to interrogate these combinations clinically.
    MeSH term(s) Aniline Compounds/administration & dosage ; Aniline Compounds/pharmacology ; Animals ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Apoptosis Regulatory Proteins/antagonists & inhibitors ; Drug Synergism ; Female ; HCT116 Cells ; Hep G2 Cells ; Humans ; K562 Cells ; Male ; Mice ; Neoplasms/drug therapy ; Neoplasms/pathology ; Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors ; Sulfonamides/administration & dosage ; Sulfonamides/pharmacology ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays ; bcl-X Protein/antagonists & inhibitors
    Chemical Substances Aniline Compounds ; Apoptosis Regulatory Proteins ; BCL2L2 protein, human ; Proto-Oncogene Proteins c-bcl-2 ; Sulfonamides ; bcl-X Protein ; navitoclax (XKJ5VVK2WD)
    Language English
    Publishing date 2011-09-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2063563-1
    ISSN 1538-8514 ; 1535-7163
    ISSN (online) 1538-8514
    ISSN 1535-7163
    DOI 10.1158/1535-7163.MCT-11-0415
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5750: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Density functional theory calculations in stereochemical determination of terpecurcumins J-W, cytotoxic terpene-conjugated curcuminoids from Curcuma longa L.

    Lin, Xionghao / Ji, Shuai / Qiao, Xue / Hu, Hongbo / Chen, Ni / Dong, Yinhui / Huang, Yun / Guo, Dean / Tu, Pengfei / Ye, Min

    The Journal of organic chemistry

    2013  Volume 78, Issue 23, Page(s) 11835–11848

    Abstract: Fourteen novel terpene-conjugated curcuminoids, terpecurcumins J-W (1-14), have been isolated ... from the rhizomes of Curcuma longa L. Among them, terpecurcumins J-Q and V represent four unprecedented skeletons ...

    Abstract Fourteen novel terpene-conjugated curcuminoids, terpecurcumins J-W (1-14), have been isolated from the rhizomes of Curcuma longa L. Among them, terpecurcumins J-Q and V represent four unprecedented skeletons featuring an unusual core of hydrobenzannulated[6,6]-spiroketal (1 and 2), bicyclo[2.2.2]octene (3-7), bicyclo[3.1.3]octene (8), and spiroepoxide (13), respectively. The structures of compounds 1-14 were elucidated by extensive spectroscopic analysis, and their absolute configurations were established by electronic circular dichroism, vibrational circular dichroism, and (13)C NMR spectroscopic data analysis, together with density functional theory calculations. The structure and configuration of 1 was further confirmed by single-crystal X-ray diffraction (Cu Kα). The biogenetic pathways of 1-14 were proposed, involving Michael addition, condensation, Diels-Alder cycloaddition, and electrophilic substitution reactions. Terpecurcumins showed more potent cytotoxic activities than curcumin and ar-/β-turmerone. Among them, terpecurcumin Q (8) exhibited IC50 of 3.9 μM against MCF-7 human breast cancer cells, and mitochondria-mediated apoptosis played an important role in the overall growth inhibition. Finally, LC/MS/MS quantitative analysis of five representative terpecurcumins indicated these novel compounds were present in C. longa at parts per million level.
    MeSH term(s) Antineoplastic Agents, Phytogenic/chemical synthesis ; Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/pharmacology ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Chromatography, High Pressure Liquid ; Curcuma/chemistry ; Curcumin/analogs & derivatives ; Curcumin/chemistry ; Curcumin/pharmacology ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Hep G2 Cells ; Humans ; MCF-7 Cells ; Mitochondria/drug effects ; Mitochondria/metabolism ; Models, Molecular ; Molecular Conformation ; Quantum Theory ; Stereoisomerism ; Structure-Activity Relationship ; Tandem Mass Spectrometry ; Terpenes/chemistry
    Chemical Substances Antineoplastic Agents, Phytogenic ; Terpenes ; Curcumin (IT942ZTH98)
    Language English
    Publishing date 2013-12-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/jo401859u
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Density Functional Theory Calculations in Stereochemical Determination of Terpecurcumins J–W, Cytotoxic Terpene-Conjugated Curcuminoids from Curcuma longa L

    Lin, Xionghao / Chen Ni / Dong Yinhui / Guo Dean / Hu Hongbo / Huang Yun / Ji Shuai / Qiao Xue / Tu Pengfei / Ye Min

    Journal of organic chemistry. 2013 Dec. 06, v. 78, no. 23

    2013  

    Abstract: Fourteen novel terpene-conjugated curcuminoids, terpecurcumins J–W (1–14), have been isolated ... from the rhizomes of Curcuma longa L. Among them, terpecurcumins J–Q and V represent four unprecedented skeletons ...

    Abstract Fourteen novel terpene-conjugated curcuminoids, terpecurcumins J–W (1–14), have been isolated from the rhizomes of Curcuma longa L. Among them, terpecurcumins J–Q and V represent four unprecedented skeletons featuring an unusual core of hydrobenzannulated[6,6]-spiroketal (1 and 2), bicyclo[2.2.2]octene (3–7), bicyclo[3.1.3]octene (8), and spiroepoxide (13), respectively. The structures of compounds 1–14 were elucidated by extensive spectroscopic analysis, and their absolute configurations were established by electronic circular dichroism, vibrational circular dichroism, and ¹³C NMR spectroscopic data analysis, together with density functional theory calculations. The structure and configuration of 1 was further confirmed by single-crystal X-ray diffraction (Cu Kα). The biogenetic pathways of 1–14 were proposed, involving Michael addition, condensation, Diels–Alder cycloaddition, and electrophilic substitution reactions. Terpecurcumins showed more potent cytotoxic activities than curcumin and ar-/β-turmerone. Among them, terpecurcumin Q (8) exhibited IC₅₀ of 3.9 μM against MCF-7 human breast cancer cells, and mitochondria-mediated apoptosis played an important role in the overall growth inhibition. Finally, LC/MS/MS quantitative analysis of five representative terpecurcumins indicated these novel compounds were present in C. longa at parts per million level.
    Keywords apoptosis ; breast neoplasms ; circular dichroism spectroscopy ; copper ; Curcuma longa ; curcumin ; cycloaddition reactions ; cytotoxicity ; growth retardation ; humans ; inhibitory concentration 50 ; Lewis acids ; neoplasm cells ; nuclear magnetic resonance spectroscopy ; organic chemistry ; quantitative analysis ; rhizomes ; spectral analysis ; stereochemistry ; terpenoids ; X-ray diffraction
    Language English
    Dates of publication 2013-1206
    Size p. 11835-11848.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021%2Fjo401859u
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    In stock of ZB MED Bonn / Germany

    Z 4' 49/42: Show issues
    Z 7.1: Show issues

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  6. Book ; Online ; E-Book: Handbook of practical immunohistochemistry

    Lin, Fan / Prichard, Jeffrey W. / Liu, Haiyan / Wilkerson, Myra L.

    frequently asked questions

    2022  

    Abstract: 1. Immunohistochemistry Quality Management And Regulation -- 2. Standardization of Diagnostic Immunohistochemistry -- 3. Automated Immunohistochemistry Overview -- 4. Immunohistochemistry: An Agilent Perspective -- 5. The Leica Biosystems Perspective : ... ...

    Author's details Fan Lin, Jeffrey W. Prichard, Haiyan Liu, Myra L. Wilkerson editors
    Abstract 1. Immunohistochemistry Quality Management And Regulation -- 2. Standardization of Diagnostic Immunohistochemistry -- 3. Automated Immunohistochemistry Overview -- 4. Immunohistochemistry: An Agilent Perspective -- 5. The Leica Biosystems Perspective : From excision to imaging – every step is critical -- 6. Immunohistochemistry: Maixin Perspective -- 7. Immunohistochemistry: Roche Tissue Diagnostics Perspective -- 8. Applications Of Rapid Immunohistochemistry On Frozen Tissue Sections During Intraoperative Pathological Diagnoses -- 9. RNA In Situ Hybridization: Applications in Anatomic Pathology -- 10. Overview of Immunohistochemistry Assessment of Cancer-Related Predictive Biomarkers and Common Genetic Alterations -- 11. Tissue Microarray -- 12. Unknown Primary/Undifferentiated Neoplasm -- 13. Exfoliative Cytology And Effusions -- 14. Breast -- 15. Predictive Biomarkers In Breast Cancer: ER, PR And HER-2/NEU -- 16. Central Nerve System -- 17. Thyroid, Parathyroid, and Adrenal glands -- 18. Salivary Glands and Head and Neck -- 19. Pleuropulmonary And Mediastinal Neoplasms -- 20. Uterus -- 21. Ovary -- 22. Prostate Gland -- 23. Urinary Bladder And Urachus -- 24. Kidney -- 25. Testis And Paratesticular Tissues -- 26. Pancreas And Ampulla -- 27. Liver, Bile Ducts And GallBladder -- 28. Upper Gastrointestinal Tract -- 29. Lower Gastrointestinal Tract And Microsatellite Instability (MSI) -- 30. Soft Tissue and Bone Tumors -- 31. Lymph Node -- 32. Bone Marrow -- 33. Cutaneous Lymphomas -- 34. Infectious diseases -- 35. Skin -- 36. Application of Direct Immunofluorescence for Skin and Mucosal Biopsies: A Practical Review -- 37. Application Of Fluorescent In Situ Hybridization (FISH) In Surgical And Cytologic Specimens (Solid Tumors, Hematopoietic Tumors, Urine, Bile Duct Brushing And Bronchoscopy).

    As in the second edition, the third edition of Handbook of Practical Immunohistochemistry – Frequently Asked Questions is written in a question and answer (Q&A) format and intended to be a practical, user-friendly, quick reference for information related to using the most up-to-date immunohistochemistry and in situ hybridization in clinical diagnosis. The new edition demonstrates a significant revision and improvement over the second edition. Five new chapters have been added that cover the following: 1) Immunohistochemistry: Leica’s perspective; 2) Immunohistochemistry: Maixin perspective; 3) RNA in situ hybridization: Applications in anatomic pathology; 4) Applications of rapid immunohistochemistry on frozen tissue sections during intraoperative pathologic diagnosis; and 5) Cutaneous lymphomas. In addition to extensive additions and changes, over 150 new questions and answers were added throughout this new edition. All chapters have been updated to include relevant new questions, new markers, more refined IHC panels, representative pictures, and current references. An extensive set of high-quality color pictures and diagnostic algorithms, if available, is included in each chapter to illustrate some of the key antibodies, including many recently discovered and substantiated antibodies used in that chapter. Written by experts in the field, Handbook of Practical Immunohistochemistry Third Edition is a comprehensive and practical guide for surgical pathologists, pathology residents and fellows, cytopathologists, and cytotechnologists.
    Keywords Pathology ; Immunohistochemistry / methods ; Immunohistochemistry
    Language English
    Size 1 Online-Ressource (xvii, 1042 Seiten), Illustrationen
    Edition Third edition
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021400239
    ISBN 978-3-030-83328-2 ; 9783030833275 ; 3-030-83328-3 ; 3030833275
    DOI 10.1007/978-3-030-83328-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  7. Article ; Online: Bioturbation in sediment cores from the Clarion-Clipperton Zone in the northeast Pacific: Evidence from excess

    Yu, W / Lin, F / Lin, L

    Marine pollution bulletin

    2023  Volume 188, Page(s) 114635

    Abstract: Radioactivity levels ... ...

    Abstract Radioactivity levels of
    MeSH term(s) Lead ; Pacific Ocean ; China
    Chemical Substances Lead (2P299V784P)
    Language English
    Publishing date 2023-02-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2001296-2
    ISSN 1879-3363 ; 0025-326X
    ISSN (online) 1879-3363
    ISSN 0025-326X
    DOI 10.1016/j.marpolbul.2023.114635
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  8. Article ; Online: Distinguish inverse Gottron's papules and inverse Gottron's sign in anti-MDA5 dermatomyositis.

    Lin, W / Yin, H / Lu, L

    QJM : monthly journal of the Association of Physicians

    2023  Volume 117, Issue 3, Page(s) 237

    MeSH term(s) Humans ; Dermatomyositis/complications ; Dermatomyositis/diagnosis
    Language English
    Publishing date 2023-12-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1199985-8
    ISSN 1460-2393 ; 0033-5622 ; 1460-2725
    ISSN (online) 1460-2393
    ISSN 0033-5622 ; 1460-2725
    DOI 10.1093/qjmed/hcad276
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    Ua VI Zs.131: Show issues Location:
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  9. Article: Erratum: Cu-Catalyzed Hydrogermylation of Dehydro Amino Acids

    Lin, W / You, L / Yuan, W / He, C

    Synfacts

    2023  Volume 19, Issue 05, Page(s) 532

    Language English
    Publishing date 2023-04-14
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 1861-194X ; 1861-1958
    ISSN (online) 1861-194X
    ISSN 1861-1958
    DOI 10.1055/s-0042-1752497
    Database Thieme publisher's database

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  10. Article: Combined Use of Trisodium Citrate and Transglutaminase to Enhance the Stiffness and Water-Holding Capacity of Acidified Yak Milk Gels

    Lin, Yang

    Journal of food quality, 1875892

    2018  

    Abstract: ... added to yak skim milk to concentrations of 0, 20, and 40 mmol/L, followed by adjusting the pH to 6.7 ... with 1.4% (w/v) gluconodelta-lactone (GDL) at 42°C for 4 h to form gels. The stiffness and ... water holding capacity (WHC) of gels exhibited higher values at 20 or 40 mmol/L than without TSC. The final storage ...

    Abstract In this research, the synergistic effect of trisodium citrate (TSC) and microbial transglutaminase (TGase) treatment on the textural properties of acidified yak skim milk gels was investigated. TSC was added to yak skim milk to concentrations of 0, 20, and 40 mmol/L, followed by adjusting the pH to 6.7. The samples were incubated with TGase for the cross-linking reaction, after which the samples were acidified with 1.4% (w/v) gluconodelta-lactone (GDL) at 42°C for 4 h to form gels. The stiffness and water holding capacity (WHC) of gels exhibited higher values at 20 or 40 mmol/L than without TSC. The final storage modulus (G′) of yak milk gels was positively related to the concentration of TSC prior to TGase treatment. Cryoscanning electron microscopy observations showed that the gel networks were more rigid with higher TSC concentrations. Overall, TSC dissociated particles in yak milk into smaller ones. The newly formed particles in yak skim milk could form acid-induced gels with greater stiffness and higher WHC in the presence of TGase.
    Language English
    Document type Article
    Database Repository for Life Sciences

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