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  1. Book ; Online: Indian Philosophy and Yoga in Germany

    Ware, Owen

    2024  

    Keywords Western philosophy, from c 1900 ; Hinduism ; Bhattacharyya ; classical Indian thought ; Dasgupta ; Friedrich Schlegel ; freedom ; Gītā ; Hegel ; Indian philosophy ; Karoline von Günderrode ; meditation ; modern philosophy ; nihilism ; Owen Ware ; pantheism ; Radhakrishnan ; Schelling ; Wilhelm von Humboldt ; Yoga Sūtras ; yoga philosophy
    Language English
    Size 1 electronic resource (198 pages)
    Publisher Taylor and Francis
    Document type Book ; Online
    Note English
    HBZ-ID HT030613320
    ISBN 9781003376088 ; 1003376088
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Loss of ADAM15 in female mice does not worsen pressure overload cardiomyopathy, independent of ovarian hormones.

    Krishnan, Vidhya / Atanasova, Nikki / Aujla, Preetinder K / Hupka, Devon / Owen, Caroline A / Kassiri, Zamaneh

    American journal of physiology. Heart and circulatory physiology

    2024  

    Abstract: Cardiac hypertrophy is a common feature in several cardiomyopathies. We previously reported that loss of ADAM15 (disintegrin and metalloproteinase 15) worsened cardiac hypertrophy and dilated cardiomyopathy following cardiac pressure overload. Here, we ... ...

    Abstract Cardiac hypertrophy is a common feature in several cardiomyopathies. We previously reported that loss of ADAM15 (disintegrin and metalloproteinase 15) worsened cardiac hypertrophy and dilated cardiomyopathy following cardiac pressure overload. Here, we investigated the impact of ADAM15 loss in female mice following cardiac pressure overload induced by transverse aortic constriction (TAC). Female
    Language English
    Publishing date 2024-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.00116.2024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Canine laparoscopic-assisted ovary-sparing hysterectomy does not increase risk of stump pyometra.

    Owen, Marjorie A / Sirr, Caroline G / Albright, Julia D / Fransson, Boel A

    Journal of the American Veterinary Medical Association

    2023  Volume 261, Issue 8, Page(s) 1166–1173

    Abstract: Objective: To evaluate incidences of pyometra and orthopedic, behavioral, urinary/reproductive, neoplastic, or atopic disease processes as outcomes for dogs undergoing either a laparoscopic-assisted ovary-sparing spay/hysterectomy (LapOSS) or a ... ...

    Abstract Objective: To evaluate incidences of pyometra and orthopedic, behavioral, urinary/reproductive, neoplastic, or atopic disease processes as outcomes for dogs undergoing either a laparoscopic-assisted ovary-sparing spay/hysterectomy (LapOSS) or a laparoscopic ovariectomy (LapOVE).
    Animals: 33 client-owned dogs.
    Procedures: Medical records of client-owned dogs presenting between August 2013 and May 2020 for elective LapOSS or LapOVE were reviewed. A multiple-choice client questionnaire was emailed to all clients whose dogs' complete medical records were available.
    Results: 17 of the 33 dogs were in the LapOSS group, and 16 of 33 dogs were in the LapOVE group. Of the 17 dogs undergoing LapOSS, 5 of 17 (29%) underwent an elective OVE at a later date. The mean follow-up time was 4.2 ± 1.8 years for the LapOSS group and 4.3 ± 2.0 years for the LapOVE group. No dogs developed stump pyometra. One LapOSS dog developed mammary tumor, and 2 others developed nonreproductive malignant neoplasia while 2 of the LapOVE dogs developed malignant neoplasia. One of the LapOSS dogs with malignant neoplasia had an ovariectomy prior to development of disease.
    Clinical relevance: Laparoscopic-assisted ovary-sparing spay appears to provide a safe and reliable method of sterilization, with no observable increased risk of pyometra with hysterectomy. Owners must be counseled prior to surgery regarding the consequences of gonadal hormone retention and multiple heat cycles.
    MeSH term(s) Female ; Animals ; Dogs ; Ovary/surgery ; Pyometra/surgery ; Pyometra/veterinary ; Dog Diseases/etiology ; Dog Diseases/surgery ; Hysterectomy/adverse effects ; Hysterectomy/veterinary ; Hysterectomy/methods ; Ovariectomy/adverse effects ; Ovariectomy/veterinary ; Ovariectomy/methods ; Laparoscopy/adverse effects ; Laparoscopy/veterinary ; Laparoscopy/methods ; Abdominal Abscess/surgery ; Abdominal Abscess/veterinary
    Language English
    Publishing date 2023-04-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390811-2
    ISSN 1943-569X ; 0003-1488
    ISSN (online) 1943-569X
    ISSN 0003-1488
    DOI 10.2460/javma.22.12.0539
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Real-world challenges in eligibility for MMR vaccination two years after autologous and allogeneic HSCT.

    Punchhi, Gopika / Negus, Rainbow / Saif, Hammad / Pritchard, Sharon / Owen, Olivia / Sehmbi, Aman / Hamm, Caroline

    Vaccine

    2023  Volume 41, Issue 41, Page(s) 5936–5939

    Abstract: Measles outbreaks have raised concerns of fatal infections in immunocompromised patients. Canadian guidelines advise administration of live vaccines, such as measles, mumps, and rubella (MMR), two yearsafter hematopoietic stem cell transplant (HSCT) yet ... ...

    Abstract Measles outbreaks have raised concerns of fatal infections in immunocompromised patients. Canadian guidelines advise administration of live vaccines, such as measles, mumps, and rubella (MMR), two yearsafter hematopoietic stem cell transplant (HSCT) yet studies have not assessed eligibility based on medication contraindications. We retrospectively reviewed the charts of 72 autologous (auto-HSCT) and 68 allogeneic (allo-HSCT) recipients at the Windsor Regional Cancer Center to determine MMR reactivity and eligibility based on administration of contraindicated medications two years post-HSCT. Reactivity to measles, mumps, and rubella in auto-HSCT recipients was 49.1 %, 28.8 %, and 52.3 %, respectively, and in allo-HSCT recipients was 75.6 %, 57.8 %, and 64.4 %, respectively. Immunity to all three components was significantly different between transplant types (p = 0.0002). Nearly 80 % of auto-HSCT patients were on a contraindicated medication at two years compared to 45 % of allo-HSCT recipients. Auto-HSCT recipients require MMR revaccination, but it is contraindicated in a large proportion of patients.
    MeSH term(s) Humans ; Mumps/prevention & control ; Retrospective Studies ; Canada/epidemiology ; Hematopoietic Stem Cell Transplantation/adverse effects ; Vaccination ; Measles ; Rubella/prevention & control
    Language English
    Publishing date 2023-08-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2023.06.075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: "T"eeing Up A Novel Therapy for Lymphangioleiomyomatosis.

    Wang, Xiaoyun / Rojas-Quintero, Joselyn / Owen, Caroline A

    American journal of respiratory cell and molecular biology

    2020  Volume 62, Issue 6, Page(s) 678–680

    MeSH term(s) Adoptive Transfer ; Humans ; Lung Neoplasms ; Lymphangioleiomyomatosis ; T-Lymphocytes
    Language English
    Publishing date 2020-02-25
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2020-0049ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Endothelial Cell Death in Emphysema: More Sugarcoating Needed?

    Rojas-Quintero, Joselyn / Wang, Xiaoyun / Owen, Caroline A

    American journal of respiratory and critical care medicine

    2019  Volume 200, Issue 9, Page(s) 1078–1080

    MeSH term(s) Emphysema ; Endothelial Cells ; Glucosylceramides ; Humans ; Lung ; Pulmonary Emphysema
    Chemical Substances Glucosylceramides
    Language English
    Publishing date 2019-07-12
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201906-1254ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Targeting ligand-dependent wnt pathway dysregulation in gastrointestinal cancers through porcupine inhibition.

    Flanagan, Dustin J / Woodcock, Simon A / Phillips, Caroline / Eagle, Catherine / Sansom, Owen J

    Pharmacology & therapeutics

    2022  Volume 238, Page(s) 108179

    Abstract: Gastrointestinal cancers are responsible for more cancer deaths than any other system of the body. This review summarises how Wnt pathway dysregulation contributes to the development of the most common gastrointestinal cancers, with a particular focus on ...

    Abstract Gastrointestinal cancers are responsible for more cancer deaths than any other system of the body. This review summarises how Wnt pathway dysregulation contributes to the development of the most common gastrointestinal cancers, with a particular focus on the nature and frequency of upstream pathway aberrations. Tumors with upstream aberrations maintain a dependency on the presence of functional Wnt ligand, and are predicted to be tractable to inhibitors of Porcupine, an enzyme that plays a key role in Wnt secretion. We summarise available pre-clinical efficacy data from Porcupine inhibitors in vitro and in vivo, as well as potential toxicities and the data from early phase clinical trials. We appraise the rationale for biomarker-defined targeted approaches, as well as outlining future opportunities for combination with other therapeutics.
    MeSH term(s) Acyltransferases/metabolism ; Gastrointestinal Neoplasms/drug therapy ; Humans ; Ligands ; Membrane Proteins/metabolism ; Wnt Signaling Pathway
    Chemical Substances Ligands ; Membrane Proteins ; Acyltransferases (EC 2.3.-)
    Language English
    Publishing date 2022-03-28
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 194735-7
    ISSN 1879-016X ; 0163-7258
    ISSN (online) 1879-016X
    ISSN 0163-7258
    DOI 10.1016/j.pharmthera.2022.108179
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Moderate to Vigorous Intensity Locomotor Training After Stroke: A Systematic Review and Meta-analysis of Mean Effects and Response Variability.

    Boyne, Pierce / Miller, Allison / Kubalak, Owen / Mink, Caroline / Reisman, Darcy S / Fulk, George

    Journal of neurologic physical therapy : JNPT

    2023  Volume 48, Issue 1, Page(s) 15–26

    Abstract: Background and purpose: This meta-analysis quantified mean effects of moderate to vigorous intensity locomotor training (LT mv ) on walking outcomes in subacute and chronic stroke, and the magnitude of variability in LT mv response.: Methods: ... ...

    Abstract Background and purpose: This meta-analysis quantified mean effects of moderate to vigorous intensity locomotor training (LT mv ) on walking outcomes in subacute and chronic stroke, and the magnitude of variability in LT mv response.
    Methods: Databases were searched for randomized trials comparing LT mv with no intervention, nongait intervention, or low-intensity gait training. Comfortable gait speed (CGS), fastest gait speed (FGS), 6-minute walk test (6MWT), walking activity (steps per day), and adverse effect/event (AE) data were extracted. Pooled estimates were calculated for mean changes, AE relative risks, and the standard deviation of response (SD response ) to LT mv versus control groups, stratified by study chronicity where possible.
    Results: There were 19 eligible studies (total N = 1096): 14 in chronic stroke (N = 839) and 5 in subacute stroke (N = 257). Compared with control interventions, LT mv yielded significantly greater increases in CGS (chronic, +0.06 m/s [95% confidence interval (CI), 0.01-0.10]; subacute, +0.16 [0.12-0.19]; subacute vs chronic, P = 0.03), FGS (chronic, +0.07 m/s [0.02-0.13]; subacute, +0.21 [0.01, 0.41]; P = 0.04), and 6MWT (chronic, +33 m [24-42]; subacute, +51 [26-77]; P = 0.054) but not steps/day (+260 [-1159 to 1679]). There were no treatment-related serious AEs among 398 LT mv participants in 14 AE-reporting studies. SD response estimates indicated substantial response variability: CGS, 0.11 m/s [0.00-0.15]; FGS, 0.14 m/s [-0.00 to 0.20]; and 6MWT, 41 m [27-51].
    Discussion and conclusions: LT mv improves mean walking capacity outcomes in subacute and chronic stroke and does not appear to have high risk of serious harm. Response magnitude varies within and between chronicity subgroups, and few studies have tested effects on daily walking activity or non-serious AEs.Video Abstract available for more insights from the authors (see the Video, Supplemental Digital Content 1 available at: http://links.lww.com/JNPT/A452 ).
    MeSH term(s) Humans ; Stroke Rehabilitation ; Stroke ; Walking/physiology ; Exercise Therapy ; Walking Speed
    Language English
    Publishing date 2023-09-07
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Video-Audio Media ; Journal Article
    ZDB-ID 2276921-3
    ISSN 1557-0584 ; 1557-0576 ; 1085-049X
    ISSN (online) 1557-0584
    ISSN 1557-0576 ; 1085-049X
    DOI 10.1097/NPT.0000000000000456
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Patterns of adverse childhood experiences and their associations with mental distress, substance use and sexual risk behaviors in Sub-Saharan Africa.

    Miedema, Stephanie Spaid / Stamatakis, Caroline / Tracy, Allison / Hegle, Jennifer / Kamagate, Maman Fathim / McOwen, Jordan / Augusto, Angelo / Manuel, Pedro / Coomer, Rachel / Kambona, Caroline / Ramphalla, Puleng / Niolon, Phyllis / Patel, Pragna / Annor, Francis B

    Child abuse & neglect

    2023  Volume 150, Page(s) 106494

    Abstract: Background: Multiple adverse childhood experiences (ACEs) are associated with poor sexual and mental health outcomes in low- and middle-income countries (LMICs). Less well understood is how discrete and gendered clustering of ACEs may influence health.!# ...

    Abstract Background: Multiple adverse childhood experiences (ACEs) are associated with poor sexual and mental health outcomes in low- and middle-income countries (LMICs). Less well understood is how discrete and gendered clustering of ACEs may influence health.
    Objective: To assess how multiple ACEs co-occur and how dominant patterns of co-occurrence are associated with mental distress, substance use, and sexual risk behaviors among young women and men in Sub-Saharan Africa.
    Participants and setting: We used pooled data of young men and women aged 19-24 from comparable, nationally representative Violence Against Children and Youth Surveys (VACS) conducted in Cote d'Ivoire, Kenya, Lesotho, Mozambique, and Namibia (n
    Methods: We estimated sex-disaggregated latent classes of six ACEs among young women and men. We ran Bolck-Croon-Hagenaars (BCH) distal outcome analysis to test the sex-stratified relationships between ACEs latent classes and health outcomes.
    Results: A six class solution best fit the female data. Classes included witnessing violence and experiencing physical violence (PV); experiencing PV; high ACEs; witnessing community violence; orphanhood; and low ACEs exposure. Among males, the best-fitting three-class solution included experiencing PV and witnessing community violence; high ACEs; and low ACEs exposure. Membership in the high ACEs class was associated with mental distress among females and males, and substance use among males. No differences in sexual risk behavior were identified by class membership among either females or males.
    Conclusions: Discrete clusters of co-occurring ACEs are associated with elevated odds of mental distress among females, and mental distress and substance use among males. Preventing ACEs may improve mental health among young women and men in LMICs in Sub-Saharan Africa.
    MeSH term(s) Male ; Adolescent ; Child ; Humans ; Female ; Adverse Childhood Experiences ; Sexual Behavior ; Substance-Related Disorders/epidemiology ; Substance-Related Disorders/psychology ; Violence ; Risk-Taking
    Language English
    Publishing date 2023-10-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 799143-5
    ISSN 1873-7757 ; 0145-2134
    ISSN (online) 1873-7757
    ISSN 0145-2134
    DOI 10.1016/j.chiabu.2023.106494
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Extracellular vesicle-encapsulated CC16 as novel nanotherapeutics for treatment of acute lung injury.

    Han, Yohan / Zhu, Yin / Almuntashiri, Sultan / Wang, Xiaoyun / Somanath, Payaningal R / Owen, Caroline A / Zhang, Duo

    Molecular therapy : the journal of the American Society of Gene Therapy

    2023  Volume 31, Issue 5, Page(s) 1346–1364

    Abstract: Acute lung injury (ALI) is still associated with high mortality. Growing evidence suggests that Club Cell Protein 16 (CC16) plays a protective role against ALI. However, the doses of recombinant CC16 (rCC16) used in preclinical studies are ... ...

    Abstract Acute lung injury (ALI) is still associated with high mortality. Growing evidence suggests that Club Cell Protein 16 (CC16) plays a protective role against ALI. However, the doses of recombinant CC16 (rCC16) used in preclinical studies are supraphysiological for clinical applications. Extracellular vesicles (EVs) are nanovesicles endogenously generated by mammalian cells. Our study demonstrated that CC16 is released via small EVs and EV-encapsulated CC16 (sEV-CC16) and has anti-inflammatory activities, which protect mice from lipopolysaccharide (LPS) or bacteria-induced ALI. Additionally, sEV-CC16 can activate the DNA damage repair signaling pathways. Consistent with this activity, we observed more severe DNA damage in lungs from Cc16 knockout (KO) than wild-type (WT) mice. Mechanistically, we elucidated that CC16 suppresses nuclear factor κB (NF-κB) signaling activation by binding to heat shock protein 60 (HSP60). We concluded that sEV-CC16 could be a potential therapeutic agent for ALI by inhibiting the inflammatory and DNA damage responses by reducing NF-κB signaling.
    MeSH term(s) Mice ; Animals ; NF-kappa B/metabolism ; Lung/metabolism ; Acute Lung Injury/drug therapy ; Signal Transduction ; Anti-Inflammatory Agents/pharmacology ; Lipopolysaccharides/pharmacology ; Mammals
    Chemical Substances NF-kappa B ; Anti-Inflammatory Agents ; Lipopolysaccharides
    Language English
    Publishing date 2023-01-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2010592-7
    ISSN 1525-0024 ; 1525-0016
    ISSN (online) 1525-0024
    ISSN 1525-0016
    DOI 10.1016/j.ymthe.2023.01.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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