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Article ; Online: Methylmercury-induced brain neuronal death in CHOP-knockout mice.

Iijima, Yuta / Miki, Ryohei / Fujimura, Masatake / Oyadomari, Seiichi / Uehara, Takashi

2024 Volume 49, Issue 2, Page(s) 55–60

Abstract: Apoptosis is one of the hallmarks of MeHg-induced neuronal cell death; however, its molecular mechanism remains unclear. We previously reported that MeHg exposure induces neuron-specific ER stress in the mouse brain. Excessive ER stress contributes to ... ...

Abstract	Apoptosis is one of the hallmarks of MeHg-induced neuronal cell death; however, its molecular mechanism remains unclear. We previously reported that MeHg exposure induces neuron-specific ER stress in the mouse brain. Excessive ER stress contributes to apoptosis, and CHOP induction is considered to be one of the major mechanisms. CHOP is also increased by MeHg exposure in the mouse brain, suggesting that it correlates with increased apoptosis. In this study, to clarify whether CHOP mediates MeHg-induced apoptosis, we examined the effect of CHOP deletion on MeHg exposure in CHOP-knockout mice. Our data showed that CHOP deletion had no effect on MeHg exposure-induced weight loss or hindlimb impairment in mice, nor did it increase apoptosis or inhibit neuronal cell loss. Hence, CHOP plays little role in MeHg toxicity, and other apoptotic pathways coupled with ER stress may be involved in MeHg-induced cell death.
MeSH term(s)	Animals ; Mice ; Apoptosis ; Brain/pathology ; Methylmercury Compounds/toxicity ; Methylmercury Compounds/metabolism ; Mice, Knockout ; Neurons/pathology
Chemical Substances	Methylmercury Compounds
Language	English
Publishing date	2024-01-31
Publishing country	Japan
Document type	Journal Article
ZDB-ID	770623-6
ISSN	1880-3989 ; 0388-1350
ISSN (online)	1880-3989
ISSN	0388-1350
DOI	10.2131/jts.49.55
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Zs.A 1682: Show issues

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Article ; Online: Repositioning of mifepristone as an integrated stress response activator to potentiate cisplatin efficacy in non-small cell lung cancer.

Namkaew, Jirapat / Zhang, Jun / Yamakawa, Norio / Hamada, Yoshimasa / Tsugawa, Kazue / Oyadomari, Miho / Miyake, Masato / Katagiri, Toyomasa / Oyadomari, Seiichi

Cancer letters

2023 Volume 582, Page(s) 216509

Abstract: Lung cancer, primarily non-small-cell lung cancer (NSCLC), is a significant cause of cancer-related mortality worldwide. Cisplatin-based chemotherapy is a standard treatment for NSCLC; however, its effectiveness is often limited due to the development of ...

Abstract	Lung cancer, primarily non-small-cell lung cancer (NSCLC), is a significant cause of cancer-related mortality worldwide. Cisplatin-based chemotherapy is a standard treatment for NSCLC; however, its effectiveness is often limited due to the development of resistance, leading to NSCLC recurrence. Thus, the identification of effective chemosensitizers for cisplatin is of paramount importance. The integrated stress response (ISR), activated by various cellular stresses and mediated by eIF2α kinases, has been implicated in drug sensitivity. ISR activation globally suppresses protein synthesis while selectively promoting the translation of ATF4 mRNA, which can induce pro-apoptotic proteins such as CHOP, ATF3, and TRIB3. To expedite and economize the development of chemosensitizers for cisplatin treatment in NSCLC, we employed a strategy to screen an FDA-approved drug library for ISR activators. In this study, we identified mifepristone as a potent ISR activator. Mifepristone activated the HRI/eIF2α/ATF4 axis, leading to the induction of pro-apoptotic factors, independent of its known role as a synthetic steroid. Our in vitro and in vivo models demonstrated mifepristone's potential to inhibit NSCLC re-proliferation following cisplatin treatment and tumor growth, respectively, via the ISR-mediated cell death pathway. These findings suggest that mifepristone, as an ISR activator, could enhance the efficacy of cisplatin-based therapy for NSCLC, highlighting the potential of drug repositioning in the search for effective chemosensitizers.
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/metabolism ; Cisplatin/pharmacology ; Cisplatin/therapeutic use ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Mifepristone/pharmacology ; Drug Repositioning ; Signal Transduction ; Cell Line, Tumor ; Drug Resistance, Neoplasm
Chemical Substances	Cisplatin (Q20Q21Q62J) ; Mifepristone (320T6RNW1F)
Language	English
Publishing date	2023-11-28
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	195674-7
ISSN	1872-7980 ; 0304-3835
ISSN (online)	1872-7980
ISSN	0304-3835
DOI	10.1016/j.canlet.2023.216509
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Zs.A 1177: Show issues

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Article ; Online: Corrigendum to "The multifaceted role of ATF4 in regulating glucose-stimulated insulin secretion" [Biochem. Biophys. Res. Commun. 611 (2022) 165-171].

Sobajima, Mitsuaki / Miyake, Masato / Hamada, Yoshimasa / Tsugawa, Kazue / Oyadomari, Miho / Inoue, Ryota / Shirakawa, Jun / Arima, Hiroshi / Oyadomari, Seiichi

Biochemical and biophysical research communications

2023 Volume 692, Page(s) 149412

Language	English
Publishing date	2023-12-23
Publishing country	United States
Document type	Published Erratum
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2023.149412
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Zs.A 116: Show issues

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Article ; Online: Trends and Complications of Distal Biceps Tendon Repair Among American Board of Orthopaedic Surgery Part II Exam Candidates.

Oyadomari, Sarah / Kaplan, Jesse / Johnston, Tyler / Wang, Dean

Journal of shoulder and elbow surgery

2022

Abstract: Background: Surgical fixation of distal biceps tendon ruptures can restore supination strength and minimize biceps fatigue, resulting in high patient satisfaction rates. Surgical approaches can vary (single-incision versus double-incision), and the ... ...

Abstract	Background: Surgical fixation of distal biceps tendon ruptures can restore supination strength and minimize biceps fatigue, resulting in high patient satisfaction rates. Surgical approaches can vary (single-incision versus double-incision), and the number of fixation techniques have increased in recent years. The reported rate of postoperative complications after surgical repair of distal biceps tendon injuries is high, ranging from 15-35%. The purpose of this study was to assess the trends and postoperative complication profile among newly trained surgeons who performed distal biceps tendon repairs utilizing the American Board of Orthopaedic Surgery (ABOS) database. Methods: The ABOS database was retrospectively queried for patients treated with distal biceps tendon repair by Part II Exam candidates between 2017 and 2020. Distal biceps tendon repairs were isolated using the Current Procedural Terminology (CPT) code: 24342. Distal triceps tendon injuries were excluded with International Classification of Diseases (ICD-10) codes: S46.3. Patient demographics, intraoperative data, and surgeon fellowship training were collected. Surgeon-reported postoperative 90-day complications, including general anesthetic, medical, and surgical complications, rates of readmission, and rates of reoperation were recorded. Comparisons of rates among patient groups organized by surgeon fellowship training were performed using the chi-squared test. Results: A total of 2,089 distal biceps tendon repairs were included in the analysis. The average patient age was 47.5 years old, and 97.3% of patients were male. The majority of cases were performed by surgeons with fellowship training in sports medicine, hand/upper extremity, and shoulder and elbow, with 867 (41.5%) cases performed by sports medicine-trained surgeons, 740 (35.4%) by hand/upper extremity-trained surgeons, and 313 (15.0%) by shoulder and elbow-trained surgeons. In total, 608 (29.1%) patients experienced an anesthetic (0.2%), medical (1.1%), or surgical (28.2%) complication. The most common surgical complications were nerve injury (20.6%), failure of tendon repair or fixation (2.4%), and infection (1.7%). The overall reoperation rate was 2.4%. There were no significant differences in complication or reoperation rates among subspecialty training received. Discussion and conclusion:** Among newly trained surgeons, those with fellowship training in sports medicine, hand/upper extremity, and shoulder and elbow performed the most distal biceps tendon repairs, and there was no difference in complication rates among subspecialty training received. Complication rates after distal biceps tendon repair performed by newly trained surgeons were similar to those previously reported in large cohort studies, with nerve injury as the most common complication.
Language	English
Publishing date	2022-10-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	1170782-3
ISSN	1532-6500 ; 1058-2746
ISSN (online)	1532-6500
ISSN	1058-2746
DOI	10.1016/j.jse.2022.09.014
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Zs.A 3973: Show issues

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Article ; Conference proceedings: Die Bedeutung von ATF4 als zentrales Effektorprotein der integrierten Stressantwort für die Toxizität freier Fettsäuren in insulinproduzierenden MIN6 Zellen

Mehmeti, Ilir / Sharifi, Sarah / Hamada, Yoshimasa / Lenzen, Sigurd / Oyadomari, Seiichi

Diabetologie und Stoffwechsel

(Diabetes Kongress 2024 – 58. Jahrestagung der DDG)

2024 Volume 19, Issue S 01

Event/congress	Diabetes. Umwelt. Leben. Perspektiven aus allen Blickwinkeln, CityCube Berlin, 2024-05-08
Series title	Diabetes Kongress 2024 – 58. Jahrestagung der DDG
Language	German
Publishing date	2024-04-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2222993-0
ISSN	1861-9010 ; 1861-9002
ISSN (online)	1861-9010
ISSN	1861-9002
DOI	10.1055/s-0044-1785339
Database	Thieme publisher's database

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Zs.A 6479: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.A 6479/X: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Comparison of growth performances, carcass characteristics, and meat qualities of Okinawan indigenous Agu pigs and crossbred pigs sired by Agu or Duroc boar.

Touma, Shihei / Oyadomari, Motoharu

Animal science journal = Nihon chikusan Gakkaiho

2020 Volume 91, Issue 1, Page(s) e13362

Abstract: Indigenous Okinawa Agu pigs are crossed with Large White × Landrace (WL) pigs to improve their meat production, but there is little information regarding the crossbreeding effects. The study aims to compare growth, carcass characteristics, and meat ... ...

Abstract	Indigenous Okinawa Agu pigs are crossed with Large White × Landrace (WL) pigs to improve their meat production, but there is little information regarding the crossbreeding effects. The study aims to compare growth, carcass characteristics, and meat qualities of Agu pigs with those of WL crossbreeds with Agu sires (WLA) or Duroc sires (WLD). WLA pigs showed better growth performance and carcass characteristics and less intramuscular fat (IMF) contents than Agu ones, but they had higher fat deposition, smaller longissimus dorsi muscle area, and higher IMF contents than WLD pigs. Agu pigs showed higher water holding capacity than the other two breeds. The inner layer of Agu backfat contains higher and lower proportions of monounsaturated fatty acids (MUFA) and polyunsaturated fatty acid (PUFA), respectively, than that in WLD animals. WLA animals had intermediate values for the fatty acid content in the inner backfat, although MUFA contents were equal to those of Agu pigs. Fatty acid profiles in IMF were similar to those in the backfat. These results indicate that crossbreeding of Agu with WL pigs improves growth performance and carcass quality. Particularly, WLA pigs have higher IMF contents and MUFA concentrations and lower PUFA concentrations than WLD pigs.
MeSH term(s)	Animals ; Breeding/methods ; Fatty Acids, Monounsaturated/metabolism ; Fatty Acids, Unsaturated/genetics ; Female ; Food Quality ; Lipid Metabolism ; Male ; Meat ; Muscle, Skeletal/metabolism ; Swine/genetics ; Swine/growth & development ; Swine/metabolism
Chemical Substances	Fatty Acids, Monounsaturated ; Fatty Acids, Unsaturated
Language	English
Publishing date	2020-03-26
Publishing country	Australia
Document type	Comparative Study ; Journal Article
ZDB-ID	2095161-9
ISSN	1740-0929 ; 1344-3941
ISSN (online)	1740-0929
ISSN	1344-3941
DOI	10.1111/asj.13362
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Article ; Online: The multifaceted role of ATF4 in regulating glucose-stimulated insulin secretion.

Sobajima, Mitsuaki / Miyake, Masato / Hamada, Yoshimasa / Tsugawa, Kazue / Oyadomari, Miho / Inoue, Ryota / Shirakawa, Jun / Arima, Hiroshi / Oyadomari, Seiichi

Biochemical and biophysical research communications

2022 Volume 611, Page(s) 165–171

Abstract: Stress-inducible transcription factor ATF4 is essential for survival and identity of β-cell during stress conditions. However, the physiological role of ATF4 in β-cell function is not yet completely understood. To understand the role of ATF4 in glucose- ... ...

Abstract	Stress-inducible transcription factor ATF4 is essential for survival and identity of β-cell during stress conditions. However, the physiological role of ATF4 in β-cell function is not yet completely understood. To understand the role of ATF4 in glucose-stimulated insulin secretion (GSIS), β-cell-specific Atf4 knockout (βAtf4KO) mice were phenotypically characterized. Insulin secretion and mechanistic analyses were performed using islets from control Atf4f/f and βAtf4KO mice to assess key regulators for triggering and amplifying signals for GSIS. βAtf4KO mice displayed glucose intolerance due to reduced insulin secretion. Moreover, βAtf4KO islets exhibited a decrease in both the insulin content and first-phase insulin secretion. The analysis of βAtf4KO islets showed that ATF4 is required for insulin production and glucose-stimulated ATP and cAMP production. The results demonstrate that ATF4 contributes to the multifaceted regulatory process in GSIS even under stress-free conditions.
MeSH term(s)	Animals ; Glucose/metabolism ; Glucose/pharmacology ; Glucose Intolerance/genetics ; Glucose Intolerance/metabolism ; Insulin/metabolism ; Insulin Secretion ; Insulin-Secreting Cells/metabolism ; Islets of Langerhans/metabolism ; Mice ; Mice, Knockout
Chemical Substances	Insulin ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2022-04-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2022.04.038
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Zs.A 116: Show issues

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Article ; Online: Reporting in clinical studies on platelet-rich plasma therapy among all medical specialties: A systematic review of Level I and II studies.

Nazaroff, Jaron / Oyadomari, Sarah / Brown, Nolan / Wang, Dean

PloS one

2021 Volume 16, Issue 4, Page(s) e0250007

Abstract: Background: The clinical practice of platelet-rich plasma (PRP) therapy has grown significantly in recent years in multiple medical specialties. However, comparisons of PRP studies across medical fields remain challenging because of inconsistent ... ...

Abstract	Background: The clinical practice of platelet-rich plasma (PRP) therapy has grown significantly in recent years in multiple medical specialties. However, comparisons of PRP studies across medical fields remain challenging because of inconsistent reporting of protocols and characterization of the PRP being administered. The purpose of this systematic review was to determine the quantity of level I/II studies within each medical specialty and compare the level of study reporting across medical fields. Methods: The Cochrane Database, PubMed, and EMBASE databases were queried for level I/II clinical studies on PRP injections across all medical specialties. From these studies, data including condition treated, PRP processing and characterization, delivery, control group, and assessed outcomes were collected. Results: A total of 132 studies met the inclusion and exclusion criteria and involved 28 different conditions across 8 specialties (cardiothoracic surgery, cosmetic, dermatology, musculoskeletal (MSK), neurology, oral maxillofacial surgery, ophthalmology, and plastic surgery). Studies on PRP for MSK injuries made up the majority of the studies (74%), with knee osteoarthritis and tendinopathy being most commonly studied. Of the 132 studies, only 44 (33%) characterized the composition of PRP used, and only 23 (17%) reported the leukocyte component. MSK studies were more likely to use patient-reported outcome measures to assess outcomes, while studies from other specialties were more likely to use clinician- or imaging-based objective outcomes. Overall, 61% of the studies found PRP to be favorable over control treatment, with no difference in favorable reporting between MSK and other medical specialties. Conclusions: The majority of level I/II clinical studies investigating PRP therapy across all medical specialties have been conducted for MSK injuries with knee osteoarthritis and tendinopathy being the most commonly studied conditions. Inconsistent reporting of PRP composition exists among all studies in medicine. Rigorous reporting in human clinical studies across all medical specialties is crucial for evaluating the effects of PRP and moving towards disease-specific and individualized treatment.
MeSH term(s)	Databases, Factual ; Humans ; Osteoarthritis, Knee/therapy ; Platelet Transfusion ; Platelet-Rich Plasma ; Soft Tissue Injuries/therapy ; Tendinopathy/therapy
Language	English
Publishing date	2021-04-23
Publishing country	United States
Document type	Journal Article ; Systematic Review
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0250007
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Article: A novel immunodetection screen for vacuolar defects identifies a unique allele of VPS35 in S. cerevisiae.

Takahashi, M Kathleen / Frost, Christopher / Oyadomari, Ken / Pinho, Marcos / Sao, Dyna / Chima-Okereke, Onyi / Gharakhanian, Editte

Molecular and cellular biochemistry

2008 Volume 311, Issue 1-2, Page(s) 121–136

Abstract: The late endosome and vacuole of yeast Saccharomyces cerevisiae are functionally equivalent to the mammalian late endosome and lysosome. The late endosome is the convergence point of the biosynthetic and endocytic trafficking to the vacuole. Here, we ... ...

Abstract	The late endosome and vacuole of yeast Saccharomyces cerevisiae are functionally equivalent to the mammalian late endosome and lysosome. The late endosome is the convergence point of the biosynthetic and endocytic trafficking to the vacuole. Here, we describe a novel immunodetection screen to isolate mutants defective in trafficking the soluble hydrolase carboxypeptidase Y (CPY) at the late endosome to vacuole interface (env mutants). Mutants exhibit vacuolar morphology and endocytosis defects as assayed by electron, fluorescent, and nomarski microscopy. In biochemical assays, they internally accumulate p2CPY in a dense membrane compartment lacking vacuolar properties yet display normal secretion phenotypes. The results suggest vacuolar morphology and function defects that are exclusively at the late endosome/vacuole interface. env mutants define five complementation groups. The first gene of the collection to be cloned, ENV1 is allelic to VPS35 whose established function is in retrograde trafficking from late endosome to trans-Golgi network (TGN). Microscopic, biochemical, and growth analyses establish that env1 is distinct from other alleles of VPS35 in vacuolar morphology, growth characteristics, and internal accumulation of p2CPY. Our results indicate that ENV genes may define new gene functions at the late endosome to vacuole interface.
MeSH term(s)	Alleles ; Animals ; Anthelmintics/metabolism ; Cathepsin A/metabolism ; Endocytosis/physiology ; Endosomes/metabolism ; Endosomes/ultrastructure ; Gene Products, env/genetics ; Gene Products, env/metabolism ; Genetic Complementation Test ; Humans ; Hygromycin B/metabolism ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Phenotype ; Saccharomyces cerevisiae/cytology ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/physiology ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Vacuoles/metabolism ; Vacuoles/pathology ; Vacuoles/ultrastructure ; Vesicular Transport Proteins/genetics ; Vesicular Transport Proteins/metabolism
Chemical Substances	Anthelmintics ; Gene Products, env ; Membrane Proteins ; Saccharomyces cerevisiae Proteins ; VPS35 protein, S cerevisiae ; Vesicular Transport Proteins ; Hygromycin B (3XQ2233B0B) ; Cathepsin A (EC 3.4.16.5)
Language	English
Publishing date	2008-01-26
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	184833-1
ISSN	1573-4919 ; 0300-8177
ISSN (online)	1573-4919
ISSN	0300-8177
DOI	10.1007/s11010-008-9703-y
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Zs.A 892: Show issues

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Article: [Inter-Organ Metabolic Communication via the Unfolded Stress Response.]

Miyake, Masato / Oyadomari, Seiichi

Clinical calcium

2018 Volume 28, Issue 11, Page(s) 1548–1553

Abstract: Organs do not independently coordinate their metabolic activity:close communication between different organ systems is essential to regulate metabolism effectively. In recent years, the unfolded protein response(UPR), which is an adaptive mechanism to ... ...

Abstract	Organs do not independently coordinate their metabolic activity:close communication between different organ systems is essential to regulate metabolism effectively. In recent years, the unfolded protein response(UPR), which is an adaptive mechanism to decrease the amount of unfolded or misfolded proteins in the ER, has been found to regulate metabolic function not only at the cellular level but also at the whole-organism level by way of inter-organ communications. This manuscript will present the most recent findings on the role of the UPR in inter-organ metabolic networks.
MeSH term(s)	Endoplasmic Reticulum/metabolism ; Humans ; Metabolic Networks and Pathways ; Proteins/chemistry ; Unfolded Protein Response
Chemical Substances	Proteins
Language	Japanese
Publishing date	2018-10-29
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2386417-5
ISSN	0917-5857
ISSN	0917-5857
DOI	CliCa181115481553
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