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Article ; Online: Molecular and Neural Bases of Nutrition-Based Feeding Decision-Making.

Sasaki, Tsutomu

Journal of nutritional science and vitaminology

2022 Volume 68, Issue Supplement, Page(s) S20–S22

Abstract: Obesity and life style-related diseases have become major burdens to global health. Not having effective diet therapy that patients can adhere to makes life-style modification difficult. Many diet therapies are developed based on solid scientific ... ...

Abstract	Obesity and life style-related diseases have become major burdens to global health. Not having effective diet therapy that patients can adhere to makes life-style modification difficult. Many diet therapies are developed based on solid scientific evidence in terms of nutrition. However, how to execute such nutritionally-effective diet therapy is not established, nor based on solid science. Current practices are mostly developed by trial-and-error (experience-based), and they do not have solid bases on how eating behavior is regulated. Therefore, one of the major bottlenecks for implementing nutritionally-effective diet therapy is our lack of understanding of the molecular and neural bases of eating behavior. Based on the concept of nutrition, we eat to maintain homeostasis, and therefore, we should be satisfied once the needs are met by the supplies. However, that is only a part of the picture regarding eating. Palatable foods, which stimulate the hedonic system, and the experience-based prediction system work in concert to regulate eating. The information that conveys needs and supplies is multi-modal, each mode working at different timing to modulate each system. Therefore, eating behavior is complex, and the whole picture remains elusive. In particular, how we sense, calculate, and predict the needs and supplies of calories and each macronutrient remains to be understood. In this minireview, the frontiers in our understanding of the mechanism that regulates eating are briefly overviewed, as a summary of the IUNS-ICN symposium entitled "Molecular and neural bases of nutrition-based feeding decision-making."
MeSH term(s)	Humans ; Feeding Behavior/physiology ; Nutritional Status ; Life Style ; Obesity ; Global Health
Language	English
Publishing date	2022-09-23
Publishing country	Japan
Document type	Journal Article
ZDB-ID	191366-9
ISSN	1881-7742 ; 0301-4800
ISSN (online)	1881-7742
ISSN	0301-4800
DOI	10.3177/jnsv.68.S20
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Article: Recipe for pituitary organoids.

Kano, Mayuko / Sasaki, Hiroo / Miwata, Tsutomu / Suga, Hidetaka

Frontiers in endocrinology

2023 Volume 13, Page(s) 1025825

Abstract: Generation of a variety of organs and tissues from human pluripotent stem cells (hPSCs) has been ... ...

Abstract	Generation of a variety of organs and tissues from human pluripotent stem cells (hPSCs) has been attempted
MeSH term(s)	Animals ; Humans ; Mice ; Cell Differentiation ; Hedgehog Proteins ; Hypopituitarism ; Organoids ; Pituitary Gland
Chemical Substances	Hedgehog Proteins
Language	English
Publishing date	2023-01-19
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.1025825
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Article ; Online: Is epigenome editing non-inheritable? Implications for ethics and the regulation of human applications.

Sasaki-Honda, Mitsuru / Akatsuka, Kyoko / Sawai, Tsutomu

Stem cell reports

2023 Volume 18, Issue 11, Page(s) 2005–2009

Abstract: Epigenome editing offers ethical advantages with non-inheritable gene expression control. However, concerns arise regarding potential transgenerational effects in humans. Ethical and regulatory evaluation is crucial, considering recent advancements and ... ...

Abstract	Epigenome editing offers ethical advantages with non-inheritable gene expression control. However, concerns arise regarding potential transgenerational effects in humans. Ethical and regulatory evaluation is crucial, considering recent advancements and enhanced understanding of transgenerational epigenetics in both mammals and humans.
MeSH term(s)	Animals ; Humans ; Epigenome ; Epigenesis, Genetic ; Epigenomics ; Gene Editing ; CRISPR-Cas Systems ; Mammals/genetics
Language	English
Publishing date	2023-11-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2720528-9
ISSN	2213-6711 ; 2213-6711
ISSN (online)	2213-6711
ISSN	2213-6711
DOI	10.1016/j.stemcr.2023.10.003
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Article ; Online: Neural and Molecular Mechanisms Involved in Controlling the Quality of Feeding Behavior: Diet Selection and Feeding Patterns.

Sasaki, Tsutomu

Nutrients

2017 Volume 9, Issue 10

Abstract: We are what we eat. There are three aspects of feeding: what, when, and how much. These aspects represent the quantity (how much) and quality (what and when) of feeding. The quantitative aspect of feeding has been studied extensively, because weight is ... ...

Abstract	We are what we eat. There are three aspects of feeding: what, when, and how much. These aspects represent the quantity (how much) and quality (what and when) of feeding. The quantitative aspect of feeding has been studied extensively, because weight is primarily determined by the balance between caloric intake and expenditure. In contrast, less is known about the mechanisms that regulate the qualitative aspects of feeding, although they also significantly impact the control of weight and health. However, two aspects of feeding quality relevant to weight loss and weight regain are discussed in this review: macronutrient-based diet selection (what) and feeding pattern (when). This review covers the importance of these two factors in controlling weight and health, and the central mechanisms that regulate them. The relatively limited and fragmented knowledge on these topics indicates that we lack an integrated understanding of the qualitative aspects of feeding behavior. To promote better understanding of weight control, research efforts must focus more on the mechanisms that control the quality and quantity of feeding behavior. This understanding will contribute to improving dietary interventions for achieving weight control and for preventing weight regain following weight loss.
MeSH term(s)	Central Nervous System/physiology ; Choice Behavior ; Circadian Rhythm ; Diet ; Feeding Behavior ; Food Preferences ; Humans ; Weight Loss
Language	English
Publishing date	2017-10-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu9101151
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Article ; Online: [Rhodococcus equi infections in humans: an emerging zoonotic pathogen].

Takai, Shinji / Mizuno, Yasutaka / Suzuki, Yasunori / Sasaki, Yukako / Kakuda, Tsutomu / Kirikae, Teruo

Nihon saikingaku zasshi. Japanese journal of bacteriology

2024 Volume 79, Issue 1, Page(s) 15–24

Abstract: Rhodococcus equi is a facultative intracellular gram-positive coccobacillus which is a well-known cause of foal pneumonia and/or enteritis in equine veterinary medicine. More than 300 cases of R. equi infection have been reported since the first ... ...

Abstract	Rhodococcus equi is a facultative intracellular gram-positive coccobacillus which is a well-known cause of foal pneumonia and/or enteritis in equine veterinary medicine. More than 300 cases of R. equi infection have been reported since the first description of human disease in 1968. Most patients who become infected with R equi are immunocompromised, such as those infected with human immunodeficiency virus (HIV), recipients of organ transplantation, and patients receiving cancer treatment. However, there are increasing reports of the immunocompetent hosts. The pathogenicity of R. equi has been attributed to the presence of plasmid-encoded virulence-associated proteins (Vap). To date, three host-associated virulence plasmid types of R. equi have been identified as follows: the circular pVAPA and pVAPB, related, respectively, to equine and porcine isolates in 1991 and 1995, and a recently described linear pVAPN plasmid associated with bovine and caprine strains in 2015. More recently, these three plasmid types have been re-found in the human isolates which were isolated during 1980s to 1990s. Not only horses, but also pigs, goats, cattle and their environment should be considered as a potential source of R. equi for humans. In this review, we shed light on the current understanding of R. equi as an emerging zoonotic pathogen.
MeSH term(s)	Humans ; Animals ; Horses ; Cattle ; Swine ; Virulence Factors/genetics ; Rhodococcus equi/genetics ; Goats ; Plasmids/genetics
Chemical Substances	Virulence Factors
Language	Japanese
Publishing date	2024-02-20
Publishing country	Japan
Document type	Review ; English Abstract ; Journal Article
ZDB-ID	604101-2
ISSN	1882-4110 ; 0021-4930
ISSN (online)	1882-4110
ISSN	0021-4930
DOI	10.3412/jsb.79.15
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Article ; Online: Association between the controlling nutritional status score and outcomes in ischemic stroke patients with active cancer.

Sakurai, Rei / Gon, Yasufumi / Shimada, Yuki / Okazaki, Shuhei / Todo, Kenichi / Sasaki, Tsutomu / Mochizuki, Hideki

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

2024 Volume 120, Page(s) 170–174

Abstract: Background: The effect of nutritional status on survival in ischemic stroke patients with active cancer remains unclear.: Methods: This study retrospectively evaluated ischemic stroke patients with active cancer admitted to a university hospital in ... ...

Abstract	Background: The effect of nutritional status on survival in ischemic stroke patients with active cancer remains unclear. Methods: This study retrospectively evaluated ischemic stroke patients with active cancer admitted to a university hospital in Japan between 2006 and 2016. Patients were followed for 2 years after stroke. The controlling nutritional status (CONUT) score was used to classify undernutrition degree into 4 groups: normal, light, moderate, and severe. Survival rates were compared using the Kaplan-Meier method. Hazard ratio (HR) and 95 % confidence intervals (CIs) for mortality were calculated using Cox regression models. Results: A total of 158 patients (31 % women; median age: 71 years) were analyzed. Of these, 47 % had distant metastasis. The median (interquartile range) National Institute of Health Stroke Scale and CONUT scores were 4 (1-10) and 5 (3-7), respectively. Kaplan-Meier curve indicated that patients with poorer nutritional status had worse outcomes (overall log-rank test, p < 0.001). The univariable Cox regression analysis showed that the HR (95 % CI) for the light, moderate, and severe groups were 1.14 (0.45-2.86), 3.01 (1.27-7.12), and 2.94 (1.10-7.84), respectively. This statistical significance did not persist after adjustment for potential confounders (HR [95 % CI] for the light, moderate, and severe groups were 0.95 [0.36-2.49], 1.56 [0.57-4.28], and 1.34 [0.37-4.92], respectively). Past stroke, distant metastasis, and plasma D-dimer levels on admission were independent predictors of prognosis. Conclusions: This single-center, retrospective study suggests that nutritional status serves as a prognostic indicator for ischemic stroke patients with active cancer. However, the effect is not statistically independent.
MeSH term(s)	Humans ; Female ; Aged ; Male ; Nutritional Status ; Retrospective Studies ; Ischemic Stroke ; Malnutrition ; Prognosis ; Neoplasms ; Stroke
Language	English
Publishing date	2024-01-20
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	1193674-5
ISSN	1532-2653 ; 0967-5868
ISSN (online)	1532-2653
ISSN	0967-5868
DOI	10.1016/j.jocn.2024.01.011
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Article ; Online: Binding Interaction Between Lauric Acid and Cluster of Differentiation 36 Underpinned by a Fluorescence- Intensifying Assay.

Tsuzuki, Satoshi / Sugawara, Tatsuya / Manabe, Yuki / Yamasaki, Masayuki / Sasaki, Tsutomu

Journal of oleo science

2023 Volume 73, Issue 1, Page(s) 113–119

Abstract: Cluster of differentiation 36 (CD36) is a scavenger receptor expressed in various vertebrate cells that contains diverse ligands, including long-chain fatty acids. This receptor has recently been suggested as a captor of specific volatile odorants (e.g., ...

Abstract	Cluster of differentiation 36 (CD36) is a scavenger receptor expressed in various vertebrate cells that contains diverse ligands, including long-chain fatty acids. This receptor has recently been suggested as a captor of specific volatile odorants (e.g., aliphatic acetates) in the mammalian nasal epithelium. This study used a fluorescence-intensifying assay to produce the first evidence that lauric acid, an odorous fatty acid, directly binds to CD36. This expansion of the repertoire of volatile ligands supports potential applications for nasal CD36. Our present findings could promote future research aimed at understanding the mechanisms of fatty acid interactions with CD36.
MeSH term(s)	Animals ; CD36 Antigens/metabolism ; Fluorescence ; Fatty Acids ; Odorants ; Lauric Acids ; Mammals/metabolism
Chemical Substances	CD36 Antigens ; Fatty Acids ; Lauric Acids
Language	English
Publishing date	2023-12-14
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2218264-0
ISSN	1347-3352 ; 1345-8957
ISSN (online)	1347-3352
ISSN	1345-8957
DOI	10.5650/jos.ess23156
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Article ; Online: Method for Recognizing Pressing Position and Shear Force Using Active Acoustic Sensing on Gel Plates.

Watanabe, Hiroki / Sasaki, Kaito / Terada, Tsutomu / Tsukamoto, Masahiko

Sensors (Basel, Switzerland)

2022 Volume 22, Issue 24

Abstract: A touch interface is an important technology used in many devices, including touch panels in smartphones. Many touch panels only detect the contact position. If devices can detect shear force in addition to the contact position, various touch ... ...

Abstract	A touch interface is an important technology used in many devices, including touch panels in smartphones. Many touch panels only detect the contact position. If devices can detect shear force in addition to the contact position, various touch interactions are possible. We propose a two-step recognition method for recognizing the pressing position and shear force using active acoustic sensing, which transmits acoustic signals to an object and recognizes the state of the object by analyzing its response. Specifically, we attach a contact speaker transmitting an ultrasonic sweep signal and a contact microphone receiving ultrasonic waves to a plate of gel. The propagation characteristics of ultrasonic waves differ due to changes in the shape of the gel caused by the user's actions on the gel. This system recognizes the pressing position and shear force on the basis of the difference in acoustic characteristics. An evaluation of our method involving a user-independent model confirmed that four pressing positions were recognized with an F1 score of 85.4%, and four shear-force directions were recognized with an F1 score of 69.4%.
Language	English
Publishing date	2022-12-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s22249951
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Article ; Online: Medium-Chain Triglycerides-Specific Appetite is Regulated by the β-oxidation of Medium-Chain Fatty Acids in the Liver.

Maruyama, Tsugunori / Matsui, Sho / Kobayashi, Ryosuke / Horii, Takuro / Oguri, Yasuo / Tsuzuki, Satoshi / Horie, Takahiro / Ono, Koh / Hatada, Izuho / Sasaki, Tsutomu

American journal of physiology. Endocrinology and metabolism

2024

Abstract: Most studies on fat appetite have focused on long-chain triglycerides (LCTs) due to their obesogenic properties. Medium-chain triglycerides (MCTs), conversely, exhibit anti-obesogenic effects; however, the regulation of MCTs intake remains elusive. Here, ...

Abstract	Most studies on fat appetite have focused on long-chain triglycerides (LCTs) due to their obesogenic properties. Medium-chain triglycerides (MCTs), conversely, exhibit anti-obesogenic effects; however, the regulation of MCTs intake remains elusive. Here, we demonstrate that mice can distinguish between MCTs and LCTs, and the specific appetite for MCTs is governed by hepatic β-oxidation. We generated liver-specific medium-chain acyl-CoA dehydrogenase (MCAD)-deficient (MCAD
Language	English
Publishing date	2024-04-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	603841-4
ISSN	1522-1555 ; 0193-1849
ISSN (online)	1522-1555
ISSN	0193-1849
DOI	10.1152/ajpendo.00031.2024
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Article ; Online: A Case of 17α-hydroxylase/17,20-lyase Deficiency Diagnosed at 45 Years of Age with Hyperaldosteronism.

Ikeya, Akira / Yamashita, Miho / Kakizawa, Keisuke / Kawauchi, Yuto / Matsushita, Akio / Fujisawa, Yasuko / Ogata, Tsutomu / Sasaki, Shigekazu

Internal medicine (Tokyo, Japan)

2024

Abstract: 17α-hydroxylase deficiency is a type of congenital adrenocortical hyperplasia that is typically diagnosed in childhood or adolescence. It manifests as hypertension with gonadal dysfunction as the primary symptom. We herein report 17α-hydroxylase/17,20- ... ...

Abstract	17α-hydroxylase deficiency is a type of congenital adrenocortical hyperplasia that is typically diagnosed in childhood or adolescence. It manifests as hypertension with gonadal dysfunction as the primary symptom. We herein report 17α-hydroxylase/17,20-lyase deficiency (17OHD) diagnosed at the age of 45 years. The patient presented with hypertension, irregular menstruation, and hyperaldosteronism. The clinical manifestations of 17OHD vary based on the specific variant pattern of CYP17A1. In this case, the variant was c.157_159 TCC del p. Phe53del, which has been frequently reported in Japan. The enzymatic deficiency due to this variant is partial, leading to a delay in making a correct diagnosis.
Language	English
Publishing date	2024-04-09
Publishing country	Japan
Document type	Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.3084-23
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