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Article ; Online: Fgf signaling controls the telencephalic distribution of Fgf-expressing progenitors generated in the rostral patterning center.

Hoch, Renée V / Clarke, Jeffrey A / Rubenstein, John L R

Neural development

2015 Volume 10, Page(s) 8

Abstract: Background: The rostral patterning center (RPC) secretes multiple fibroblast growth factors (Fgfs) essential for telencephalon growth and patterning. Fgf expression patterns suggest that they mark functionally distinct RPC subdomains. We generated Fgf8( ... ...

Abstract	Background: The rostral patterning center (RPC) secretes multiple fibroblast growth factors (Fgfs) essential for telencephalon growth and patterning. Fgf expression patterns suggest that they mark functionally distinct RPC subdomains. We generated Fgf8(CreER) and Fgf17(CreER) mice and used them to analyze the lineages of Fgf8- versus Fgf17-expressing RPC cells. Results: Both lineages contributed to medial structures of the rostroventral telencephalon structures including the septum and medial prefrontral cortex. In addition, RPC-derived progenitors were observed in other regions of the early telencephalic neuroepithelium and generated neurons in the olfactory bulb, neocortex, and basal ganglia. Surprisingly, Fgf8(+) RPC progenitors generated the majority of basal ganglia cholinergic neurons. Compared to the Fgf8 lineage, the Fgf17 lineage was more restricted in its early dispersion and its contributions to the telencephalon. Mutant studies suggested that Fgf8 and Fgf17 restrict spread of RPC progenitor subpopulations. Conclusions: We identified the RPC as an important source of progenitors that contribute broadly to the telencephalon and found that two molecularly distinct progenitor subtypes in the RPC make different contributions to the developing forebrain.
MeSH term(s)	Animals ; Basal Ganglia/cytology ; Basal Ganglia/embryology ; Body Patterning/physiology ; Cell Lineage ; Cholinergic Neurons/cytology ; Fibroblast Growth Factor 8/genetics ; Fibroblast Growth Factor 8/physiology ; Fibroblast Growth Factors/genetics ; Fibroblast Growth Factors/physiology ; Gene Expression Regulation, Developmental ; Gene Knock-In Techniques ; Genes, Synthetic ; Gestational Age ; Mice ; Neural Stem Cells/classification ; Neural Stem Cells/cytology ; Olfactory Bulb/cytology ; Olfactory Bulb/embryology ; Prosencephalon/cytology ; Prosencephalon/embryology ; Recombinant Fusion Proteins/biosynthesis ; Signal Transduction/physiology ; Telencephalon/cytology ; Telencephalon/embryology
Chemical Substances	Fgf17 protein, mouse ; Fgf8 protein, mouse ; Recombinant Fusion Proteins ; Fibroblast Growth Factor 8 (148997-75-5) ; Fibroblast Growth Factors (62031-54-3)
Language	English
Publishing date	2015-03-31
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	1749-8104
ISSN (online)	1749-8104
DOI	10.1186/s13064-015-0037-7
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Article ; Online: OTX2 Transcription Factor Controls Regional Patterning within the Medial Ganglionic Eminence and Regional Identity of the Septum.

Hoch, Renée V / Lindtner, Susan / Price, James D / Rubenstein, John L R

Cell reports

2015 Volume 12, Issue 3, Page(s) 482–494

Abstract: The Otx2 homeodomain transcription factor is essential for gastrulation and early neural development. We generated Otx2 conditional knockout (cKO) mice to investigate its roles in telencephalon development after neurulation (approximately embryonic day 9. ...

Abstract	The Otx2 homeodomain transcription factor is essential for gastrulation and early neural development. We generated Otx2 conditional knockout (cKO) mice to investigate its roles in telencephalon development after neurulation (approximately embryonic day 9.0). We conducted transcriptional profiling and in situ hybridization to identify genes de-regulated in Otx2 cKO ventral forebrain. In parallel, we used chromatin immunoprecipitation sequencing to identify enhancer elements, the OTX2 binding motif, and de-regulated genes that are likely direct targets of OTX2 transcriptional regulation. We found that Otx2 was essential in septum specification, regulation of Fgf signaling in the rostral telencephalon, and medial ganglionic eminence (MGE) patterning, neurogenesis, and oligodendrogenesis. Within the MGE, Otx2 was required for ventral, but not dorsal, identity, thus controlling the production of specific MGE derivatives.
MeSH term(s)	Animals ; Cerebral Cortex/cytology ; Cerebral Cortex/embryology ; Female ; Gene Expression ; Mice ; Otx Transcription Factors/genetics ; Otx Transcription Factors/metabolism
Chemical Substances	Otx Transcription Factors ; Otx2 protein, mouse
Language	English
Publishing date	2015-07-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2015.06.043
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Article: Hydrogeomorphic Recovery and Temporal Changes in Rainfall Thresholds for Debris Flows Following Wildfire

Hoch, Olivia J. / McGuire, Luke A. / Youberg, Ann M. / Rengers, Francis K.

Journal of geophysical research. 2021 Dec., v. 126, no. 12

2021

Abstract: Wildfire‐induced changes to soil and vegetation promote runoff‐generated debris flows in steep watersheds. Postfire debris flows are most commonly observed in steep watersheds during the first wet season following a wildfire, but it is unclear how long ... ...

Abstract	Wildfire‐induced changes to soil and vegetation promote runoff‐generated debris flows in steep watersheds. Postfire debris flows are most commonly observed in steep watersheds during the first wet season following a wildfire, but it is unclear how long the elevated threat of debris flow persists and why debris‐flow potential changes in recovering burned areas. This work quantifies how rainfall intensity‐duration (ID) thresholds for debris‐flow initiation change with time since burning and provides a mechanistic explanation for these changes. We constrained a hydrologic model using field and remotely sensed measurements of soil‐infiltration capacity, vegetation cover, runoff, and debris‐flow activity. We applied this model to estimate rainfall ID thresholds for debris‐flow initiation within three burned areas in the southwestern United States over a postfire recovery period of three to four years. Modeling suggests ID thresholds are lowest immediately following the fire (below a one‐year recurrence interval [RI] storm) and increase with time, such that a 10‐ to 25‐year RI storm would be required to generate a debris flow after three years of recovery. Modeled changes in rainfall ID thresholds result from increases in soil infiltration capacity, canopy interception, hydraulic roughness, and median grain size of sediment entrained in an incipient debris flow. The relative importance of each of these factors varied among our three sites. Results improve our ability to assess temporal changes in postfire debris‐flow potential, highlight how site‐specific factors may alter the persistence of postfire debris‐flow hazards, and provide additional constraints on the timescale of recovery following wildfire.
Keywords	geophysics ; hydrologic models ; mass movement ; rain ; remote sensing ; research ; roughness ; runoff ; sediments ; soil ; storms ; vegetation cover ; water interception ; wet season ; wildfires
Language	English
Dates of publication	2021-12
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ISSN	2169-9003
DOI	10.1029/2021JF006374
Database	NAL-Catalogue (AGRICOLA)

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Article: Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development.

Hoch, Renée V / Soriano, Philippe

Development (Cambridge, England)

2006 Volume 133, Issue 4, Page(s) 663–673

Abstract: Fibroblast growth factor receptor 1 (Fgfr1) plays pleiotropic roles during embryonic development, but the mechanisms by which this receptor signals in vivo have not previously been elucidated. Biochemical studies have implicated Fgf receptor-specific ... ...

Abstract	Fibroblast growth factor receptor 1 (Fgfr1) plays pleiotropic roles during embryonic development, but the mechanisms by which this receptor signals in vivo have not previously been elucidated. Biochemical studies have implicated Fgf receptor-specific substrates (Frs2, Frs3) as the principal mediators of Fgfr1 signal transduction to the MAPK and PI3K pathways. To determine the developmental requirements for Fgfr1-Frs signaling, we generated mice (Fgfr1(Delta)Frs/DeltaFrs) in which the Frs2/3-binding site on Fgfr1 is deleted. Fgfr1(Delta)Frs/DeltaFrs embryos die during late embryogenesis, and exhibit defects in neural tube closure and in the development of the tail bud and pharyngeal arches. However, the mutant receptor is able to drive Fgfr1 functions during gastrulation and somitogenesis, and drives normal MAPK responses to Fgf. These findings indicate that Fgfr1 uses distinct signal transduction mechanisms in different developmental contexts, and that some essential functions of this receptor are mediated by Frs-independent signaling.
MeSH term(s)	Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Branchial Region/embryology ; Branchial Region/metabolism ; Central Nervous System/embryology ; Central Nervous System/metabolism ; Embryo Loss ; Embryonic Development ; Gastrula/physiology ; MAP Kinase Signaling System/physiology ; Mice ; Mice, Transgenic ; Mutation ; Phosphatidylinositol 3-Kinases/metabolism ; Receptor, Fibroblast Growth Factor, Type 1/genetics ; Receptor, Fibroblast Growth Factor, Type 1/metabolism ; Signal Transduction ; Somites/metabolism ; Tail/embryology ; Tail/metabolism
Chemical Substances	Adaptor Proteins, Signal Transducing ; Frs3 protein, mouse ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Fgfr1 protein, mouse (EC 2.7.10.1) ; Receptor, Fibroblast Growth Factor, Type 1 (EC 2.7.10.1)
Language	English
Publishing date	2006-01-18
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	90607-4
ISSN	1477-9129 ; 0950-1991
ISSN (online)	1477-9129
ISSN	0950-1991
DOI	10.1242/dev.02242
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Article ; Online: Fgfr1 regulates development through the combinatorial use of signaling proteins.

Brewer, J Richard / Molotkov, Andrei / Mazot, Pierre / Hoch, Renée V / Soriano, Philippe

Genes & development

2015 Volume 29, Issue 17, Page(s) 1863–1874

Abstract: Fibroblast growth factor (Fgf) signaling governs multiple processes important in development and disease. Many lines of evidence have implicated Erk1/2 signaling induced through Frs2 as the predominant effector pathway downstream from Fgf receptors ( ... ...

Abstract	Fibroblast growth factor (Fgf) signaling governs multiple processes important in development and disease. Many lines of evidence have implicated Erk1/2 signaling induced through Frs2 as the predominant effector pathway downstream from Fgf receptors (Fgfrs), but these receptors can also signal through other mechanisms. To explore the functional significance of the full range of signaling downstream from Fgfrs in mice, we engineered an allelic series of knock-in point mutations designed to disrupt Fgfr1 signaling functions individually and in combination. Analysis of each mutant indicates that Frs2 binding to Fgfr1 has the most pleiotropic functions in development but also that the receptor uses multiple proteins additively in vivo. In addition to Frs2, Crk proteins and Plcγ also contribute to Erk1/2 activation, affecting axis elongation and craniofacial and limb development and providing a biochemical mechanism for additive signaling requirements. Disruption of all known signaling functions diminished Erk1/2 and Plcγ activation but did not recapitulate the peri-implantation Fgfr1-null phenotype. This suggests that Erk1/2-independent signaling pathways are functionally important for Fgf signaling in vivo.
MeSH term(s)	Alleles ; Animals ; Embryo, Mammalian ; Embryonic Development/genetics ; Endoderm/embryology ; Gene Expression Regulation, Developmental/genetics ; Gene Knock-In Techniques ; Intracellular Signaling Peptides and Proteins/metabolism ; Mice ; Mutation ; Receptor, Fibroblast Growth Factor, Type 1/genetics ; Receptor, Fibroblast Growth Factor, Type 1/metabolism ; Signal Transduction
Chemical Substances	Intracellular Signaling Peptides and Proteins ; Fgfr1 protein, mouse (EC 2.7.10.1) ; Receptor, Fibroblast Growth Factor, Type 1 (EC 2.7.10.1)
Language	English
Publishing date	2015-05-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	806684-x
ISSN	1549-5477 ; 0890-9369
ISSN (online)	1549-5477
ISSN	0890-9369
DOI	10.1101/gad.264994.115
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Article ; Online: OTX2 Transcription Factor Controls Regional Patterning within the Medial Ganglionic Eminence and Regional Identity of the Septum

Renée V. Hoch / Susan Lindtner / James D. Price / John L.R. Rubenstein

Cell Reports, Vol 12, Iss 3, Pp 482-

2015 Volume 494

Abstract	The Otx2 homeodomain transcription factor is essential for gastrulation and early neural development. We generated Otx2 conditional knockout (cKO) mice to investigate its roles in telencephalon development after neurulation (approximately embryonic day 9.0). We conducted transcriptional profiling and in situ hybridization to identify genes de-regulated in Otx2 cKO ventral forebrain. In parallel, we used chromatin immunoprecipitation sequencing to identify enhancer elements, the OTX2 binding motif, and de-regulated genes that are likely direct targets of OTX2 transcriptional regulation. We found that Otx2 was essential in septum specification, regulation of Fgf signaling in the rostral telencephalon, and medial ganglionic eminence (MGE) patterning, neurogenesis, and oligodendrogenesis. Within the MGE, Otx2 was required for ventral, but not dorsal, identity, thus controlling the production of specific MGE derivatives.
Keywords	Biology (General) ; QH301-705.5
Subject code	570
Language	English
Publishing date	2015-07-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Genes and signaling events that establish regional patterning of the mammalian forebrain.

Hoch, Renée V / Rubenstein, John L R / Pleasure, Sam

Seminars in cell & developmental biology

2009 Volume 20, Issue 4, Page(s) 378–386

Abstract: Embryonic development of the mammalian forebrain is guided by signals from four patterning centers. The concerted actions of these signals transform the anterior neural plate and prosencephalon into discrete forebrain structures including the ... ...

Abstract	Embryonic development of the mammalian forebrain is guided by signals from four patterning centers. The concerted actions of these signals transform the anterior neural plate and prosencephalon into discrete forebrain structures including the telencephalon (cerebral cortex and basal ganglia) and hypothalamus. In this review, we describe the signaling, transcriptional, and regulatory events that lead to induction of the prospective telencephalon, and that instruct regional development of distinct telencephalic areas along the rostrocaudal and dorsoventral axes.
MeSH term(s)	Animals ; Body Patterning/genetics ; Embryo, Mammalian ; Embryonic Development ; Prosencephalon/anatomy & histology ; Prosencephalon/embryology ; Prosencephalon/growth & development ; Signal Transduction
Language	English
Publishing date	2009-06
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1312473-0
ISSN	1096-3634 ; 1084-9521
ISSN (online)	1096-3634
ISSN	1084-9521
DOI	10.1016/j.semcdb.2009.02.005
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Article: Roles of PDGF in animal development.

Hoch, Renée V / Soriano, Philippe

Development (Cambridge, England)

2003 Volume 130, Issue 20, Page(s) 4769–4784

Abstract: Recent advances in genetic manipulation have greatly expanded our understanding of cellular responses to platelet-derived growth factors (PDGFs) during animal development. In addition to driving mesenchymal proliferation, PDGFs have been shown to direct ... ...

Abstract	Recent advances in genetic manipulation have greatly expanded our understanding of cellular responses to platelet-derived growth factors (PDGFs) during animal development. In addition to driving mesenchymal proliferation, PDGFs have been shown to direct the migration, differentiation and function of a variety of specialized mesenchymal and migratory cell types, both during development and in the adult animal. Furthermore, the availability of genomic sequence data has facilitated the identification of novel PDGF and PDGF receptor (PDGFR) family members in C. elegans, Drosophila, Xenopus, zebrafish and mouse. Early data from these different systems suggest that some functions of PDGFs have been evolutionarily conserved.
MeSH term(s)	Animals ; Blood Vessels/embryology ; Blood Vessels/metabolism ; Drosophila/embryology ; Drosophila/metabolism ; Embryo, Mammalian/metabolism ; Embryo, Nonmammalian ; Humans ; Mice ; Neural Crest/embryology ; Neural Crest/metabolism ; Organogenesis/physiology ; Platelet-Derived Growth Factor/metabolism ; Spinal Cord/embryology ; Spinal Cord/metabolism ; Vascular Endothelial Growth Factor A/metabolism
Chemical Substances	Platelet-Derived Growth Factor ; Vascular Endothelial Growth Factor A
Language	English
Publishing date	2003-10
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	90607-4
ISSN	1477-9129 ; 0950-1991
ISSN (online)	1477-9129
ISSN	0950-1991
DOI	10.1242/dev.00721
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Article: Benchmarking flexible meshes and regular grids for large-scale fluvial inundation modelling

Hoch, Jannis M / Rens van Beek / Hessel C. Winsemius / Marc F.P. Bierkens

Advances in water resources. 2018 Nov., v. 121

2018

Abstract: Damage resulting from flood events is increasing world-wide, requiring the implementation of mitigation and adaption measures. To facilitate their implementation, it is essential to correctly model flood hazard at the large scale, yet fine spatial ... ...

Abstract	Damage resulting from flood events is increasing world-wide, requiring the implementation of mitigation and adaption measures. To facilitate their implementation, it is essential to correctly model flood hazard at the large scale, yet fine spatial resolution. To reduce the computational load of models, flexible meshes are an efficient means compared to uniform regular grids. Yet, thus far they have been applied only for bespoke small-scale studies requiring a high level of a priori grid preparation. To better understand possible advantages as well as shortcomings of their application for large-scale riverine inundation simulations, three different flexible meshes were derived from Height Above Nearest Drainage (HAND) data and compared with regular grids under identical spatially explicit hydrologic forcing by using GLOFRIM, a framework for integrated hydrologic-hydrodynamic inundation modelling. By means of GLOFRIM, output from the global hydrologic model PCR-GLOBWB was passed to the hydrodynamic model Delft3D Flexible Mesh. Results show that applying flexible meshes can be beneficial depending on the envisaged purpose. For discharge simulations, similar model accuracy was obtained between flexible and regular grids, with the former generally having shorter run times. For inundation extent simulations, however, the coarser gridding of flexible meshes in upstream areas results in a poorer performance if assessed by contingency maps. Moreover, while the ratio between minimum and maximum spatial resolution of flexible meshes has limited impact on discharge simulations, water level estimates may be stronger influenced by the application of larger grid cells. . As this study presents only a small set of possible realizations, additional research needs to unravel how the data and methods used as well as the choices for discretizations influence model performance. Generally, the application and particularly discretization process of flexible meshes involves more options, bringing more responsibilities for the user. Once an a priori decision is made on the model purpose, flexible meshes can be a valuable addition to modelling approaches where short run times are essential, facilitating large-scale flood simulations, ensemble modelling or operational flood forecasting.
Keywords	drainage ; hydrologic models ; model validation ; porous media ; water resources
Language	English
Dates of publication	2018-11
Size	p. 350-360.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2023320-6
ISSN	1872-9657 ; 0309-1708
ISSN (online)	1872-9657
ISSN	0309-1708
DOI	10.1016/j.advwatres.2018.09.003
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Article ; Online: A high-resolution enhancer atlas of the developing telencephalon.

Visel, Axel / Taher, Leila / Girgis, Hani / May, Dalit / Golonzhka, Olga / Hoch, Renee V / McKinsey, Gabriel L / Pattabiraman, Kartik / Silberberg, Shanni N / Blow, Matthew J / Hansen, David V / Nord, Alex S / Akiyama, Jennifer A / Holt, Amy / Hosseini, Roya / Phouanenavong, Sengthavy / Plajzer-Frick, Ingrid / Shoukry, Malak / Afzal, Veena /

Kaplan, Tommy / Kriegstein, Arnold R / Rubin, Edward M / Ovcharenko, Ivan / Pennacchio, Len A / Rubenstein, John L R

Cell

2013 Volume 152, Issue 4, Page(s) 895–908

Abstract: The mammalian telencephalon plays critical roles in cognition, motor function, and emotion. Though many of the genes required for its development have been identified, the distant-acting regulatory sequences orchestrating their in vivo expression are ... ...

Abstract	The mammalian telencephalon plays critical roles in cognition, motor function, and emotion. Though many of the genes required for its development have been identified, the distant-acting regulatory sequences orchestrating their in vivo expression are mostly unknown. Here, we describe a digital atlas of in vivo enhancers active in subregions of the developing telencephalon. We identified more than 4,600 candidate embryonic forebrain enhancers and studied the in vivo activity of 329 of these sequences in transgenic mouse embryos. We generated serial sets of histological brain sections for 145 reproducible forebrain enhancers, resulting in a publicly accessible web-based data collection comprising more than 32,000 sections. We also used epigenomic analysis of human and mouse cortex tissue to directly compare the genome-wide enhancer architecture in these species. These data provide a primary resource for investigating gene regulatory mechanisms of telencephalon development and enable studies of the role of distant-acting enhancers in neurodevelopmental disorders.
MeSH term(s)	Animals ; Embryo, Mammalian/metabolism ; Enhancer Elements, Genetic ; Fetus/metabolism ; Genome-Wide Association Study ; Humans ; Mice ; Telencephalon/embryology ; Telencephalon/metabolism ; Transcriptome ; p300-CBP Transcription Factors/metabolism
Chemical Substances	p300-CBP Transcription Factors (EC 2.3.1.48)
Language	English
Publishing date	2013-01-31
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2012.12.041
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