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  1. Article ; Online: Performance Measures for Lung Transplantation: Change Is Coming.

    Saddoughi, Sahar A / Cypel, Marcelo

    The Annals of thoracic surgery

    2022  Volume 114, Issue 1, Page(s) 232–233

    MeSH term(s) Humans ; Immunosuppression Therapy ; Lung Transplantation
    Language English
    Publishing date 2022-03-23
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2022.03.009
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  2. Article ; Online: The gift of organ donation as a last wish.

    Saddoughi, Sahar A / Cypel, Marcelo

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

    2022  Volume 41, Issue 6, Page(s) 755–756

    MeSH term(s) Humans ; Organ Transplantation ; Tissue and Organ Procurement
    Language English
    Publishing date 2022-03-29
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1062522-7
    ISSN 1557-3117 ; 1053-2498
    ISSN (online) 1557-3117
    ISSN 1053-2498
    DOI 10.1016/j.healun.2022.03.016
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  3. Article ; Online: Expanding the Lung Donor Pool: Donation After Circulatory Death, Ex-Vivo Lung Perfusion and Hepatitis C Donors.

    Saddoughi, Sahar A / Cypel, Marcelo

    Clinics in chest medicine

    2022  Volume 44, Issue 1, Page(s) 77–83

    Abstract: Organ shortage remains a limiting factor in lung transplantation. Traditionally, donation after brain death has been the main source of lungs used for transplantation; however, to meet the demand of patients requiring lung transplantation it is crucial ... ...

    Abstract "Organ shortage remains a limiting factor in lung transplantation. Traditionally, donation after brain death has been the main source of lungs used for transplantation; however, to meet the demand of patients requiring lung transplantation it is crucial to find innovative methods for organ donation. The implementation of extended donors, lung donation after cardiac death (DCD), the use of ex-vivo lung perfusion (EVLP) systems, and more recently the acceptance of hepatitis C donors have started to close the gap between organ donors and recipients in need of lung transplantation. This article focuses on the expansion of donor lungs for transplantation after DCD, the use of EVLP in evaluating extended criteria lungs, and the use of lung grafts from donors with hepatitis C."
    MeSH term(s) Humans ; Perfusion/methods ; Lung ; Tissue Donors ; Lung Transplantation/methods ; Hepatitis C
    Language English
    Publishing date 2022-11-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 447455-7
    ISSN 1557-8216 ; 0272-5231
    ISSN (online) 1557-8216
    ISSN 0272-5231
    DOI 10.1016/j.ccm.2022.10.006
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  4. Article ; Online: To Re-resect or Not to Re-resect, That Is the Question.

    Saddoughi, Sahar A / Blackmon, Shanda H

    The Annals of thoracic surgery

    2021  Volume 113, Issue 4, Page(s) 1391–1392

    Language English
    Publishing date 2021-06-05
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2021.05.030
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  5. Article ; Online: Progress in genome-inspired treatment decisions for multifocal lung adenocarcinoma.

    Powell, Chelsea L / Saddoughi, Sahar A / Wigle, Dennis A

    Expert review of respiratory medicine

    2023  Volume 17, Issue 11, Page(s) 1009–1021

    Abstract: Introduction: Multifocal lung adenocarcinoma (MFLA) is becoming increasingly recognized as a distinct subset of lung cancer, with unique biology, disease course, and treatment outcomes. While definitions remain controversial, MFLA is characterized by ... ...

    Abstract Introduction: Multifocal lung adenocarcinoma (MFLA) is becoming increasingly recognized as a distinct subset of lung cancer, with unique biology, disease course, and treatment outcomes. While definitions remain controversial, MFLA is characterized by the development and concurrent presence of multiple independent (non-metastatic) lesions on the lung adenocarcinoma spectrum. Disease progression typically follows an indolent course measured in years, with a lower propensity for nodal and distant metastases than other more common forms of non-small cell lung cancer.
    Areas covered: Traditional imaging and histopathological analyses of tumor biopsies are frequently unable to fully characterize the disease, prompting interest in molecular diagnosis. We highlight some of the key questions in the field, including accurate definitions to identify and stage MLFA, molecular tests to stratify patients and treatment decisions, and the lack of clinical trial data to delineate best management for this poorly understood subset of lung cancer patients. We review the existing literature and progress toward a genomic diagnosis for this unique disease entity.
    Expert opinion: Multifocal lung adenocarcinoma behaves differently than other forms of non-small cell lung cancer. Progress in molecular diagnosis may enhance potential for accurate definition, diagnosis, and optimizing treatment approach.
    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Lung Neoplasms/genetics ; Lung Neoplasms/therapy ; Lung Neoplasms/diagnosis ; Adenocarcinoma/genetics ; Adenocarcinoma/therapy ; Neoplasm Staging ; Adenocarcinoma of Lung/genetics ; Adenocarcinoma of Lung/therapy
    Language English
    Publishing date 2023-12-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2479146-5
    ISSN 1747-6356 ; 1747-6348
    ISSN (online) 1747-6356
    ISSN 1747-6348
    DOI 10.1080/17476348.2023.2286277
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  6. Article ; Online: Reply to Gorton et al.

    Schumer, Erin M / Saddoughi, Sahar A / Spencer, Philip J / Villavicencio, Mauricio A

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2023  Volume 64, Issue 1

    Language English
    Publishing date 2023-07-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezad248
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  7. Article ; Online: Reply: There is no substitution for a surgeon's eyes, but sometimes she might need glasses.

    Saddoughi, Sahar A / Garijo, Jacobo Moreno / Yeung, Jonathan C

    JTCVS techniques

    2021  Volume 15, Page(s) 210–211

    Language English
    Publishing date 2021-08-14
    Publishing country United States
    Document type Journal Article
    ISSN 2666-2507
    ISSN (online) 2666-2507
    DOI 10.1016/j.xjtc.2021.08.012
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  8. Article ; Online: Cumulative epinephrine dose during cardiac arrest and neurologic outcome after extracorporeal cardiopulmonary resuscitation.

    Garcia, Samuel I / Seelhammer, Troy G / Saddoughi, Sahar A / Finch, Alexander S / Park, John G / Wieruszewski, Patrick M

    The American journal of emergency medicine

    2024  Volume 80, Page(s) 61–66

    Abstract: Background: Epinephrine is recommended without an apparent ceiling dosage during cardiac arrest. However, excessive alpha- and beta-adrenergic stimulation may contribute to unnecessarily high aortic afterload, promote post-arrest myocardial dysfunction, ...

    Abstract Background: Epinephrine is recommended without an apparent ceiling dosage during cardiac arrest. However, excessive alpha- and beta-adrenergic stimulation may contribute to unnecessarily high aortic afterload, promote post-arrest myocardial dysfunction, and result in cerebral microvascular insufficiency in patients receiving extracorporeal cardiopulmonary resuscitation (ECPR).
    Methods: This was a retrospective cohort study of adults (≥ 18 years) who received ECPR at large academic ECMO center from 2018 to 2022. Patients were grouped based on the amount of epinephrine given during cardiac arrest into low (≤ 3 mg) and high (> 3 mg) groups. The primary endpoint was neurologic outcome at hospital discharge, defined by cerebral performance category (CPC). Multivariable logistic regression was used to assess the relationship between cumulative epinephrine dosage during arrest and neurologic outcome.
    Results: Among 51 included ECPR cases, the median age of patients was 60 years, and 55% were male. The mean cumulative epinephrine dose administered during arrest was 6.2 mg but ranged from 0 to 24 mg. There were 18 patients in the low-dose (≤ 3 mg) and 25 patients in the high-dose (> 3 mg) epinephrine groups. Favorable neurologic outcome at discharge was significantly greater in the low-dose (55%) compared to the high-dose (24%) group (p = 0.025). After adjusting for age, those who received higher doses of epinephrine during the arrest were more likely to have unfavorable neurologic outcomes at hospital discharge (odds ratio 4.6, 95% CI 1.3, 18.0, p = 0.017).
    Conclusion: After adjusting for age, cumulative epinephrine doses above 3 mg during cardiac arrest may be associated with unfavorable neurologic outcomes after ECPR and require further investigation.
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2024.03.013
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  9. Article ; Online: Heart-Lung Transplantation From Donation After Circulatory Death Using Mobile Normothermic Regional Perfusion.

    Spencer, Philip J / Saddoughi, Sahar A / Choi, Kukbin / Dickinson, Timothy A / Richman, Adam / Reynolds, F Alex / Villavicencio, Mauricio A

    ASAIO journal (American Society for Artificial Internal Organs : 1992)

    2023  Volume 70, Issue 1, Page(s) e13–e15

    Abstract: Combined heart-lung transplant (HTLx) is the most durable treatment available for end-stage heart and lung failure. Many patients are unable to receive combined organs due to organ availability and allocation policies prioritizing separate heart or lung ... ...

    Abstract Combined heart-lung transplant (HTLx) is the most durable treatment available for end-stage heart and lung failure. Many patients are unable to receive combined organs due to organ availability and allocation policies prioritizing separate heart or lung transplantation. While an average of 45 HTLxs have been performed per year in the United States half the listed patients do not receive organs. Recently, donation after circulatory death (DCD) utilizing normothermic regional perfusion (NRP) has been utilized for heart allografts with excellent results, and here, we present a case utilizing mobile NRP to procure a heart and lung block from a circulatory death donor and successful implantation for a recipient in a separate center.
    MeSH term(s) Humans ; Heart-Lung Transplantation ; Heart Transplantation ; Organ Preservation/methods ; Tissue Donors ; Perfusion/methods ; Tissue and Organ Procurement ; Graft Survival
    Language English
    Publishing date 2023-12-23
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 759982-1
    ISSN 1538-943X ; 0162-1432 ; 1058-2916
    ISSN (online) 1538-943X
    ISSN 0162-1432 ; 1058-2916
    DOI 10.1097/MAT.0000000000002029
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  10. Article ; Online: Bilateral lung transplantation from a left ventricular assist device supported donor.

    Choi, Kukbin / Spadaccio, Cristiano / Altarabsheh, Salah E / Knop, Gustavo / Spencer, Philip J / Saddoughi, Sahar A / Tabar, Kiumars R / Hassler, Kenneth R / Villavicencio, Mauricio A

    JTCVS techniques

    2023  Volume 19, Page(s) 164–165

    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Case Reports
    ISSN 2666-2507
    ISSN (online) 2666-2507
    DOI 10.1016/j.xjtc.2023.03.024
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