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Article: The Relationship Between Childhood Trauma and Non-Suicidal Self-Injury Behavior in Adolescents with Depression: The Mediating Role of Rumination.

Fu, Wenxian / Li, Xinyi / Ji, Sifan / Yang, Tingting / Chen, Lu / Guo, Yaru / He, Kongliang

Psychology research and behavior management

2024 Volume 17, Page(s) 1477–1485

Abstract: Objective: Non-suicidal self-injury (NSSI) behavior is very common in adolescents with depression, and childhood trauma is considered one of the distal risk factors for its exacerbation. Rumination caused by adverse traumatic experiences, which can be ... ...

Abstract	Objective: Non-suicidal self-injury (NSSI) behavior is very common in adolescents with depression, and childhood trauma is considered one of the distal risk factors for its exacerbation. Rumination caused by adverse traumatic experiences, which can be transferred through NSSI behavior, can alleviate symptoms of depression in adolescents. The current research focuses on the relationship between the three, further exploring whether rumination is a mediator in the relationship between childhood trauma and NSSI behavior on the basis of previous studies, and provides some suggestions for future early intervention for adolescents with depression. Methods: A total of 833 adolescent patients with depression who met the DSM-5 criteria for depressive episode were recruited from 12 hospitals in China. The Chinese version of the Function Assessment of Self-mutilation, Childhood Trauma Questionnaire, and Rumination Inventory were used as research tools. Results: The scores of childhood trauma and rumination in adolescents with depression in the NSSI group were higher than those in the non-NSSI group. A Pearson's correlation analysis showed that childhood trauma was positively correlated with rumination ( Conclusion: Childhood trauma and rumination were key factors for NSSI behavior in adolescents with depression. Childhood trauma not only has a direct effect on NSSI behavior in adolescent depression, but also plays an indirect effect on NSSI behavior through rumination.
Language	English
Publishing date	2024-04-06
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2495093-2
ISSN	1179-1578
ISSN	1179-1578
DOI	10.2147/PRBM.S448248
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Article ; Online: Transcriptional regulation of Treg homeostasis and functional specification.

Wang, Ke / Fu, Wenxian

Cellular and molecular life sciences : CMLS

2020 Volume 77, Issue 21, Page(s) 4269–4287

Abstract: ... ...

Abstract	CD4
MeSH term(s)	Animals ; Epigenesis, Genetic ; Humans ; Inflammation/genetics ; Inflammation/metabolism ; Inflammation/pathology ; Signal Transduction ; T-Lymphocytes, Regulatory/cytology ; T-Lymphocytes, Regulatory/metabolism ; T-Lymphocytes, Regulatory/pathology ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transcriptional Activation
Chemical Substances	Transcription Factors
Language	English
Publishing date	2020-04-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1358415-7
ISSN	1420-9071 ; 1420-682X
ISSN (online)	1420-9071
ISSN	1420-682X
DOI	10.1007/s00018-020-03534-7
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Article ; Online: Improved skill for tracheal intubation using optical stylets through remote training model: a before and after interventional study.

Fu, Danyun / Li, Weixing / Li, Wenxian / Han, Yuan

BMC medical education

2022 Volume 22, Issue 1, Page(s) 668

Abstract: Background: Conducting on-site, hands-on training during the Coronavirus disease 2019 (COVID-19) pandemic has been challenging. We conducted a before and after interventional study to estimate the efficacy of a new remote hands-on training model for ... ...

Abstract	Background: Conducting on-site, hands-on training during the Coronavirus disease 2019 (COVID-19) pandemic has been challenging. We conducted a before and after interventional study to estimate the efficacy of a new remote hands-on training model for improving the trainees' tracheal intubation competency using optical stylets. Methods: Residents or physicians in anesthesiology apartment who have not received the nominated training in tracheal intubation using optical stylets were enrolled. The 4-week training course contains theoretical knowledge along with preclinical and clinical training of optical stylets techniques. Competency of intubation using optical stylets on patients with normal airways was evaluated according to an assessment tool with a maximum score of 29 points based on video recording pre-post training performance. Pre-post questionnaires measured theoretical knowledge and self-efficacy. Results: Twenty-two participants were included (8 females, 14 men, mean age of 33.5 years). The total score of intubation competency was significantly improved after training from 14.6±3.7 to 25.3±2.6 (P < 0.0001). The scores of three subitems (anatomical identification, hand-eye coordination, and optimized intubation condition) were all significantly increased after training (P < 0.0001). The total percentage of correct answers in the multiple-choice questionnaire increased from 58.2%±8.2% before training to 85.2%±7.2% shortly after training (P < 0.0001). In addition, the self-efficacy score was significantly increased from 2.5±1.2 to 4.4±0.6 (P < 0.0001). Conclusions: The new remote and progressively advanced hands-on training model improved the competency of intubation using optical stylets under the COVID-19 pandemic.
MeSH term(s)	Adult ; Anesthesiology/education ; COVID-19/epidemiology ; Clinical Competence ; Female ; Humans ; Intubation, Intratracheal ; Male ; Pandemics
Language	English
Publishing date	2022-09-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2044473-4
ISSN	1472-6920 ; 1472-6920
ISSN (online)	1472-6920
ISSN	1472-6920
DOI	10.1186/s12909-022-03715-x
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Article ; Online: Immune regulation of islet homeostasis and adaptation.

Guo, Jinglong / Fu, Wenxian

Journal of molecular cell biology

2020 Volume 12, Issue 10, Page(s) 764–774

Abstract: The islet of Langerhans produces endocrine hormones to regulate glucose homeostasis. The normal function of the islet relies on the homeostatic regulations of cellular composition and cell-cell interactions within the islet microenvironment. Immune cells ...

Abstract	The islet of Langerhans produces endocrine hormones to regulate glucose homeostasis. The normal function of the islet relies on the homeostatic regulations of cellular composition and cell-cell interactions within the islet microenvironment. Immune cells populate the islet during embryonic development and participate in islet organogenesis and function. In obesity, a low-grade inflammation manifests in multiple organs, including pancreatic islets. Obesity-associated islet inflammation is evident in both animal models and humans, characterized by the accumulation of immune cells and elevated production of inflammatory cytokines/chemokines and metabolic mediators. Myeloid lineage cells (monocytes and macrophages) are the dominant types of immune cells in islet inflammation during the development of obesity and type 2 diabetes mellitus (T2DM). In this review, we will discuss the role of the immune system in islet homeostasis and inflammation and summarize recent findings of the cellular and molecular factors that alter islet microenvironment and β cell function in obesity and T2DM.
MeSH term(s)	Adaptation, Physiological/immunology ; Animals ; Diabetes Mellitus, Type 2/immunology ; Homeostasis ; Humans ; Inflammation/pathology ; Islets of Langerhans/immunology ; Islets of Langerhans/pathology ; Islets of Langerhans/physiopathology ; Obesity/immunology ; Obesity/pathology
Language	English
Publishing date	2020-10-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2500949-7
ISSN	1759-4685 ; 1674-2788
ISSN (online)	1759-4685
ISSN	1674-2788
DOI	10.1093/jmcb/mjaa009
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Article ; Online: Growth performance, antioxidant response, biodegradation and transcriptome analysis of Chlorella pyrenoidosa after nonylphenol exposure.

Feng, Yu / Wang, Ao / Fu, Wenxian / Song, Donghui

The Science of the total environment

2021 Volume 806, Issue Pt 1, Page(s) 150507

Abstract: Chlorella pyrenoidosa was exposed to nonylphenol (NP) to investigate the tolerance, antioxidant response, removal efficiency, and biodegradation mechanism. We conducted studies on algal biomass, chlorophyll a content, and photosynthetic activity, and ... ...

Abstract	Chlorella pyrenoidosa was exposed to nonylphenol (NP) to investigate the tolerance, antioxidant response, removal efficiency, and biodegradation mechanism. We conducted studies on algal biomass, chlorophyll a content, and photosynthetic activity, and found that C. pyrenoidosa exhibited a high tolerance even at 8 mg L
MeSH term(s)	Antioxidants ; Chlorella ; Chlorophyll ; Chlorophyll A ; Gene Expression Profiling ; Phenols ; Water Pollutants, Chemical/analysis ; Water Pollutants, Chemical/toxicity
Chemical Substances	Antioxidants ; Phenols ; Water Pollutants, Chemical ; Chlorophyll (1406-65-1) ; nonylphenol (79F6A2ILP5) ; Chlorophyll A (YF5Q9EJC8Y)
Language	English
Publishing date	2021-09-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2021.150507
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Zs.A 949: Show issues

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Article ; Online: Enhanced degradation of bisphenol A: Influence of optimization of removal, kinetic model studies, application of machine learning and microalgae-bacteria consortia.

Fu, Wenxian / Li, Xiong'e / Yang, Yuru / Song, Donghui

The Science of the total environment

2022 Volume 858, Issue Pt 2, Page(s) 159876

Abstract: Bisphenol A (BPA), a typical endocrine disruptor and a contaminant of emerging concern (CECs), has detrimental impacts not only on the environment and ecosystems, but also on human health. Therefore, it is essential to investigate the degrading processes ...

Abstract	Bisphenol A (BPA), a typical endocrine disruptor and a contaminant of emerging concern (CECs), has detrimental impacts not only on the environment and ecosystems, but also on human health. Therefore, it is essential to investigate the degrading processes of BPA in order to diminish its persistent effects on ecological environmental safety. With this objective, the present study reports on the effectiveness of biotic/abiotic factors in optimizing BPA removal and evaluates the kinetic models of the biodegradation processes. The results showed that BPA affected chlorophyll a, superoxide dismutase (SOD) and peroxidase (POD) activities, malondialdehyde (MDA) content, and photosystem intrinsic PSII efficiency (Fv/Fm) in the microalga Chlorella pyrenoidosa, which degraded 43.0 % of BPA (8.0 mg L
MeSH term(s)	Humans ; Microalgae/metabolism ; Ecosystem ; Chlorella/metabolism ; Chlorophyll A/metabolism ; Artificial Intelligence ; Benzhydryl Compounds/metabolism ; Biodegradation, Environmental ; Bacteria/metabolism ; Machine Learning
Chemical Substances	bisphenol A (MLT3645I99) ; Chlorophyll A (YF5Q9EJC8Y) ; Benzhydryl Compounds
Language	English
Publishing date	2022-11-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.159876
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Article: Growth performance, antioxidant response, biodegradation and transcriptome analysis of Chlorella pyrenoidosa after nonylphenol exposure

Feng, Yu / Wang, Ao / Fu, Wenxian / Song, Donghui

Science of the total environment. 2022 Feb. 01, v. 806

2022

Abstract	Chlorella pyrenoidosa was exposed to nonylphenol (NP) to investigate the tolerance, antioxidant response, removal efficiency, and biodegradation mechanism. We conducted studies on algal biomass, chlorophyll a content, and photosynthetic activity, and found that C. pyrenoidosa exhibited a high tolerance even at 8 mg L⁻¹ of NP. Changes in peroxidase (POD) and superoxide dismutase (SOD) activities indicated that the NP-induced oxidative stress caused oxidant damage, which increased the malondialdehyde (MDA) content. After culturing for 120 h, the NP removal efficiency of C. pyrenoidosa was 89%, 59%, 49%, and 48% in the 2, 4, 6, and 8 mg L⁻¹ treatment groups, respectively. Degradation intermediates determined by GC–MS suggested that the biodegradation of NP in C. pyrenoidosa originated from the long alkyl chain. In addition, transcriptome analysis indicated that NP affected photosynthesis, antioxidase, and oxidoreductase activity-related genes. In summary, our results indicated that C. pyrenoidosa is a species that exhibits high tolerance and biodegradation capacity toward NP.
Keywords	Chlorella pyrenoidosa ; algae ; antioxidant activity ; biodegradation ; biomass ; chlorophyll ; environment ; growth performance ; malondialdehyde ; nonylphenols ; oxidants ; oxidative stress ; peroxidase ; photosynthesis ; superoxide dismutase ; transcriptomics
Language	English
Dates of publication	2022-0201
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2021.150507
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Article ; Online: Fibroblast-macrophage reciprocal interactions in health, fibrosis, and cancer.

Buechler, Matthew B / Fu, Wenxian / Turley, Shannon J

Immunity

2021 Volume 54, Issue 5, Page(s) 903–915

Abstract: Fibroblasts and macrophages are present in all tissues, and mounting evidence supports that these cells engage in direct communication to influence the overall tissue microenvironment and affect disease outcomes. Here, we review the current understanding ...

Abstract	Fibroblasts and macrophages are present in all tissues, and mounting evidence supports that these cells engage in direct communication to influence the overall tissue microenvironment and affect disease outcomes. Here, we review the current understanding of the molecular mechanisms that underlie fibroblast-macrophage interactions in health, fibrosis, and cancer. We present an integrated view of fibroblast-macrophage interactions that is centered on the CSF1-CSF1R axis and discuss how additional molecular programs linking these cell types can underpin disease onset, progression, and resolution. These programs may be tissue and context dependent, affected also by macrophage and fibroblast origin and state, as seen most clearly in cancer. Continued efforts to understand these cells and the means by which they interact may provide therapeutic approaches for the treatment of fibrosis and cancer.
MeSH term(s)	Animals ; Cell Differentiation/physiology ; Fibroblasts/metabolism ; Fibrosis/metabolism ; Humans ; Macrophage Colony-Stimulating Factor/metabolism ; Macrophages/metabolism ; Neoplasms/metabolism ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/metabolism ; Tumor Microenvironment/physiology
Chemical Substances	Receptors, Granulocyte-Macrophage Colony-Stimulating Factor ; Macrophage Colony-Stimulating Factor (81627-83-0)
Language	English
Publishing date	2021-05-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2021.04.021
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Zs.A 4227: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Synergetic effects of microbial-phytoremediation reshape microbial communities and improve degradation of petroleum contaminants.

Wang, Ao / Fu, Wenxian / Feng, Yu / Liu, Zhimin / Song, Donghui

Journal of hazardous materials

2022 Volume 429, Page(s) 128396

Abstract: Microbial-phytoremediation is an effective bioremediation technology that introduces petroleum-degrading bacteria and oil-tolerant plants into oil-contaminated soils in order to achieve effective degradation of total petroleum hydrocarbons (TPH). In this ...

Abstract	Microbial-phytoremediation is an effective bioremediation technology that introduces petroleum-degrading bacteria and oil-tolerant plants into oil-contaminated soils in order to achieve effective degradation of total petroleum hydrocarbons (TPH). In this work, natural attenuation (NA), microbial remediation (MR, using Acinetobacter sp. Tust-DM21), phytoremediation (PR, using Suaeda glauca), and microbial-phytoremediation (MPR, using both species) were utilized to degrade petroleum hydrocarbons. We evaluated four different biological treatments, assessing TPH degradation rates, soil enzyme activities, and the structure of microbial community in the petroleum-contaminated soil. This finding revealed that the roots of Suaeda glauca adsorbed small amounts of polycyclic aromatic hydrocarbons, causing the structure of soil microbiota community to reshape. The abundance of petroleum-degrading bacteria and plant growth-promoting rhizobacteria (PGPR) has increased, as has microbial diversity. According to correlation research, these genera increased soil enzyme activity, boosted the number of degradation-functional genes in the petroleum hydrocarbon degradation pathway, and accelerated the dissipation and degradation of TPH in petroleum-contaminated soil. This evidence contributes to a better understanding of the mechanisms involved in the combined microbial-phytoremediation strategies for contaminated soil, specifically the interaction between microflora and plants in co-remediation and the effects on the structural reshaping of rhizosphere microbial communities.
MeSH term(s)	Biodegradation, Environmental ; Hydrocarbons/metabolism ; Microbiota ; Petroleum/metabolism ; Soil/chemistry ; Soil Microbiology ; Soil Pollutants/metabolism
Chemical Substances	Hydrocarbons ; Petroleum ; Soil ; Soil Pollutants
Language	English
Publishing date	2022-02-01
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2022.128396
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Article ; Online: Pretreatment with Low-Dose Esketamine for Reduction of Propofol Injection Pain: A Randomized Controlled Trial.

Fu, Danyun / Wang, Dingding / Li, Wenxian / Han, Yuan / Jia, Jie

Pain research & management

2022 Volume 2022, Page(s) 4289905

Abstract: Background: Propofol-induced injection pain is a common adverse effect during the induction of general anesthesia. The purpose of this study is to investigate the effect of low-dose esketamine in preventing propofol injection pain.: Methods: In this ... ...

Abstract	Background: Propofol-induced injection pain is a common adverse effect during the induction of general anesthesia. The purpose of this study is to investigate the effect of low-dose esketamine in preventing propofol injection pain. Methods: In this double-blind, randomized, controlled trial, patients scheduled for elective ear surgery under general anesthesia received either normal saline (NS), or 40 mg lidocaine, or 0.15 mg/kg esketamine 30 seconds before manual injection of propofol. The primary outcome of this study was the incidence of propofol injection pain. The secondary outcomes included injection pain score, vital signs, total dosage of vasoactive drugs used within 5 minutes after induction, and adverse events related to drugs. Results: A total of 105 patients were included. Compared with the NS group (67%), pretreatment with esketamine and lidocaine significantly reduced the incidence of injection pain to 29% and 33%, respectively (both Conclusions: Pretreatment with a low-dose esketamine can not only reduce the incidence of propofol injection pain but also provide a more stable circulation in patients after anesthesia induction. This convenient, well-tolerated, and economic treatment appears as an option to be routinely applied in clinic practice.
MeSH term(s)	Anesthetics, Intravenous/adverse effects ; Double-Blind Method ; Humans ; Ketamine ; Lidocaine/therapeutic use ; Pain/chemically induced ; Pain/etiology ; Propofol/adverse effects
Chemical Substances	Anesthetics, Intravenous ; Esketamine (50LFG02TXD) ; Ketamine (690G0D6V8H) ; Lidocaine (98PI200987) ; Propofol (YI7VU623SF)
Language	English
Publishing date	2022-08-02
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2041085-2
ISSN	1918-1523 ; 1203-6765
ISSN (online)	1918-1523
ISSN	1203-6765
DOI	10.1155/2022/4289905
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