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Article: Integrative Approach to Identifying System-Level Mechanisms of Chung-Sang-Bo-Ha-Hwan's Influence on Respiratory Tract Diseases: A Network Pharmacological Analysis with Experimental Validation.

Park, Sa-Yoon / Kim, Kang-Sub / Lee, Won-Yung / Kim, Chang-Eop / Lee, Sullim

2023 Volume 12, Issue 17

Abstract: Chung-Sang-Bo-Ha-Hwan (CSBHH) is an herbal prescription widely used to treat various ...

Abstract	Chung-Sang-Bo-Ha-Hwan (CSBHH) is an herbal prescription widely used to treat various chronic respiratory diseases. To investigate the system-level treatment mechanisms of CSBHH in respiratory tract diseases, we identified 56 active ingredients of CSBHH and evaluated the degree of overlap between their targets and respiratory tract disease-associated proteins. We then investigated the respiratory tract disease-related signaling pathways associated with CSBHH targets. Enrichment analysis showed that the CSBHH targets were significantly associated with various signaling pathways related to inflammation, alveolar structure, and tissue fibrosis. Experimental validation was conducted using phorbol-12-myristate-13-acetate (PMA)-stimulated NCI-H292 cells by analyzing the mRNA expression levels of biomarkers (IL-1β and TNF-α for inflammation; GSTP1, GSTM1, and PTEN for apoptosis) derived from network pharmacological analysis, in addition to the mucin genes MUC5AC and MUC2, to investigate the phlegm-expelling effect of CSBHH. The mRNA expression levels of these genes were consistent with network pharmacological predictions in a concentration-dependent manner. These results suggest that the therapeutic mechanisms of CSBHH in respiratory tract diseases could be attributed to the simultaneous action of multiple active ingredients in the herbal prescription.
Language	English
Publishing date	2023-08-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants12173024
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Article ; Online: The PIKK-AKT connection in the DNA damage response.

Shin, Sejeong / Walker, Katherine A / Yoon, Sang-Oh

Science signaling

2022 Volume 15, Issue 715, Page(s) eabm6211

Abstract: DNA damage and subsequent cellular response are the basis for many cancer treatments. In this issue ... ...

Abstract	DNA damage and subsequent cellular response are the basis for many cancer treatments. In this issue of
MeSH term(s)	DNA Damage ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2022-01-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Comment
ZDB-ID	2417226-1
ISSN	1937-9145 ; 1945-0877
ISSN (online)	1937-9145
ISSN	1945-0877
DOI	10.1126/scisignal.abm6211
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Article ; Online: Native Whole Blood (TRUE-NATEM) and Recalcified Citrated Blood (NATEM) Reference Value Validation with ROTEM Delta.

Yoon, Uzung

Seminars in cardiothoracic and vascular anesthesia

2023 Volume 27, Issue 3, Page(s) 199–207

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Adult ; Humans ; Female ; Reference Values ; Blood Coagulation ; Thrombelastography/methods ; Citric Acid ; Citrates
Chemical Substances	antineoplaston A10 (16VY3TM7ZO) ; Citric Acid (2968PHW8QP) ; Citrates
Language	English
Publishing date	2023-01-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2012371-1
ISSN	1940-5596 ; 1089-2532
ISSN (online)	1940-5596
ISSN	1089-2532
DOI	10.1177/10892532231151528
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Article ; Online: Blood-inspired random bit generation using microfluidics system.

Yoon, Inkwon / Han, Jong Hyeok / Park, Byeong Uk / Jeon, Hee-Jae

Scientific reports

2024 Volume 14, Issue 1, Page(s) 7474

Abstract: ... In this study, we present a blood-inspired RNG system with a microfluidics device, designed to generate random ... unpredictability. Our blood-inspired RNG, utilizing whole blood, offers a pathway for affordable, high-output ...

Abstract	The development of random number generators (RNGs) using speckle patterns is pivotal for secure encryption key generation, drawing from the recent statistical properties identified in speckle-based imaging. Speckle-based RNG systems generate a sequence of random numbers through the unpredictable and reproducible nature of speckle patterns, ensuring a source of randomness that is independent of algorithms. However, to guarantee their effectiveness and reliability, these systems demand a meticulous and rigorous approach. In this study, we present a blood-inspired RNG system with a microfluidics device, designed to generate random numbers at a rate of 5.5 MHz and a high-speed of 1250 fps. This process is achieved by directing a laser beam through a volumetric scattering medium to procure speckle patterns. Additionally, designed microfluidic device requires only a minimal blood sample of 5 µl to capture these speckle patterns effectively. After implementing the two-pass tuple-output von Neumann debiasing algorithm to counteract statistical biases, we utilized the randomness statistical test suite from the National Institute of Standards and Technology for validation. The generated numbers successfully passed these tests, ensuring their randomness and unpredictability. Our blood-inspired RNG, utilizing whole blood, offers a pathway for affordable, high-output applications in fields like encryption, computer security, and data protection.
Language	English
Publishing date	2024-03-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-58088-6
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Article ; Online: Blood eosinophil count as a prognostic biomarker in COPD.

Oh, Yeon-Mok / Lee, Keu Sung / Hong, Yoonki / Hwang, Sung Chul / Kim, Jae Yeol / Kim, Deog Keom / Yoo, Kwang Ha / Lee, Ji-Hyun / Kim, Tae-Hyung / Lim, Seong Yong / Rhee, Chin Kook / Yoon, Hyoung Kyu / Lee, Sang Yeub / Park, Yong Bum / Jung, Jin Hee / Kim, Woo Jin / Lee, Sang-Do / Park, Joo Hun

International journal of chronic obstructive pulmonary disease

2018 Volume 13, Page(s) 3589–3596

Abstract: Background: High blood eosinophil count is a predictive biomarker for response to inhaled ... corticosteroids in prevention of acute exacerbation of COPD, and low blood eosinophil count is associated ... with pneumonia risk in COPD patients taking inhaled corticosteroids. However, the prognostic role of blood ...

Abstract	Background: High blood eosinophil count is a predictive biomarker for response to inhaled corticosteroids in prevention of acute exacerbation of COPD, and low blood eosinophil count is associated with pneumonia risk in COPD patients taking inhaled corticosteroids. However, the prognostic role of blood eosinophil count remains underexplored. Therefore, we investigated the associated factors and mortality based on blood eosinophil count in COPD. Methods: Patients with COPD were recruited from 16 hospitals of the Korean Obstructive Lung Disease cohort (n=395) and COPD in Dusty Area cohort (n=234) of Kangwon University Hospital. The two merged cohorts were divided based on blood eosinophil count into three groups: high (≥5%), middle (2%-5%), and low (<2%). Results: The high group had longer six-minute walk distance (high =445.8±81.4, middle =428.5±88.0, and low =414.7±86.3 m), higher body mass index (23.3±3.1, 23.1±3.1, and 22.5±3.2 kg/m Conclusion: In COPD, the severity of emphysema was independently linked with low blood eosinophil count and the longer survival period was associated with increased blood eosinophil count, though it was not proven in the multivariate analysis.
MeSH term(s)	Aged ; Body Mass Index ; Case-Control Studies ; Eosinophils ; Exercise Tolerance ; Female ; Humans ; Leukocytes ; Lung/physiopathology ; Male ; Middle Aged ; Prognosis ; Pulmonary Disease, Chronic Obstructive/blood ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/mortality ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Pulmonary Emphysema/blood ; Pulmonary Emphysema/diagnosis ; Pulmonary Emphysema/mortality ; Pulmonary Emphysema/physiopathology ; Republic of Korea ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; Time Factors ; Walk Test
Language	English
Publishing date	2018-10-31
Publishing country	New Zealand
Document type	Journal Article ; Multicenter Study
ZDB-ID	2212419-6
ISSN	1178-2005 ; 1176-9106
ISSN (online)	1178-2005
ISSN	1176-9106
DOI	10.2147/COPD.S179734
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Article ; Online: Effect of tranexamic acid on blood loss after reverse total shoulder arthroplasty according to the administration method: a prospective, multicenter, randomized, controlled study.

Yoon, Ji Young / Park, Joo Hyun / Kim, Yang Soo / Shin, Sang Jin / Yoo, Jae Chul / Oh, Joo Han

Journal of shoulder and elbow surgery

2020 Volume 29, Issue 6, Page(s) 1087–1095

Abstract: ... secondary outcomes were total drain volume, transfusion rate, and calculated total blood loss.: Results ... 270), and total blood loss (701.1 ± 352.3 vs. 656.5 ± 285.6 vs. 699.0 ± 248.7 mL, P = .810) were not ... group, although the difference was not statistically significant (P = .084).: Conclusion: Blood loss ...

Abstract	Background: The ideal method of administering tranexamic acid (TXA) for reverse total shoulder arthroplasty (RTSA) remains unknown. We aimed to evaluate TXA efficacy according to 3 administration methods after RTSA. Methods: Overall, 102 patients who underwent RTSA using a single implant between September 2016 and November 2018 were randomized to the following groups according to the TXA administration method: intravenous (n = 34; 1 g + 0.9% normal saline 100 mL), topical (n = 33; 2 g + 0.9% normal saline 50 mL), and combined groups (n = 34). Patients were enrolled in 4 tertial referral hospitals for prospective multicenter studies. The primary outcome was a hemoglobin decrease in 24 hours postoperatively; secondary outcomes were total drain volume, transfusion rate, and calculated total blood loss. Results: Demographic data, including preoperative hemoglobin levels, were not different among the 3 groups, but the average age was higher in the combined group (P = .038). Hemoglobin decrease (1.8 ± 1.1 vs. 1.8 ± 1.0 vs. 2.0 ± 1.1 g/dL, P = .769), total drain volume (209.2 ± 147.6 vs. 167.2 ± 102.0 vs. 166.0 ± 118.7, P = .270), and total blood loss (701.1 ± 352.3 vs. 656.5 ± 285.6 vs. 699.0 ± 248.7 mL, P = .810) were not significantly different among the 3 groups (all P > .05). The transfusion rate was higher in the intravenous group (n = 4), whereas only 1 patient had transfusion in the topical group and none in the combined group, although the difference was not statistically significant (P = .084). Conclusion: Blood loss did not differ among TXA administration methods after RTSA. However, considering the risk of complication in intravenous TXA, topical TXA after RTSA may be safer, even for patients with normal risk for venous thromboembolic complication.
MeSH term(s)	Administration, Intravenous ; Administration, Topical ; Aged ; Antifibrinolytic Agents/administration & dosage ; Arthritis/diagnosis ; Arthritis/etiology ; Arthritis/surgery ; Arthroplasty, Replacement, Shoulder/adverse effects ; Arthroplasty, Replacement, Shoulder/methods ; Blood Loss, Surgical/prevention & control ; Blood Transfusion ; Drainage ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Tranexamic Acid/administration & dosage
Chemical Substances	Antifibrinolytic Agents ; Tranexamic Acid (6T84R30KC1)
Language	English
Publishing date	2020-04-22
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	1170782-3
ISSN	1532-6500 ; 1058-2746
ISSN (online)	1532-6500
ISSN	1058-2746
DOI	10.1016/j.jse.2020.02.013
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Article: Association between diet quality and type of meal companion: the 2013-2015 Korea National Health and Nutrition Examination Survey (KNHANES).

Yoon, Yeong Sook / Oh, Sang Woo

Nutrition research and practice

2023 Volume 17, Issue 3, Page(s) 553–564

Abstract: Background/objectives: A meal companion is an important social determinant of eating behaviors and is related to what and how much a person will eat within the social context. This study examined the difference in diet quality according to the type of ... ...

Abstract	Background/objectives: A meal companion is an important social determinant of eating behaviors and is related to what and how much a person will eat within the social context. This study examined the difference in diet quality according to the type of dining companion. Subjects/methods: This study included 15,074 adults (6,180 men and 8,894 women, ≥ 19 years) who participated in the 6th (2013-2015) Korea National Health and Nutrition Examination Survey. Korean Healthy Eating Index (KHEI) scores were calculated using the food frequency questionnaire data. Survey multivariate linear regression analysis was used to assess the association of dining companions (ordinary type, eating with family members, eating alone, and eating with others) and the total and component scores of KHEI. Results: People who exclusively ate with someone other than family or exclusively ate alone had lower total KHEI scores in both men (57.23 ± 0.67, 58.56 ± 0.73 vs. 62.71 ± 0.26) and women (57.6 3±0.97, 63.89±0.58 vs. 65.79±0.22) compared to people with the ordinary type (all Conclusion: The diet quality differed according to the meal companion type. People who always ate with someone other than family members and men who ate alone showed lower diet quality scores than the ordinary type. More research will be needed to improve their adherence to dietary recommendations.
Language	English
Publishing date	2023-01-25
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2387946-4
ISSN	2005-6168 ; 1976-1457
ISSN (online)	2005-6168
ISSN	1976-1457
DOI	10.4162/nrp.2023.17.3.553
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Article: Sustainable animal agriculture in the United States and the implication in Republic of Korea.

Yoon, Inkuk / Oh, Sang-Hyon / Kim, Sung Woo

Journal of animal science and technology

2024 Volume 66, Issue 2, Page(s) 279–294

Abstract: Agriculture has played a significant role in the national economy, contributing to food security, driving economic growth, and safeguarding the dietary habits of the population. Korean agriculture has been compelled to focus on intensive farming due to ... ...

Abstract	Agriculture has played a significant role in the national economy, contributing to food security, driving economic growth, and safeguarding the dietary habits of the population. Korean agriculture has been compelled to focus on intensive farming due to its limited cultivation area, excessive input costs, and the limitations of agricultural mechanization. In the Republic of Korea (R.O.K), the concept of environmentally friendly animal agriculture began to be introduced in the early 2000s. This concept ultimately aims to cultivate sustainable animal agriculture (SAA) through environmentally friendly production practices, ensuring the healthy rearing of animals to supply safe animal products. Despite the government's efforts, there are still significant challenges in implementing environmentally friendly agriculture and SAA in the R.O.K. Therefore, the objective of this review is to establish the direction that the animal agriculture sector should take in the era of climate crisis, and to develop effective strategies for SAA tailored to the current situation in the R.O.K by examining the trends in SAA in the U.S. The animal agriculture sector in the U.S. has been working towards creating a SAA system where humans, animals, and the environment can coexist through government initiatives, industry research, technological support, and individual efforts. Efforts have been made to reduce emissions like carbon, and improve factors affecting the environment such as the carbon footprint, odor, and greenhouse gases associated with animal agriculture processes for animals such as cattle and pigs. The transition of the U.S. towards SAA appears to be driven by both external goals related to addressing climate change and the primary objectives of responding to the demand for safe animal products, expanding consumption, and securing competitiveness in overseas export markets. The demand for animal welfare, organic animal products, and processed goods has been increasing in the U.S. consumer market. A major factor in the transformation of the U.S. animal agriculture sector in terms of livestock specifications is attributed to environmentally friendly practices such as high-quality feed, heat stress reduction, improvements in reproductive ability and growth period reduction, and efforts in animal genetic enhancement.
Language	English
Publishing date	2024-03-31
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2775231-8
ISSN	2055-0391
ISSN	2055-0391
DOI	10.5187/jast.2024.e19
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Article ; Online: Ran-Binding Protein 3 Phosphorylation Links the Ras and PI3-Kinase Pathways to Nucleocytoplasmic Transport.

Yoon, Sang-Oh / Shin, Sejeong / Liu, Yuzhen / Ballif, Bryan A / Woo, Michele S / Gygi, Steven P / Blenis, John

Molecular cell

2023 Volume 83, Issue 22, Page(s) 4190

MeSH term(s)	Phosphorylation ; Active Transport, Cell Nucleus ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Signal Transduction ; Phosphatidylinositol 3-Kinase/metabolism ; ran GTP-Binding Protein/genetics ; ran GTP-Binding Protein/metabolism ; Proto-Oncogene Proteins c-akt/metabolism
Chemical Substances	Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Phosphatidylinositol 3-Kinase (EC 2.7.1.137) ; ran GTP-Binding Protein (EC 3.6.5.2) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2023-11-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	1415236-8
ISSN	1097-4164 ; 1097-2765
ISSN (online)	1097-4164
ISSN	1097-2765
DOI	10.1016/j.molcel.2023.10.041
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Zs.A 5055: Show issues

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Article: Diagnostic value of peripheral blood immune profiling in colorectal cancer.

Choi, Joungbum / Maeng, Hyung Gun / Lee, Su Jin / Kim, Young Joo / Kim, Da Woon / Lee, Ha Na / Namgung, Ji Hyeon / Oh, Hyun-Mee / Kim, Tae Joo / Jeong, Ji Eun / Park, Sang Jean / Choi, Yong Man / Kang, Yong Won / Yoon, Seo Gue / Lee, Jong Kyun

Annals of surgical treatment and research

2018 Volume 94, Issue 6, Page(s) 312–321

Abstract: Purpose: Little is known about the clinical value of peripheral blood immune profiling. Here ... we aimed to identify colorectal cancer (CRC)-related peripheral blood immune cells and develop liquid ... biopsy-based immune profiling models for CRC diagnosis.: Methods: Peripheral blood from 131 ...

Abstract	Purpose: Little is known about the clinical value of peripheral blood immune profiling. Here, we aimed to identify colorectal cancer (CRC)-related peripheral blood immune cells and develop liquid biopsy-based immune profiling models for CRC diagnosis. Methods: Peripheral blood from 131 preoperative patients with CRC and 174 healthy controls was analyzed by flow cytometry and automated hematology. CRC-related immune factors were identified by comparing the mean values of immune cell percentages and counts. Subsequently, CRC diagnostic algorithms were constructed using binary logistic regression. Results: Significant differences were observed in percentages and counts of white blood cells, lymphocytes, neutrophils, regulatory T cells, and myeloid-derived suppressor cells (MDSCs) of patients and controls. The neutrophil/lymphocyte and Th1/Th2 ratios were also significantly different. Likewise, the percentages and counts of peripheral blood programed death 1, cytotoxic T lymphocyte antigen 4, B-and T-lymphocyte attenuator, and lymphocyte activation gene-3 were higher in patients with CRC. The binary logistic regression model included 12 variables, age, CD3 Conclusion: Peripheral blood immune profiling may be valuable in evaluating the immunity of CRC patients. Our liquid biopsy-based immune diagnostic method and its algorithms may serve as a novel tool for CRC diagnosis. Future largescale studies are needed for better characterization of its diagnostic value and potential for clinical application.
Language	English
Publishing date	2018-05-29
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	3012234-X
ISSN	2288-6796 ; 2288-6575
ISSN (online)	2288-6796
ISSN	2288-6575
DOI	10.4174/astr.2018.94.6.312
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